Gene: COPA

1314
AILJK|HEP-COP
coatomer protein complex subunit alpha
protein-coding
1q23.2
Ensembl:ENSG00000122218 MIM:601924 Vega:OTTHUMG00000033111 UniprotKB:P53621
NG_050927.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  1.534e-1 (ND)   (Frontal_Cortex)
5.915e-1 (AD)  6.334e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPO70.959
CKAP50.957
CUL10.954
AP2B10.953
SENP20.953
KPNA60.952
USP70.952
CSNK2A10.952
WDR820.951
RAD23B0.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.721
OR4F29-0.683
MTRNR2L6-0.287
KLRB1-0.28
MTRNR2L10-0.277
MTRNR2L9-0.268
TFPI2-0.261
CSAG1-0.261
FZD10-0.255
ASB4-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of COPA mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of COPA mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of COPA mRNA17562736
C015001arsenitearsenite results in increased methylation of COPA promoter23974009
D001280AtrazineAtrazine results in decreased expression of COPA mRNA22378314
C547126AZM551248AZM551248 results in increased expression of COPA mRNA22323515
C006780bisphenol Abisphenol A affects the expression of COPA mRNA21786754
C006780bisphenol Abisphenol A affects the expression of COPA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of COPA mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of COPA mRNA15336504
C584509C646 compoundC646 compound results in increased expression of COPA mRNA26191083
C100187chloropicrinchloropicrin results in increased expression of COPA mRNA26352163
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of COPA mRNA16197558
C018021cobaltous chloridecobaltous chloride results in decreased expression of COPA mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of COPA mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COPA mRNA]27941970
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of COPA mRNA"25908611
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of COPA mRNA20227414
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to COPA protein27129696
D005485FlutamideFlutamide results in increased expression of COPA mRNA24136188
D005839GentamicinsGentamicins results in increased expression of COPA mRNA22061828
D005897GlafenineGlafenine results in increased expression of COPA mRNA24136188
C051890irinotecanirinotecan analog results in increased expression of COPA mRNA18927307
C410337K 7174K 7174 results in increased expression of COPA mRNA24086573
D007854LeadLead results in decreased expression of COPA mRNA19921347
D008627Mercuric ChlorideMercuric Chloride affects the expression of COPA mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of COPA mRNA28001369
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COPA mRNA]12710931
D008777MethyltestosteroneMethyltestosterone results in increased expression of COPA mRNA29191790
C025256nonylphenolnonylphenol results in increased expression of COPA mRNA22982499
C494474perchlorateperchlorate results in increased expression of COPA mRNA18801409
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of COPA protein26879310
D010578PetroleumPetroleum affects the expression of COPA mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of COPA mRNA23091169
C009277sodium arsenatesodium arsenate results in increased expression of COPA mRNA16882884|2392266
D012969Sodium FluorideSodium Fluoride results in decreased expression of COPA protein28918527
D019284ThapsigarginThapsigargin results in increased expression of COPA mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of COPA mRNA28065790
D014415TunicamycinTunicamycin results in increased expression of COPA mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of COPA mRNA17127020
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COPA mRNA]12710931
D014635Valproic AcidValproic Acid results in decreased methylation of COPA gene29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of COPA mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IEA-  
GO:0005198structural molecule activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006888ER to Golgi vesicle-mediated transport-IBA21873635  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-IBA21873635  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TAS-  
GO:0006891intra-Golgi vesicle-mediated transport-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030157pancreatic juice secretion-IDA1429581  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005615extracellular space-IDA1429581  
GO:0005737cytoplasm-IDA9115636  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030126COPI vesicle coat-IBA21873635  
GO:0030126COPI vesicle coat-IDA14729954  
GO:0030126COPI vesicle coat-ISS-  
GO:0030133transport vesicle-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10500942Arterial to end-tidal carbon dioxide tension difference in anaesthetized adults mechanically ventilated via a laryngeal mask or a cuffed oropharyngeal airway. (1999 Aug)Casati AEur J Anaesthesiol