Gene: CD200R1

131450
CD200R|HCRTR2|MOX2R|OX2R
CD200 receptor 1
protein-coding
3q13.2
Ensembl:ENSG00000163606 MIM:607546 Vega:OTTHUMG00000159298 UniprotKB:Q8TD46
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.076e-2 (AD)  9.436e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN160.745
PPIP5K20.732
RINT10.732
ANAPC10.732
TTC39C0.731
CAPS20.731
SLC26A40.73
ATR0.73
GTPBP100.729
SLC25A360.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.426
FOXJ1-0.415
CCDC102A-0.411
MYL3-0.405
S100A1-0.397
LYPD1-0.387
EVC2-0.387
HIGD1B-0.386
WSCD1-0.386
ROM1-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CD200R1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD200R1 mRNA"25380136
D020106AcrylamideAcrylamide results in increased expression of CD200R1 mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CD200R1 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD200R1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD200R1 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of CD200R1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CD200R1 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD200R1 mRNA20938992
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
D004041Dietary FatsDietary Fats results in decreased expression of CD200R1 mRNA18721800
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CD200R1 mRNA28085963
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CD200R1 mRNA25380136
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD200R1 mRNA20938992
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA27424125
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200R1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CD200R1 mRNA27432991
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CD200R1 mRNA25890327
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD200R1 mRNA20938992
C523799MRK 003CD200R1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD200R1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD200R1 mRNA"25554681
D009532NickelNickel results in decreased expression of CD200R1 mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD200R1 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of CD200R1 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of CD200R1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CD200R1 mRNA19073995
D053260SootSoot results in increased expression of CD200R1 mRNA22461453
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200R1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD200R1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD200R1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD200R1 mRNA25729387
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD200R1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  
GO ID GO Term Qualifier Evidence PubMed
GO:0016032viral process-IEA-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27710895CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-kappaB pathway in cigarette smoke extract induced endothelial cells. (2016 Dec)Xu JBiomed Pharmacother