Gene: LRRC15

131578
LIB
leucine rich repeat containing 15
protein-coding
3q29
Ensembl:ENSG00000172061 Vega:OTTHUMG00000156048 UniprotKB:Q8TF66
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.294e-1 (AD)  9.628e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAX0.861
ITK0.856
CALCA0.855
CHRNB40.831
POU4F10.804
PLEKHS10.777
DMBX10.776
MMP100.767
TSLP0.741
ADM20.729

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB37-0.253
OMG-0.249
EIF4E1B-0.248
HS3ST4-0.248
CKMT1B-0.242
SHD-0.239
C2orf27A-0.239
IGLON5-0.237
FAM19A1-0.237
NEUROD2-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of LRRC15 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of LRRC15 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LRRC15 mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of LRRC15 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of LRRC15 mRNA25181051
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LRRC15 mRNA20360939
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRC15 gene20938992
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LRRC15 mRNA20360939
D002117CalcitriolCalcitriol results in decreased expression of LRRC15 mRNA26485663
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of LRRC15 promoter27415467
D005419FlavonoidsFlavonoids results in decreased expression of LRRC15 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRC15 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of LRRC15 mRNA19167457
D019833GenisteinGenistein results in increased expression of LRRC15 mRNA20884965
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LRRC15 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRC15 gene20938992
C028007nickel monoxidenickel monoxide results in decreased expression of LRRC15 mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LRRC15 mRNA26705709
D011192Potassium DichromatePotassium Dichromate results in increased expression of LRRC15 mRNA23608068
C017947sodium arsenitesodium arsenite results in increased expression of LRRC15 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRRC15 mRNA22903824
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of LRRC15 mRNA28973375
D014520UrethaneUrethane results in increased expression of LRRC15 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LRRC15 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LRRC15 mRNA23179753|2800136
D014638VanadatesVanadates results in increased expression of LRRC15 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRRC15 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001968fibronectin binding-IDA16098915  
GO:0005518collagen binding-IDA16098915  
GO:0043236laminin binding-IDA16098915  
GO ID GO Term Qualifier Evidence PubMed
GO:0030335positive regulation of cell migration-IMP16098915  
GO:0046813receptor-mediated virion attachment to host cell-IMP18385238  
GO:1903077negative regulation of protein localization to plasma membrane-IMP18385238  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0031012extracellular matrixcolocalizes_withIDA16098915  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24641868Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)Evans RLCancer Prev Res (Phila)