Gene: KLF6

1316
BCD1|CBA1|COPEB|CPBP|GBF|PAC1|ST12|ZF9
Kruppel like factor 6
protein-coding
10p15.2
Ensembl:ENSG00000067082 MIM:602053 Vega:OTTHUMG00000017567 UniprotKB:Q99612
NG_012277.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  1.827e-1 (ND)   (Frontal_Cortex)
2.639e-1 (AD)  7.447e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01496720chr10:3825398KLF62.000e-9Smoking27651444
cg24287110chr10:3824687KLF63.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCL10.806
CTTNBP2NL0.787
HLA-E0.771
B4GALT10.769
TNFAIP30.766
VCL0.764
FOSL20.763
NFKB10.762
NFKBIA0.762
ARF60.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.428
OR4F5-0.387
LYPD8-0.271
CRYBA2-0.23
MYADML2-0.222
NKX2-8-0.216
NEU4-0.204
MYCNOS-0.196
DIAPH3-0.192
C20orf85-0.19

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C09724015-deoxy-delta(12,14)-prostaglandin J2"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein"16611854
C09724015-deoxy-delta(12,14)-prostaglandin J2"RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]"16611854
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF6 mRNA28329830
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of KLF6 mRNA17690111
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of KLF6 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLF6 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KLF6 mRNA"21346803
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KLF6 mRNA"20816883
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KLF6 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of KLF6 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of KLF6 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of KLF6 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of KLF6 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KLF6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF6 mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of KLF6 mRNA17202762
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]18098314
D012436S-AdenosylmethionineS-Adenosylmethionine results in decreased expression of KLF6 mRNA18098314
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KLF6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KLF6 mRNA19770486
C430898AGN 194204AGN 194204 results in decreased expression of KLF6 mRNA16339527
C000188alachloralachlor results in increased expression of KLF6 mRNA12419858
C103303alitretinoin"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein"16611854
C103303alitretinoin"RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]"16611854
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of KLF6 mRNA21298039
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KLF6 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLF6 mRNA16483693
D000965AntimonyAntimony results in increased expression of KLF6 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of KLF6 mRNA17547211
C015001arsenitearsenite affects the expression of KLF6 mRNA22959463
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KLF6 mRNA"18687144|2535159
D001280AtrazineAtrazine results in increased expression of KLF6 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of KLF6 mRNA21245298
D001374AzacitidineTP73 protein promotes the reaction [Azacitidine results in increased expression of KLF6 mRNA]21245298
D001379AzathioprineAzathioprine results in increased expression of KLF6 mRNA22623647
D001554BenzeneBenzene results in decreased expression of KLF6 mRNA19162166
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of KLF6 mRNA19737606
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of KLF6 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLF6 mRNA21871943|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLF6 mRNA19770486|2156981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLF6 mRNA"20018196
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of KLF6 mRNA]24758408
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of KLF6 mRNA20404318
D004958EstradiolEstradiol results in decreased expression of KLF6 mRNA19167446|2475840
D004958EstradiolEstradiol results in increased expression of KLF6 mRNA20106945
C044887beta-methylcholinebeta-methylcholine affects the expression of KLF6 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of KLF6 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of KLF6 mRNA20977926
D002104CadmiumCadmium results in increased expression of KLF6 mRNA21120746|2428428
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KLF6 mRNA19010381
D002220CarbamazepineCarbamazepine affects the expression of KLF6 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLF6 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLF6 mRNA15728706
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of KLF6 mRNA19395590
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of KLF6 mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of KLF6 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of KLF6 mRNA23125180
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLF6 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of KLF6 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF6 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KLF6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF6 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of KLF6 mRNA22941251
C018021cobaltous chloridecobaltous chloride results in increased expression of KLF6 mRNA24386269
D003078ColchicineColchicine results in increased expression of KLF6 mRNA24211769
D019327Copper SulfateCopper Sulfate results in increased expression of KLF6 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLF6 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of KLF6 mRNA19167446
C029892cupric chloridecupric chloride affects the expression of KLF6 mRNA17211630
D003474CurcuminCurcumin results in increased expression of KLF6 mRNA15713895
D016572CyclosporineCyclosporine results in increased expression of KLF6 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of KLF6 mRNA21865292
C089595cylindrospermopsincylindrospermopsin results in increased expression of KLF6 mRNA24921660
C014347decitabinedecitabine affects the expression of KLF6 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of KLF6 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KLF6 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KLF6 mRNA21266533
D003997DicarbethoxydihydrocollidineDicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA18098314
D003997DicarbethoxydihydrocollidineS-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]18098314
D002945CisplatinCisplatin affects the expression of KLF6 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KLF6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KLF6 mRNA19561079|2421176
D002945CisplatinCisplatin results in decreased expression of KLF6 mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of KLF6 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of KLF6 mRNA19030233|2260994
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA]19030233
D004041Dietary FatsDietary Fats results in increased expression of KLF6 mRNA17903364
D004041Dietary Fatsrosiglitazone inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA]17903364
D019422Dietary SucroseDietary Sucrose results in increased expression of KLF6 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KLF6 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KLF6 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of KLF6 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of KLF6 mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of KLF6 mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of KLF6 mRNA16314067|1737439
D004237DiuronDiuron results in decreased expression of KLF6 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of KLF6 mRNA15205334
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF6 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of KLF6 mRNA24211769
D005047EtoposideEtoposide results in decreased expression of KLF6 mRNA24211769
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF6 mRNA28329830
D005472FluorouracilFluorouracil results in decreased expression of KLF6 mRNA15205334
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF6 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of KLF6 mRNA23416264|2364984
C056933fumonisin B1fumonisin B1 results in increased expression of KLF6 mRNA16221962
D005839GentamicinsGentamicins results in increased expression of KLF6 mRNA22061828
D005947GlucoseGlucose results in increased expression of KLF6 mRNA17178593
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of KLF6 mRNA16206274
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of KLF6 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KLF6 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of KLF6 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of KLF6 mRNA21396975
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KLF6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLF6 mRNA23086925
C410337K 7174K 7174 results in increased expression of KLF6 mRNA24086573
C119620kenpaullonekenpaullone results in decreased expression of KLF6 mRNA17993264
D007649KetamineKetamine results in decreased expression of KLF6 mRNA20080153
C008261lead acetatelead acetate results in increased expression of KLF6 mRNA25270620
C045463leflunomideleflunomide results in increased expression of KLF6 mRNA28988120
C533894LG 100815LG 100815 results in increased expression of KLF6 mRNA16951191
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of KLF6 mRNA26582142
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of KLF6 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA]16415329
D008094LithiumLithium affects the expression of KLF6 mRNA21092101
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of KLF6 mRNA26378955
C042720mercuric bromidemercuric bromide results in increased expression of KLF6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of KLF6 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of KLF6 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF6 mRNA20938992
C005223methyleugenolmethyleugenol results in increased expression of KLF6 mRNA23411599
C002950methylformamidemethylformamide affects the expression of KLF6 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of KLF6 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KLF6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KLF6 mRNA24211769
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KLF6 mRNA16026605
D008777MethyltestosteroneMethyltestosterone results in increased expression of KLF6 mRNA29191790
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of KLF6 mRNA27344345
D016685MitomycinMitomycin results in decreased expression of KLF6 mRNA24211769
D009151Mustard GasMustard Gas affects the expression of KLF6 mRNA15651846
C064769N-acetylsphingosineN-acetylsphingosine results in increased expression of KLF6 mRNA18270325
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLF6 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of KLF6 mRNA25380136
D009532NickelNickel results in increased expression of KLF6 mRNA12540486
C022838nickel chloridenickel chloride results in increased expression of KLF6 mRNA17547211
C022838nickel chloridenickel chloride affects the expression of KLF6 mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of KLF6 mRNA16314067|1737439
C570897NSC668394NSC668394 results in increased expression of KLF6 mRNA27137931
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of KLF6 mRNA"16951191
C507134ON 01910ON 01910 results in increased expression of KLF6 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of KLF6 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of KLF6 mRNA17374397|2399941
D010100OxygenOxygen deficiency results in increased expression of KLF6 mRNA24236059
D010126OzoneOzone results in increased expression of KLF6 mRNA16716893
D000073878Palm OilPalm Oil results in decreased expression of KLF6 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of KLF6 mRNA26272509
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KLF6 mRNA18593933
C046012pentanalpentanal results in decreased expression of KLF6 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of KLF6 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of KLF6 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KLF6 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of KLF6 mRNA23091169
D019800PhenolPhenol results in increased expression of KLF6 mRNA17547211
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KLF6 mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of KLF6 mRNA23411599
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLF6 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of KLF6 mRNA18445702
D010938Plant OilsPlant Oils results in increased expression of KLF6 mRNA23370395
D059808PolyphenolsPolyphenols results in decreased expression of KLF6 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KLF6 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of KLF6 mRNA18070364|2086464
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA]15477007
D011794QuercetinQuercetin results in increased expression of KLF6 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of KLF6 mRNA15576828
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA]16415329
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of KLF6 mRNA25800948
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of KLF6 mRNA21127053
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA]19030233
C089730rosiglitazonerosiglitazone inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA]17903364
C010327salinomycinsalinomycin results in increased expression of KLF6 mRNA22215106
C541923sandostatinLARsandostatinLAR results in increased expression of KLF6 mRNA17210224
D012643SeleniumSelenium results in increased expression of KLF6 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KLF6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of KLF6 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of KLF6 mRNA19073995|2322117
D012834SilverSilver results in increased expression of KLF6 mRNA26014281|2895954
D019821SimvastatinSimvastatin results in increased expression of KLF6 mRNA17428261
D020123SirolimusSirolimus results in decreased phosphorylation of KLF6 protein16611854
C009277sodium arsenatesodium arsenate results in increased expression of KLF6 mRNA21795629
C016104sodium bichromatesodium bichromate results in increased expression of KLF6 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of KLF6 mRNA27862939
D012999SomanSoman results in increased expression of KLF6 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of KLF6 mRNA26378955
D016559TacrolimusTacrolimus results in increased expression of KLF6 mRNA21865292
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF6 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLF6 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF6 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF6 mRNA11752688
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of KLF6 mRNA28973375
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF6 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of KLF6 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of KLF6 mRNA23411599
C009495titanium dioxidetitanium dioxide analog results in increased expression of KLF6 mRNA25111187
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of KLF6 mRNA25729387
D019772TopotecanTopotecan results in increased expression of KLF6 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of KLF6 mRNA23228038
D014241TrichloroethyleneTrichloroethylene results in increased methylation of KLF6 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of KLF6 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF6 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of KLF6 mRNA19140230
D014520UrethaneUrethane results in increased expression of KLF6 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of KLF6 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KLF6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLF6 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of KLF6 mRNA24383497|2627250
D014640VancomycinVancomycin results in decreased expression of KLF6 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased expression of KLF6 mRNA19465080
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of KLF6 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of KLF6 mRNA19015723
D014750VincristineVincristine results in increased expression of KLF6 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of KLF6 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of KLF6 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of KLF6 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KLF6 mRNA18593933
D015032ZincZinc deficiency results in increased expression of KLF6 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18755691  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18755691  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0005515protein binding-IPI24634218  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0030183B cell differentiation-NAS9000136  
GO:0045893positive regulation of transcription, DNA-templated-TAS9083102  9689109  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18755691  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-TAS9689109  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17621627KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma. (2007 Nov 1)Teixeira MSInt J Cancer
27323854Tobacco smoking and methylation of genes related to lung cancer development. (2016 Sep 13)Gao XOncotarget
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol