Gene: UROC1

131669
HMFN0320|UROCD
urocanate hydratase 1
protein-coding
3q21.3
Ensembl:ENSG00000159650 MIM:613012 Vega:OTTHUMG00000162753 UniprotKB:Q96N76
NG_016286.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.089e-2 (AD)  2.632e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1687482chr3:126496851 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1430.624
EML60.623
CYP2E10.622
IQCC0.616
P2RX60.611
ZFR20.609
PNMA30.609
ENDOV0.607
NOXA10.605
CPNE70.605

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPBP-0.42
MTRNR2L9-0.415
CNN2-0.41
CST7-0.408
WWTR1-0.401
S100A4-0.4
PGF-0.396
SPINK8-0.393
RAI14-0.39
KIAA0040-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of UROC1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of UROC1 mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of UROC1 protein16687475
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of UROC1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UROC1 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UROC1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of UROC1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UROC1 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of UROC1 mRNA27339419
D002994ClofibrateClofibrate results in decreased expression of UROC1 protein19952500
D016572CyclosporineCyclosporine results in decreased expression of UROC1 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of UROC1 mRNA24317228
D003671DEETDEET results in decreased expression of UROC1 mRNA27091632
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UROC1 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of UROC1 gene22964155
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UROC1 mRNA17555576
C000591741Firemaster 550Firemaster 550 results in decreased expression of UROC1 mRNA27957850
C412815GW 4064GW 4064 results in increased expression of UROC1 mRNA26655953
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UROC1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UROC1 mRNA26011545
C464660obeticholic acidobeticholic acid results in increased expression of UROC1 mRNA27939613
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of UROC1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of UROC1 mRNA19429403
D010634PhenobarbitalPhenobarbital results in decreased expression of UROC1 protein19952500
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of UROC1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of UROC1 mRNA19482888
D011192Potassium DichromatePotassium Dichromate results in decreased expression of UROC1 mRNA23608068
D017035PravastatinPravastatin results in decreased expression of UROC1 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of UROC1 mRNA27225895
C045950propiconazolepropiconazole results in decreased expression of UROC1 mRNA21278054
C016104sodium bichromatesodium bichromate results in decreased expression of UROC1 mRNA24612858
C075117squalestatin 1squalestatin 1 affects the expression of UROC1 mRNA27225895
C075117squalestatin 1squalestatin 1 affects the expression of UROC1 mRNA27225895
D013629TamoxifenTamoxifen affects the expression of UROC1 mRNA17555576
D013853ThioacetamideThioacetamide results in decreased expression of UROC1 mRNA23411599
C029297vinylidene chloridevinylidene chloride results in decreased expression of UROC1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016153urocanate hydratase activity-EXP19304569  
GO:0016153urocanate hydratase activity-IDA19304569  
GO ID GO Term Qualifier Evidence PubMed
GO:0006548histidine catabolic process-IMP19304569  
GO:0006548histidine catabolic process-TAS-  
GO:0019556histidine catabolic process to glutamate and formamide-IEA-  
GO:0019557histidine catabolic process to glutamate and formate-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA19304569  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00340Histidine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70921Histidine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal