Gene: SLC31A1

1317
COPT1|CTR1
solute carrier family 31 member 1
protein-coding
9q32
Ensembl:ENSG00000136868 MIM:603085 Vega:OTTHUMG00000020519 UniprotKB:O15431
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.670e-1 (AD)  6.787e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNS0.832
AQR0.826
CXorf380.821
CALU0.819
ACOT90.817
RECQL0.814
DCAF120.806
CTTNBP2NL0.806
ANKHD10.804
CCNT10.799

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.482
OR4F29-0.466
FAM186A-0.265
LCN1-0.224
TNFRSF13B-0.199
TBX10-0.194
OR7C1-0.194
IFNA2-0.193
UPK1A-0.189
INSL5-0.187

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00515CisplatinSmall Molecule15663-27-1ApprovedTransporter
DB00526OxaliplatinSmall Molecule61825-94-3Approved|InvestigationalTransporter
DB00958CarboplatinSmall Molecule41575-94-4ApprovedTransporter
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC31A1 mRNA]"19467301
C4879483-iodothyronamineSLC31A1 mRNA affects the uptake of 3-iodothyronamine19074582
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased expression of SLC31A1 protein21177414
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin21177414
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC31A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC31A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC31A1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of SLC31A1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC31A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC31A1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC31A1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC31A1 mRNA19770486
D000584AmilorideAmiloride inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC31A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC31A1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SLC31A1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SLC31A1 mRNA22982499
D001310AuranofinAuranofin results in decreased expression of SLC31A1 mRNA27813112
C028559bathocuproine sulfonatebathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]18483225
C028559bathocuproine sulfonate[bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA18483225
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC31A1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC31A1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC31A1 mRNA21569818|2719552
C090535benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinalbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D004958EstradiolEstradiol inhibits the reaction [Copper results in decreased expression of SLC31A1 protein]19685012
D004958EstradiolEstradiol promotes the reaction [Copper affects the expression of SLC31A1 mRNA]19685012
D004958EstradiolEstradiol results in increased expression of SLC31A1 mRNA19685012
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SLC31A1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of SLC31A1 mRNA19371625
C006780bisphenol Abisphenol A results in decreased expression of SLC31A1 mRNA27690074
C006780bisphenol Abisphenol A results in decreased expression of SLC31A1 protein27690074
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SLC31A1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC31A1 mRNA25181051
D000069286BortezomibBortezomib inhibits the reaction [Cisplatin results in decreased expression of SLC31A1 protein]19147760
D000069286Bortezomib[Bortezomib inhibits the reaction [Cisplatin results in decreased expression of SLC31A1 protein]] which results in increased uptake of Cisplatin19147760
D000069286BortezomibBortezomib results in decreased degradation of SLC31A1 protein24209693
D000069286Bortezomib[Bortezomib results in decreased degradation of SLC31A1 protein] which results in increased uptake of Platinum24209693
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]23426973
D019328Buthionine Sulfoximine[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]23426973
D019328Buthionine Sulfoximineglutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]]23426973
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SLC31A1 mRNA14729362
C028031cadmium acetatecadmium acetate results in decreased expression of SLC31A1 mRNA24132751
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC31A1 mRNA26472689
C054133casticincasticin results in increased expression of SLC31A1 mRNA28444820
D000068579CelecoxibCelecoxib results in decreased expression of SLC31A1 protein21177414
D000068579Celecoxib[Celecoxib results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin21177414
D000068579CelecoxibCelecoxib affects the expression of SLC31A1 mRNA20562220
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC31A1 mRNA23650126
D002746ChlorpromazineChlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]12501239
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC31A1 mRNA28472532
C057270cisplatin-DNA adductSLC31A1 protein affects the abundance of cisplatin-DNA adduct27270317
C057270cisplatin-DNA adduct[SLC31A1 protein affects the uptake of Cisplatin] which affects the abundance of cisplatin-DNA adduct27270317
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC31A1 mRNA17602206
D060729Coal AshCoal Ash results in decreased expression of SLC31A1 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC31A1 mRNA24614111
C018021cobaltous chlorideSLC31A1 mutant form inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]26174737
C018021cobaltous chlorideSLC31A1 mutant form inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]26174737
D003300Copper[bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA18483225
D003300CopperButhionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]23426973
D003300Copper[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]23426973
D003300CopperChlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]12501239
D003300CopperCisplatin inhibits the reaction [SLC31A1 protein results in increased import of Copper]24132751
D003300Copper[CLDN3 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper23053666
D003300Copper[CLDN4 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper23053666
D003300CopperCopper affects the localization of SLC31A1 protein12501239|2354341
D003300CopperCopper deficiency promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]22172574
D003300CopperCopper deficiency results in increased expression of SLC31A1 mRNA18483225
D003300CopperCopper deficiency results in increased expression of SLC31A1 protein24708542
D003300CopperCopper inhibits the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]18483225
D003300CopperCopper results in decreased expression of and affects the localization of SLC31A1 protein24485600
D003300CopperCopper results in decreased expression of SLC31A1 mRNA18483225|1968501
D003300Copper[Copper results in decreased expression of SLC31A1 mRNA] which results in decreased uptake of Copper18483225
D003300CopperCopper results in decreased expression of SLC31A1 protein19685012|2606757
D003300CopperCopper results in increased degradation of and affects the localization of SLC31A1 protein14976198
D003300CopperCopper results in increased degradation of SLC31A1 protein12501239|1710813
D003300CopperCopper results in increased expression of SLC31A1 protein18779306
D003300CopperEstradiol inhibits the reaction [Copper results in decreased expression of SLC31A1 protein]19685012
D003300CopperEstradiol promotes the reaction [Copper affects the expression of SLC31A1 mRNA]19685012
D003300Copperglutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]]23426973
D003300Copper[ITGAV protein results in decreased expression of SLC31A1 protein] which results in decreased abundance of Copper25594011
D003300Coppermethyl-beta-cyclodextrin inhibits the reaction [Copper affects the localization of SLC31A1 protein]12501239
D003300Copper[Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper25320179
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SLC31A1 mRNA20971185
D003300Copper[SLC11A2 protein co-treated with SLC31A1 protein] affects the uptake of Copper26067577
D003300CopperSLC31A1 mutant form results in decreased uptake of Copper23543413
D003300CopperSLC31A1 protein affects the uptake of Copper12872841
D003300CopperSLC31A1 protein mutant form results in decreased susceptibility to Copper20519567
D003300CopperSLC31A1 protein mutant form results in decreased transport of Copper20519567
D003300CopperSLC31A1 protein mutant form results in increased uptake of Copper23543413
D003300CopperSLC31A1 protein results in increased import of Copper23426973|2365801
D003300CopperSLC31A1 protein results in increased transport of Copper12220667|1698219
D003300CopperSLC31A1 protein results in increased uptake of Copper12177073|1250123
D003300Copper[ATP7B gene mutant form results in decreased export of Copper] which results in decreased expression of SLC31A1 protein22802922
D003300Copper[ATP7B gene mutant form results in increased uptake of Copper] which results in decreased expression of SLC31A1 protein20647314
D003300CopperCopper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of SOD1 protein]12177073
D003300CopperCopper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein]12177073
D003300CopperCopper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein]12177073
D003300Copper[Oxygen deficiency results in increased expression of SLC31A1 protein] which results in increased uptake of Copper19351718
D003300CopperSLC31A1 gene mutant form affects the abundance of Copper12177073
D003300Copper[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of SOD1 protein12177073
D003300Copper[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein12177073
D003300Copper[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein12177073
D003300Copper[SLC31A1 gene mutant form results in increased abundance of CCS protein] which results in decreased abundance of Copper22842628
D003300CopperSLC31A1 protein affects the transport of Copper17268249
D003300CopperSLC31A1 protein modified form results in decreased abundance of Copper24167251
D003300CopperSLC31A1 protein results in increased abundance of Copper24522273
D003300CopperSLC31A1 protein results in increased uptake of and results in increased abundance of Copper24167251
D003300CopperSLC31A1 protein results in increased uptake of Copper11391004|1217707
D003300CopperSLC31A2 protein inhibits the reaction [SLC31A1 protein results in increased uptake of and results in increased abundance of Copper]24167251
D003300Copper[SLC31A2 protein results in increased expression of SLC31A1 protein modified form] which results in decreased abundance of Copper24167251
D003300CopperCopper deficiency results in increased expression of SLC31A1 mRNA22362149
D003300CopperCopper deficiency results in increased expression of SLC31A1 protein21781943
D003300CopperCopper inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]23123662
D003300CopperCopper results in increased expression of SLC31A1 mRNA15591161
D003300CopperCopper results in increased expression of SLC31A1 protein15591161
D003300CopperFructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein]21781943
D003300Copperlead acetate promotes the reaction [SLC31A1 protein results in increased uptake of Copper]24316150
D003300CopperPRL protein promotes the reaction [SLC31A1 protein results in increased secretion of Copper]16741141
D003300CopperSilver inhibits the reaction [SLC31A1 protein results in increased import of Copper]23123662
D003300CopperSLC31A1 mutant form inhibits the reaction [Lead results in decreased export of Copper]24316150
D003300CopperSLC31A1 protein results in increased import of Copper23123662
D003300CopperSLC31A1 protein results in increased secretion of Copper16741141
D003300CopperSLC31A1 protein results in increased transport of Copper22465424
D003300CopperSLC31A1 protein results in increased uptake of Copper24316150
D003300CopperZinc inhibits the reaction [SLC31A1 protein results in increased import of Copper]23123662
D003300CopperCopper results in decreased expression of SLC31A1 mRNA18304880
D003300CopperCopper results in increased expression of SLC31A1 mRNA18304880
D003300CopperCopper deficiency results in increased expression of SLC31A122914438
D003300CopperSLC31A1 protein results in increased uptake of Copper18779302|1882015
C098468copper histidinecopper histidine inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]23556474
C098468copper histidineSLC31A1 protein results in increased import of copper histidine23556474
D019327Copper Sulfate"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC31A1 mRNA"18987288
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC31A1 protein18987288
D019327Copper Sulfate"Iron, Dietary inhibits the reaction [Copper Sulfate results in decreased expression of SLC31A1 protein]"18987288
D019327Copper SulfateCopper Sulfate inhibits the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]24132751
D019327Copper SulfateCopper Sulfate inhibits the reaction [SLC31A1 protein results in increased import of Cisplatin]24132751
D019327Copper SulfateCopper Sulfate inhibits the reaction [SP1 protein binds to SLC31A1 promoter]22172574
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC31A1 mRNA19549813|2217257
D019327Copper Sulfate[Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA22172574
D019327Copper SulfateCopper Sulfate inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]22842628
D019327Copper SulfateCopper Sulfate inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]22842628
D019327Copper SulfateCopper Sulfate results in decreased activity of SLC31A1 protein20631178
D019327Copper Sulfate[Copper Sulfate results in decreased activity of SLC31A1 protein] which results in decreased uptake of Cisplatin20631178
D003375CoumestrolCoumestrol results in increased expression of SLC31A1 mRNA19167446
C029892cupric chloridecupric chloride affects the expression of SLC31A1 mRNA24658744
C029892cupric chloridecupric chloride affects the localization of SLC31A1 protein24658744
C029892cupric chloridecupric chloride results in decreased expression of SLC31A1 protein24800945
C029892cupric chloridecupric chloride results in decreased expression of SLC31A1 protein24316150
C030973cupric oxidecupric oxide analog results in increased expression of SLC31A1 mRNA24815816
C030973cupric oxidecupric oxide analog results in increased expression of SLC31A1 protein24815816
D003471CuprizoneCuprizone affects the expression of SLC31A1 mRNA27523638
D015638Cytochalasin DCytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
C014347decitabinedecitabine results in increased expression of SLC31A1 protein19470736
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SLC31A1 mRNA]27941970
D016190Carboplatin[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
D016190CarboplatinSLC31A1 protein results in increased susceptibility to Carboplatin15634647
D016190CarboplatinSLC31A1 protein results in increased uptake of Carboplatin15634647
D016190Carboplatin[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
D016190Carboplatin[Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
D016190CarboplatinSLC31A1 gene mutant form results in decreased susceptibility to Carboplatin16847145
D016190CarboplatinSLC31A1 protein results in increased uptake of Carboplatin16847145|1950913
D016190CarboplatinSLC31A1 protein results in increased import of Carboplatin23123662
D003976DiazinonDiazinon results in increased methylation of SLC31A1 gene22964155
C016366dibenzothiophenedibenzothiophene results in increased expression of SLC31A1 mRNA23656968
D002945Cisplatin[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin21177414
D002945CisplatinAmiloride inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D002945Cisplatinbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D002945Cisplatinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D002945CisplatinBortezomib inhibits the reaction [Cisplatin results in decreased expression of SLC31A1 protein]19147760
D002945Cisplatin[Bortezomib inhibits the reaction [Cisplatin results in decreased expression of SLC31A1 protein]] which results in increased uptake of Cisplatin19147760
D002945Cisplatin[Celecoxib results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin21177414
D002945CisplatinCisplatin inhibits the reaction [SLC31A1 protein results in increased import of Copper]24132751
D002945CisplatinCisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]22914438
D002945CisplatinCisplatin promotes the reaction [SLC31A1 protein binds to SLC31A1 protein]19570948
D002945CisplatinCisplatin results in decreased expression of SLC31A1 protein19147760|2480094
D002945CisplatinCisplatin results in increased degradation of SLC31A1 protein17108132|1914776
D002945CisplatinCisplatin results in increased expression of SLC31A1 mRNA22914438|2413275
D002945CisplatinCisplatin results in increased expression of SLC31A1 protein24132751
D002945Cisplatin[Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 mRNA24132751
D002945Cisplatin[CLDN3 protein results in increased expression of SLC31A1 protein] which results in increased import of Cisplatin23053666
D002945Cisplatin[CLDN4 protein results in increased expression of SLC31A1 protein] which results in increased import of Cisplatin23053666
D002945CisplatinCopper Sulfate inhibits the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]24132751
D002945CisplatinCopper Sulfate inhibits the reaction [SLC31A1 protein results in increased import of Cisplatin]24132751
D002945CisplatinCytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D002945Cisplatinepigallocatechin gallate inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]25927922|2727031
D002945Cisplatin[ITGAV protein results in decreased expression of SLC31A1 protein] which results in decreased abundance of Cisplatin25594011
D002945Cisplatinlactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D002945CisplatinPenicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]22914438
D002945Cisplatin[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
D002945CisplatinSLC31A1 mRNA affects the susceptibility to Cisplatin18610736
D002945CisplatinSLC31A1 protein affects the susceptibility to Cisplatin22914438
D002945CisplatinSLC31A1 protein affects the uptake of Cisplatin15985617|2727031
D002945Cisplatin[SLC31A1 protein affects the uptake of Cisplatin] which affects the abundance of cisplatin-DNA adduct27270317
D002945CisplatinSLC31A1 protein mutant form results in increased susceptibility to Cisplatin20519567
D002945CisplatinSLC31A1 protein mutant form results in increased uptake of Cisplatin20519567
D002945CisplatinSLC31A1 protein results in decreased susceptibility to Cisplatin24800945
D002945CisplatinSLC31A1 protein results in increased import of and results in increased susceptibility to Cisplatin23010323
D002945CisplatinSLC31A1 protein results in increased import of Cisplatin24132751
D002945CisplatinSLC31A1 protein results in increased susceptibility to Cisplatin15634647|2305366
D002945CisplatinSLC31A1 protein results in increased transport of Cisplatin19570948
D002945CisplatinSLC31A1 protein results in increased uptake of and results in increased susceptibility to Cisplatin19144690|2263908
D002945CisplatinSLC31A1 protein results in increased uptake of Cisplatin15634647|2256984
D002945Cisplatin[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
D002945Cisplatin[Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
D002945Cisplatin[Copper Sulfate results in decreased activity of SLC31A1 protein] which results in decreased uptake of Cisplatin20631178
D002945CisplatinSLC31A1 gene mutant form results in decreased susceptibility to Cisplatin16847145
D002945CisplatinSLC31A1 gene mutant form results in decreased uptake of and results in decreased susceptibility to Cisplatin16170571
D002945CisplatinSLC31A1 protein results in increased uptake of Cisplatin16847145|1950913
D002945CisplatinCisplatin results in increased expression of SLC31A1 mRNA26739623
D002945CisplatinSLC31A1 protein results in increased import of Cisplatin23123662
D002945CisplatinSLC31A1 protein results in increased susceptibility to Cisplatin19144690
D002945CisplatinCisplatin results in increased degradation of SLC31A1 protein20194531
D002945Cisplatin[Glutathione results in increased expression of SLC31A1] which results in increased transport of Cisplatin22914438
D002945CisplatinSLC31A1 protein results in increased transport of Cisplatin22670529
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA15784690
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC31A1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC31A1 mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC31A1 mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLC31A1 mRNA21658437
D004237DiuronDiuron results in increased expression of SLC31A1 mRNA25152437
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]25927922|2727031
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of and affects the localization of SLC31A1 protein27270317
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of SLC31A1 mRNA25927922|2727031
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of SLC31A1 protein25927922
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC31A1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC31A1 mRNA27690074
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC31A1 protein27690074
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC31A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC31A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC31A1 mRNA26865667
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLC31A1 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of SLC31A1 mRNA19371625
D005485FlutamideFlutamide results in increased expression of SLC31A1 mRNA21126777
D005557FormaldehydeFormaldehyde results in decreased expression of SLC31A1 mRNA23649840
D005632FructoseFructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein]21781943
C069837fullerene C60fullerene C60 results in decreased expression of SLC31A1 mRNA19167457
C056933fumonisin B1fumonisin B1 results in decreased expression of SLC31A1 mRNA16221962
D019833GenisteinGenistein results in increased expression of SLC31A1 mRNA19371625|2686566
D005978Glutathione[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]23426973
D005978GlutathioneGlutathione results in increased expression of SLC31A122914438
D005978Glutathione[Glutathione results in increased expression of SLC31A1] which results in increased transport of Cisplatin22914438
C083627glutathione diethyl esterglutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]]23426973
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]22842628
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]22842628
D007477Ions[Water co-treated with Ions deficiency] results in increased expression of SLC31A1 mRNA17299134
C051890irinotecanirinotecan affects the expression of SLC31A1 mRNA20097248
D019266Iron, Dietary"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC31A1 mRNA"18987288
D019266Iron, Dietary"Iron, Dietary inhibits the reaction [Copper Sulfate results in decreased expression of SLC31A1 protein]"18987288
C067713lactacystinlactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]17108132
D007854LeadSLC31A1 mutant form inhibits the reaction [Lead results in decreased export of Copper]24316150
C008261lead acetatelead acetate promotes the reaction [SLC31A1 protein results in increased uptake of Copper]24316150
C008261lead acetatelead acetate results in increased expression of and affects the localization of SLC31A1 protein25579025
C008261lead acetatelead acetate results in increased expression of SLC31A1 mRNA24316150|2557902
C008261lead acetatelead acetate results in increased expression of SLC31A1 protein24316150
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLC31A1 mRNA22369063
D008148LovastatinLovastatin results in increased expression of SLC31A1 mRNA26739623
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of SLC31A1 mRNA28349193
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [Copper affects the localization of SLC31A1 protein]12501239
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC31A1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC31A1 mRNA23649840
D015741MetriboloneAR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]25320179
D015741MetriboloneAR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]25320179
D015741MetriboloneMetribolone results in increased expression of SLC31A1 mRNA25320179
D015741MetriboloneMetribolone results in increased expression of SLC31A1 protein25320179
D015741Metribolone[Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper25320179
C028007nickel monoxidenickel monoxide results in decreased expression of SLC31A1 mRNA19167457
C007350nitrofennitrofen results in decreased expression of SLC31A1 mRNA25319798
C007350nitrofennitrofen results in decreased expression of SLC31A1 protein25319798
C025256nonylphenolnonylphenol results in decreased expression of SLC31A1 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SLC31A1 mRNA20971185
C511311NSC73306NSC73306 results in decreased expression of SLC31A1 protein24800945
C511311NSC73306SLC31A1 protein results in increased uptake of NSC7330624800945
C474055octylphenoloctylphenol results in decreased expression of SLC31A1 mRNA27690074
C474055octylphenoloctylphenol results in decreased expression of SLC31A1 protein27690074
C016340o,p'-DDT"o,p'-DDT results in increased expression of SLC31A1 mRNA"19371625
C030110oxaliplatin[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
C030110oxaliplatinSLC31A1 protein affects the susceptibility to oxaliplatin16773204
C030110oxaliplatinSLC31A1 protein results in increased susceptibility to oxaliplatin15634647
C030110oxaliplatinSLC31A1 protein results in increased uptake of oxaliplatin15634647
C030110oxaliplatin[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
C030110oxaliplatin[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
C030110oxaliplatinSLC31A1 gene mutant form results in decreased susceptibility to oxaliplatin16847145
C030110oxaliplatinSLC31A1 protein results in increased uptake of oxaliplatin16847145
C030110oxaliplatincopper histidine inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]23556474
C030110oxaliplatinCopper inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]23123662
C030110oxaliplatinoxaliplatin results in decreased expression of SLC31A1 protein20836889
C030110oxaliplatinSLC31A1 protein results in increased import of oxaliplatin23123662
D010100OxygenHIF1A mRNA promotes the reaction [Oxygen deficiency results in increased expression of SLC31A1 mRNA]24614111
D010100OxygenOxygen deficiency results in increased expression of SLC31A1 mRNA24614111
D010100OxygenOxygen deficiency results in increased expression of SLC31A1 mRNA24614111
D010100OxygenOxygen deficiency results in increased expression of SLC31A1 protein19351718|2461411
D010100Oxygen[Oxygen deficiency results in increased expression of SLC31A1 protein] which results in increased uptake of Copper19351718
D017239PaclitaxelPaclitaxel results in increased expression of SLC31A1 mRNA20737486
D010269ParaquatParaquat results in decreased expression of SLC31A1 mRNA17275934
D010396PenicillamineCisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]22914438
D010396PenicillaminePenicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]22914438
D010396PenicillaminePenicillamine results in increased expression of SLC31A1 mRNA22914438
D010396Penicillamine[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
D010396Penicillamine[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
D010396Penicillamine[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC31A1 mRNA23427857
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC31A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC31A1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SLC31A1 mRNA18445702|2381119
D010984Platinum[Bortezomib results in decreased degradation of SLC31A1 protein] which results in increased uptake of Platinum24209693
D010984PlatinumSLC31A1 affects the susceptibility to Platinum21570711
D010984PlatinumSLC31A1 protein results in increased uptake of Platinum22491798
D010984PlatinumTrientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]22491798
C059514resveratrolresveratrol results in increased expression of SLC31A1 mRNA19371625
D015474IsotretinoinIsotretinoin results in decreased expression of SLC31A1 mRNA20436886
D012834SilverSilver inhibits the reaction [SLC31A1 protein results in increased import of Copper]23123662
D012834SilverSLC31A1 protein results in increased transport of Silver22670529
D012835Silver NitrateSilver Nitrate results in increased expression of SLC31A1 mRNA24132751
C016104sodium bichromatesodium bichromate results in decreased expression of SLC31A1 mRNA22561333
D013311StreptozocinStreptozocin results in decreased expression of SLC31A1 mRNA24927960
D013311StreptozocinStreptozocin results in decreased expression of SLC31A1 protein24927960
D013629TamoxifenTamoxifen affects the expression of SLC31A1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC31A1 mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC31A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC31A1 mRNA17942748
C020809tetrathiomolybdatetetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]22172574
C020809tetrathiomolybdatetetrathiomolybdate results in increased expression of SLC31A1 mRNA22914438
C020809tetrathiomolybdate[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
C020809tetrathiomolybdate[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
C020809tetrathiomolybdate[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
C009495titanium dioxidetitanium dioxide affects the expression of SLC31A1 mRNA17656681
D014212TretinoinTretinoin results in increased expression of SLC31A1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of SLC31A1 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of SLC31A1 mRNA28542535
D014266TrientineTrientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]22491798
D014266TrientineTrientine results in increased expression of SLC31A1 mRNA22914438
D014266Trientine[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin22914438
D014266Trientine[Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin22914438
D014266Trientine[Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin22914438
D014266TrientineTrientine results in increased expression of SLC31A1 protein22914438
D014266TrientineTrientine results in increased expression of SLC31A1 mRNA22362149
C406224valdecoxibvaldecoxib results in decreased expression of SLC31A1 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of SLC31A1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of SLC31A1 gene29154799
D014639VanadiumVanadium results in decreased expression of SLC31A1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC31A1 gene25560391
D014867Water[Water co-treated with Ions deficiency] results in increased expression of SLC31A1 mRNA17299134
C108830Y 27632Y 27632 results in decreased expression of SLC31A1 mRNA20878077
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA15784690
D015032ZincZinc inhibits the reaction [SLC31A1 protein results in increased import of Copper]23123662
D019345Zinc AcetateZinc Acetate results in increased expression of SLC31A1 mRNA24132751
D015034Zinc OxideZinc Oxide analog results in decreased expression of SLC31A1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005375copper ion transmembrane transporter activity-TAS-  
GO:0042802identical protein binding-IPI16501047  19240214  
GO ID GO Term Qualifier Evidence PubMed
GO:0006825copper ion transport-TAS9207117  
GO:0006855drug transmembrane transport-IEA-  
GO:0006878cellular copper ion homeostasis-IEA-  
GO:0072719cellular response to cisplatin-IEA-  
GO:0098705copper ion import across plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005770late endosome-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9207117  
GO:0043025neuronal cell body-IEA-  
GO:0055037recycling endosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23303382Genome-wide association study of serum albumin:globulin ratio in Korean populations. (2013 Mar)Hong KWJ Hum Genet