| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| NNAT | 0.858 |
| SST | 0.856 |
| RPP25 | 0.853 |
| TAC1 | 0.848 |
| LRRC73 | 0.847 |
| SLC32A1 | 0.843 |
| SPEF1 | 0.842 |
| PCP4L1 | 0.835 |
| KCNF1 | 0.834 |
| CRHBP | 0.828 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| FCGR3B | -0.595 |
| WWTR1 | -0.579 |
| CXCR2 | -0.568 |
| IL18RAP | -0.567 |
| VNN2 | -0.562 |
| CXCR1 | -0.562 |
| REST | -0.552 |
| CST7 | -0.546 |
| CLEC2B | -0.546 |
| NEDD4 | -0.546 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C582212 | 1NMPP1 compound | [NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of CORT mRNA | 27417517 |
| C029790 | 2,2',3',4,4',5-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| C081766 | 2,4,4'-trichlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| C009828 | 2,4,5,2',5'-pentachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| C009407 | 2,5,2',5'-tetrachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in decreased expression of CORT mRNA" | 18648102 |
| D020106 | Acrylamide | Acrylamide results in decreased expression of CORT mRNA | 28959563 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CORT mRNA | 16483693 |
| C006780 | bisphenol A | bisphenol A results in decreased methylation of CORT promoter | 27312807 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CORT mRNA | 25181051 |
| D002110 | Caffeine | Caffeine results in decreased expression of CORT protein | 25868845 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of CORT mRNA | 21356183 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of CORT mRNA | 26775027 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of CORT mRNA | 19376846 |
| D003300 | Copper | Copper deficiency results in increased expression of CORT mRNA | 26033743 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of CORT mRNA | 19789285 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of CORT mRNA | 19789285 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of CORT mRNA | 19549813 |
| D003471 | Cuprizone | Cuprizone results in decreased expression of CORT mRNA | 26577399 |
| C000541 | cyclopamine | cyclopamine results in decreased expression of CORT mRNA | 22265815 |
| D004026 | Dieldrin | Dieldrin affects the expression of CORT mRNA | 22546817 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of CORT mRNA | 18503570|2501614 |
| D019422 | Dietary Sucrose | Dietary Sucrose results in increased expression of CORT mRNA | 26033743 |
| C015835 | dimethyl-4-toluidine | dimethyl-4-toluidine results in decreased expression of CORT mRNA | 27638505 |
| D000431 | Ethanol | Ethanol results in increased expression of CORT protein | 27338645 |
| C004312 | glycidol | glycidol results in decreased expression of CORT mRNA | 24915197 |
| C544151 | jinfukang | jinfukang results in decreased expression of CORT mRNA | 27392435 |
| C410337 | K 7174 | K 7174 results in decreased expression of CORT mRNA | 24086573 |
| D007649 | Ketamine | Ketamine results in increased expression of CORT mRNA | 20080153 |
| D008727 | Methotrexate | Methotrexate affects the expression of CORT mRNA | 18502557 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in increased expression of CORT mRNA | 26011545 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [CORT protein results in increased expression of TNFRSF11B mRNA] | 27338645 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon affects the expression of CORT mRNA" | 23845593 |
| D009538 | Nicotine | Nicotine affects the expression of CORT protein | 22975262 |
| D009538 | Nicotine | Nicotine results in decreased expression of CORT protein | 26776438 |
| C410127 | PCB 180 | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CORT mRNA" | 25510870 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased expression of CORT mRNA | 24780913 |
| D013749 | Tetrachlorodibenzodioxin | CORT protein promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein] | 18086832 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of CORT mRNA | 21570461 |
| D014302 | Trinitrobenzenesulfonic Acid | Trinitrobenzenesulfonic Acid results in increased expression of CORT protein | 11959675 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | - | IBA | 21873635 |
| GO:0001664 | G-protein coupled receptor binding | - | IPI | 12915402 |
| GO:0003682 | chromatin binding | - | IBA | 21873635 |
| GO:0003690 | double-stranded DNA binding | - | IBA | 21873635 |
| GO:0005184 | neuropeptide hormone activity | - | IBA | 21873635 |
| GO:0005184 | neuropeptide hormone activity | - | IDA | 9125122 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000712 | resolution of meiotic recombination intermediates | - | IBA | 21873635 |
| GO:0007186 | G-protein coupled receptor signaling pathway | - | TAS | - |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | - | IBA | 21873635 |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | - | IDA | 9125122 |
| GO:0007268 | chemical synaptic transmission | - | NAS | 9125122 |
| GO:0010469 | regulation of signaling receptor activity | - | IEA | - |
| GO:0031297 | replication fork processing | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | TAS | - |
| GO:0005615 | extracellular space | - | NAS | 9125122 |
| GO:0043240 | Fanconi anaemia nuclear complex | - | IBA | 21873635 |
| GO:0043240 | Fanconi anaemia nuclear complex | NOT | IBA | 21873635 |
| GO:0071821 | FANCM-MHF complex | - | IBA | 21873635 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-372790 | Signaling by GPCR | TAS |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | TAS |
| R-HSA-375276 | Peptide ligand-binding receptors | TAS |
| R-HSA-388396 | GPCR downstream signalling | TAS |
| R-HSA-418594 | G alpha (i) signalling events | TAS |
| R-HSA-500792 | GPCR ligand binding | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 10606489 | Experimentally induced aggressiveness in adult children of alcoholics (ACOAs): preliminary behavioral and neuroendocrine findings. (1999 Nov) | Gerra G | J Stud Alcohol |
| 10871318 | Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. (2000 Jul) | Mantsch JR | J Pharmacol Exp Ther |
| 17293045 | Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration. (2007 Mar 30) | Mantsch JR | Neurosci Lett |
| 11797058 | Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats. (2001 Dec) | Zorrilla EP | Psychopharmacology (Berl) |
| 23889203 | Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner. (2013 Dec) | Butler TR | Alcohol Clin Exp Res |
| 28647675 | Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors. (2017 Oct) | Somkuwar SS | Psychoneuroendocrinology |
| 28155001 | Change in urinary cortisol excretion mediates the effect of angry/hostile mood on 9 month diastolic blood pressure in HIV+ adults. (2017 Aug) | McIntosh RC | J Behav Med |
| 21075083 | Effects of perinatal cocaine exposure on open field behavior and the response to corticotropin releasing hormone (CRH) in rat offspring. (2011 Jan 25) | Sithisarn T | Brain Res |
| 12892653 | Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use. (2003 Oct) | Mantsch JR | Psychoneuroendocrinology |
| 24427122 | The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. (2014) | Butler TR | Front Integr Neurosci |
| 10776662 | Analysis of heritability of hormonal responses to alcohol in twins: beta-endorphin as a potential biomarker of genetic risk for alcoholism. (2000 Mar) | Froehlich JC | Alcohol Clin Exp Res |
| 22016195 | The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. (2012 Apr) | Besheer J | Psychopharmacology (Berl) |
| 22334120 | Chronic corticosterone exposure during adolescence reduces impulsive action but increases impulsive choice and sensitivity to yohimbine in male Sprague-Dawley rats. (2012 Jun) | Torregrossa MM | Neuropsychopharmacology |
| 17481591 | Major depression in late life is associated with both hypo- and hypercortisolemia. (2007 Sep 1) | Bremmer MA | Biol Psychiatry |
| 18279498 | Prolactin response to fenfluramine in abstinent, alcohol-dependent patients. (2008 Sep) | Porter RJ | Addict Biol |
| 26842248 | Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks. (2016 Feb) | Guo R | Alcohol Clin Exp Res |
| 28550455 | Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats. (2017 Aug) | Valenza M | Psychopharmacology (Berl) |
| 15369760 | Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects. (2004 Oct 15) | Haddad JJ | Biochem Biophys Res Commun |
| 18760716 | Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice. (2008 Sep) | Parker CC | Alcohol |
| 23331637 | Relation between corticosterone and fear-related behavior in mice selectively bred for high or low alcohol preference. (2014 Jul) | Chester JA | Addict Biol |
| 17689506 | Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats. (2007 Sep 5) | Mantsch JR | Brain Res |
| 26192911 | Cocaine self-administration in Wistar-Kyoto rats: a behavioral and biochemical analysis. (2015 Oct 15) | Jastrzebska J | Behav Brain Res |
| 29572015 | Differential effects of single versus repeated minocycline administration-Lack of significant interaction with chronic alcohol history. (2018 May) | Harper KM | Pharmacol Biochem Behav |
| 20666641 | Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice. (2010 Nov) | Zhou Y | Stress |
| 18945222 | Sex differences in ethanol-induced hypothermia in ethanol-naive and ethanol-dependent/withdrawn rats. (2009 Jan) | Taylor AN | Alcohol Clin Exp Res |