Gene info: ID 1327

Gene: COX4I1

GENE ID: 1327

Synonyms: COX IV-1|COX4|COX4-1|COXIV|COXIV-1

Description: cytochrome c oxidase subunit 4I1

Gene type: protein-coding

Location: 16q24.1

dbXrefs: Ensembl:ENSG00000131143 MIM:123864 Vega:OTTHUMG00000137649 UniprotKB:P13073

RefSeq: NG_042280.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.042e-1 (AD) 9.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NDUFB8	0.975
NDUFB10	0.971
NDUFS5	0.968
NDUFA13	0.966
PARK7	0.965
COX7C	0.964
NME1-NME2	0.963
COX6A1	0.962
MRPL51	0.961
EDF1	0.959

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.892
OR4F5	-0.891
CXCR6	-0.149
RAET1E	-0.146
PZP	-0.142
VNN1	-0.142
PABPC4L	-0.141
C9orf84	-0.138
CXCR2	-0.137
CCR8	-0.137

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]"	24041027
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]"	24041027
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of COX4I1 protein"	21856379
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C078765	2,3,5-(triglutathion-S-yl)hydroquinone	"2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of COX4I1 mRNA"	14587099
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of COX4I1 protein]	24041027
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein]	24041027
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C549041	3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone	"3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [arsenic trioxide results in decreased expression of COX4I1 protein]"	27318970
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid results in increased expression of COX4I1 protein"	27385396
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of COX4I1 protein]"	27363784
C016276	8-bromocyclic GMP	8-bromocyclic GMP results in increased expression of COX4I1 protein	24041027
C016276	8-bromocyclic GMP	tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of COX4I1 protein]	24041027
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of COX4I1 gene	28458013
D000496	Alloxan	Alloxan results in decreased expression of COX4I1 protein	28483572
D000496	Alloxan	imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein]	28483572
D000638	Amiodarone	Amiodarone affects the expression of COX4I1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of COX4I1 mRNA	16483693
C006632	arsenic trioxide	"3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [arsenic trioxide results in decreased expression of COX4I1 protein]"	27318970
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of COX4I1 protein	27318970
C006632	arsenic trioxide	arsenic trioxide results in increased expression of COX4I1 mRNA	20458559
C006632	arsenic trioxide	Cyclosporine inhibits the reaction [arsenic trioxide results in decreased expression of COX4I1 protein]	27318970
D001280	Atrazine	Atrazine results in decreased expression of COX4I1 mRNA	22378314
D001553	Benzbromarone	Benzbromarone affects the expression of COX4I1 mRNA	19483382
D001622	Betaine	Betaine inhibits the reaction [Copper deficiency results in decreased expression of COX4I1 protein]	25150618
C006780	bisphenol A	bisphenol A affects the expression of COX4I1 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of COX4I1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of COX4I1 protein	26139607
C006780	bisphenol A	bisphenol A results in increased expression of COX4I1 mRNA	25181051
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of COX4I1 mRNA	15878706
D002104	Cadmium	Cadmium results in increased expression of COX4I1 mRNA	26187450
C028031	cadmium acetate	cadmium acetate affects the expression of COX4I1 mRNA	16249259
D002211	Capsaicin	Capsaicin results in increased expression of COX4I1 protein	18079164
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of COX4I1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of COX4I1 mRNA	17805973
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4I1 protein	27318970
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of COX4I1 mRNA	24763279
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of COX4I1 mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of COX4I1 mRNA	26352163
D002994	Clofibrate	Clofibrate affects the expression of COX4I1 mRNA	19483382
C007095	cobaltiprotoporphyrin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of COX4I1 protein]	24041027
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin results in increased expression of COX4I1 protein	24041027
C007095	cobaltiprotoporphyrin	NFE2L2 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of COX4I1 protein]	24041027
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of COX4I1 protein	18515279
C018021	cobaltous chloride	cobaltous chloride results in increased expression of COX4I1 mRNA	22982409
D003300	Copper	Betaine inhibits the reaction [Copper deficiency results in decreased expression of COX4I1 protein]	25150618
D003300	Copper	Copper deficiency results in decreased expression of COX4I1 protein	25150618
D003300	Copper	[AP1S1 gene mutant form affects the metabolism of Copper] which results in decreased expression of COX4I1 protein	23423674
D003300	Copper	Copper deficiency results in decreased expression of COX4I1 protein	16446493
D019327	Copper Sulfate	Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]	23818984
D016572	Cyclosporine	Cyclosporine inhibits the reaction [arsenic trioxide results in decreased expression of COX4I1 protein]	27318970
D003630	Daunorubicin	Daunorubicin results in decreased expression of COX4I1 mRNA	23831762
D003630	Daunorubicin	Dexrazoxane inhibits the reaction [Daunorubicin results in decreased expression of COX4I1 mRNA]	23831762
D003676	Deferoxamine	Deferoxamine inhibits the reaction [EPAS1 protein results in increased degradation of COX4I1 protein]	18515279
D064730	Dexrazoxane	Dexrazoxane results in increased expression of COX4I1 mRNA	26873546
D064730	Dexrazoxane	Dexrazoxane inhibits the reaction [Daunorubicin results in decreased expression of COX4I1 mRNA]	23831762
D004041	Dietary Fats	Dietary Fats results in decreased expression of COX4I1 mRNA	25436770
D004041	Dietary Fats	Dietary Fats results in increased expression of COX4I1 protein	22496244
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of COX4I1 mRNA	27638505
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of COX4I1 protein	27385396
D019297	2,4-Dinitrophenol	"2,4-Dinitrophenol results in increased expression of COX4I1 mRNA"	11784294
D004317	Doxorubicin	Doxorubicin results in decreased expression of COX4I1 protein	28456571
D004317	Doxorubicin	Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of COX4I1 protein]	28456571
D004317	Doxorubicin	Doxorubicin results in increased expression of COX4I1 protein	21251210
D004317	Doxorubicin	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of COX4I1 protein]	21251210
C042986	ebselen	ebselen results in increased expression of COX4I1 protein	27385396
D004921	Erythropoietin	Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of COX4I1 protein]	28456571
D000431	Ethanol	Ethanol results in increased expression of COX4I1 mRNA	23273579
D005001	Ethionine	Ethionine affects the expression of COX4I1 mRNA	19483382
C054207	etomoxir	etomoxir results in increased expression of COX4I1 mRNA	19234235
D005485	Flutamide	Flutamide results in decreased expression of COX4I1 mRNA	19442681
D005557	Formaldehyde	Formaldehyde results in increased expression of COX4I1 mRNA	18045764
D005947	Glucose	Glucose deficiency results in increased expression of COX4I1 mRNA	26811028
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of COX4I1 mRNA	24763279
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of COX4I1 protein	18515279
C121876	imisopasem manganese	imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein]	28483572
C121876	imisopasem manganese	imisopasem manganese results in increased expression of COX4I1 protein	28483572
D007213	Indomethacin	Indomethacin results in increased expression of COX4I1 mRNA	28201806
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of COX4I1 mRNA	15618438
C008281	limonene	limonene results in increased expression of COX4I1 mRNA	12815608
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 promotes the reaction [resveratrol results in increased expression of COX4I1 protein]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"tin protoporphyrin IX inhibits the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [resveratrol results in increased expression of COX4I1 protein]]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein]]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"tin protoporphyrin IX inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein]]"	24041027
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of COX4I1 mRNA	20353558
D008727	Methotrexate	Methotrexate results in decreased expression of COX4I1 mRNA	24449571
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]	20348232
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of COX4I1 mRNA	23273579
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of COX4I1 mRNA	21598289
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of COX4I1 protein	21598289
D009532	Nickel	Nickel results in decreased expression of COX4I1 mRNA	24084258
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of COX4I1 mRNA	15878706
D009853	Omeprazole	Omeprazole affects the expression of COX4I1 mRNA	19483382
D008939	Mitotane	Mitotane results in decreased expression of COX4I1 mRNA	23696597
C106408	OSW 1	OSW 1 results in increased expression of COX4I1 mRNA	16333034
D010100	Oxygen	Oxygen deficiency results in decreased expression of COX4I1 protein	28751209
D010269	Paraquat	Paraquat affects the expression of COX4I1 mRNA	15206577
D010269	Paraquat	Paraquat results in decreased expression of COX4I1 mRNA	18198484
D010269	Paraquat	Paraquat results in increased expression of COX4I1 protein	24521700
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COX4I1 mRNA"	25510870
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of COX4I1 mRNA	20936131
C076994	perfluorooctane sulfonic acid	PPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of COX4I1 mRNA]	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of COX4I1 protein	19616056
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of COX4I1 mRNA	19616056
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]	23818984
D010634	Phenobarbital	Phenobarbital results in decreased expression of COX4I1 mRNA	23273579
D010656	Phenylephrine	Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]	23818984
D010656	Phenylephrine	periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]	23818984
D010656	Phenylephrine	Phenylephrine results in decreased expression of COX4I1 protein	23818984
C006253	pirinixic acid	pirinixic acid affects the expression of COX4I1 mRNA	19483382
D028321	Plant Preparations	Plant Preparations affects the expression of COX4I1 mRNA	16046712
C531249	Poly(amidoamine)	Poly(amidoamine) results in decreased expression of COX4I1 mRNA	19643170
D011374	Progesterone	COX4I1 protein results in increased abundance of Progesterone	21558439
D011374	Progesterone	Progesterone results in increased expression of COX4I1 mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil affects the expression of COX4I1 mRNA	19483382
D011748	Pyrogallol	Pyrogallol results in increased expression of COX4I1 mRNA	20362636
C059514	resveratrol	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]"	24041027
C059514	resveratrol	HMOX1 mutant form inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]	24041027
C059514	resveratrol	"lipopolysaccharide, E coli O55-B5 promotes the reaction [resveratrol results in increased expression of COX4I1 protein]"	24041027
C059514	resveratrol	"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein]"	24041027
C059514	resveratrol	"tin protoporphyrin IX inhibits the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [resveratrol results in increased expression of COX4I1 protein]]"	24041027
C059514	resveratrol	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein]]"	24041027
C059514	resveratrol	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]	24041027
C059514	resveratrol	"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein]"	24041027
C059514	resveratrol	resveratrol results in decreased expression of COX4I1 protein	25505154
C059514	resveratrol	resveratrol results in increased expression of COX4I1 protein	24041027
C059514	resveratrol	"tin protoporphyrin IX inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein]]"	24041027
C059514	resveratrol	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]	24041027
C059514	resveratrol	resveratrol results in increased expression of COX4I1 mRNA	21715682
C059514	resveratrol	resveratrol results in increased expression of COX4I1 protein	21715682
C089730	rosiglitazone	rosiglitazone affects the expression of COX4I1 mRNA	22013433
D012402	Rotenone	CRTC3 protein affects the reaction [Rotenone results in increased expression of COX4I1 mRNA]	21536665
D012402	Rotenone	CRTC3 protein affects the reaction [Rotenone results in increased expression of COX4I1 protein]	21536665
D012402	Rotenone	Rotenone results in increased expression of COX4I1 mRNA	18191903\|2153666
D012402	Rotenone	Rotenone results in increased expression of COX4I1 protein	21536665
D012402	Rotenone	CRTC3 protein affects the reaction [Rotenone results in increased expression of COX4I1 mRNA]	21536665
D012402	Rotenone	PPARGC1A protein affects the reaction [Rotenone results in increased expression of COX4I1 mRNA]	21536665
D012402	Rotenone	Rotenone results in increased expression of COX4I1 mRNA	21536665
D012402	Rotenone	Rotenone results in increased expression of COX4I1 protein	21536665
C066198	SDZ 51641	SDZ 51641 results in increased expression of COX4I1 mRNA	19234235
C110822	SDZ CPI 975	SDZ CPI 975 results in increased expression of COX4I1 mRNA	19234235
C094089	SDZ FOX 988	SDZ FOX 988 results in increased expression of COX4I1 mRNA	19234235
C110881	S-nitro-N-acetylpenicillamine	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]"	24041027
C110881	S-nitro-N-acetylpenicillamine	HMOX1 mutant form inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]	24041027
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein	24041027
C110881	S-nitro-N-acetylpenicillamine	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]	24041027
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein	24041027
C110881	S-nitro-N-acetylpenicillamine	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]	24041027
C017947	sodium arsenite	sodium arsenite results in decreased expression of COX4I1 mRNA	26767369\|2742564
C016104	sodium bichromate	sodium bichromate results in increased expression of COX4I1 mRNA	17685462
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of COX4I1 protein	28918527
C031618	sodium nitrate	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of COX4I1 protein]	21251210
D018038	Sodium Selenite	Sodium Selenite results in increased expression of COX4I1 mRNA	18175754
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of COX4I1 mRNA	22677886
D013605	T-2 Toxin	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of COX4I1 protein]"	27363784
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of COX4I1 protein	27363784
C047246	temozolomide	COX4I1 protein affects the susceptibility to temozolomide	20870728
C047246	temozolomide	temozolomide results in increased expression of COX4I1 protein	20870728
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COX4I1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COX4I1 protein	27105554
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COX4I1 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COX4I1 mRNA	18172213\|2039979
D013849	Thimerosal	Thimerosal results in increased expression of COX4I1 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of COX4I1 mRNA	19483382
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of COX4I1 protein]	24041027
C032628	tin protoporphyrin IX	"tin protoporphyrin IX inhibits the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [resveratrol results in increased expression of COX4I1 protein]]"	24041027
C032628	tin protoporphyrin IX	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of COX4I1 protein]]"	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]	24041027
C032628	tin protoporphyrin IX	"tin protoporphyrin IX inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of COX4I1 protein]]"	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein]	24041027
D014050	Toluene	Toluene affects the expression of COX4I1 mRNA	21827849
D014212	Tretinoin	[IFNB1 protein co-treated with Tretinoin] results in increased expression of COX4I1 protein	16826196
C476530	tricarbonylchloro(glycinato)ruthenium(II)	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein]	24041027
C476530	tricarbonylchloro(glycinato)ruthenium(II)	NFE2L2 mutant form inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein]	24041027
C476530	tricarbonylchloro(glycinato)ruthenium(II)	tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein	24041027
D014635	Valproic Acid	Valproic Acid results in increased expression of COX4I1 mRNA	23179753

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004129	cytochrome-c oxidase activity	CONTRIBUTES_TO	IBA	21873635
GO:0005515	protein binding	-	IPI	23260140 25416956 26321642 26759378

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006091	generation of precursor metabolites and energy	-	TAS	2157630
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	-	IBA	21873635
GO:0007584	response to nutrient	-	IEA	-
GO:1902600	proton transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005739	mitochondrion	-	HDA	20833797
GO:0005739	mitochondrion	-	IDA	15565177
GO:0005743	mitochondrial inner membrane	-	TAS	-
GO:0005751	mitochondrial respiratory chain complex IV	-	IBA	21873635
GO:0005751	mitochondrial respiratory chain complex IV	-	IMP	19393246
GO:0016020	membrane	-	HDA	19946888

KEGG ID	KEGG Term
hsa00190	Oxidative phosphorylation
hsa01100	Metabolic pathways
hsa04260	Cardiac muscle contraction
hsa05010	Alzheimer's disease
hsa05012	Parkinson's disease
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-611105	Respiratory electron transport	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25869607	Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity and type 2 diabetes in humans and mice. (2015 Aug)	Van der Schueren B	Int J Obes (Lond)