Gene: EVC2

132884
LBN|WAD
EvC ciliary complex subunit 2
protein-coding
4p16.2
Ensembl:ENSG00000173040 MIM:607261 Vega:OTTHUMG00000125493 UniprotKB:Q86UK5
NG_015821.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.789e-1 (AD)  1.302e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03278643chr4:5710767EVC22.990e-9Maternal smoking in pregnancy27040690
cg17242664chr4:5710761EVC23.380e-8Maternal smoking in pregnancy27040690
cg03278643chr4:5710767EVC24.500e-10Maternal smoking in pregnancy27040690
cg17242664chr4:5710761EVC28.220e-9Maternal smoking in pregnancy27040690
cg03278643chr4:5710767EVC24.690e-11Maternal smoking in pregnancy27040690
cg17242664chr4:5710761EVC21.140e-10Maternal smoking in pregnancy27040690
cg01290904chr4:5708474EVC24.000e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D4A0.77
FOXJ10.761
CASP70.757
ABHD30.745
BAG30.744
MICB0.742
KCTD110.738
P4HA10.736
SERPINH10.735
CSF10.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.577
PPEF1-0.555
PCYOX1L-0.547
CDH8-0.544
HMGCLL1-0.536
ASIC2-0.536
KCNS2-0.534
CHRNB2-0.533
FSTL4-0.532
NUDT18-0.531

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EVC2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EVC2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EVC2 mRNA23630614
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EVC2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of EVC2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EVC2 promoter]19654925
D004958EstradiolEstradiol affects the expression of EVC2 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of EVC2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of EVC2 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EVC2 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of EVC2 mRNA26577399
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EVC2 mRNA20938992
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of EVC2 mRNA"24972896
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of EVC2 mRNA28341135
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EVC2 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EVC2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EVC2 mRNA"20188158
C523799MRK 003EVC2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EVC2 mRNA"25620056
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EVC2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EVC2 mRNA26272509
D013849ThimerosalThimerosal results in decreased expression of EVC2 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased expression of EVC2 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of EVC2 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of EVC2 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007224smoothened signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005929cilium-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0060170ciliary membrane-TAS-  
GO:0098797plasma membrane protein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOIEA
R-HSA-5635838Activation of SMOTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29618728Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)Miyake KSci Rep