Gene: PDCL2

132954
GCPHLP
phosducin like 2
protein-coding
4q12
Ensembl:ENSG00000163440 MIM:611676 Vega:OTTHUMG00000160674 UniprotKB:Q8N4E4
NC_000004.12
PubMed
0   ANCO-SNPs
OD|CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.520e-1 (AD)  6.154e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MS4A120.399
HOXD120.395
SPATA31D30.39
OR12D10.388
OR5D140.386
HOXD110.38
SPAG11B0.377
RASEF0.368
POTEH0.363
FSCB0.361

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2orf73-0.281
ROPN1B-0.273
C16orf74-0.26
FGGY-0.253
HKDC1-0.253
TMC1-0.241
NRL-0.233
MMP28-0.233
CABLES1-0.231
SLC25A53-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDCL2 mRNA]18700144
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PDCL2 mRNA21298039
D003471CuprizoneCuprizone results in decreased expression of PDCL2 mRNA26577399
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDCL2 mRNA19710929
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDCL2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27762075Sex-specific linkage scans in opioid dependence. (2017 Apr)Yang BZAm J Med Genet B Neuropsychiatr Genet