Gene info: ID 133

Gene: ADM

GENE ID: 133

Synonyms: AM|PAMP

Description: adrenomedullin

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000148926 MIM:103275 Vega:OTTHUMG00000165907 UniprotKB:P35318

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.181e-1 (AD) 1.220e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAFF	0.799
CDKN1A	0.784
GADD45B	0.77
SERPINE1	0.76
YBX3	0.76
SERTAD1	0.758
EMP1	0.756
PLAUR	0.755
NFKB2	0.75
CEBPD	0.748

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KIT	-0.519
NEUROD6	-0.497
SLC32A1	-0.488
MARCH4	-0.488
HAPLN1	-0.485
ERBB4	-0.476
SLC7A4	-0.474
LHX6	-0.473
GRIN3A	-0.472
VWC2	-0.469

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of ADM mRNA"	26377693
C000591541	1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine	"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]"	24403227
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADM mRNA"	19114083
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ADM mRNA"	17547211
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of ADM mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ADM mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in increased expression of ADM mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ADM mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of ADM mRNA	11264010\|1854490
D000242	Cyclic AMP	ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]	17306419
D000242	Cyclic AMP	ADM protein results in increased abundance of Cyclic AMP	17306419
D000242	Cyclic AMP	ADM results in increased abundance of Cyclic AMP	10374718
D000242	Cyclic AMP	CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]	17306419
D000242	Cyclic AMP	Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]	17306419
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ADM protein	20106945
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of ADM mRNA	17113911
D013196	Dihydrotestosterone	VEGFA protein affects the reaction [Dihydrotestosterone results in increased expression of ADM mRNA]	17113911
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ADM mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADM mRNA	16483693
D000965	Antimony	Antimony results in increased expression of ADM mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of ADM mRNA	17547211
D001151	Arsenic	Arsenic results in increased methylation of ADM promoter	21291286
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ADM mRNA	20471514
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ADM mRNA	19128835
C006632	arsenic trioxide	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of ADM mRNA]	20471514
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of ADM mRNA"	18687144
D001379	Azathioprine	Azathioprine results in increased expression of ADM mRNA	22623647
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of ADM mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADM mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADM mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ADM mRNA	26377693
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of ADM mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADM mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADM mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADM mRNA	19770486\|2156981
D004958	Estradiol	CALCA protein modified form inhibits the reaction [ADM protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]	18401014
D004958	Estradiol	Estradiol affects the expression of ADM mRNA	22574217
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in decreased expression of ADM mRNA	20404318
D004958	Estradiol	Estradiol affects the expression of ADM mRNA	15598610
D004958	Estradiol	ADM protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]	18401014
D004958	Estradiol	ADM protein results in increased abundance of Estradiol	21824440
C044887	beta-methylcholine	beta-methylcholine affects the expression of ADM mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of ADM mRNA	25181051
D000069286	Bortezomib	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of ADM mRNA]	20471514
D000069286	Bortezomib	Bortezomib results in decreased expression of ADM mRNA	20471514
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
D020122	tert-Butylhydroperoxide	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ADM mRNA	15336504\|2084711
D020122	tert-Butylhydroperoxide	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ADM mRNA	14729362\|1500399
D002104	Cadmium	Cadmium results in increased expression of ADM mRNA	21172416
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ADM mRNA	19010381
C058636	calcitonin gene-related peptide (8-37)	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]	21803157
C058636	calcitonin gene-related peptide (8-37)	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]	21803157
C058636	calcitonin gene-related peptide (8-37)	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]	21803157
D002118	Calcium	Calcium results in decreased expression of ADM mRNA	20682585
D002220	Carbamazepine	Carbamazepine affects the expression of ADM mRNA	25979313
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of ADM mRNA	10666155
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of ADM protein	10666155
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ADM mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ADM mRNA	16713642
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ADM protein	16610064\|1671364
C100187	chloropicrin	chloropicrin results in increased expression of ADM mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of ADM mRNA	23125180
D002857	Chromium	Chromium results in increased expression of ADM mRNA	17547211
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADM mRNA	27858113
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of ADM mRNA	19524605
D002994	Clofibrate	Clofibrate results in decreased expression of ADM mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ADM mRNA	11754965\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of ADM protein	22178239
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ADM mRNA]	22202117
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ADM mRNA	10666155\|2438626
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of ADM mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ADM mRNA	19549813
D003345	Corticosterone	Corticosterone results in increased expression of ADM mRNA	15755911
D003471	Cuprizone	Cuprizone results in increased expression of ADM mRNA	27523638
D003513	Cycloheximide	Cycloheximide promotes the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	11032871
D003513	Cycloheximide	Cycloheximide results in increased expression of ADM mRNA	11032871
D003520	Cyclophosphamide	ADM protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADM mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of ADM mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADM mRNA	19770486
C121414	dai-kenchu-to	dai-kenchu-to results in increased secretion of ADM protein	21808981
C515055	darinaparsin	darinaparsin results in increased expression of ADM mRNA	22535156
C515055	darinaparsin	Oxygen deficiency inhibits the reaction [darinaparsin results in increased expression of ADM mRNA]	22535156
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ADM mRNA	23914054
C014347	decitabine	decitabine affects the expression of ADM mRNA	23300844
D003676	Deferoxamine	Deferoxamine results in increased expression of ADM mRNA	11754965
C107676	deguelin	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22745725
D003907	Dexamethasone	Dexamethasone results in increased expression of ADM mRNA	19853017\|2504701
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of ADM mRNA	22733784
D003994	Bucladesine	Bucladesine results in decreased expression of ADM mRNA	19253104
D002945	Cisplatin	Cisplatin affects the expression of ADM mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of ADM mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of ADM mRNA	22023808
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of ADM mRNA	15885261
D004041	Dietary Fats	Dietary Fats results in decreased expression of ADM mRNA	25016146
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ADM mRNA	27614199
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ADM mRNA"	19480007
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of ADM mRNA	25236440
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of ADM mRNA	23999411
C493087	diphenylarsinic acid	diphenylarsinic acid results in increased secretion of ADM protein	26645585\|2808783
C493087	diphenylarsinic acid	SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]	28087833
C493087	diphenylarsinic acid	SCH772984 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]	28087833
C029402	diphenylcyclopropenone	diphenylcyclopropenone results in increased expression of ADM mRNA	25236440
D004178	Diquat	Diquat results in increased expression of ADM mRNA	21172416
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA	24690739
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of ADM mRNA"	23811387
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased secretion of ADM protein	22178239
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ADM mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ADM mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ADM mRNA	12655037\|1583489
C000499	ferric oxide	ferric oxide analog results in increased expression of ADM mRNA	25086211
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]	15680492
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein]	15680492
D005419	Flavonoids	Flavonoids results in increased expression of ADM mRNA	18035473
D005472	Fluorouracil	ADM protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in decreased expression of ADM mRNA	15885261
D005557	Formaldehyde	Formaldehyde results in increased expression of ADM mRNA	20655997
C039281	furan	furan results in increased expression of ADM mRNA	27387713
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in increased expression of ADM mRNA	16206274
D017313	Fenretinide	Fenretinide results in increased expression of ADM mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ADM mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of ADM	18687144
D015759	Ionomycin	[Ionomycin co-treated with Lipopolysaccharides] results in decreased expression of ADM protein	20682585
D015759	Ionomycin	Ionomycin results in decreased expression of ADM mRNA	20682585
D015759	Ionomycin	Ionomycin results in decreased expression of ADM protein	20682585
D015759	Ionomycin	Ionomycin results in decreased expression of ADM mRNA	11470465
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNA	16054899
D007545	Isoproterenol	ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]	17306419
D007545	Isoproterenol	CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]	17306419
D007545	Isoproterenol	Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]	17306419
D007545	Isoproterenol	Isoproterenol results in increased expression of ADM mRNA	12732346\|1725092
D007545	Isoproterenol	Isoproterenol results in increased expression of ADM protein	12732346
D007545	Isoproterenol	[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA	17250927
D007545	Isoproterenol	[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein	17250927
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of ADM mRNA	17085751
C410337	K 7174	K 7174 results in increased expression of ADM mRNA	24086573
C119620	kenpaullone	kenpaullone results in decreased expression of ADM mRNA	17993264
C045463	leflunomide	leflunomide results in increased expression of ADM mRNA	28988120
D008070	Lipopolysaccharides	[Ionomycin co-treated with Lipopolysaccharides] results in decreased expression of ADM protein	20682585
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of ADM mRNA	20682585
D008070	Lipopolysaccharides	ADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	21803157
D008070	Lipopolysaccharides	ADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]	21803157
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ADM protein	14766677
D008070	Lipopolysaccharides	ADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]	21803157
D008070	Lipopolysaccharides	ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]	21803157
D008070	Lipopolysaccharides	ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]	21803157
D008070	Lipopolysaccharides	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]	21803157
D008070	Lipopolysaccharides	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]	21803157
D008070	Lipopolysaccharides	calcitonin gene-related peptide (8-37) inhibits the reaction [ADM protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]	21803157
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ADM mRNA	21641980
D008345	Manganese	Manganese results in increased expression of ADM mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of ADM mRNA	17175027
D015122	Mercaptopurine	Mercaptopurine results in increased expression of ADM mRNA	23358152
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
D008627	Mercuric Chloride	Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]	15680492
D008627	Mercuric Chloride	Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein]	15680492
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of ADM mRNA	15680492\|1650778
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of ADM protein	15063164\|1568049
D008627	Mercuric Chloride	Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein]	15063164
D008628	Mercury	Mercury results in increased expression of ADM mRNA	17547211
D008713	Methimazole	Methimazole results in increased expression of ADM mRNA	22504374
D008727	Methotrexate	Methotrexate results in decreased expression of ADM mRNA	17400583
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ADM mRNA	23179753\|2718838
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ADM mRNA	28001369
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ADM mRNA	16026605
C500085	muraglitazar	muraglitazar results in increased expression of ADM mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of ADM mRNA	15674844
D009151	Mustard Gas	Mustard Gas results in increased expression of ADM mRNA	18988085
D009173	Mycophenolic Acid	Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein]	15063164
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADM protein results in decreased activity of MAPK1 protein]	10374718
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of ADM mRNA	16052530
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of ADM mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of ADM mRNA"	25554681
D009285	Naphthoquinones	Naphthoquinones results in increased expression of ADM mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of ADM mRNA	19812364
C022838	nickel chloride	nickel chloride results in increased expression of ADM mRNA	17312168\|1754721
C022838	nickel chloride	nickel chloride affects the expression of ADM mRNA	22110744
C029938	nickel sulfate	nickel sulfate results in decreased expression of ADM mRNA	22714537
C029938	nickel sulfate	nickel sulfate results in increased expression of ADM mRNA	18651567
D009566	Nitrates	ADM protein affects the abundance of Nitrates	15370692
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of ADM mRNA	16326922
C007350	nitrofen	nitrofen results in increased expression of ADM mRNA	16226985
C007350	nitrofen	nitrofen results in increased expression of ADM protein	16226985
D009599	Nitroprusside	Nitroprusside results in decreased expression of ADM mRNA	12899678
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of ADM mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased expression of ADM mRNA	23358140
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ADM mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ADM mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of ADM mRNA	23999411
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ADM mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ADM mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ADM mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ADM mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ADM mRNA]	17655762
D010100	Oxygen	"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]"	24403227
D010100	Oxygen	Cycloheximide promotes the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	11032871
D010100	Oxygen	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22745725
D010100	Oxygen	Oxygen deficiency inhibits the reaction [darinaparsin results in increased expression of ADM mRNA]	22535156
D010100	Oxygen	Oxygen deficiency results in increased expression of ADM mRNA	11032871\|1175496
D010100	Oxygen	Oxygen deficiency results in increased expression of ADM protein	11032871
D010100	Oxygen	Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22279137
D010100	Oxygen	Propolis inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22279137
D010100	Oxygen	Oxygen deficiency affects the expression of ADM mRNA	17193925
D010100	Oxygen	Oxygen deficiency results in increased expression of ADM mRNA	10666155
D010100	Oxygen	Oxygen deficiency results in increased expression of ADM protein	10666155
D010126	Ozone	Ozone results in increased expression of ADM mRNA	27206323
D010126	Ozone	Ozone results in increased expression of ADM mRNA	16716893
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ADM mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of ADM mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ADM mRNA]	17655762
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ADM mRNA	18593933
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ADM mRNA	27614199
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of ADM mRNA	17097637
D015232	Dinoprostone	Dinoprostone results in decreased expression of ADM mRNA	19253104
D010634	Phenobarbital	Phenobarbital affects the expression of ADM mRNA	19159669
D010656	Phenylephrine	ADM protein results in decreased susceptibility to Phenylephrine	15370692
D010656	Phenylephrine	ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]	11470465
D010656	Phenylephrine	ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]	11470465
D010656	Phenylephrine	ADM protein results in decreased susceptibility to Phenylephrine	15370692
D010656	Phenylephrine	[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA	17250927
D010656	Phenylephrine	[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein	17250927
D010656	Phenylephrine	Phenylephrine results in decreased expression of ADM mRNA	11470465
D010656	Phenylephrine	Phenylephrine results in decreased secretion of ADM protein	11470465
D010656	Phenylephrine	Phenylephrine results in increased expression of ADM mRNA	17250927
D010656	Phenylephrine	Phenylephrine results in increased expression of ADM protein	17250927
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADM mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ADM mRNA	26272509
C121565	pifithrin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]	20064835
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
D010894	Piroxicam	Piroxicam results in increased expression of ADM mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased secretion of ADM protein	21808981
D010938	Plant Oils	Plant Oils results in increased expression of ADM mRNA	23370395
D059808	Polyphenols	Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22279137
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of ADM mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of ADM mRNA	17547211
D011374	Progesterone	Progesterone results in decreased expression of ADM mRNA	23018184
D011374	Progesterone	ADM protein modified form inhibits the reaction [ADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]]	18401014
D011374	Progesterone	ADM protein affects the abundance of Progesterone	21824440
D011374	Progesterone	ADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]	18401014
D011429	Propolis	Propolis inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]	22279137
D011433	Propranolol	Propranolol results in decreased susceptibility to ADM protein	9845272
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ADM mRNA	22504374
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ADM mRNA	27029645
D011794	Quercetin	Quercetin results in increased expression of ADM mRNA	21632981
C041125	quinapril	quinapril results in decreased expression of ADM protein	10334802
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of ADM mRNA	21632981
C059514	resveratrol	resveratrol results in decreased secretion of ADM protein	22178239
C013672	riddelliine	riddelliine results in decreased expression of ADM mRNA	18047727
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
C089730	rosiglitazone	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]	20847119
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of ADM mRNA	21515302
C100574	sanshool	sanshool analog results in increased secretion of ADM protein	21808981
C093642	SB 203580	SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]	28087833
C093642	SB 203580	SB 203580 results in increased secretion of ADM protein	28087833
C587178	SCH772984	SCH772984 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]	28087833
C587178	SCH772984	SCH772984 results in decreased secretion of ADM protein	28087833
D012834	Silver	Silver results in increased expression of ADM mRNA	26014281\|2895954
D012999	Soman	Soman results in increased expression of ADM mRNA	19281266
D053260	Soot	Soot results in increased expression of ADM mRNA	26551751
D019311	Staurosporine	Staurosporine results in decreased expression of ADM mRNA	19253104
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ADM mRNA	21641980
C016766	sulforafan	sulforafan results in increased expression of ADM mRNA	26833863
C025462	sulindac sulfide	sulindac sulfide results in increased expression of ADM mRNA	16184548
D013629	Tamoxifen	Tamoxifen affects the expression of ADM mRNA	17555576\|2093736
C501413	tesaglitazar	tesaglitazar results in increased expression of ADM mRNA	21515302
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of ADM mRNA	20189893
D013749	Tetrachlorodibenzodioxin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]	20064835
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ADM mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ADM mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADM mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of ADM protein	16343043
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of ADM mRNA	11470465
D019284	Thapsigargin	Thapsigargin results in decreased expression of ADM mRNA	20682585
D019284	Thapsigargin	Thapsigargin results in increased expression of ADM mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of ADM mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in decreased expression of ADM mRNA	27760801
C009495	titanium dioxide	titanium dioxide results in increased expression of ADM mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ADM mRNA	22363418\|2806579
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of ADM mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ADM mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ADM mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of ADM mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of ADM mRNA	16054129\|2372400
D014212	Tretinoin	Tretinoin results in increased expression of ADM mRNA	22262565
C012589	trichostatin A	trichostatin A results in increased expression of ADM mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADM mRNA"	26179874
C057693	troglitazone	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]	20847119
D014520	Urethane	Urethane results in increased expression of ADM mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of ADM mRNA	25979313\|2607246
D014635	Valproic Acid	Valproic Acid results in decreased expression of ADM mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of ADM mRNA	23527032\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of ADM gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ADM mRNA	26072468
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ADM mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of ADM mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ADM mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of ADM mRNA	19465080
C111237	vorinostat	vorinostat results in decreased expression of ADM mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ADM mRNA	18593933
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ADM mRNA]	22202117
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of ADM mRNA	16330358

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	8074714 8524787
GO:0005179	hormone activity	-	IEA	-
GO:0031700	adrenomedullin receptor binding	-	IDA	20074556

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001570	vasculogenesis	-	IDA	16964401
GO:0001666	response to hypoxia	-	IEA	-
GO:0001843	neural tube closure	-	IEA	-
GO:0002026	regulation of the force of heart contraction	-	IEA	-
GO:0002031	G-protein coupled receptor internalization	-	IDA	10882736
GO:0003073	regulation of systemic arterial blood pressure	-	IDA	18434369
GO:0006171	cAMP biosynthetic process	-	TAS	8074714
GO:0006701	progesterone biosynthetic process	-	TAS	10822232
GO:0007165	signal transduction	-	TAS	10822232
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IDA	10882736 18434369 20074556
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007267	cell-cell signaling	-	TAS	8074714
GO:0007507	heart development	-	IEA	-
GO:0007565	female pregnancy	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0008015	blood circulation	-	TAS	8074714
GO:0008209	androgen metabolic process	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009409	response to cold	-	IEA	-
GO:0009611	response to wounding	-	IEA	-
GO:0010460	positive regulation of heart rate	-	IDA	18434369
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0031102	neuron projection regeneration	-	IEA	-
GO:0031623	receptor internalization	-	IDA	10882736 15613468 20074556
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032868	response to insulin	-	IEA	-
GO:0035809	regulation of urine volume	-	IDA	18434369
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0042594	response to starvation	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043116	negative regulation of vascular permeability	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0045906	negative regulation of vasoconstriction	-	IDA	11410113
GO:0046879	hormone secretion	-	IEA	-
GO:0048589	developmental growth	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0060670	branching involved in labyrinthine layer morphogenesis	-	IEA	-
GO:0060712	spongiotrophoblast layer development	-	IEA	-
GO:0097084	vascular smooth muscle cell development	-	IEA	-
GO:0097647	amylin receptor signaling pathway	-	IGI	22500019
GO:1990410	adrenomedullin receptor signaling pathway	-	IDA	10882736 18434369 20074556
GO:2001214	positive regulation of vasculogenesis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	12379507
GO:0005737	cytoplasm	-	IDA	12379507

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-419812	Calcitonin-like ligand receptors	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19424162	Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension. (2009 Aug)	Al-Omari MA	Am J Hypertens
24107729	Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure. (2013 Oct)	Gottsater M	J Hypertens
22993405	Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice. (2012 Nov 15)	Portal-Nunez S	Cancer Res
23653390	Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion. (2014 Jan)	Kraus DM	Reprod Sci
24927863	Immediate breast reconstruction with acellular dermal matrix: factors affecting outcome. (2014 Aug)	Lardi AM	J Plast Reconstr Aesthet Surg
12479634	Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: a comparative 1-year clinical study. (2002 Nov)	Paolantonio M	J Periodontol
24909166	Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages. (2015 Apr 16)	Kumar S	Oncogene