Gene: EMB

133418
GP70
embigin
protein-coding
5q11.1
Ensembl:ENSG00000170571 MIM:615669 Vega:OTTHUMG00000131161 UniprotKB:Q6PCB8
NC_000005.10
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.692e-1 (AD)  2.742e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13157992chr5:50444074 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2036902chr5:50401098 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCTD90.775
ST8SIA40.769
USP150.756
MIS18BP10.753
PLA2G4A0.75
BCAT10.748
GMIP0.747
ALG90.741
TMEM87B0.738
CCL280.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.498
NTSR2-0.493
SALL3-0.463
NWD1-0.461
GRIN2C-0.451
SLC25A48-0.445
GPR143-0.434
CNTFR-0.432
S100A1-0.423
PYGM-0.422

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EMB mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EMB mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EMB mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of EMB mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EMB mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of EMB mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of EMB mRNA28522335
D000499AllylamineAllylamine results in increased expression of EMB mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EMB mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EMB mRNA24449571
C028559bathocuproine sulfonatebathocuproine sulfonate results in decreased expression of EMB mRNA16973896
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EMB mRNA22228805|2373587
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of EMB mRNA26496021
C006780bisphenol Abisphenol A affects the expression of EMB mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of EMB mRNA26496021
D002101Cacodylic AcidCacodylic Acid results in increased expression of EMB mRNA16122865
D002509CephaloridineCephaloridine results in increased expression of EMB mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EMB mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMB mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EMB gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EMB mRNA20971185
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA]18200517
C089595cylindrospermopsincylindrospermopsin results in decreased expression of EMB mRNA24921660
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EMB mRNA16054899
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EMB mRNA17394237
D002117CalcitriolCalcitriol results in increased expression of EMB mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of EMB mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of EMB mRNA17374397
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EMB mRNA17557909
D005054EugenolEugenol results in decreased expression of EMB mRNA17374397
D005419FlavonoidsFlavonoids results in decreased expression of EMB mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMB mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EMB gene20938992
D005839GentamicinsGentamicins results in decreased expression of EMB mRNA22061828
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of EMB mRNA15159207
D017313FenretinideFenretinide results in increased expression of EMB mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of EMB mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EMB mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EMB mRNA16054899
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EMB mRNA26752646
C045463leflunomideleflunomide results in increased expression of EMB mRNA19751817
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of EMB mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMB mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EMB gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EMB mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in increased expression of EMB mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EMB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EMB mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of EMB mRNA25380136
D009532NickelNickel results in increased expression of EMB mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of EMB mRNA]14575637
C029938nickel sulfatenickel sulfate results in decreased expression of EMB mRNA17374397
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EMB mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EMB mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of EMB mRNA17374397
D010615PhenacetinPhenacetin results in increased expression of EMB mRNA17082564
C030299phenylhydrazinephenylhydrazine results in increased expression of EMB mRNA17082564
C006253pirinixic acidpirinixic acid results in increased expression of EMB mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EMB mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EMB mRNA22698814
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of EMB mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of EMB mRNA17556502
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EMB mRNA16054899
D012715Sesame OilSesame Oil results in decreased expression of EMB mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of EMB mRNA23221170
D012834SilverSilver results in increased expression of EMB mRNA27131904
D012906SmokeSmoke affects the expression of EMB mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of EMB mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of EMB mRNA18175754
D012999SomanSoman results in increased expression of EMB mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of EMB mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EMB mRNA24680724|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EMB mRNA19933214
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of EMB mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EMB mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EMB mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of EMB mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EMB mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EMB mRNA25729387
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of EMB mRNA]14575637
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of EMB mRNA18200517
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EMB gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of EMB mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008028monocarboxylic acid transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035879plasma membrane lactate transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-433692Proton-coupled monocarboxylate transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
212815[Studies of resumption of treatment with rifampin and ethambutol in patients with recurrent pulmonary tuberculosis]. (1978 Jul-Sep)Jozefovics FRev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol