Gene info: ID 133522

Gene: PPARGC1B

GENE ID: 133522

Synonyms: ERRL1|PERC|PGC-1(beta)|PGC1B

Description: PPARG coactivator 1 beta

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000155846 MIM:608886 Vega:OTTHUMG00000130055 UniprotKB:Q86YN6

RefSeq: NG_016747.1

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.957e-1 (AD) 9.066e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs880770	chr5:149775272 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs4705371	chr5:149758061 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs4705088	chr5:149757069 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16786458	chr5:149108820	PPARGC1B		4.700e-17	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHST15	0.797
SLC7A6	0.796
RASAL2	0.788
CTC1	0.785
PIAS2	0.783
HEATR5B	0.783
GIT2	0.781
TRIO	0.778
PTPRE	0.777
SLC1A1	0.775

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A1	-0.447
COPZ2	-0.411
AAMDC	-0.4
HEY2	-0.39
MPST	-0.379
BCL7C	-0.378
C16orf74	-0.378
RBP1	-0.373
CDKN2C	-0.368
AQP5	-0.368

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PPARGC1B mRNA"	21354444\|2890350
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPARGC1B mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PPARGC1B mRNA"	28433925
C050147	3-(2,2,2-trimethylhydrazine)propionate	"3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA"	27559315
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PPARGC1B mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of PPARGC1B mRNA	17562736
D024502	alpha-Tocopherol	alpha-Tocopherol deficiency results in increased expression of PPARGC1B mRNA	24657723
D000638	Amiodarone	Amiodarone results in increased expression of PPARGC1B mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PPARGC1B mRNA	16483693
C027423	aroclor 1242	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
C026987	aroclor 1260	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
D001151	Arsenic	Arsenic affects the methylation of PPARGC1B gene	25304211
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of PPARGC1B mRNA"	17331233
D000069059	Atorvastatin Calcium	Atorvastatin Calcium affects the expression of PPARGC1B mRNA	21775390
D000069059	Atorvastatin Calcium	Quercetin inhibits the reaction [Atorvastatin Calcium affects the expression of PPARGC1B mRNA]	21775390
C487081	belinostat	belinostat results in increased expression of PPARGC1B mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PPARGC1B mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PPARGC1B mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PPARGC1B mRNA	25566086
D004958	Estradiol	Estradiol results in increased expression of PPARGC1B mRNA	23019147
D004958	Estradiol	Estradiol results in decreased expression of PPARGC1B mRNA	20068009
C006780	bisphenol A	bisphenol A results in increased expression of PPARGC1B mRNA	26063408
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PPARGC1B mRNA"	28433925
C006780	bisphenol A	bisphenol A results in increased expression of PPARGC1B mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of PPARGC1B mRNA	25388156
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of PPARGC1B mRNA	27339419
D020111	Chlorodiphenyl (54% Chlorine)	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
D008078	Cholesterol, LDL	"PPARGC1B results in increased abundance of Cholesterol, LDL"	17932310
D015243	Cholesterol, VLDL	"PPARGC1B results in increased abundance of Cholesterol, VLDL"	17932310
D002922	Ciguatoxins	Ciguatoxins affects the expression of PPARGC1B mRNA	18353800
D005576	Colforsin	Colforsin results in increased expression of PPARGC1B mRNA	16357189
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of PPARGC1B mRNA	20971185
D017485	1-Deoxynojirimycin	[1-Deoxynojirimycin co-treated with Dietary Fats] results in increased expression of PPARGC1B mRNA	25445511
D002945	Cisplatin	Cisplatin results in decreased expression of PPARGC1B mRNA	27594783
D004008	Diclofenac	Diclofenac results in decreased expression of PPARGC1B mRNA	26934552
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of PPARGC1B mRNA	26924002
D004041	Dietary Fats	[1-Deoxynojirimycin co-treated with Dietary Fats] results in increased expression of PPARGC1B mRNA	25445511
D004041	Dietary Fats	Dietary Fats results in decreased expression of PPARGC1B mRNA	17456854
D004041	Dietary Fats	Dietary Fats results in increased expression of PPARGC1B mRNA	17932310\|1804283
D004041	Dietary Fats	PPARGC1B protein inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein inhibits the reaction [Dietary Fats results in increased expression of PPARA mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein promotes the reaction [Dietary Fats results in increased expression of ACACA mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein promotes the reaction [Dietary Fats results in increased expression of FASN mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein promotes the reaction [Dietary Fats results in increased expression of GPAM mRNA]	17932310
D004041	Dietary Fats	PPARGC1B protein results in increased susceptibility to Dietary Fats	17932310
D004041	Dietary Fats	rosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]	17456854
D004041	Dietary Fats	Dietary Fats results in decreased expression of PPARGC1B mRNA	22464149
D004041	Dietary Fats	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]	22464149
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PPARGC1B mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PPARGC1B mRNA	22672789
C014476	diethyl maleate	diethyl maleate results in decreased expression of PPARGC1B mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PPARGC1B mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PPARGC1B mRNA	20360939
C118756	dihydroxy-vitamin D3	dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to PPARGC1B protein modified form]	20947021
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of PPARGC1B mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of PPARGC1B mRNA	20463971
C012301	domoic acid	domoic acid results in increased expression of PPARGC1B mRNA	18936300
C547512	eldecalcitol	eldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to PPARGC1B protein modified form]	20947021
C118739	entinostat	entinostat results in increased expression of PPARGC1B mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PPARGC1B mRNA	17942748
D005047	Etoposide	Etoposide results in increased expression of PPARGC1B mRNA	26259609
D005227	Fatty Acids	PPARGC1B protein results in increased uptake of and results in increased oxidation of Fatty Acids	17932310
D005557	Formaldehyde	Formaldehyde results in decreased expression of PPARGC1B mRNA	20655997
D019833	Genistein	Genistein results in increased expression of PPARGC1B mRNA	23019147
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PPARGC1B mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PPARGC1B mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in decreased expression of PPARGC1B mRNA	20003209
C544151	jinfukang	jinfukang results in increased expression of PPARGC1B mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PPARGC1B mRNA	26752646
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PPARGC1B mRNA	16847310\|2187342
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PPARGC1B mRNA	25613284
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of PPARGC1B mRNA	22129749
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of PPARGC1B mRNA	24810058
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of PPARGC1B mRNA	26924002
C523799	MRK 003	MRK 003 results in increased expression of PPARGC1B mRNA	21169257
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PPARGC1B mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PPARGC1B mRNA"	25620056
C028007	nickel monoxide	nickel monoxide affects the expression of PPARGC1B mRNA	19167457
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of PPARGC1B mRNA	20971185
D019787	Linoleic Acid	Linoleic Acid results in increased expression of PPARGC1B mRNA	23056435
D062907	Oxaloacetic Acid	Oxaloacetic Acid results in increased expression of PPARGC1B protein	26811028
D010100	Oxygen	Oxygen deficiency results in decreased expression of PPARGC1B mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in increased expression of PPARGC1B mRNA	23539316
D000073878	Palm Oil	Palm Oil results in increased expression of PPARGC1B mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PPARGC1B mRNA	26272509
C086401	pentabromodiphenyl ether	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
C076994	perfluorooctane sulfonic acid	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PPARGC1B mRNA	17681415
D010578	Petroleum	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PPARGC1B mRNA	24535843
D010634	Phenobarbital	Phenobarbital affects the expression of PPARGC1B mRNA	23091169
D010713	Phosphatidylcholines	PPARGC1B results in increased abundance of Phosphatidylcholines	17932310
C483858	phosphatidylethanolamine	PPARGC1B results in increased abundance of phosphatidylethanolamine	17932310
D010836	Phytol	Phytol results in increased activity of PPARGC1B protein	17015885
D010840	Phytosterols	APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA]	18155511
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPARGC1B mRNA	19710929
C006253	pirinixic acid	pirinixic acid promotes the reaction [PPARGC1B protein results in decreased expression of PPARGC1A mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of ACADM mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of CYP4A10 mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of PLIN2 mRNA]	17932310
C006253	pirinixic acid	PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]	17932310
D010936	Plant Extracts	Plant Extracts results in decreased expression of PPARGC1B mRNA	24677778
D011078	Polychlorinated Biphenyls	[Petroleum analog co-treated with aroclor 1242 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260 co-treated with Polychlorinated Biphenyls co-treated with pentabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in decreased expression of PPARGC1B mRNA	23266412
C045950	propiconazole	propiconazole results in decreased expression of PPARGC1B mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PPARGC1B mRNA	24780913
D011794	Quercetin	Quercetin inhibits the reaction [Atorvastatin Calcium affects the expression of PPARGC1B mRNA]	21775390
C089730	rosiglitazone	rosiglitazone affects the expression of PPARGC1B mRNA	22013433
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]	17456854
D012402	Rotenone	Rotenone results in decreased expression of PPARGC1B mRNA	19693701
D012402	Rotenone	Rotenone results in decreased expression of PPARGC1B protein	19693701
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PPARGC1B mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of PPARGC1B mRNA	19073995
D018038	Sodium Selenite	Sodium Selenite results in increased expression of PPARGC1B mRNA	18175754
C525422	SRT1720	[SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of PPARGC1B mRNA	21212096
C004648	testosterone enanthate	testosterone enanthate results in increased expression of PPARGC1B mRNA	25603467
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPARGC1B mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PPARGC1B mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PPARGC1B mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPARGC1B mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PPARGC1B mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PPARGC1B mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of PPARGC1B mRNA	23411599
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]	22464149
D008063	Thioctic Acid	Thioctic Acid results in decreased acetylation of PPARGC1B protein	22327056
D008063	Thioctic Acid	[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein	22327056
D014212	Tretinoin	Tretinoin results in increased expression of PPARGC1B mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PPARGC1B mRNA	26272509
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PPARGC1B mRNA"	26743178
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of PPARGC1B mRNA	29024780
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of PPARGC1B mRNA	27776230
D014415	Tunicamycin	Tunicamycin results in increased expression of PPARGC1B mRNA	22414386
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PPARGC1B mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PPARGC1B mRNA	23179753\|2438349
C030106	very low density lipoprotein triglyceride	PPARGC1B results in increased abundance of very low density lipoprotein triglyceride	17932310
C025643	vinclozolin	vinclozolin results in decreased expression of PPARGC1B mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PPARGC1B mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003712	transcription coregulator activity	-	IDA	11854298
GO:0003723	RNA binding	-	NAS	11854298
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0030331	estrogen receptor binding	-	IDA	11854298
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	-	IBA	21873635
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	-	IDA	11854298
GO:0050682	AF-2 domain binding	-	IPI	11854298

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001503	ossification	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IDA	23836911
GO:0006390	mitochondrial transcription	-	IEA	-
GO:0007015	actin filament organization	-	IEA	-
GO:0010694	positive regulation of alkaline phosphatase activity	-	IEA	-
GO:0030520	intracellular estrogen receptor signaling pathway	-	IDA	11854298
GO:0034614	cellular response to reactive oxygen species	-	IEA	-
GO:0042327	positive regulation of phosphorylation	-	IEA	-
GO:0045672	positive regulation of osteoclast differentiation	-	IEA	-
GO:0045780	positive regulation of bone resorption	-	IEA	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	11854298
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IBA	21873635
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051591	response to cAMP	-	IEA	-
GO:0060346	bone trabecula formation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	11854298
GO:0005654	nucleoplasm	-	TAS	-
GO:0005739	mitochondrion	-	IEA	-
GO:0016592	mediator complex	-	IDA	11854298

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	IEA
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26672058	Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study. (2016 Jul)	Pieters N	Environ Health Perspect
28418876	PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level. (2017 Jun 6)	Zhu L	Oncotarget
25129674	Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)	McClintick JN	Alcohol