Gene: ADORA1

134
RDC7
adenosine A1 receptor
protein-coding
1q32.1
Ensembl:ENSG00000163485 MIM:102775 Vega:OTTHUMG00000042125 UniprotKB:P30542
NG_052917.1
PubMed
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.846e-1 (AD)  4.220e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROGDI0.908
TBC1D10B0.906
APBB10.905
TMEM151A0.901
NACAD0.9
MAP7D10.899
TUBB4A0.898
FZR10.895
MPP20.895
ARL8A0.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.586
EBF1-0.462
WEE1-0.457
GJB2-0.454
PABPC4L-0.453
TFPI2-0.448
SPTLC3-0.445
SIX1-0.439
CLEC2B-0.434

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB00277TheophyllineSmall Molecule58-55-9ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00640AdenosineSmall Molecule58-61-7Approved|InvestigationalTarget
DB00651DyphyllineSmall Molecule479-18-5ApprovedTarget
DB00806PentoxifyllineSmall Molecule6493-05-6Approved|InvestigationalTarget
DB00824EnprofyllineSmall Molecule41078-02-8Approved|InvestigationalTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01223AminophyllineSmall Molecule317-34-0ApprovedTarget
DB01303OxtriphyllineSmall Molecule4499-40-5ApprovedTarget
DB01412TheobromineSmall Molecule83-67-0Approved|InvestigationalTarget
DB04932DefibrotideBiotechDrug83712-60-1Approved|InvestigationalTarget
DB04954TecadenosonSmall Molecule204512-90-3InvestigationalTarget
DB06471NaxifyllineSmall Molecule166374-49-8InvestigationalTarget
DB12569TonapofyllineSmall Molecule340021-17-2InvestigationalTarget
DB12670RolofyllineSmall Molecule136199-02-5InvestigationalTarget
ID Drug Name Action PubMed
C0972801,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine"1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine binds to and results in decreased activity of ADORA1 protein"10636259|1171488
C0463791,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine"8987795
C0463791,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"8987795
C0463791,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine"8987795
C0538961,3-dipropyl-8-(4-sulfophenyl)xanthine"1,3-dipropyl-8-(4-sulfophenyl)xanthine binds to and results in decreased activity of ADORA1 protein"10642308
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein"16793905
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to ADORA1 protein"21186795|2167577
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein"18727925|2216426
C0513601,3-dipropyl-8-cyclopentylxanthine"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Oxygen deficiency"23437309
C0513601,3-dipropyl-8-cyclopentylxanthine"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in increased susceptibility to cobaltous chloride"18727925
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein"10642308|1067759
C0513601,3-dipropyl-8-cyclopentylxanthine"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to 2-chloro-N(6)cyclopentyladenosine"11311893
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]"19966059
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]"19966059
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein"10401785|1074664
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein"17414428|1942923
C0513601,3-dipropyl-8-cyclopentylxanthine"[1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Amitriptyline"19429234
C0513601,3-dipropyl-8-cyclopentylxanthine"Propranolol inhibits the reaction [[1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Amitriptyline]"19429234
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ADORA1 mRNA"28903501
C0480861-deazaadenosine1-deazaadenosine analog binds to and results in increased activity of ADORA1 protein10649980
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADORA1 mRNA19933214
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ADORA1 mRNA"28433925
C5622252-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one"2-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one binds to and results in decreased activity of ADORA1 protein"21667953
C0583942-chloro-N(6)cyclopentyladenosine2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein16793905
C0583942-chloro-N(6)cyclopentyladenosine2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein10952960|1576515
C0583942-chloro-N(6)cyclopentyladenosine"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to 2-chloro-N(6)cyclopentyladenosine"11311893
C0583942-chloro-N(6)cyclopentyladenosine2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein10413299
C0583942-chloro-N(6)cyclopentyladenosine2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein11311893
C0583942-chloro-N(6)cyclopentyladenosine[2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine11311893
C0583942-chloro-N(6)cyclopentyladenosineCadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
C0583942-chloro-N(6)cyclopentyladenosineCadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
C0583942-chloro-N(6)cyclopentyladenosineCysteine inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
C0583942-chloro-N(6)cyclopentyladenosineDiethyl Pyrocarbonate inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
C0583942-chloro-N(6)cyclopentyladenosineDithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
C0583942-chloro-N(6)cyclopentyladenosineDithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
C0583942-chloro-N(6)cyclopentyladenosine[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
C0583942-chloro-N(6)cyclopentyladenosine[Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
C0583942-chloro-N(6)cyclopentyladenosineDithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
C0583942-chloro-N(6)cyclopentyladenosineDithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
C0583942-chloro-N(6)cyclopentyladenosine2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein8246158
C0578373,7-dimethyl-1-propargylxanthine"3,7-dimethyl-1-propargylxanthine binds to and results in decreased activity of ADORA1 protein"18313046
C0578373,7-dimethyl-1-propargylxanthine"3,7-dimethyl-1-propargylxanthine binds to and results in decreased activity of ADORA1 protein"15849377
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA12419474
C5246995-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one binds to and results in decreased activity of ADORA1 protein17684118
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
C5170597,8-dihydro-8-ethyl-2-(4-bicyclo(2.2.2)octan-1-ol)-4-propyl-1H-imidazo(2,1-i)purin-5(4H)-one"7,8-dihydro-8-ethyl-2-(4-bicyclo(2.2.2)octan-1-ol)-4-propyl-1H-imidazo(2,1-i)purin-5(4H)-one binds to and results in decreased activity of ADORA1 protein"21675777
C0539078-cyclopentyl-1,3-dimethylxanthine"[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]"7996441
C0539078-cyclopentyl-1,3-dimethylxanthine"[8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]"15345477
C0539078-cyclopentyl-1,3-dimethylxanthine"[8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to resveratrol"15345477
C0539078-cyclopentyl-1,3-dimethylxanthine"8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein"15187444|7996441
C0539078-cyclopentyl-1,3-dimethylxanthine"8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein"15345477
C1006408-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine binds to and results in decreased activity of ADORA1 protein18079280
C0671978-(dicyclopropylmethyl)-1,3-dipropylxanthine"8-(dicyclopropylmethyl)-1,3-dipropylxanthine binds to and results in decreased activity of ADORA1 protein"8355252
C0671978-(dicyclopropylmethyl)-1,3-dipropylxanthine"8-(dicyclopropylmethyl)-1,3-dipropylxanthine binds to and results in decreased activity of ADORA1 protein"7496369
C0283228-phenyltheophylline8-phenyltheophylline binds to and results in decreased activity of ADORA1 protein8720578|9218695
C1100419-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline"9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline binds to and results in decreased activity of ADORA1 protein"11911839
C095427A 86929A 86929 binds to ADORA1 protein8558425
D000082AcetaminophenAcetaminophen results in decreased expression of ADORA1 mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ADORA1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADORA1 mRNA]17585979
D000241AdenosineAdenosine results in increased activity of ADORA1 protein16793905
D000241AdenosineAdenosine analog binds to and affects the activity of ADORA1 protein20571079
D000241AdenosineAdenosine analog binds to and results in decreased activity of ADORA1 protein18404447
D000241AdenosineAdenosine binds to ADORA1 protein18404447
D000241AdenosinePD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]20571079
D000241AdenosineVUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]20571079
D000241AdenosineAdenosine analog binds to and results in increased activity of ADORA1 protein10649980|1152020
D000241Adenosine[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine20932874
D000241AdenosineAdenosine results in increased activity of ADORA1 protein19488739
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADORA1 gene27153756
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"8987795
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]"19966059
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]"19966059
D000639Amitriptyline"[1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Amitriptyline"19429234
D000639Amitriptyline"Propranolol inhibits the reaction [[1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Amitriptyline]"19429234
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADORA1 mRNA16483693
D001151ArsenicArsenic results in increased expression of ADORA1 mRNA24019935
D001241AspirinADORA1 polymorphism affects the susceptibility to Aspirin19019667
C006683bamifyllinebamifylline binds to and results in decreased activity of ADORA1 protein8339412
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ADORA1 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADORA1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADORA1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADORA1 mRNA22228805
C110027beta-apocarotenoid-14',13'-dioxygenase"beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein"12684268
C110027beta-apocarotenoid-14',13'-dioxygenase"[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]"12684268
C110027beta-apocarotenoid-14',13'-dioxygenase"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to ADORA1 promoter]19698761
D004958EstradiolEstradiol results in increased expression of ADORA1 mRNA23019147
D004958EstradiolEstradiol results in decreased expression of ADORA1 protein18950269
C006780bisphenol Abisphenol A results in increased expression of ADORA1 mRNA25594700
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ADORA1 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of ADORA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADORA1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ADORA1 mRNA12419474
C018475butyraldehydebutyraldehyde results in increased expression of ADORA1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D019256Cadmium ChlorideCysteine inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D019256Cadmium ChlorideDithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D019256Cadmium Chloride[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D019256Cadmium ChlorideDithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D002110CaffeineCaffeine results in decreased activity of ADORA1 protein23611293
D002110Caffeine"[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]"7996441
D002110Caffeine[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine7996441
D002110CaffeineCaffeine deficiency results in decreased expression of ADORA1 mRNA29107002
D002110CaffeineCaffeine results in decreased activity of ADORA1 protein22164264
D002110CaffeineCaffeine results in increased expression of ADORA1 protein7996441
D002110Caffeine[Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA29107002
D002110Caffeine[Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA29107002
D002110Caffeine[Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA29107002
D002110CaffeineCaffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]10401785
D002110CaffeineCaffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]3003150
D002110CaffeineCaffeine results in decreased activity of ADORA1 protein15708489
D002110CaffeineCaffeine results in decreased expression of ADORA1 mRNA12153486
D002110CaffeineCaffeine affects the activity of ADORA1 protein20532872
D002110CaffeineCaffeine binds to and results in decreased activity of ADORA1 protein20520601
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADORA1 mRNA18263696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ADORA1 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ADORA1 protein12629582
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of ADORA1 mRNA19395590
D015283Citalopram[Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA29107002
D015283Citalopram[Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA29107002
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ADORA1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ADORA1 mRNA]17585979
D003000Clonidine"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine"8987795
C018021cobaltous chloride"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in increased susceptibility to cobaltous chloride"18727925
C018021cobaltous chlorideADORA1 protein results in decreased susceptibility to cobaltous chloride18727925
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADORA1 mRNA24386269
D003042CocaineADORA1 affects the susceptibility to Cocaine19092996
D003042CocaineCocaine affects the expression of ADORA1 mRNA12358776
D003042CocaineCocaine affects the expression of ADORA1 protein12358776
D003545CysteineCysteine inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D003562CytidineCytidine results in increased activity of ADORA1 protein18313046
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADORA1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADORA1 mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of ADORA1 mRNA26924002
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ADORA1 mRNA"28433925
D004047Diethyl PyrocarbonateDiethyl Pyrocarbonate inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ADORA1 mRNA15766595
D002117CalcitriolCalcitriol results in decreased expression of ADORA1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of ADORA1 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ADORA1 mRNA27638505
C024629dimethyl phthalatedimethyl phthalate affects the expression of ADORA1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in increased expression of ADORA1 mRNA26924002
D004228Dithionitrobenzoic AcidCadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D004228Dithionitrobenzoic AcidDithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D004228Dithionitrobenzoic AcidDithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D004228Dithionitrobenzoic Acid[Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D004228Dithionitrobenzoic AcidDithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D004229Dithiothreitol[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D004229Dithiothreitol[Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]10413299
D004229DithiothreitolDithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D004229DithiothreitolDithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]10413299
D004298Dopamine[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine]11043458
D000431EthanolADORA1 gene mutant form promotes the reaction [Ethanol results in increased abundance of Triglycerides]23692951
D000431EthanolADORA1 gene mutant form results in increased susceptibility to Ethanol23692951
D000431Ethanol[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of ACACA mRNA23692951
D000431Ethanol[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of DGAT2 mRNA23692951
D000431Ethanol[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of FASN mRNA23692951
D000431Ethanol[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of PPARG mRNA23692951
D000431Ethanol[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of SCD1 mRNA23692951
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) binds to and results in increased activity of ADORA1 protein12523489
C024565ethylene dichlorideethylene dichloride results in decreased expression of ADORA1 mRNA28189721
C102861FK 838FK 838 binds to and results in decreased activity of ADORA1 protein12922924
D005473Fluoxetine[Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA29107002
D005473Fluoxetine"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
C069837fullerene C60fullerene C60 results in decreased expression of ADORA1 mRNA19167457
C039281furanfuran results in increased expression of ADORA1 mRNA26194646
C419708gefitinibgefitinib results in decreased expression of ADORA1 mRNA16685379
D005990GlycerolGlycerol affects the expression of ADORA1 protein10677590
D017313FenretinideFenretinide results in increased expression of ADORA1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ADORA1 mRNA12419474
C016517indole-3-carbinolindole-3-carbinol affects the expression of ADORA1 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADORA1 mRNA26752646|2743299
C076920KF 20274KF 20274 binds to and results in decreased activity of ADORA1 protein21675777
D007854LeadLead results in decreased expression of ADORA1 mRNA19921347
C008261lead acetate[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA26478469
C008261lead acetate[lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein26478469
C008261lead acetatelead acetate results in increased expression of ADORA1 mRNA26478469
C008261lead acetatelead acetate results in increased expression of ADORA1 protein20932874|2647846
C008261lead acetate[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine20932874
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA23017109
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of ADORA1 protein10677590
D008694Methamphetamine"[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]"7996441
D008694Methamphetamine[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine7996441
D008694Methamphetamine[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine]11043458
D008694Methamphetamine[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] which results in increased susceptibility to Methamphetamine11043458
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADORA1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ADORA1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of ADORA1 mRNA12710931
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ADORA1 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of ADORA1 mRNA26924002
D009020MorphineADORA1 protein affects the susceptibility to Morphine9407998
D009020Morphine[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA26478469
D009020Morphine[lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein26478469
D009020MorphineMorphine results in increased expression of ADORA1 mRNA26478469
D009020MorphineMorphine results in increased expression of ADORA1 protein26478469
D009151Mustard GasMustard Gas results in increased expression of ADORA1 mRNA15674843
C047235N-(1-methyl-2-phenylethyl)adenosineN-(1-methyl-2-phenylethyl)adenosine binds to and results in increased activity of ADORA1 protein15987273
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ADORA1 mRNA"29244179
C027513N(6)-cyclohexyladenosineN(6)-cyclohexyladenosine binds to ADORA1 protein10413299
C027513N(6)-cyclohexyladenosine[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine]11043458
C027513N(6)-cyclohexyladenosine[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] which results in increased susceptibility to Methamphetamine11043458
C027513N(6)-cyclohexyladenosinezinc chloride inhibits the reaction [N(6)-cyclohexyladenosine binds to ADORA1 protein]10413299
C027513N(6)-cyclohexyladenosineN(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein11043458|8720578
C048599N(6)-cyclopentyladenosine"[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]"7996441
C048599N(6)-cyclopentyladenosine[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine7996441
C048599N(6)-cyclopentyladenosine"[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine"8987795
C048599N(6)-cyclopentyladenosine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]"19966059
C048599N(6)-cyclopentyladenosine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]"19966059
C048599N(6)-cyclopentyladenosineCaffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]10401785
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein15452191|1996605
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]19966059
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]19966059
C048599N(6)-cyclopentyladenosineN(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein10401785|1074664
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ADORA1 mRNA"23845593|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADORA1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADORA1 mRNA"25554681
D0150581-NaphthylisothiocyanateADORA1 protein results in increased susceptibility to 1-Naphthylisothiocyanate22956627
D009532NickelNickel results in decreased expression of ADORA1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of ADORA1 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADORA1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADORA1 mRNA27935865
C106996NRA 0045NRA 0045 binds to ADORA1 protein9223539
D009966OrphenadrineOrphenadrine affects the expression of ADORA1 mRNA23665939
D010100Oxygen"[1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Oxygen deficiency"23437309
D010126OzoneOzone results in increased expression of ADORA1 mRNA28623178
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA23017109
C075004PD 81723PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]20571079
D010416PentachlorophenolPentachlorophenol results in increased expression of ADORA1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ADORA1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADORA1 mRNA20136073
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ADORA1 mRNA19429403
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [ADORA1 protein results in increased activity of MAPK1 protein]16322354
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [ADORA1 protein results in increased activity of MAPK3 protein]16322354
D037342Pertussis ToxinPertussis Toxin results in increased expression of ADORA1 mRNA16322354
D037342Pertussis ToxinPertussis Toxin results in increased expression of ADORA1 protein16322354
D037342Pertussis Toxinprolinedithiocarbamate inhibits the reaction [Pertussis Toxin results in increased expression of ADORA1 protein]16322354
D010656Phenylephrine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]"19966059
D010656Phenylephrine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]"19966059
D010656PhenylephrineADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]"19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]"19966059
D010656PhenylephrineN(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]19966059
D010656PhenylephrineN(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA1 mRNA19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA1 protein19966059
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]19966059
D010660PhenylisopropyladenosineCaffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]3003150
D010660PhenylisopropyladenosinePhenylisopropyladenosine binds to and results in increased activity of ADORA1 protein3003150|9535120
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ADORA1 mRNA26272509
D010862Pilocarpine[2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine11311893
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADORA1 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of ADORA1 mRNA23557933
D010938Plant OilsPlant Oils results in decreased expression of ADORA1 mRNA23370395
D011188Potassium"[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]"12684268
D011188Potassium"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]19966059
D011372ProgestinsProgestins results in increased expression of ADORA1 mRNA19609016
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [Pertussis Toxin results in increased expression of ADORA1 protein]16322354
D011433Propranolol"Propranolol inhibits the reaction [[1,3-dipropyl-8-cyclopentylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Amitriptyline]"19429234
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADORA1 mRNA24780913
C059514resveratrol"[8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]"15345477
C059514resveratrol"[8-cyclopentyl-1,3-dimethylxanthine results in decreased activity of ADORA1 protein] which results in decreased susceptibility to resveratrol"15345477
C073525rolofyllinerolofylline binds to and results in increased activity of ADORA1 protein7967229
C073525rolofyllinerolofylline results in decreased activity of ADORA1 protein11231000|9263988
D012524SarinSarin results in increased expression of ADORA1 mRNA19522546
D053260SootSoot results in increased expression of ADORA1 mRNA22461453|2655175
D014284TriiodothyronineTriiodothyronine results in increased expression of ADORA1 mRNA17403546
D013629TamoxifenTamoxifen affects the expression of ADORA1 mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of ADORA1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ADORA1 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ADORA1 mRNA25172293
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ADORA1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADORA1 mRNA18172886|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADORA1 mRNA19933214
D013806TheophyllineTheophylline binds to and results in decreased activity of ADORA1 protein14992338|9535120
D013806TheophyllineTheophylline results in decreased activity of ADORA1 protein15708489
D013806TheophyllineTheophylline results in decreased expression of ADORA1 mRNA12153486
D013853ThioacetamideThioacetamide results in increased expression of ADORA1 mRNA23411599
D013974ThyroxineThyroxine results in decreased expression of ADORA1 mRNA17403546
C009495titanium dioxidetitanium dioxide results in increased expression of ADORA1 mRNA21259345|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADORA1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ADORA1 mRNA16137721
C012589trichostatin Atrichostatin A results in decreased expression of ADORA1 mRNA24935251
D014280TriglyceridesADORA1 gene mutant form promotes the reaction [Ethanol results in increased abundance of Triglycerides]23692951
D014529UridineUridine results in increased activity of ADORA1 protein18313046
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADORA1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ADORA1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of ADORA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ADORA1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ADORA1 mRNA23034163
C438612VUF 5455VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]20571079
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADORA1 mRNA27935865
C016837zinc chloridezinc chloride inhibits the reaction [N(6)-cyclohexyladenosine binds to ADORA1 protein]10413299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001609G-protein coupled adenosine receptor activity-IEA-  
GO:0001664G-protein coupled receptor binding-IEA-  
GO:0001883purine nucleoside binding-IEA-  
GO:0004629phospholipase C activity-IEA-  
GO:0005515protein binding-IPI16481441  
GO:0031072heat shock protein binding-IEA-  
GO:0031683G-protein beta/gamma-subunit complex binding-IEA-  
GO:0032795heterotrimeric G-protein binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-IEA-  
GO:0001659temperature homeostasis-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001973adenosine receptor signaling pathway-IEA-  
GO:0002087regulation of respiratory gaseous exchange by neurological system process-IEA-  
GO:0002674negative regulation of acute inflammatory response-IEA-  
GO:0002686negative regulation of leukocyte migration-IEA-  
GO:0002793positive regulation of peptide secretion-IEA-  
GO:0003084positive regulation of systemic arterial blood pressure-IEA-  
GO:0003085negative regulation of systemic arterial blood pressure-IEA-  
GO:0003093regulation of glomerular filtration-IEA-  
GO:0006612protein targeting to membrane-IEA-  
GO:0006909phagocytosis-TAS8360491  
GO:0006954inflammatory response-TAS8360491  
GO:0007165signal transduction-TAS1530647  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007267cell-cell signaling-TAS7818494  
GO:0007399nervous system development-TAS8450977  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0014050negative regulation of glutamate secretion-IEA-  
GO:0016042lipid catabolic process-IEA-  
GO:0032229negative regulation of synaptic transmission, GABAergic-IEA-  
GO:0032244positive regulation of nucleoside transport-IEA-  
GO:0032900negative regulation of neurotrophin production-IEA-  
GO:0035307positive regulation of protein dephosphorylation-IEA-  
GO:0035814negative regulation of renal sodium excretion-IEA-  
GO:0042323negative regulation of circadian sleep/wake cycle, non-REM sleep-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043268positive regulation of potassium ion transport-IEA-  
GO:0045741positive regulation of epidermal growth factor-activated receptor activity-IEA-  
GO:0046888negative regulation of hormone secretion-IEA-  
GO:0050890cognition-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IEA-  
GO:0050995negative regulation of lipid catabolic process-IEA-  
GO:0050996positive regulation of lipid catabolic process-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0051967negative regulation of synaptic transmission, glutamatergic-IEA-  
GO:0055089fatty acid homeostasis-IEA-  
GO:0055118negative regulation of cardiac muscle contraction-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060087relaxation of vascular smooth muscle-IEA-  
GO:0070256negative regulation of mucus secretion-IEA-  
GO:0070328triglyceride homeostasis-IEA-  
GO:0097190apoptotic signaling pathway-TAS7818494  
GO:0097756negative regulation of blood vessel diameter-IEA-  
GO:1900272negative regulation of long-term synaptic potentiation-IEA-  
GO:1900453negative regulation of long term synaptic depression-IEA-  
GO:1901216positive regulation of neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IDA27134041  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1530647  
GO:0014069postsynaptic density-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0030673axolemma-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0048786presynaptic active zone-IEA-  
GO:0099055integral component of postsynaptic membrane-IEA-  
GO:0099056integral component of presynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-417973Adenosine P1 receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24943643Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain. (2014 Dec)Hohoff CNeuropsychopharmacology
28196272Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. (2017 Apr)Clark SLAlcohol Clin Exp Res