Gene: POC5

134359
C5orf37
POC5 centriolar protein
protein-coding
5q13.3
Ensembl:ENSG00000152359 MIM:617880 Vega:OTTHUMG00000162487 UniprotKB:Q8NA72
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.913e-1 (AD)  5.871e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OSBPL90.816
EXOSC80.804
ANKRD13A0.804
NSMCE4A0.798
DIMT10.798
RARS20.797
GCA0.796
ZNF4510.793
STAMBP0.792
MBD40.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.405
OR4F5-0.403
EPPIN-0.348
WNT7B-0.317
CHRNA2-0.288
MMP23B-0.276
CELSR1-0.27
DIO2-0.262
HGFAC-0.257
ADAMTSL5-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of POC5 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of POC5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of POC5 gene27153756
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of POC5 mRNA"19446018
D004958EstradiolEstradiol results in increased expression of POC5 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of POC5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of POC5 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of POC5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of POC5 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of POC5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of POC5 mRNA20106945|2798913
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POC5 mRNA22079256
C544151jinfukangjinfukang results in decreased expression of POC5 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of POC5 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of POC5 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of POC5 mRNA29191790
D010416PentachlorophenolPentachlorophenol results in increased expression of POC5 mRNA24642059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of POC5 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of POC5 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POC5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of POC5 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of POC5 mRNA23012394
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of POC5 mRNA25895662
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of POC5 mRNA"26680231
C012589trichostatin Atrichostatin A results in increased expression of POC5 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of POC5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of POC5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of POC5 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of POC5 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26638075  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IDA21399614  
GO:0005814centriole-IEA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26537541Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. (2015 Nov 4)Young KLBMC Genet