Gene info: ID 134864

Gene: TAAR1

GENE ID: 134864

Synonyms: TA1|TAR1|TRAR1

Description: trace amine associated receptor 1

Gene type: protein-coding

Location: 6q23.2

dbXrefs: Ensembl:ENSG00000146399 MIM:609333 Vega:OTTHUMG00000015583 UniprotKB:Q96RJ0

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.749e-1 (AD) 6.485e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DUXA	0.856
OR2W5	0.83
MYF5	0.822
OR7G1	0.818
INSL4	0.797
OR52K1	0.792
C18orf63	0.782
OTOR	0.781
FGF19	0.778
CNGA2	0.777

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NDP	-0.278
CDH20	-0.274
FUT9	-0.268
PEX11A	-0.265
C2orf72	-0.261
GABRG1	-0.26
CADM1	-0.259
PARS2	-0.253
ADCY2	-0.249
SLC1A4	-0.249

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB01576	Dextroamphetamine	Small Molecule	51-64-9	Approved\|Illicit	Target
DB01577	Methamphetamine	Small Molecule	537-46-2	Approved\|Illicit	Target
DB06714	Propylhexedrine	Small Molecule	101-40-6	Approved	Target

ID	Drug Name	Action	PubMed
C031065	3-hydroxy-4-methoxyphenethylamine	3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein	19725810
C031065	3-hydroxy-4-methoxyphenethylamine	[3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C001746	3-methoxytyramine	3-methoxytyramine results in increased activity of TAAR1 protein	19725810
C001746	3-methoxytyramine	[3-methoxytyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C028169	3-tyramine	3-tyramine results in increased activity of TAAR1 protein	19725810
C028169	3-tyramine	[3-tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C097364	4-chloro-2-(imidazolin-2-yl)isoindoline	4-chloro-2-(imidazolin-2-yl)isoindoline results in increased activity of TAAR1 protein	19725810
C097364	4-chloro-2-(imidazolin-2-yl)isoindoline	[4-chloro-2-(imidazolin-2-yl)isoindoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C074266	4-phenyl-1,2,3,4-tetrahydroisoquinoline	"4-phenyl-1,2,3,4-tetrahydroisoquinoline results in increased activity of TAAR1 protein"	19725810
C074266	4-phenyl-1,2,3,4-tetrahydroisoquinoline	"[4-phenyl-1,2,3,4-tetrahydroisoquinoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP"	19725810
C031227	6-nitroquipazine	6-nitroquipazine analog results in increased activity of TAAR1 protein	19725810
C031227	6-nitroquipazine	[6-nitroquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D020106	Acrylamide	Acrylamide results in decreased expression of TAAR1 mRNA	28959563
D000242	Cyclic AMP	[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Amphetamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
D000242	Cyclic AMP	"[N-Methyl-3,4-methylenedioxyamphetamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP"	15764732
D000242	Cyclic AMP	[phenethylamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
D000242	Cyclic AMP	[Tyramine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
D000242	Cyclic AMP	[3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[3-methoxytyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[3-tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[4-chloro-2-(imidazolin-2-yl)isoindoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	"[4-phenyl-1,2,3,4-tetrahydroisoquinoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP"	19725810
D000242	Cyclic AMP	[5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[6-nitroquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[BE 2254 results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[cirazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[efaroxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Guanabenz results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Idazoxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Methoxydimethyltryptamines results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[moxonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[N-methylquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Quipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[rilmenidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Tryptamines analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000242	Cyclic AMP	[Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TAAR1 mRNA	16483693
D000661	Amphetamine	Amphetamine binds to and results in increased activity of TAAR1 protein	15764732
D000661	Amphetamine	[Amphetamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
D000661	Amphetamine	Amphetamine results in increased activity of TAAR1 protein	17234900
D000661	Amphetamine	SLC6A3 protein promotes the reaction [Amphetamine results in increased activity of TAAR1 protein]	15764732
D000865	Antazoline	Antazoline results in increased activity of TAAR1 protein	19725810
D000865	Antazoline	[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D001280	Atrazine	Atrazine results in decreased expression of TAAR1 mRNA	25929836
C010652	BE 2254	BE 2254 results in increased activity of TAAR1 protein	19725810
C010652	BE 2254	[BE 2254 results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of TAAR1 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of TAAR1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of TAAR1 mRNA	25181051
C014282	cirazoline	cirazoline results in increased activity of TAAR1 protein	19725810
C014282	cirazoline	[cirazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D015283	Citalopram	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D015283	Citalopram	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D015283	Citalopram	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D015283	Citalopram	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
D015283	Citalopram	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D003000	Clonidine	Clonidine results in increased activity of TAAR1 protein	19725810
D003000	Clonidine	[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D003891	Desipramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D003891	Desipramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D003891	Desipramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D003891	Desipramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
D003891	Desipramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TAAR1 mRNA	28962523
D004298	Dopamine	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D004298	Dopamine	SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]	17234900
D004298	Dopamine	SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]	17234900
D004298	Dopamine	SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]	17234900
D004298	Dopamine	Dopamine results in increased activity of TAAR1 protein	17234900
C062597	efaroxan	efaroxan results in increased activity of TAAR1 protein	19725810
C062597	efaroxan	[efaroxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D018818	Fenoldopam	Fenoldopam results in increased activity of TAAR1 protein	19725810
D018818	Fenoldopam	[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D005419	Flavonoids	Flavonoids results in decreased expression of TAAR1 mRNA	18035473
D006143	Guanabenz	Guanabenz results in increased activity of TAAR1 protein	19725810
D006143	Guanabenz	[Guanabenz results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C005010	harman	harman results in increased activity of TAAR1 protein	19725810
C005010	harman	[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D006632	Histamine	Histamine results in increased activity of TAAR1 protein	19725810
D006632	Histamine	[Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D012701	Serotonin	SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]	17234900
D012701	Serotonin	SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]	17234900
D012701	Serotonin	SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]	17234900
D012701	Serotonin	Serotonin results in increased activity of TAAR1 protein	17234900
D019329	Idazoxan	Idazoxan results in increased activity of TAAR1 protein	19725810
D019329	Idazoxan	[Idazoxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C418119	indatraline	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C418119	indatraline	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008694	Methamphetamine	SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]	17234900
D008694	Methamphetamine	SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]	17234900
D008694	Methamphetamine	SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]	17234900
D008694	Methamphetamine	Methamphetamine results in increased activity of TAAR1 protein	17234900
D008694	Methamphetamine	TAAR1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]	28919515
D008694	Methamphetamine	TAAR1 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]	28919515
D008694	Methamphetamine	TAAR1 protein affects the susceptibility to Methamphetamine	28919515
D008732	Methoxydimethyltryptamines	Methoxydimethyltryptamines results in increased activity of TAAR1 protein	19725810
D008732	Methoxydimethyltryptamines	[Methoxydimethyltryptamines results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D008735	5-Methoxytryptamine	5-Methoxytryptamine results in increased activity of TAAR1 protein	19725810
D008735	5-Methoxytryptamine	[5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine binds to and results in increased activity of TAAR1 protein"	15764732
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"[N-Methyl-3,4-methylenedioxyamphetamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP"	15764732
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of TAAR1 protein"	17234900
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"SLC6A3 protein promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of TAAR1 protein]"	15764732
D008774	Methylphenidate	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]	17234900
D008774	Methylphenidate	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	17234900
D008774	Methylphenidate	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D008774	Methylphenidate	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
D008774	Methylphenidate	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of TAAR1 mRNA	26924002
C043482	moxonidine	moxonidine results in increased activity of TAAR1 protein	19725810
C043482	moxonidine	[moxonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C109625	N-methylquipazine	N-methylquipazine analog results in increased activity of TAAR1 protein	19725810
C109625	N-methylquipazine	[N-methylquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D009638	Norepinephrine	SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]	17234900
D009638	Norepinephrine	SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]	17234900
D009638	Norepinephrine	SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]	17234900
D009638	Norepinephrine	Norepinephrine results in increased activity of TAAR1 protein	17234900
D009655	Octopamine	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]	17234900
D009655	Octopamine	Octopamine results in increased activity of TAAR1 protein	19725810
D009655	Octopamine	[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D009655	Octopamine	SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]	17234900
D009655	Octopamine	SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]	17234900
D009655	Octopamine	SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]	17234900
D009655	Octopamine	Octopamine results in increased activity of TAAR1 protein	17234900
D009655	Octopamine	Octopamine results in increased activity of TAAR1 protein	19725810
D009655	Octopamine	[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C008510	O-methyltyramine	O-methyltyramine results in increased activity of TAAR1 protein	19725810
C008510	O-methyltyramine	[O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C029261	phenethylamine	phenethylamine results in increased activity of TAAR1 protein	19725810
C029261	phenethylamine	[phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C029261	phenethylamine	SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]	17234900
C029261	phenethylamine	SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]	17234900
C029261	phenethylamine	SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]	17234900
C029261	phenethylamine	phenethylamine binds to and results in increased activity of TAAR1 protein	15764732
C029261	phenethylamine	[phenethylamine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
C029261	phenethylamine	phenethylamine results in increased activity of TAAR1 protein	17234900
C029261	phenethylamine	SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]	15764732
C029261	phenethylamine	phenethylamine results in increased activity of TAAR1 protein	19725810
C029261	phenethylamine	[phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D010634	Phenobarbital	Phenobarbital results in decreased expression of TAAR1 mRNA	25270620
D011814	Quipazine	Quipazine analog results in increased activity of TAAR1 protein	19725810
D011814	Quipazine	[Quipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C032302	rilmenidine	rilmenidine results in increased activity of TAAR1 protein	19725810
C032302	rilmenidine	[rilmenidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C583451	RO5166017	RO5166017 results in increased activity of TAAR1 protein	28123023
C501413	tesaglitazar	tesaglitazar results in increased expression of TAAR1 mRNA	21515302
D014191	Tranylcypromine	Tranylcypromine results in increased activity of TAAR1 protein	19725810
D014191	Tranylcypromine	[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C030820	tryptamine	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]	17234900
C030820	tryptamine	SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]	17234900
C030820	tryptamine	SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]	17234900
C030820	tryptamine	SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]	17234900
C030820	tryptamine	tryptamine results in increased activity of TAAR1 protein	19725810
C030820	tryptamine	[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
C030820	tryptamine	tryptamine results in increased activity of TAAR1 protein	17234900
C030820	tryptamine	tryptamine results in increased activity of TAAR1 protein	19725810
C030820	tryptamine	[tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D014363	Tryptamines	Tryptamines analog results in increased activity of TAAR1 protein	19725810
D014363	Tryptamines	[Tryptamines analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D014439	Tyramine	Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]	17234900
D014439	Tyramine	SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]	17234900
D014439	Tyramine	SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]	17234900
D014439	Tyramine	SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]	17234900
D014439	Tyramine	Tyramine results in increased activity of TAAR1 protein	19725810
D014439	Tyramine	[Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D014439	Tyramine	Tyramine binds to and results in increased activity of TAAR1 protein	15764732
D014439	Tyramine	[Tyramine binds to and results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	15764732
D014439	Tyramine	Tyramine results in increased activity of TAAR1 protein	17234900
D014439	Tyramine	Tyramine results in increased activity of TAAR1 protein	19725810
D014439	Tyramine	[Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP	19725810
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of TAAR1 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001594	trace-amine receptor activity	-	IBA	21873635
GO:0004930	G-protein coupled receptor activity	-	IDA	11723224

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24722355	Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. (2014 Sep)	Pei Y	Neuropsychopharmacology
28123023	Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. (2017 Jan 25)	Liu JF	J Neurosci
26048337	Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. (2015 Dec 3)	Pei Y	Prog Neuropsychopharmacol Biol Psychiatry
29681856	Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine. (2018)	Sukhanov I	Front Pharmacol
23861588	Trace amine associated receptor 1 modulates behavioral effects of ethanol. (2013)	Lynch LJ	Subst Abuse
27193165	A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment. (2017 Sep)	Pei Y	Addict Biol