Gene: ADORA2A

135
A2aR|ADORA2|RDC8
adenosine A2a receptor
protein-coding
22q11.23
Ensembl:ENSG00000128271 MIM:102776 Vega:OTTHUMG00000150761 UniprotKB:P29274
NG_052804.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.157e-1 (AD)  2.109e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL3RA0.649
PRKCH0.622
PLOD10.613
SMTN0.607
TMPRSS60.598
C15orf390.582
GDPD30.582
CCDC102A0.581
FLT10.581
TNFRSF80.58

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCYAP1-0.378
PPEF1-0.35
CRH-0.346
SPDEF-0.338
CDH13-0.332
PCSK1-0.323
RAB3B-0.315
KCNC2-0.314
NXPH1-0.313
GRIK1-0.307

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB00277TheophyllineSmall Molecule58-55-9ApprovedTarget
DB00358MefloquineSmall Molecule53230-10-7Approved|InvestigationalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00640AdenosineSmall Molecule58-61-7Approved|InvestigationalTarget
DB00651DyphyllineSmall Molecule479-18-5ApprovedTarget
DB00806PentoxifyllineSmall Molecule6493-05-6Approved|InvestigationalTarget
DB00824EnprofyllineSmall Molecule41078-02-8Approved|InvestigationalTarget
DB01303OxtriphyllineSmall Molecule4499-40-5ApprovedTarget
DB01412TheobromineSmall Molecule83-67-0Approved|InvestigationalTarget
DB04853BinodenosonSmall Molecule144348-08-3InvestigationalTarget
DB04932DefibrotideBiotechDrug83712-60-1Approved|InvestigationalTarget
DB05009ApadenosonSmall Molecule250386-15-3InvestigationalTarget
DB05191Atl146eSmall Molecule-InvestigationalTarget
DB06213RegadenosonSmall Molecule313348-27-5Approved|InvestigationalTarget
DB087704-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenolSmall MoleculeExperimentalTarget
DB09273DoxofyllineSmall Molecule69975-86-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4940341,2,4-triazolo(1,5-c)pyrimidine"1,2,4-triazolo(1,5-c)pyrimidine analog binds to and results in decreased activity of ADORA2A protein"19109019
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein"21210664
C0513601,3-dipropyl-8-cyclopentylxanthine"2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein]"21210664
C0513601,3-dipropyl-8-cyclopentylxanthine"istradefylline inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein]"21210664
C5399972-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine"2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein]"21210664
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein16793905
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]26367767
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]26367767
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineADORA2A protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine11172060
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein15452191|1974916
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]19966059
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]19966059
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A mRNA]27289578
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A protein]27289578
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]19966059
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]19966059
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosinePRKCZ protein affects the reaction [[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein] which results in decreased expression of VEGFA mRNA]12590138
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in decreased activity of ADORA2A protein10591873
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein12523489|1259013
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADORA2A mRNA"21346803
C5622252-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one"2-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one binds to and results in decreased activity of ADORA2A protein"21667953
C4926562-furan-2-yl-7-3-(4-(4-(4-methylpiperazine-1-sulfonyl)phenylethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo-(1,5-c)pyrimdin-5-ylamine)"2-furan-2-yl-7-3-(4-(4-(4-methylpiperazine-1-sulfonyl)phenylethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo-(1,5-c)pyrimdin-5-ylamine) binds to and results in decreased activity of ADORA2A protein"16780890
C0768642-hexynyladenosine-5'-N-ethylcarboxamide2-hexynyladenosine-5'-N-ethylcarboxamide binds to and results in increased activity of ADORA2A protein9300315
C5062912-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine"[2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine binds to ADORA2A protein] which results in decreased susceptibility to Rotenone"19416678
C5062912-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine"2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine binds to and results in decreased activity of ADORA2A protein"19416678
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADORA2A mRNA"23196670
C0578373,7-dimethyl-1-propargylxanthine"3,7-dimethyl-1-propargylxanthine binds to and results in decreased activity of ADORA2A protein"11023991|1199240
C0578373,7-dimethyl-1-propargylxanthine"3,7-dimethyl-1-propargylxanthine results in decreased activity of ADORA2A protein"9263988
C5246995-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one binds to and results in decreased activity of ADORA2A protein17684118
C5246995-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one binds to ADORA2A protein18552135
C0986575-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine"5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A protein"16793905
C0986575-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine"5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A protein"22164264
C0986575-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine"5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A protein"19749167|1995878
C0986575-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine"5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A protein"12834887|1511124
C534887(7-(2-(4-difluorophenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine"(7-(2-(4-difluorophenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine binds to and results in decreased activity of ADORA2A protein"18594798
C0813208-(3-chlorostyryl)caffeineADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine11172060
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein15641640|1860825
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]19966059
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]19966059
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]21195062
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein10199625|1518744
C0813208-(3-chlorostyryl)caffeine[8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein] inhibits the reaction [Plant Preparations results in decreased susceptibility to Methamphetamine]15187444
C0813208-(3-chlorostyryl)caffeine8-(3-chlorostyryl)caffeine results in decreased activity of ADORA2A protein15345477
C1100419-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline"9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline binds to and results in decreased activity of ADORA2A protein"11911839
D000082AcetaminophenAcetaminophen affects the expression of ADORA2A mRNA17562736
D000109AcetylcholineADORA2A protein results in increased susceptibility to Acetylcholine16616212
D000109AcetylcholineZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]16616212
D000241AdenosineAdenosine results in increased activity of ADORA2A protein16793905
D000241AdenosineAdenosine analog binds to and results in decreased activity of ADORA2A protein18404447
D000241AdenosineAdenosine binds to ADORA2A protein18404447
D000241AdenosineAdenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]20067761
D000241AdenosineAdenosine results in increased activity of ADORA2A protein19488739
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]"14756803
D018350alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acidalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A protein16601261
D018350alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid[ZM 241385 binds to and results in decreased activity of ADORA2A protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid16601261
D018350alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidZM 241385 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A protein]16601261
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]"19966059
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]"19966059
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADORA2A mRNA16483693
D000661AmphetamineADORA2A gene polymorphism results in increased susceptibility to Amphetamine16118787
D000661AmphetamineADORA2A protein affects the susceptibility to Amphetamine16118787
D000661AmphetamineADORA2A protein affects the reaction [Amphetamine results in increased expression of PDYN mRNA]12700712
D000661AmphetamineADORA2A protein results in increased susceptibility to Amphetamine12700712
D001152ArsenicalsArsenicals results in decreased expression of ADORA2A mRNA28625800
D001241AspirinADORA2A polymorphism affects the susceptibility to Aspirin19019667
C431129ATL 146eATL 146e binds to and results in increased activity of ADORA2A protein12427424
D001379AzathioprineAzathioprine results in decreased expression of ADORA2A mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ADORA2A promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADORA2A mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADORA2A mRNA21839799
D004958EstradiolEstradiol results in increased expression of ADORA2A mRNA20068009
D001629BezafibrateBezafibrate results in increased expression of ADORA2A mRNA18787029
C006780bisphenol Abisphenol A results in increased expression of ADORA2A mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ADORA2A mRNA26079696
D002104Cadmium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of ADORA2A mRNA21481475
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ADORA2A promoter22457795
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] results in decreased expression of ADORA2A mRNA22342292
D002110Caffeine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]26367767
D002110Caffeine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]26367767
D002110CaffeineADORA2A polymorphism affects the susceptibility to Caffeine18305461|2195073
D002110CaffeineADORA2A polymorphism results in increased susceptibility to Caffeine12825092|1622176
D002110CaffeineADORA2A SNP results in increased susceptibility to Caffeine20520601
D002110CaffeineCaffeine results in decreased activity of ADORA2A protein23611293
D002110CaffeineCaffeine results in decreased expression of ADORA2A mRNA26367767
D002110CaffeineCaffeine results in decreased expression of ADORA2A protein26367767
D002110CaffeineADORA2A protein affects the susceptibility to Caffeine16470403
D002110CaffeineADORA2A protein results in increased susceptibility to Caffeine11172060
D002110CaffeineCaffeine analog binds to ADORA2A protein10214707
D002110CaffeineCaffeine analog binds to and results in decreased activity of ADORA2A protein12077927
D002110CaffeineCaffeine binds to and results in decreased activity of ADORA2A protein16470403
D002110CaffeineCaffeine analog binds to ADORA2A protein10214707
D002110CaffeineCaffeine analog binds to and results in decreased activity of ADORA2A protein15452191
D002110CaffeineCaffeine results in decreased expression of ADORA2A mRNA16771831|2636776
D002110CaffeineCaffeine affects the activity of ADORA2A protein20532872
D002110CaffeineCaffeine binds to and results in decreased activity of ADORA2A protein20520601
D002251Carbon TetrachlorideADORA2A gene mutant form results in decreased susceptibility to Carbon Tetrachloride16783407
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADORA2A mRNA18263696
D002509CephaloridineCephaloridine results in increased expression of ADORA2A mRNA18500788
C007020chlorophyllin"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of ADORA2A mRNA"22485181
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of ADORA2A mRNA19192274
D003024ClozapineClozapine results in decreased expression of ADORA2A mRNA17266109
D003042CocaineADORA2A results in increased susceptibility to Cocaine16123743
C058120cordycepinADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]24704558
C058120cordycepinADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]24704558
C058120cordycepinADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]24704558
D003471CuprizoneCuprizone results in increased expression of ADORA2A mRNA26577399
D003562CytidineCytidine results in increased activity of ADORA2A protein18313046
D013759DronabinolDronabinol results in decreased expression of ADORA2A mRNA21955143
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADORA2A mRNA15620428
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of ADORA2A mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of ADORA2A mRNA27392435
D002945CisplatinCisplatin results in increased expression of ADORA2A mRNA27594783
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of ADORA2A mRNA]27392435
D004008DiclofenacDiclofenac results in increased expression of ADORA2A mRNA26934552
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ADORA2A mRNA15620428
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ADORA2A mRNA20920545
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ADORA2A mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of ADORA2A mRNA"22485181
D007980Levodopa8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]21195062
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A mRNA15065221
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein21195062
D000431EthanolEthanol results in decreased expression of ADORA2A mRNA21955143
D000431EthanolADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
D005419FlavonoidsFlavonoids results in increased expression of ADORA2A mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of ADORA2A mRNA12679049
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of ADORA2A mRNA19192274
D016244Guanosine 5'-O-(3-Thiotriphosphate)"ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]"14756803
D006220HaloperidolADORA2A protein affects the susceptibility to Haloperidol11172060
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADORA2A mRNA25613284
C111599istradefylline"istradefylline inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein]"21210664
C111599istradefyllineistradefylline binds to and results in decreased activity of ADORA2A protein10739638|1261434
C111599istradefyllineistradefylline binds to and results in increased activity of ADORA2A protein10591873
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of ADORA2A mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of ADORA2A mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of ADORA2A mRNA27392435
C081198KF 17837KF 17837 binds to and results in decreased activity of ADORA2A protein15111244|8045270
C045463leflunomideleflunomide affects the expression of ADORA2A mRNA28988120
D008070LipopolysaccharidesAdenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]20067761
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADORA2A mRNA16387843|2006776
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADORA2A protein16387843
D008694MethamphetamineADORA2A gene SNP results in increased susceptibility to Methamphetamine20799992
D008694Methamphetamine[8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein] inhibits the reaction [Plant Preparations results in decreased susceptibility to Methamphetamine]15187444
D008727MethotrexateMethotrexate results in increased expression of ADORA2A mRNA22682496
D008727MethotrexateMethotrexate results in increased expression of ADORA2A protein17101059
C014085methotrexate polyglutamate[ADORA2A gene SNP co-treated with ATIC gene SNP] affects the abundance of methotrexate polyglutamate20954192
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA2A mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ADORA2A mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ADORA2A mRNA16026605
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADORA2A mRNA"16739115
D008775MethylprednisoloneMethylprednisolone results in decreased expression of ADORA2A mRNA19192274
C001801mitragyninemitragynine binds to ADORA2A protein27192616
D009020MorphineADORA2A protein affects the susceptibility to Morphine14756803
D009020MorphineMorphine results in increased expression of ADORA2A mRNA21955143
C043482moxonidineADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
C113602MSX 3 compoundMSX 3 compound binds to and results in decreased activity of ADORA2A protein19958787
C113602MSX 3 compoundMSX 3 compound binds to and results in decreased activity of ADORA2A protein15342103|1850845
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADORA2A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADORA2A mRNA"25554681
D009532NickelNickel results in increased expression of ADORA2A mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of ADORA2A mRNA16780908|2271453
D009538NicotineNicotine results in decreased expression of ADORA2A mRNA21955143
C025589ochratoxin Aochratoxin A results in increased acetylation of ADORA2A promoter29098329
D016627Oxidopamine8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]21195062
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A mRNA15065221
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein21195062
D009966OrphenadrineOrphenadrine affects the expression of ADORA2A mRNA23665939
D010100OxygenOxygen deficiency results in increased expression of ADORA2A mRNA26516004
D010100Oxygen2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A mRNA]27289578
D010100Oxygen2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A protein]27289578
D010100OxygenOxygen deficiency results in increased expression of ADORA2A mRNA27289578
D010100OxygenOxygen deficiency results in increased expression of ADORA2A protein27289578
D010269ParaquatParaquat affects the expression of ADORA2A mRNA16854511
D010269ParaquatParaquat results in increased expression of ADORA2A mRNA17077588|1819848
D010433PentylenetetrazoleADORA2A protein affects the susceptibility to Pentylenetetrazole19488739
D010622PhencyclidinePhencyclidine results in decreased expression of ADORA2A mRNA17266109
D010642PhenoxyacetatesPhenoxyacetates binds to and results in decreased activity of ADORA2A protein18329269
D010656Phenylephrine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]19966059
D010656Phenylephrine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]19966059
D010656Phenylephrine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]19966059
D010656Phenylephrine8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]19966059
D010656PhenylephrineADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]"19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]"19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA2A mRNA19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA2A protein19966059
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]19966059
C559609phosphoric acid mono-(2-(4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzoylimino)thiazol-3-ylmethyl) ester"phosphoric acid mono-(2-(4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzoylimino)thiazol-3-ylmethyl) ester binds to and results in decreased activity of ADORA2A protein"21210664
D010862PilocarpineADORA2A protein affects the susceptibility to Pilocarpine19488739
D010894PiroxicamPiroxicam results in decreased expression of ADORA2A mRNA19192274
D010936Plant ExtractsPlant Extracts results in decreased expression of ADORA2A mRNA23557933
D028321Plant Preparations[8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein] inhibits the reaction [Plant Preparations results in decreased susceptibility to Methamphetamine]15187444
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]19966059
D011239PrednisolonePrednisolone results in decreased expression of ADORA2A mRNA19192274
C005556propionaldehydepropionaldehyde results in increased expression of ADORA2A mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADORA2A mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of ADORA2A mRNA27029645
D011794QuercetinQuercetin results in decreased expression of ADORA2A mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of ADORA2A mRNA15849065
C059514resveratrolADORA2A protein promotes the reaction [resveratrol results in increased expression of ABCA1 protein]23041272
C059514resveratrolADORA2A protein promotes the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C059514resveratrolADORA2A protein promotes the reaction [resveratrol results in increased expression of NR1H3 protein]23041272
D012293RifampinRifampin results in decreased expression of ADORA2A mRNA24552687
C089730rosiglitazonerosiglitazone results in increased expression of ADORA2A mRNA21515302
D012402Rotenone"[2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine binds to ADORA2A protein] which results in decreased susceptibility to Rotenone"19416678
D012402Rotenone[ZM 241385 binds to ADORA2A protein] which results in decreased susceptibility to Rotenone19416678
D012524SarinSarin results in decreased expression of ADORA2A mRNA19522546
C416650SCH 442416SCH 442416 binds to ADORA2A protein18552135
D012643Selenium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of ADORA2A mRNA21481475
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ADORA2A mRNA25895662
D012834SilverSilver results in decreased expression of ADORA2A mRNA22342292
D012999SomanSoman results in increased expression of ADORA2A mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of ADORA2A protein26654777
C016766sulforafansulforafan results in increased expression of ADORA2A mRNA26833863
D013654TaurineTaurine results in decreased expression of ADORA2A mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADORA2A mRNA21802500
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA2A mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADORA2A mRNA25613284
D013853ThioacetamideADORA2A gene mutant form results in decreased susceptibility to Thioacetamide16783407
D013853ThioacetamideThioacetamide results in increased expression of ADORA2A mRNA16783407
C009495titanium dioxidetitanium dioxide results in decreased expression of ADORA2A mRNA22342292
C009495titanium dioxidetitanium dioxide results in increased expression of ADORA2A mRNA23557971
C057693troglitazonetroglitazone results in increased expression of ADORA2A mRNA28973697
D014520UrethaneUrethane results in decreased expression of ADORA2A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ADORA2A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ADORA2A mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ADORA2A mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ADORA2A mRNA23665938
C070417Win 55212-2ADORA2A protein results in decreased susceptibility to Win 55212-226526685
C031238zinc sulfide[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of ADORA2A mRNA21481475
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] results in decreased expression of ADORA2A mRNA22342292
C097270ZM 241385ZM 241385 binds to ADORA2A protein21186795|2167577
C097270ZM 241385ZM 241385 binds to and results in decreased activity of ADORA2A protein23041272
C097270ZM 241385ZM 241385 binds to ADORA2A protein21210664
C097270ZM 241385[ZM 241385 binds to ADORA2A protein] which results in decreased susceptibility to Rotenone19416678
C097270ZM 241385ZM 241385 binds to and results in decreased activity of ADORA2A protein16601261|1661621
C097270ZM 241385[ZM 241385 binds to and results in decreased activity of ADORA2A protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid16601261
C097270ZM 241385ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]16616212
C097270ZM 241385ZM 241385 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A protein]16601261
C097270ZM 241385ZM 241385 binds to and results in decreased activity of ADORA2A protein17167068|1941667

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001609G-protein coupled adenosine receptor activity-IDA21393508  21593763  
GO:0005515protein binding-IPI11571652  12189203  16027149  16339847  16481441  17689978  
19632986  19694902  
GO:0019899enzyme binding-IPI16339847  
GO:0031802type 5 metabotropic glutamate receptor binding-IEA-  
GO:0042802identical protein binding-IPI18675812  19013155  
GO:0046982protein heterodimerization activity-IEA-  
GO:0051393alpha-actinin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001963synaptic transmission, dopaminergic-IEA-  
GO:0001973adenosine receptor signaling pathway-IEA-  
GO:0001975response to amphetamine-IEA-  
GO:0006171cAMP biosynthetic process-TAS10899090  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0006909phagocytosis-TAS8360491  
GO:0006915apoptotic process-TAS7818494  
GO:0006954inflammatory response-TAS8360491  
GO:0006968cellular defense response-TAS10051547  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-TAS10899090  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA21393508  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007267cell-cell signaling-TAS7818494  
GO:0007271synaptic transmission, cholinergic-IEA-  
GO:0007417central nervous system development-TAS10945659  
GO:0007596blood coagulation-TAS10899090  
GO:0007600sensory perception-TAS9262401  
GO:0007626locomotory behavior-IEA-  
GO:0008015blood circulation-TAS9262401  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0014049positive regulation of glutamate secretion-IEA-  
GO:0014057positive regulation of acetylcholine secretion, neurotransmission-IEA-  
GO:0014061regulation of norepinephrine secretion-IEA-  
GO:0031000response to caffeine-IEA-  
GO:0032230positive regulation of synaptic transmission, GABAergic-IEA-  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0035810positive regulation of urine volume-IEA-  
GO:0035815positive regulation of renal sodium excretion-IEA-  
GO:0040013negative regulation of locomotion-IEA-  
GO:0042311vasodilation-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043116negative regulation of vascular permeability-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045938positive regulation of circadian sleep/wake cycle, sleep-IEA-  
GO:0046636negative regulation of alpha-beta T cell activation-IEA-  
GO:0048143astrocyte activation-IEA-  
GO:0048812neuron projection morphogenesis-IEA-  
GO:0050714positive regulation of protein secretion-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0051881regulation of mitochondrial membrane potential-IEA-  
GO:0051899membrane depolarization-IEA-  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060080inhibitory postsynaptic potential-IEA-  
GO:0060134prepulse inhibition-IEA-  
GO:1900273positive regulation of long-term synaptic potentiation-IEA-  
GO:2001235positive regulation of apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005882intermediate filament-IEA-  
GO:0005886plasma membrane-IDA16339847  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP21393508  
GO:0012505endomembrane system-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-TAS10051547  
GO:0030425dendrite-IEA-  
GO:0030673axolemma-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0048786presynaptic active zone-IEA-  
GO:0099055integral component of postsynaptic membrane-IEA-  
GO:0099056integral component of presynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-187015Activation of TRKA receptorsIEA
R-HSA-187024NGF-independant TRKA activationIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-417973Adenosine P1 receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24943643Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain. (2014 Dec)Hohoff CNeuropsychopharmacology
27770044Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins. (2016 Dec)Soukup TInt J Immunopathol Pharmacol