Gene: COX10

1352
-
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
protein-coding
17p12
Ensembl:ENSG00000006695 MIM:602125 Vega:OTTHUMG00000058814 UniprotKB:Q12887
NG_008034.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.847e-1 (AD)  7.567e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIAPIN10.894
DHDDS0.888
COPG10.882
POLR3A0.88
AREL10.878
PPME10.878
AAGAB0.878
FARSB0.878
CLTC0.878
UBFD10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.458
RAI14-0.415
CSAG1-0.405
YES1-0.396
HEY2-0.38
PGF-0.375
KLRK1-0.366
SH2D1A-0.365
KLRC2-0.362

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of COX10 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of COX10 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of COX10 mRNA17562736
D001151ArsenicArsenic affects the methylation of COX10 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of COX10 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COX10 mRNA19770486|2171566
D002104CadmiumCadmium results in decreased expression of COX10 mRNA23369406
D002220CarbamazepineCarbamazepine affects the expression of COX10 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of COX10 gene20938992
D016572CyclosporineCyclosporine results in increased expression of COX10 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of COX10 mRNA24921660
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COX10 mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of COX10 mRNA28302478
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of COX10 gene20938992
D007213IndomethacinIndomethacin results in decreased expression of COX10 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COX10 mRNA23086925
D007854LeadLead results in decreased expression of COX10 mRNA19921347
C045463leflunomideleflunomide results in increased expression of COX10 mRNA28988120
D008694MethamphetamineMethamphetamine results in increased expression of COX10 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of COX10 gene20938992
D010100OxygenCOX10 protein affects the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010416PentachlorophenolPentachlorophenol results in decreased expression of COX10 mRNA24642059
D053260SootSoot results in increased expression of COX10 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COX10 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COX10 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COX10 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COX10 mRNA28213091
D019284ThapsigarginThapsigargin results in increased expression of COX10 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COX10 mRNA18087596
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of COX10 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of COX10 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of COX10 gene29154799
D014635Valproic AcidValproic Acid affects the expression of COX10 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of COX10 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004129cytochrome-c oxidase activitycontributes_toIMP12928484  
GO:0004311farnesyltranstransferase activity-IBA21873635  
GO:0004311farnesyltranstransferase activity-TAS8078902  
GO:0008495protoheme IX farnesyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000266mitochondrial fission-IEA-  
GO:0006123mitochondrial electron transport, cytochrome c to oxygen-IC12928484  
GO:0006783heme biosynthetic process-IBA21873635  
GO:0006783heme biosynthetic process-TAS-  
GO:0006784heme a biosynthetic process-IMP12928484  
GO:0008535respiratory chain complex IV assembly-IMP14607829  
GO:0045333cellular respiration-IBA21873635  
GO:0045333cellular respiration-IGI10767350  
GO:0048034heme O biosynthetic process-IEA-  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IC14607829  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0070069cytochrome complex-IMP12928484  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25869607Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity and type 2 diabetes in humans and mice. (2015 Aug)Van der Schueren BInt J Obes (Lond)