Gene: COX11

1353
COX11P
COX11, cytochrome c oxidase copper chaperone
protein-coding
17q22
Ensembl:ENSG00000166260 MIM:603648 Vega:OTTHUMG00000177838 UniprotKB:Q9Y6N1
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
8.343e-1 (AD)  1.786e-2 (ND)   (Frontal_Cortex)
8.993e-1 (AD)  5.113e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMTOR30.947
VPS290.939
RAB11A0.938
RAB2A0.938
SCOC0.934
UBA50.933
WASL0.933
ACP10.932
NUDT210.932
SHOC20.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.65
OR4F29-0.611
CSAG1-0.358
MAGEA12-0.313
WDR38-0.301
EVC2-0.292
RUNX3-0.285
MTRNR2L6-0.285
MTRNR2L10-0.281
ZBTB20-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX11 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of COX11 mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of COX11 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of COX11 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of COX11 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of COX11 mRNA22521957
D001280AtrazineAtrazine results in decreased expression of COX11 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COX11 mRNA22228805
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of COX11 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of COX11 mRNA25181051
D002104CadmiumCadmium results in decreased expression of COX11 mRNA21297354
C018021cobaltous chloridecobaltous chloride results in decreased expression of COX11 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of COX11 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of COX11 mRNA19549813
D019327Copper SulfateCopper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]23818984
D016572CyclosporineCyclosporine results in decreased expression of COX11 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of COX11 mRNA28628672
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of COX11 mRNA21852083
C118739entinostatentinostat results in decreased expression of COX11 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COX11 mRNA"27188386
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of COX11 mRNA27776689
D005557FormaldehydeFormaldehyde results in decreased expression of COX11 mRNA23649840
C039281furanfuran results in increased methylation of COX11 gene22079235
D005839GentamicinsGentamicins results in decreased expression of COX11 mRNA22061828
D006046GoldGold results in decreased expression of COX11 mRNA25523186
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of COX11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of COX11 mRNA28628672
D007538IsoniazidIsoniazid affects the expression of COX11 mRNA24848797
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COX11 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COX11 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COX11 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of COX11 mRNA"25620056
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of COX11 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of COX11 mRNA25729387
C016030pantogabpantogab results in decreased expression of COX11 mRNA17379144
C027579periodate-oxidized adenosineperiodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]23818984
D010656PhenylephrineCopper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]23818984
D010656Phenylephrineperiodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]23818984
D010656PhenylephrinePhenylephrine results in decreased expression of COX11 protein23818984|2510789
D010656PhenylephrineVEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]25107896
D059808PolyphenolsPolyphenols results in decreased expression of COX11 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of COX11 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of COX11 mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of COX11 mRNA21852083
C017947sodium arsenitesodium arsenite affects the expression of COX11 mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COX11 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COX11 mRNA23152189
D019284ThapsigarginThapsigargin results in increased expression of COX11 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COX11 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of COX11 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of COX11 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of COX11 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of COX11 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of COX11 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of COX11 gene25560391
C025643vinclozolinvinclozolin results in increased expression of COX11 mRNA23034163
D015215ZidovudineZidovudine results in decreased expression of COX11 mRNA16894629

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004129cytochrome-c oxidase activity-TAS9878253  
GO:0005507copper ion binding-IEA-  
GO:0005515protein binding-IPI15840172  
GO:0009055electron transfer activity-TAS9878253  
GO ID GO Term Qualifier Evidence PubMed
GO:0007585respiratory gaseous exchange-TAS9878253  
GO:0008535respiratory chain complex IV assembly-TAS9878253  
GO:0022900electron transport chain-IEA-  
GO:0033132negative regulation of glucokinase activity-IEA-  
GO:0055065metal ion homeostasis-IDA15840172  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-TAS9878253  
GO:0031305integral component of mitochondrial inner membrane-IDA15229189  
GO:0032991protein-containing complex-IDA15840172  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst