Gene info: ID 1356

Gene: CP

GENE ID: 1356

Synonyms: CP-2

Description: ceruloplasmin

Gene type: protein-coding

Location: 3q24-q25.1

dbXrefs: Ensembl:ENSG00000047457 MIM:117700 Vega:OTTHUMG00000159563 UniprotKB:P00450

RefSeq: NG_011800.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 193

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.451e-1 (AD) 2.279e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OSMR	0.862
CFI	0.856
IL4R	0.846
CFH	0.845
ELOVL7	0.839
TGM2	0.824
ACSL5	0.814
CFB	0.809
MPZL2	0.786
CASP4	0.782

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRH	-0.616
KCNIP3	-0.596
CPLX3	-0.569
NEUROD6	-0.568
ABCC12	-0.557
SPATA2L	-0.554
FLRT1	-0.545
MARCH4	-0.539
ADRA1D	-0.539
CYP1A1	-0.539

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06778	Cupric sulfate	Small Molecule	7758-98-7	Approved	Transporter
DB00055	Drotrecogin alfa	BiotechDrug	98530-76-8	Approved\|Investigational\|Withdrawn	Target
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB01592	Iron	Small Molecule	7439-89-6	Approved	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Carrier

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of CP mRNA"	16269432
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of CP mRNA"	19162173
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of CP mRNA	20566314
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CP mRNA"	25614096
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of CP mRNA"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of CP mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of CP mRNA]"	19414516
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of CP mRNA	22193206
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CP mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CP mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CP mRNA"	23196670
C006261	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one results in decreased secretion of [CP protein binds to Copper]	19007772
C499782	3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl	"CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl"	22824865
C499782	3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl	"Deferoxamine inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
C499782	3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl	"Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
C499782	3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl	"Pentetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CP mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CP mRNA"	18289764
C027576	4-hydroxy-2-nonenal	CP protein affects the abundance of 4-hydroxy-2-nonenal	12572680
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CP mRNA	19191707
C010590	4-hydroxyphenylpyruvic acid	[CP protein co-treated with 4-hydroxyphenylpyruvic acid] results in decreased activity of MIF protein	26091949
C041594	4-nonylphenol	4-nonylphenol affects the expression of CP mRNA	15792627
D000082	Acetaminophen	Acetaminophen results in decreased expression of CP mRNA	26946349
D000082	Acetaminophen	Acetaminophen results in decreased expression of CP mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of CP mRNA	17562736
D000171	Acrolein	CP protein inhibits the reaction [Rotenone results in increased abundance of Acrolein]	18804145
D020106	Acrylamide	Acrylamide results in decreased expression of CP mRNA	28959563
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of CP mRNA]"	19414516
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of CP mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CP gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CP mRNA	19770486
D000438	Alcohols	Alcohols results in increased expression of CP mRNA	24025710
D000447	Aldehydes	Aldehydes results in decreased expression of CP mRNA	25014914
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of CP protein]	15261977
C006495	aminoacetone	aminoacetone results in decreased activity of CP protein	14703801
D000638	Amiodarone	Amiodarone results in decreased expression of CP mRNA	26946349
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CP mRNA	16483693
C022175	ammonium molybdate	[ammonium molybdate co-treated with cadmium sulfate] affects the expression of CP mRNA	26105546
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of CP mRNA"	22863853
D000667	Ampicillin	Ampicillin results in increased expression of CP mRNA	21632981
D000968	Antimycin A	Antimycin A results in decreased expression of CP mRNA	19019832
D000968	Antimycin A	Antimycin A results in decreased expression of CP protein	19019832
D000968	Antimycin A	Antimycin A results in increased degradation of CP mRNA	19019832
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CP mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CP mRNA	20458559
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CP mRNA"	24160326
D001205	Ascorbic Acid	Copper affects the reaction [CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]]	14707133
D001205	Ascorbic Acid	CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]	14707133
D001280	Atrazine	Atrazine results in decreased expression of CP mRNA	22982499
D001414	Bacitracin	Bacitracin results in increased expression of CP mRNA	18289764
C500175	bacoside A	bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CP protein]	16226278
C002478	bathocuproine	bathocuproine inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]	17032174
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]	17032174
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CP mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CP mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CP mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CP mRNA	19770486
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CP mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of CP mRNA	18191855\|1961957
D004958	Estradiol	Estradiol affects the expression of CP mRNA	15598610
D004958	Estradiol	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of CP mRNA]	16977382
D004958	Estradiol	Estradiol results in increased expression of CP mRNA	15289156\|1668458
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in decreased expression of CP mRNA	15912405
C006780	bisphenol A	bisphenol A results in increased expression of CP mRNA	26364221
C006780	bisphenol A	bisphenol A results in decreased expression of CP mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of CP gene	22576693
C006780	bisphenol A	bisphenol A affects the expression of CP mRNA	25181051
D001761	Bleomycin	Bleomycin results in increased expression of CP protein	12624602
D001761	Bleomycin	tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]	12624602
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CP mRNA	14729362
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CP mRNA	18804290
C018475	butyraldehyde	butyraldehyde results in decreased expression of CP mRNA	26079696
D002104	Cadmium	CP protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CP mRNA	18213484
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CP mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CP mRNA	25993096
C037123	cadmium sulfate	[ammonium molybdate co-treated with cadmium sulfate] affects the expression of CP mRNA	26105546
D002118	Calcium	Calcium binds to CP protein	17242517
D002118	Calcium	[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]	22534743
D002220	Carbamazepine	Carbamazepine results in decreased expression of CP mRNA	17381134
C024714	caryophyllene	caryophyllene inhibits the reaction [Streptozocin results in decreased expression of CP protein]	26748309
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of CP mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CP mRNA	23650126
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CP mRNA	18804290
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CP mRNA	18178546
C418118	CI 1044	CI 1044 results in increased expression of CP mRNA	17569694
C059262	cidofovir	cidofovir results in increased expression of CP mRNA	25596134
C039671	ciglitazone	ciglitazone results in decreased expression of CP mRNA	22193206
D002994	Clofibrate	Clofibrate results in decreased expression of CP protein	131008
D002994	Clofibrate	Clofibrate results in decreased activity of CP protein	11969379
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CP mRNA	10777486
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CP mRNA	24386269
D003078	Colchicine	Colchicine results in increased expression of CP mRNA	20624997
D003300	Copper	Copper binds to CP protein	17242517
D003300	Copper	Copper deficiency results in decreased activity of CP protein	11580917\|1251426
D003300	Copper	Copper deficiency results in decreased expression of CP protein	18505688\|2470854
D003300	Copper	Copper promotes the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]	17032174
D003300	Copper	Copper promotes the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]	17032174
D003300	Copper	Copper results in increased activity of CP protein	10949969
D003300	Copper	CP protein binds to Copper	16842975\|2389642
D003300	Copper	ATP7A protein promotes the reaction [Copper binds to CP protein]	19351718
D003300	Copper	Copper deficiency affects the N-linked glycosylation of and results in decreased secretion of CP protein	16405854
D003300	Copper	Copper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of CP mRNA]	24901380
D003300	Copper	Copper deficiency results in decreased expression of CP protein modified form	21355016
D003300	Copper	[Copper co-treated with Diethylnitrosamine] results in increased expression of CP protein	20302851
D003300	Copper	Copper deficiency results in decreased activity of CP protein	11983831\|1276090
D003300	Copper	Copper deficiency results in decreased expression of CP mRNA	19497425
D003300	Copper	Copper deficiency results in decreased expression of CP protein	21781943\|2178488
D003300	Copper	Copper deficiency results in decreased expression of CP protein modified form	21355016
D003300	Copper	Copper results in decreased expression of CP mRNA	19497425
D003300	Copper	Copper results in increased expression of CP protein	23527585
D003300	Copper	[Fructose co-treated with Copper deficiency] results in decreased activity of CP protein	25813056
D003300	Copper	Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein]	21781943
D003300	Copper	Copper deficiency results in decreased expression of CP protein	21355016
D003300	Copper	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one results in decreased secretion of [CP protein binds to Copper]	19007772
D003300	Copper	ATP7B protein promotes the reaction [Copper binds to CP protein]	18779302
D003300	Copper	ATP7B protein promotes the reaction [CP protein binds to Copper]	15634671
D003300	Copper	Copper affects the reaction [CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]]	14707133
D003300	Copper	Copper deficiency results in decreased stability of CP protein	22332037
D003300	Copper	Copper deficiency results in decreased stability of CP protein modified form	22332037
D003300	Copper	NPC1 protein affects the secretion of [CP protein binds to Copper]	19007772
C098468	copper histidine	copper histidine results in increased expression of CP protein	22695177
D019327	Copper Sulfate	[Copper Sulfate co-treated with CP protein] results in increased expression of CCS mRNA	17683925
D019327	Copper Sulfate	[Copper Sulfate co-treated with CP protein] results in increased expression of SOD1 mRNA	17683925
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CP mRNA	19549813
D019327	Copper Sulfate	[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein	12899943
D019327	Copper Sulfate	Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of CP protein]	23298529
D019327	Copper Sulfate	Copper Sulfate results in increased activity of CP protein	12899943\|2329852
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CP mRNA	23298529
D003345	Corticosterone	Corticosterone results in increased expression of CP mRNA	15755911
C030123	coumarin	coumarin results in decreased expression of CP mRNA	26946349
C029892	cupric chloride	cupric chloride results in increased secretion of CP protein	12835505
C029892	cupric chloride	cupric chloride results in increased expression of CP mRNA	15741220
D003471	Cuprizone	Cuprizone results in increased expression of CP mRNA	26577399\|2752363
C009160	cyclonite	cyclonite results in increased expression of CP mRNA	25559034
D016572	Cyclosporine	Cyclosporine results in decreased expression of CP mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of CP mRNA	19770486
D016572	Cyclosporine	[Cyclosporine co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased expression of CP protein	25637670
D016572	Cyclosporine	Cyclosporine results in increased expression of CP mRNA	21865292
D003676	Deferoxamine	"Deferoxamine inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of CP mRNA	22733784
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of CP mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of CP mRNA]	20032058
D003976	Diazinon	Diazinon results in increased expression of CP mRNA	29108742
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CP mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CP mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CP mRNA	18289764
D002945	Cisplatin	Cisplatin results in increased secretion of CP protein	28885000
C000944	dicrotophos	dicrotophos results in decreased expression of CP mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of CP mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of CP mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of CP mRNA	18503570
C014476	diethyl maleate	diethyl maleate results in decreased expression of CP mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of and results in increased activity of CP protein	19061943
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CP mRNA	19061943\|2453584
D004052	Diethylnitrosamine	Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein]	19061943
D004052	Diethylnitrosamine	[Copper co-treated with Diethylnitrosamine] results in increased expression of CP protein	20302851
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CP mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CP mRNA	15289156
D002117	Calcitriol	Calcitriol results in increased expression of CP mRNA	14996990\|2648566
D002117	Calcitriol	Calcitriol results in increased expression of CP protein	14996990\|2710755
C012457	diisopropanolnitrosamine	[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of CP protein	19497425
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CP mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CP mRNA	22193206
D004147	Dioxins	Dioxins affects the expression of CP mRNA	20463971
D004050	Ditiocarb	Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D004237	Diuron	Diuron results in decreased expression of CP mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in increased expression of CP mRNA	15033991
D004317	Doxorubicin	Doxorubicin results in increased secretion of CP protein	28885000
D004492	Edetic Acid	"Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
D004785	Environmental Pollutants	Environmental Pollutants results in increased activity of CP protein	18600367
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CP mRNA	12655031
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CP mRNA	16954407
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CP mRNA	20227414
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CP protein	12616983
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CP mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CP mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CP mRNA	15576828\|1694001
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in increased expression of CP protein	12616983
C047360	felbamate	felbamate results in decreased expression of CP mRNA	17381134
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CP mRNA	17690111
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CP mRNA]	15016801
D005485	Flutamide	Flutamide results in decreased expression of CP mRNA	24136188
C030544	formic acid	formic acid inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of CP protein	19330884\|2569866
D005620	Freund's Adjuvant	[Indomethacin co-treated with morin] inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D005620	Freund's Adjuvant	Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D005620	Freund's Adjuvant	Kalpaamruthaa inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	19330884
D005620	Freund's Adjuvant	morin inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D005620	Freund's Adjuvant	Plant Extracts inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	19330884
D005632	Fructose	[Fructose co-treated with Copper deficiency] results in decreased activity of CP protein	25813056
D005632	Fructose	Fructose promotes the reaction [Copper deficiency results in decreased expression of CP protein]	21781943
C056933	fumonisin B1	fumonisin B1 results in increased expression of CP mRNA	16221962
C039281	furan	furan results in decreased expression of CP mRNA	15120968\|2619464
C040029	gabapentin	gabapentin results in decreased expression of CP mRNA	17381134
D019833	Genistein	Genistein results in increased expression of CP mRNA	15289156
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of CP mRNA	21782745
D005839	Gentamicins	Gentamicins results in increased expression of CP mRNA	18289764
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CP protein	12616983
D005897	Glafenine	Glafenine results in increased expression of CP mRNA	24136188
D005905	Glyburide	Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein]	26748309
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in decreased expression of CP mRNA	16206274
C010176	halofuginone	halofuginone results in increased expression of CP mRNA	17180598
D006497	Heparitin Sulfate	Copper affects the reaction [CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]]	14707133
D006497	Heparitin Sulfate	CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]	14707133
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of CP mRNA	20566314
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of CP mRNA	15159207
D017313	Fenretinide	Fenretinide results in increased expression of CP mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CP mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of and results in decreased secretion of CP protein	19019832
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CP mRNA	19019832\|2633960
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased degradation of CP mRNA	19019832
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CP mRNA	14729362
D007213	Indomethacin	[Indomethacin co-treated with morin] inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D007213	Indomethacin	Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CP mRNA	25613284
D007501	Iron	[CP protein co-treated with TF protein] results in increased export of Iron	16806171
D007501	Iron	CP protein promotes the reaction [TF protein binds to Iron]	16806171
D007501	Iron	CP protein results in increased export of Iron	16806171
D007501	Iron	ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter]	10777486
D007501	Iron	CP gene mutant form results in decreased export of Iron	20801540
D007501	Iron	CP protein binds to [TF protein binds to Iron]	21049900
D007501	Iron	CP protein results in increased oxidation of Iron	12572680\|2065538
D007501	Iron	[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein	20655381
D007501	Iron	Iron deficiency results in increased activity of CP promoter	10777486
D007501	Iron	CP gene mutant form results in increased abundance of Iron	16988052
D007501	Iron	[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA	16988052
D007501	Iron	[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA	16988052
D007501	Iron	[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA	16988052
D007501	Iron	[CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA	16988052
D007501	Iron	Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein]	19061943
D007501	Iron	Iron deficiency results in increased expression of CP protein	23814049
D007501	Iron	Iron deficiency results in increased expression of CP protein modified form	22457245
D007501	Iron	[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]	22534743
D007502	Iron Chelating Agents	Iron Chelating Agents results in increased chemical synthesis of CP protein	10777486
D007502	Iron Chelating Agents	Iron Chelating Agents results in increased expression of CP mRNA	10777486
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D007545	Isoproterenol	Isoproterenol results in increased expression of CP mRNA	20003209
D007545	Isoproterenol	allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of CP protein]	15261977
D007545	Isoproterenol	Isoproterenol results in decreased activity of CP protein	15261977
D007545	Isoproterenol	Isoproterenol results in increased expression of CP protein	1521861
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CP mRNA	27392435
C510231	Kalpaamruthaa	Kalpaamruthaa inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	19330884
C067713	lactacystin	lactacystin results in decreased degradation of CP protein	16405854
D007840	Latex	Latex analog results in decreased expression of CP mRNA	24768652
D007854	Lead	CP protein binds to Lead	23896426
D007854	Lead	Lead affects the expression of CP mRNA	28903495
D007854	Lead	Lead binds to and results in decreased activity of CP protein	15703452
D007854	Lead	Lead results in increased expression of CP protein	22923205
C008261	lead acetate	lead acetate results in decreased expression of CP protein	22534743
C008261	lead acetate	[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]	22534743
C008261	lead acetate	lead acetate results in decreased expression of and results in decreased activity of CP protein	24148954
C008261	lead acetate	Quercetin inhibits the reaction [lead acetate results in decreased expression of CP protein]	24148954
C045463	leflunomide	leflunomide results in increased expression of CP mRNA	24136188
D008070	Lipopolysaccharides	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of CP mRNA]	16977382
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CP mRNA	16977382\|2236906
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CP mRNA	26378955
D008315	Malondialdehyde	CP protein affects the abundance of Malondialdehyde	12572680
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of CP mRNA	20353558
D008628	Mercury	Mercury affects the expression of CP protein	22030286
D008701	Methapyrilene	Methapyrilene results in increased expression of CP mRNA	28935588
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of CP mRNA	21782745
D008748	Methylcholanthrene	Methylcholanthrene affects the expression of CP mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CP mRNA	17961207
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of CP mRNA	27544571
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased activity of CP protein	23298529
D015655	1-Methyl-4-phenylpyridinium	Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of CP protein]	23298529
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone affects the expression of CP mRNA]	22414680
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of CP mRNA	26924002
C008548	morin	[Indomethacin co-treated with morin] inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
C008548	morin	morin inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	25698669
D019810	Sodium Azide	Sodium Azide inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CP mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CP mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CP mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CP mRNA	18289764
D010866	Natamycin	Natamycin results in increased expression of CP mRNA	22863853
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of CP mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of CP mRNA	24136188
D009532	Nickel	CP protein binds to Nickel	23896426
C119536	nickel acetate	nickel acetate affects the expression of CP mRNA	12915101
C022838	nickel chloride	nickel chloride results in increased expression of CP mRNA	21455298
C012655	nimesulide	nimesulide results in decreased expression of CP mRNA	24136188
D009573	Nitrites	CP protein results in increased abundance of Nitrites	17727827
D009573	Nitrites	SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]	17727827
D009573	Nitrites	SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]	17727827
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of CP mRNA	12102619
D009761	Nystatin	Nystatin results in increased expression of CP mRNA	22863853
C025589	ochratoxin A	ochratoxin A results in decreased expression of CP mRNA	29274910
C025589	ochratoxin A	ochratoxin A results in decreased expression of CP protein	29274910
C025589	ochratoxin A	ochratoxin A results in increased expression of CP mRNA	12700408
C076029	olanzapine	olanzapine affects the phosphorylation of CP protein	25821032
D010100	Oxygen	ARNT protein affects the reaction [Oxygen deficiency results in increased activity of CP promoter]	10777486
D010100	Oxygen	Oxygen deficiency results in increased activity of CP promoter	10777486
D010100	Oxygen	Oxygen deficiency results in increased expression of CP mRNA	10777486\|1574122
D010100	Oxygen	Oxygen deficiency results in increased expression of CP protein	15741220\|1935171
D017239	Paclitaxel	Paclitaxel results in increased expression of CP mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of CP mRNA	18042831
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of CP mRNA	17715259
D052638	Particulate Matter	Particulate Matter results in decreased expression of CP mRNA	22178795
D010396	Penicillamine	Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]	24368744
D010396	Penicillamine	Penicillamine results in decreased expression of CP protein	24013775
C046012	pentanal	pentanal results in decreased expression of CP mRNA	26079696
D004369	Pentetic Acid	"Pentetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]"	22824865
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CP mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CP mRNA	18804290
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CP mRNA	19162173
D015232	Dinoprostone	CP protein results in increased secretion of Dinoprostone	17727827
D010634	Phenobarbital	Phenobarbital affects the expression of CP mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in decreased expression of CP mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of CP mRNA	17381134
D010672	Phenytoin	Phenytoin results in decreased expression of CP mRNA	17381134
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of CP mRNA	17715259
C006253	pirinixic acid	pirinixic acid results in decreased expression of CP mRNA	16221962
C006253	pirinixic acid	pirinixic acid results in decreased expression of CP mRNA	19162173
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Freund's Adjuvant results in increased expression of CP protein]	19330884
D028321	Plant Preparations	Plant Preparations results in decreased expression of CP protein	28284660
C043435	polylactic acid-polyglycolic acid copolymer	[Cyclosporine co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased expression of CP protein	25637670
C009007	potassium persulfate	potassium persulfate results in increased expression of CP protein	20815409
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone affects the expression of CP mRNA]	22414680
D011374	Progesterone	Progesterone affects the expression of CP mRNA	17251523
D011374	Progesterone	Progesterone results in increased expression of CP mRNA	20726854
C005556	propionaldehyde	propionaldehyde results in decreased expression of CP mRNA	26079696
D011441	Propylthiouracil	[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of CP protein	19497425
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CP mRNA	24780913
C020972	pyrrolidine dithiocarbamic acid	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]	17032174
C020972	pyrrolidine dithiocarbamic acid	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]	17032174
C020972	pyrrolidine dithiocarbamic acid	Copper promotes the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]	17032174
C020972	pyrrolidine dithiocarbamic acid	Copper promotes the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]	17032174
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of CP mRNA	17032174
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of CP protein	17032174
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased secretion of CP protein	17032174
D011765	Pyruvaldehyde	bathocuproine inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D011765	Pyruvaldehyde	Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D011765	Pyruvaldehyde	formic acid inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D011765	Pyruvaldehyde	Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]	16756764
D011765	Pyruvaldehyde	Pyruvaldehyde results in decreased activity of CP protein	16756764
D011765	Pyruvaldehyde	Sodium Azide inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]	16756764
D011794	Quercetin	Quercetin results in increased expression of CP mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [lead acetate results in decreased expression of CP protein]	24148954
D017378	Quinolinic Acid	[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein	12899943
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA	16054899
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D012402	Rotenone	Rotenone results in decreased expression of CP mRNA	19019832
D012402	Rotenone	Rotenone results in decreased expression of CP protein	19019832
D012402	Rotenone	Rotenone results in increased degradation of CP mRNA	19019832
D012402	Rotenone	CP protein affects the susceptibility to Rotenone	18804145
D012402	Rotenone	CP protein inhibits the reaction [Rotenone results in increased abundance of Acrolein]	18804145
D012439	Saccharin	Saccharin results in decreased expression of CP mRNA	26946349
C093642	SB 203580	SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]	17727827
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of CP mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CP mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CP mRNA	23221170
D012834	Silver	Silver binds to and affects the folding of CP protein	20965708
D012834	Silver	Silver binds to and affects the folding of CP protein	20965708
D020123	Sirolimus	Sirolimus results in increased expression of CP mRNA	21865292
D012906	Smoke	Smoke results in decreased nitrosation of CP protein	21652289
C118258	SN50 peptide	SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]	17727827
C118258	SN50 peptide	SN50 peptide inhibits the reaction [CP protein results in increased secretion of TNF protein]	17727827
D012964	Sodium	Sodium binds to CP protein	17242517
C017947	sodium arsenite	sodium arsenite affects the expression of CP mRNA	16507464
C016104	sodium bichromate	sodium bichromate results in decreased expression of CP mRNA	24612858
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CP mRNA	27862939
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CP protein	28918527
D012999	Soman	Soman results in increased expression of CP mRNA	19281266
D053260	Soot	Soot results in increased expression of CP mRNA	22461453\|2655175
D013311	Streptozocin	caryophyllene inhibits the reaction [Streptozocin results in decreased expression of CP protein]	26748309
D013311	Streptozocin	Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein]	26748309
D013311	Streptozocin	Streptozocin results in decreased expression of CP protein	26748309
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CP mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in increased expression of CP mRNA	21865292
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of CP mRNA]	20032058
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of CP mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CP mRNA	17884332
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CP mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CP mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CP mRNA	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CP mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CP mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CP gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CP mRNA	18172886\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CP mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CP mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CP mRNA	25613284
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased secretion of CP protein	10656425
C020809	tetrathiomolybdate	tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]	12624602
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased activity of CP protein	21724870
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased expression of CP protein	24013775
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased expression of CP protein	21784888
C009495	titanium dioxide	titanium dioxide affects the expression of CP mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of CP mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CP mRNA	20133372
D014028	Tobacco Smoke Pollution	bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CP protein]	16226278
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased activity of CP protein	16226278
C066340	tolcapone	tolcapone results in increased expression of CP mRNA	24136188
D014050	Toluene	Toluene results in increased expression of CP mRNA	22967744
D014212	Tretinoin	Tretinoin results in increased expression of CP mRNA	21934132\|2383079
C012589	trichostatin A	trichostatin A results in decreased expression of CP mRNA	15901671
D014266	Trientine	Trientine results in decreased expression of CP protein	24013775
C057693	troglitazone	[troglitazone co-treated with TNF protein] results in increased expression of CP mRNA	12732648
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in increased expression of CP mRNA]	12732648
C022884	undecane	undecane results in increased expression of CP protein	17337753
D014501	Uranium	Uranium results in increased expression of CP mRNA	18375546
D014520	Urethane	Urethane results in decreased expression of CP mRNA	28818685
D014527	Uric Acid	Uric Acid affects the activity of CP protein	10949969
C406224	valdecoxib	valdecoxib results in increased expression of CP mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of CP mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in decreased expression of CP mRNA	25716160\|2915479
D014635	Valproic Acid	Valproic Acid affects the expression of CP mRNA	17963808
D014640	Vancomycin	Vancomycin results in decreased expression of CP mRNA	18930951
D014640	Vancomycin	Vancomycin results in increased expression of CP mRNA	18289764
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CP gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CP mRNA	19165385
D014747	Vinblastine	Vinblastine results in increased expression of CP mRNA	20624997
C025643	vinclozolin	vinclozolin results in increased expression of CP mRNA	23555832
D014750	Vincristine	Vincristine results in increased expression of CP mRNA	20624997
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CP mRNA	26682919
D015032	Zinc	CP protein binds to Zinc	23896426
D015032	Zinc	[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]	22534743
D015032	Zinc	Zinc deficiency results in decreased expression of CP mRNA	12672911
D015032	Zinc	Zinc deficiency results in increased expression of CP mRNA	12672911
D015032	Zinc	Copper affects the reaction [CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]]	14707133
D015032	Zinc	CP mRNA affects the reaction [[Ascorbic Acid co-treated with Zinc] results in increased degradation of Heparitin Sulfate]	14707133
C016837	zinc chloride	zinc chloride results in increased expression of CP mRNA	18947441
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]	24368744
C088658	zoledronic acid	zoledronic acid results in increased expression of CP mRNA	24714768\|2559613

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004322	ferroxidase activity	-	TAS	-
GO:0005507	copper ion binding	-	IEA	-
GO:0016722	oxidoreductase activity, oxidizing metal ions	-	IBA	21873635
GO:0051087	chaperone binding	-	IPI	19996109

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006825	copper ion transport	-	IEA	-
GO:0006879	cellular iron ion homeostasis	-	TAS	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 20551380
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	19996109
GO:0005765	lysosomal membrane	-	HDA	17897319
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa00860	Porphyrin and chlorophyll metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-425366	Transport of bile salts and organic acids, metal ions and amine compounds	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-425410	Metal ion SLC transporters	TAS
R-HSA-5619060	Defective CP causes aceruloplasminemia (ACERULOP)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS
R-HSA-917937	Iron uptake and transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24178795	Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. (2014 Jan)	Register TC	J Clin Endocrinol Metab
15732863	Augmented transforming growth factor-beta1 in gingival crevicular fluid of smokers with chronic periodontitis. (2004 Dec)	Stein SH	J Periodontol
15645646	Homozygous (TG)11 allele in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against bicarbonate decrease in pure pancreatic juice among Japanese male alcoholics. (2004 Dec)	Nakamura Y	Intern Med
18834248	The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population. (2008 Oct)	Holla LI	J Periodontol
18823344	Effects of treatment on soluble tumour necrosis factor receptor type 1 and 2 in chronic periodontitis. (2008 Nov)	Ikezawa-Suzuki I	J Clin Periodontol
25253127	Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)	Derikx MH	Gut
24780137	Smoking effect on chemokines of the human chronic periodontitis. (2014 Aug)	Souto GR	Immunobiology
11588007	Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs. (2001 Sep)	Kwong K	Am J Respir Cell Mol Biol
23587006	Validation of reported genetic risk factors for periodontitis in a large-scale replication study. (2013 Jun)	Schaefer AS	J Clin Periodontol
11122350	Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. (2000 Dec)	Lu L	Eur J Neurosci
16512757	No association between selected candidate gene polymorphisms and severe chronic periodontitis. (2006 Mar)	Wohlfahrt JC	J Periodontol
29727221	Proportion of Orofacial Clefts Attributable to Recognized Risk Factors. (2018 Jan 1)	Raut JR	Cleft Palate Craniofac J
23151275	Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. (2012 Nov 14)	Murea M	BMC Nephrol
17608581	Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis. (2007 Jul)	Gurkan A	J Periodontol
12963084	NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones. (2004 Jan)	Nagy J	Neurochem Int
26658868	Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. (2015 Dec 9)	McGee TP	J Neurosci
11221586	[Chlamydia pneumoniae and Helicobacter pylori infections in acute myocardial infarction]. (2000 Dec)	Di Tano G	Ital Heart J Suppl
27574557	Utility of different serum fibrosis markers in diagnosing patients with chronic pancreatitis and pancreatic adenocarcinoma. (2016 Aug 15)	Kozak A	World J Gastrointest Oncol
17182930	Activators of plasminogen and the progression of small abdominal aortic aneurysms. (2006 Nov)	Lindholt JS	Ann N Y Acad Sci
25557162	Cytomorphological features of ALK-positive lung adenocarcinomas: psammoma bodies and signet ring cells. (2015 Mar)	Pareja F	Cancer Cytopathol
15057640	Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism? (2004 Apr)	Nagy J	IDrugs
28600657	Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. (2017 Aug)	Conwell DL	Dig Dis Sci
23701482	Saliva and serum levels of B-cell activating factors and tumor necrosis factor-alpha in patients with periodontitis. (2014 Feb)	Gumus P	J Periodontol
11699473	The Fc gamma receptor genotype as a severity factor for chronic periodontitis in Japanese patients. (2001 Oct)	Kobayashi T	J Periodontol
8883265	Elevated circulating P-selectin in insulin dependent diabetes mellitus. (1996 Sep)	Jilma B	Thromb Haemost
17215030	Plasma viscosity and related cardiovascular risk factors in a Spanish Mediterranean population. (2007)	Vaya A	Thromb Res
20646231	Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis. (2011 Jan)	Ozcaka O	Oral Dis
29737428	The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit. (2018 May 8)	Miranda TS	Clin Oral Investig
17209795	The potential prognostic value of some periodontal factors for tooth loss: a retrospective multilevel analysis on periodontal patients treated and maintained over 10 years. (2006 Dec)	Muzzi L	J Periodontol
20717068	Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis? (2010 Nov)	Muddana V	Pancreas
3005032	[Ceruloplasmin activity and content of the blood of persons with acute and chronic alcoholic intoxication]. (1986 Jan-Feb)	Moshkov KA	Farmakol Toksikol
29407532	The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice. (2018 Jun 8)	Valero E	Prog Neuropsychopharmacol Biol Psychiatry
12740284	Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs. (2003 May)	Selman M	Chest
20922511	Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients. (2011 Mar)	Esposito P	Cell Stress Chaperones
18173398	Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. (2008 Jan)	Ho YP	J Clin Periodontol
26854620	Determination of NLRP3 (rs4612666) and IL-1B (rs1143634) genetic polymorphisms in periodontally diseased and healthy subjects. (2016 May)	Isaza-Guzman DM	Arch Oral Biol
9684776	Infant TGF-alpha genotype, orofacial clefts, and maternal periconceptional multivitamin use. (1998 Jul)	Shaw GM	Cleft Palate Craniofac J
11454503	A case-control study of nonsyndromic oral clefts in Maryland. (2001 Aug)	Beaty TH	Ann Epidemiol
12237954	Evidence that anandamide-signaling regulates human sperm functions required for fertilization. (2002 Nov)	Schuel H	Mol Reprod Dev
23184281	Evaluation of chemically diverse 5-HT(2)c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. (2013 Apr)	Higgins GA	Psychopharmacology (Berl)
24905365	TNF-alpha gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies. (2014 Aug)	Ding C	J Clin Periodontol
11472696	Chlamydia pneumoniae exposure and inflammatory markers in acute coronary syndrome (CIMACS). (2001 Aug 1)	Chandra HR	Am J Cardiol
23646852	Comparative analysis of serum proteins in relation to rheumatoid arthritis and chronic periodontitis. (2014 Jan)	Yokoyama T	J Periodontol
22574675	Cholinergic receptor system as a target for treating alcohol abuse and dependence. (2012 Aug)	Rahman S	Recent Pat CNS Drug Discov
16213478	High cardiovascular risk in young Saudi males: cardiovascular risk factors, diet and inflammatory markers. (2006 Mar)	Alissa EM	Clin Chim Acta
22251071	Common genetic risk variants of TLR2 are not associated with periodontitis in large European case-control populations. (2012 Apr)	Richter GM	J Clin Periodontol
28214075	Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. (2017 Mar 15)	Lee DYW	Bioorg Med Chem Lett
25349168	ADAR2-dependent GluA2 editing regulates cocaine seeking. (2015 Nov)	Schmidt HD	Mol Psychiatry
27356020	Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. (2016 Aug)	Yuan M	Obesity (Silver Spring)
28025440	Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis. (2016)	Yu H	J Oral Sci
21437982	Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. (2011 Jul)	Divers J	J Bone Miner Res
23322468	Carotid plaque characteristics and disease activity in rheumatoid arthritis. (2013 Apr)	Semb AG	J Rheumatol
16274685	Autoantibodies against oxidized LDL correlate with serum concentrations of ceruloplasmin in patients with cardiovascular disease. (2006 Mar)	Awadallah SM	Clin Chim Acta
9753050	Low-dose aspirin does not lower in vivo platelet activation in healthy smokers. (1998 Sep)	Pernerstorfer T	Br J Haematol
28559203	Is antimicrobial photodynamic therapy an effective treatment for chronic periodontitis in diabetes mellitus and cigarette smokers: a systematic review and meta-analysis. (2017 Sep)	Al-Hamoudi N	Photodiagnosis Photodyn Ther
29752711	Evaluation of Stress, Serum and Salivary Cortisol and Interleukin-1beta Levels in Smokers and Non-Smokers with Chronic Periodontitis. (2018 May 11)	Bawankar PV	J Periodontol
15019433	Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. (2004 Jan)	Smith JE	Neurosci Biobehav Rev
22122521	Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. (2012 Jul)	Ishida K	J Periodontol
24109187	Role of nucleus accumbens glutamatergic plasticity in drug addiction. (2013)	Quintero GC	Neuropsychiatr Dis Treat
25569187	The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. (2015 Jan 8)	LaRusch J	Clin Transl Gastroenterol
28855420	Dietary Patterns Exhibit Sex-Specific Associations with Adiposity and Metabolic Risk in a Cross-Sectional Study in Urban Mexican Adolescents. (2017 Oct)	Perng W	J Nutr
23130632	p16 immunohistochemistry alone is a better prognosticator in tonsil cancer than human papillomavirus in situ hybridization with or without p16 immunohistochemistry. (2013 Mar)	Park K	Acta Otolaryngol
21948134	Role of matrix metalloproteinase 3 gene promoter polymorphism in chronic pancreatitis. (2011 Sep)	Sri Manjari K	Indian J Gastroenterol
27491013	Vitamin D Receptor Gene Polymorphism and Smoking in the Risk of Chronic Periodontitis. (2016 Nov)	Chantarangsu S	J Periodontol
26863688	Associations of Residential Long-Term Air Pollution Exposures and Satellite-Derived Greenness with Insulin Resistance in German Adolescents. (2016 Aug)	Thiering E	Environ Health Perspect
22443520	Individual composition of human leukocyte antigens and periodontopathogens in the background of periodontitis. (2013 Jan)	Reichert S	J Periodontol
29193859	Comparative evaluation of salivary hepatocyte growth factor in smokers and non-smokers with chronic periodontitis. (2018 May)	Guru S	J Investig Clin Dent
22109105	PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis. (2012 Feb)	Gao F	Mol Med Rep
21375584	Presence of SPINK-1 variant alters the course of chronic pancreatitis. (2011 Jun)	Sandhu B	J Gastroenterol Hepatol
23459936	Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (2013 Jun 1)	Divaris K	Hum Mol Genet
21901748	Molecular analysis of ceruloplasmin in a South African cohort presenting with oesophageal cancer. (2012 Aug 1)	Strickland NJ	Int J Cancer
12787697	Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms. (2003 Jun)	Lindholt JS	Eur J Vasc Endovasc Surg
11525435	Regulation of cytokine production in human gingival fibroblasts following treatment with nicotine and lipopolysaccharide. (2001 Aug)	Wendell KJ	J Periodontol
28655148	Genetic Variants in the Manganese Superoxide Dismutase 2 Gene and in the Catalase Gene are not Associated With Alcoholic Chronic Pancreatitis. (2017 Sep 1)	Schneider A	Alcohol Alcohol
21219099	The impact of smoking status on antioxidant enzyme activity and malondialdehyde levels in chronic periodontitis. (2011 Sep)	Tonguc MO	J Periodontol
15886011	Interleukin-12 and interleukin-16 in periodontal disease. (2005 Jul 7)	Tsai IS	Cytokine
27171516	Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. (2016 Jul)	Setiawan VW	Pancreas
28968289	Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients. (2017 Dec)	Grabarczyk AM	J Pediatr Gastroenterol Nutr
20332662	Cigarette smoking is independently associated with chronic pancreatitis. (2010)	Law R	Pancreatology
9869158	Contribution of acute-phase proteins and cardiovascular risk factors to erythrocyte aggregation in normolipidemic and hyperlipidemic individuals. (1998 Dec)	Weng X	Thromb Haemost
29735453	[Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus]. (2018 Apr 20)	Liang Q	Nan Fang Yi Ke Da Xue Xue Bao
19549135	Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population. (2009 Nov)	Xiao LM	Oral Dis
28267790	Cigarette smoking is associated with high HIV viral load among adults presenting for antiretroviral therapy in Vietnam. (2017)	Pollack TM	PLoS One
29186065	Binge Alcohol Exposure Transiently Changes the Endocannabinoid System: A Potential Target to Prevent Alcohol-Induced Neurodegeneration. (2017 Nov 29)	Liput DJ	Brain Sci
16646270	[Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project]. (2005 Sep-Dec)	Bolognesi C	Epidemiol Prev
19211971	Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats. (2008 Nov-Dec)	Przegalinski E	Pharmacol Rep
15450037	Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI Study. (2004 Oct)	Blanc P	J Am Geriatr Soc
17209340	[Influence of tobacco smoking and periodontitis on selected factors of oxidative stress]. (2006)	Konopka T	Wiad Lek
14966476	Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims. (2004 Feb)	Hungund BL	Mol Psychiatry
8808434	Effects of ethanol on meal-stimulated secretion of pancreatic polypeptide and cholecystokinin: comparison of healthy volunteers, heavy drinkers, and patients with chronic pancreatitis. (1996 Feb)	Hirano H	J Gastroenterol
27563196	Comparison of serum erythropoietin levels in smokers and nonsmokers with periodontitis: A biochemical study. (2016 May-Jun)	Singh V	J Indian Soc Periodontol
26102702	9A.06: IMPACT OF METABOLIC, HEMODYNAMIC AND INFLAMMATORY FACTORS ON TARGET ORGAN DAMAGE IN HEALTHY SUBJECTS. (2015 Jun)	Blicher M	J Hypertens
12614667	The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded rats. (2003)	Lodge DJ	Neuroscience
10824693	Elevated serum levels of antibodies to carbonic anhydrase I and II in patients with chronic pancreatitis. (2000 May)	Frulloni L	Pancreas
9927220	Oral clefts, transforming growth factor alpha gene variants, and maternal smoking: a population-based case-control study in Denmark, 1991-1994. (1999 Feb 1)	Christensen K	Am J Epidemiol
25172546	Effect of smoking on immunity in human chronic periodontitis. (2014 Dec)	Souto GR	Immunobiology
25865730	Journal abstracts from current research in the field of child and adolescent mental health. (2009 Dec)	-	J Child Adolesc Ment Health
16395294	Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. (2006 Oct)	Schank JR	Neuropsychopharmacology
25628487	Assessment of Matrix Metalloproteinases-8 and -9 in Gingival Crevicular Fluid of Smokers and Non-smokers with Chronic Periodontitis Using ELISA. (2014 Nov-Dec)	Victor DJ	J Int Oral Health
29288864	Assessment of subclinical atherosclerosis in systemic lupus erythematosus: A systematic review and meta-analysis. (2018 Mar)	Henrot P	Joint Bone Spine
27769811	Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis. (2016 Dec)	Xue J	Gastroenterology
17138786	Perinatal factors associated with cerebral palsy in children born in Sweden. (2006 Dec)	Thorngren-Jerneck K	Obstet Gynecol
10770899	[Hypoinsulinemia in alcoholics with minimal liver disease]. (2000 Jan-Mar)	Neves MM	Rev Assoc Med Bras (1992)
23543659	Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. (2013 May)	Register TC	J Clin Endocrinol Metab
12848920	[Study on the correlation of between infection, inflammation and coronary artery disease]. (2003 Jun)	Cai XJ	Zhonghua Liu Xing Bing Xue Za Zhi
2149913	Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study. (1990 May-Jun)	Granata A	Acta Eur Fertil
18410395	Vitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis. (2008 Jul)	Nibali L	J Clin Periodontol
9988882	Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts. (1999 Jan)	Romitti PA	Teratology
22754497	Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? (2012)	Wolf ME	Front Mol Neurosci
26547698	Does smoking affect gingival crevicular fluid LL-37 levels following non-surgical periodontal treatment in chronic periodontitis? (2016 Jan)	Turkoglu O	Arch Oral Biol
18985807	Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects? (2008 Oct 28)	Aparisi L	World J Gastroenterol
7647736	[Evaluation of selected factors induced by antioxidative activity in serum of cigarette smokers and in patients with early phase emphysema]. (1995)	Piotrowski WJ	Pneumonol Alergol Pol
25203431	The effect of smoking on endothelin-1 in patients with chronic pancreatitis. (2015 Apr)	Sliwinska-Mosson M	Appl Immunohistochem Mol Morphol
27518468	Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. (2016 Nov)	Midha S	Pancreas
10943688	Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats. (2000 Aug 3)	Lu L	Neuroreport
28194001	Enhancing VTA Cav1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. (2017 Dec)	Martinez-Rivera A	Mol Psychiatry
24512552	Single-nucleotide polymorphisms interact to affect ADH7 transcription. (2014 Apr)	Jairam S	Alcohol Clin Exp Res
25623657	An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study. (2015 Feb)	Duggan SN	Am J Gastroenterol
12441166	Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. (2003 Jan)	Nagy J	Neurochem Int
10519977	Change point in VCO2 during incremental exercise test: a new method for assessment of human exercise tolerance. (1999 Sep)	Zoladz JA	Acta Physiol Scand
26095761	Role of Parathyroid Hormone-Related Protein Signaling in Chronic Pancreatitis. (2015 Jun 18)	Falzon M	Cancers (Basel)
23680694	Sex-dependent changes in brain CB1R expression and functionality and immune CB2R expression as a consequence of maternal deprivation and adolescent cocaine exposure. (2013 Aug)	Llorente-Berzal A	Pharmacol Res
24407598	Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters. (2014 Feb)	Zivkovic M	Mol Biol Rep
28548211	A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis. (2017 Oct)	Munz M	J Clin Periodontol
24369697	Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. (2014 Mar 19)	Pentkowski NS	ACS Chem Neurosci
21048701	Partial agonists of the alpha3beta4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. (2011 Feb)	Chatterjee S	Neuropsychopharmacology
17702903	Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. (2007 Nov)	Valdez GR	J Pharmacol Exp Ther
14572874	Vitamin D receptor gene polymorphism is associated with chronic periodontitis. (2003 Nov 14)	Tachi Y	Life Sci
25741578	The utility of gingival crevicular fluid matrix metalloproteinase-8 response patterns in prediction of site-level clinical treatment outcome. (2015 Jun)	Leppilahti JM	J Periodontol
21871150	Synthetic cannabinoids in oral fluid. (2011 Sep)	Coulter C	J Anal Toxicol
12834496	Fcgamma receptor polymorphisms in relation to periodontitis. (2003 Jul)	Loos BG	J Clin Periodontol
19127818	[The effect of environmental and genetic factors in the pathogenesis of periodontitis]. (2008)	Drozdzik A	Ann Acad Med Stetin
26196951	Vitamin D Associations With Renal, Bone, and Cardiovascular Phenotypes: African American-Diabetes Heart Study. (2015 Oct)	Freedman BI	J Clin Endocrinol Metab
21618603	Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. (2011 Sep)	Beaty TH	Genet Epidemiol
24188156	Higher numbers of circulating endothelial progenitor cells in stroke patients with intracranial arterial stenosis. (2013 Nov 5)	Liu Z	BMC Neurol
28394081	The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment on gingival crevicular fluid levels of transforming growth factor-beta 1, tissue plasminogen activator and plasminogen activator inhibitor 1 in smoking and non-smoking chronic periodontitis patients: A split-mouth, randomized control study. (2017 Oct)	Pamuk F	J Periodontal Res
22898629	The effect of smoking on expression of IL-6 and antioxidants in pancreatic fluids and tissues in patients with chronic pancreatitis. (2012 Jul-Aug)	Sliwinska-Mosson M	Pancreatology
20626027	Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis. (2010)	Djuric T	J Clin Lab Anal
23125289	Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. (2013 Jan)	Register TC	J Clin Endocrinol Metab
24708273	SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis. (2014 Jun)	de Jong TM	J Clin Periodontol
19799717	Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis. (2009 Nov)	Li X	J Clin Periodontol
14514230	Lifestyle and psychosocial factors associated with chronic periodontitis in Taiwanese adults. (2003 Aug)	Teng HC	J Periodontol
26446985	Gingival crevicular fluid interleukin-8 and lipoxin A4 levels of smokers and nonsmokers with different periodontal status: a cross-sectional study. (2016 Aug)	Lutfioglu M	J Periodontal Res
25193410	Impact of periodontitis on chemokines in smokers. (2015 Jun)	Haytural O	Clin Oral Investig
22879519	The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis. (2013 Oct)	Tyler AD	Gut
22207703	Chronic pelvic pain syndrome and semen quality of Korean men in their fourth decade. (2012 Sep-Oct)	Byun JS	J Androl
16139885	Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats. (2005 Oct)	Przegalinski E	Neuropeptides
26339134	HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. (2015)	Sippert EA	Mediators Inflamm
17071590	An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P. (2006 Nov)	Wang X	Am J Pathol
10704630	The relationship of oxidized lipids to coronary artery stenosis. (2000 Mar)	Kummerow FA	Atherosclerosis
15608595	Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. (2004 Dec)	Radcliffe RA	Alcohol Clin Exp Res
17264580	Plasma gastrin levels in alcoholic and idiopathic chronic pancreatitis patients free from Helicobacter pylori infection. (2001 Jan-Mar)	Al-Eryani S	Ann Saudi Med
29243300	Antagonists of Wnt/beta-catenin signalling in the periodontitis associated with type 2 diabetes and smoking. (2018 Mar)	Miranda TS	J Clin Periodontol
9278131	Concentration of metals, ceruloplasmin, metallothionein and the activity of N-acetyl-beta-D-glucosaminidase and gamma-glutamyltransferase in pregnant women who smoke and in those environmentally exposed to tobacco smoke and in their infants. Part I. (1997)	Milnerowicz H	Int J Occup Med Environ Health
24702466	Clinical application of genetics to guide prevention and treatment of oral diseases. (2014 Jul)	Kornman KS	Clin Genet
20810573	Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. (2010 Dec)	Divers J	J Clin Endocrinol Metab
18953248	Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. (2008 Nov)	Frulloni L	Pancreas
22825367	Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. (2012 Oct)	Rebours V	Am J Gastroenterol
23670871	Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. (2013 Aug)	Butali A	Birth Defects Res A Clin Mol Teratol
28777039	Alarm Anti-protease Trappin-2 Negatively Correlates With Proinflammatory Cytokines in Patients With Periodontitis. (2017 Aug 4)	Afacan B	J Periodontol
25304102	Application of systematic coronary risk evaluation chart to identify chronic myeloid leukemia patients at risk of cardiovascular diseases during nilotinib treatment. (2015 Mar)	Breccia M	Ann Hematol
28968711	Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)	Couto PP	Carcinogenesis
26812355	RNA-sequencing study of peripheral blood monocytes in chronic periodontitis. (2016 May 1)	Liu YZ	Gene
7429058	Blood viscosity in young male diabetics with and without retinopathy. (1980 May)	Lowe GD	Diabetologia
19287329	The role of epoxide hydrolase Y113H gene variant in pancreatic diseases. (2009 May)	Ockenga J	Pancreas
23550892	Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. (2013 Aug)	Yokoyama A	Alcohol Clin Exp Res
23706125	Safety of neurokinin-1 receptor antagonists. (2013 Sep)	Munoz M	Expert Opin Drug Saf
15643916	Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. (2005 Jan)	Zeiger JS	Cleft Palate Craniofac J
25397464	Relationship between innate immunity, soluble markers and metabolic-clinical parameters in HIV+ patients ART treated with HIV-RNA<50 cp/mL. (2014)	Dentone C	J Int AIDS Soc
21942788	Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in patients with chronic periodontitis. (2012 Jun)	Takeuchi Y	J Periodontol
15247627	Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (2004 Jun)	Verlaan M	Pharmacogenetics
17288189	[Immunohistochemical localization of p53 protein in smoking patients with chronic pancreatitis]. (2006)	Sliwinska-Mosson M	Przegl Lek
22092455	MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese. (2011 Dec)	Chou YH	J Clin Periodontol
29520783	The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study. (2018 Mar)	Kobayashi T	J Periodontol
23039038	Association of salivary levels of the bone remodelling regulators sRANKL and OPG with periodontal clinical status. (2012 Dec)	Tobon-Arroyave SI	J Clin Periodontol
8435246	Exercise, fibrinogen, and other risk factors for ischaemic heart disease. Caerphilly Prospective Heart Disease Study. (1993 Feb)	Elwood PC	Br Heart J
27063304	[Expressions of EMMPRIN and its ligand CyPA in gingival crevicular fluid of chronic periodontitis patients]. (2016 Feb)	He YP	Shanghai Kou Qiang Yi Xue
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