Gene: CPA1

1357
CPA
carboxypeptidase A1
protein-coding
7q32.2
Ensembl:ENSG00000091704 MIM:114850 Vega:OTTHUMG00000157826 UniprotKB:P15085
NG_042276.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.278e-1 (AD)  1.259e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRSS10.981
CELA3A0.978
CLPS0.968
CTRB10.967
CTRB20.964
PNLIP0.955
GP20.951
PLA2G1B0.943
CELA3B0.942
CPB10.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.232
PSG11-0.215
CYP2A6-0.207
CRLF2-0.203
DNTT-0.196
HMGA2-0.194
FGF23-0.193
RNF133-0.19
FOXN4-0.188
GOLGA8N-0.188

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02494Alpha-Hydroxy-Beta-Phenyl-Propionic AcidSmall MoleculeExperimentalTarget
DB02652L-[(N-Hydroxyamino)Carbonyl]PhenylalanineSmall MoleculeExperimentalTarget
DB03012Phenylalanine-N-SulfonamideSmall MoleculeExperimentalTarget
DB03201D-CysteineSmall Molecule921-01-7ExperimentalTarget
DB034412-Benzyl-3-Iodopropanoic AcidSmall MoleculeExperimentalTarget
DB04058D-[(Amino)Carbonyl]PhenylalanineSmall MoleculeExperimentalTarget
DB04316D-[(N-Hydroxyamino)Carbonyl]PhenylalanineSmall MoleculeExperimentalTarget
DB06924(2R)-2-benzyl-3-nitropropanoic acidSmall MoleculeExperimentalTarget
DB07351O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATESmall MoleculeExperimentalTarget
DB07484(2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acidSmall MoleculeExperimentalTarget
DB07506L-BENZYLSUCCINIC ACIDSmall MoleculeExperimentalTarget
DB08368OCTANE-1,3,5,7-TETRACARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB08762O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACIDSmall MoleculeExperimentalTarget
DB11095DesirudinBiotechDrug120993-53-5ApprovedEnzyme
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CPA1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CPA1 mRNA"27291303
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CPA1 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CPA1 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CPA1 mRNA"20959002
D020106AcrylamideAcrylamide results in decreased expression of CPA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CPA1 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CPA1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CPA1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPA1 mRNA26001963
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of CPA1 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of CPA1 mRNA15901920|2518105
D002104CadmiumCadmium results in decreased activity of CPA1 protein15865404
D019256Cadmium ChlorideCadmium Chloride affects the expression of CPA1 mRNA18409656
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CPA1 mRNA18154678
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CPA1 mRNA18804290
D019327Copper SulfateCopper Sulfate results in decreased expression of CPA1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of CPA1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of CPA1 mRNA19264136
D003907DexamethasoneDexamethasone results in decreased expression of CPA1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CPA1 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CPA1 mRNA17379624|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CPA1 mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of CPA1 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CPA1 mRNA28412506
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CPA1 mRNA19638242
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of CPA1 mRNA26924002
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of CPA1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CPA1 mRNA15901920
C017690fenvaleratefenvalerate affects the expression of CPA1 mRNA20003521
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of CPA1 mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of CPA1 mRNA18035473
C039281furanfuran results in decreased expression of CPA1 mRNA26194646
C039281furanfuran results in increased methylation of CPA1 gene22079235
D019833GenisteinGenistein results in decreased expression of CPA1 mRNA23019147
D019833GenisteinGenistein results in decreased expression of CPA1 mRNA15901920
C008261lead acetatelead acetate results in increased expression of CPA1 mRNA20542052
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CPA1 mRNA"19264136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CPA1 mRNA26011545
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CPA1 mRNA24128854
C059539midostaurinmidostaurin results in increased expression of CPA1 mRNA20980353
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of CPA1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CPA1 mRNA"25620056
D000069463Olive OilOlive Oil analog affects the expression of CPA1 mRNA17349074
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CPA1 mRNA19162173
C014153pirimiphos methylpirimiphos methyl results in decreased expression of CPA1 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CPA1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CPA1 mRNA17426115|2081375
C541923sandostatinLARsandostatinLAR results in decreased expression of CPA1 mRNA17210224
C009277sodium arsenatesodium arsenate results in decreased expression of CPA1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of CPA1 mRNA22561333
C016104sodium bichromatesodium bichromate results in increased expression of CPA1 mRNA22561333
D012969Sodium FluorideSodium Fluoride results in decreased expression of CPA1 mRNA27862939
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of CPA1 mRNA17630414
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CPA1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPA1 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CPA1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPA1 mRNA20959002
C009495titanium dioxidetitanium dioxide results in increased expression of CPA1 mRNA23409001
C025643vinclozolinvinclozolin results in increased expression of CPA1 mRNA20566332
D015032ZincZinc results in increased activity of CPA1 protein17093223
C016837zinc chloridezinc chloride results in increased expression of CPA1 mRNA17328222
D015034Zinc OxideZinc Oxide results in increased activity of CPA1 protein17093223

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004181metallocarboxypeptidase activity-IBA21873635  
GO:0005515protein binding-IPI19179285  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA2920728  
KEGG ID KEGG Term
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28454201[Identical Variants Different Disease Course - Genetics of Chronic Pancreatitis]. (2017 May)Beer SDtsch Med Wochenschr