Gene: NOBOX

135935
OG-2|OG2|OG2X|POF5|TCAG_12042
NOBOX oogenesis homeobox
protein-coding
7q35
Ensembl:ENSG00000106410 MIM:610934 Vega:OTTHUMG00000158051 UniprotKB:O60393
NG_028979.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.710e-1 (AD)  3.200e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2T350.483
VN1R50.444
SEMG10.426
HEMGN0.388
OR2T110.381
OR6C40.362
DLX40.358
ADAM20.355
H1FOO0.341
CLEC6A0.332

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLIG1-0.196
GHRHR-0.192
RFTN2-0.191
C5orf64-0.186
KRT83-0.184
TMEM253-0.184
MTRNR2L9-0.179
KCNJ16-0.176
IL36G-0.176
C11orf86-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of NOBOX gene25304211
C006780bisphenol Abisphenol A results in decreased expression of NOBOX mRNA22699882|2445853
C006780bisphenol Abisphenol A results in increased expression of NOBOX mRNA22699882
C006780bisphenol Abisphenol A results in decreased expression of NOBOX mRNA25181051
D003300CopperCopper deficiency results in increased expression of NOBOX mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of NOBOX mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NOBOX mRNA24458533
D015025ZearalenoneZearalenone results in decreased expression of NOBOX mRNA28089945
C033789fenarimolfenarimol results in increased expression of NOBOX mRNA21722721
C033789fenarimolfenarimol results in increased expression of NOBOX protein21722721
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NOBOX mRNA22634610
D011192Potassium DichromatePotassium Dichromate results in increased expression of NOBOX mRNA23608068
D012969Sodium FluorideSodium Fluoride results in decreased expression of NOBOX mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NOBOX mRNA24058054
D014635Valproic AcidValproic Acid results in increased methylation of NOBOX gene29154799
C025643vinclozolinvinclozolin results in increased expression of NOBOX mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0043565sequence-specific DNA binding-IDA27798098  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA27798098  
GO:0007275multicellular organism development-IEA-  
GO:0048477oogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24847019In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)Fowler PAHum Reprod