| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg07156669 | chr17:28705245 | CPD | Promoter | 1.120e-4 | Alcohol use disorders | 26763658 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ITSN2 | 0.91 |
| USP15 | 0.901 |
| SEL1L | 0.894 |
| MGAT4A | 0.894 |
| RPS6KB1 | 0.893 |
| AGFG1 | 0.892 |
| ZBTB38 | 0.891 |
| TRIP12 | 0.89 |
| ITCH | 0.886 |
| SCYL2 | 0.885 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.493 |
| OR4F29 | -0.485 |
| HES5 | -0.422 |
| PLA2G5 | -0.392 |
| WNT7B | -0.38 |
| BTBD17 | -0.374 |
| NXNL1 | -0.364 |
| PPP1R3G | -0.357 |
| RLBP1 | -0.355 |
| C16orf74 | -0.351 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB04489 | Guanidinoethylmercaptosuccinic acid | Small Molecule | 77482-44-1 | Experimental | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C024566 | 1,1,1-trichloroethane | "1,1,1-trichloroethane results in decreased expression of CPD mRNA" | 25270620 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA" | 27188386 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of CPD protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of CPD gene | 27153756 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CPD mRNA | 16483693 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of CPD mRNA | 22228805 |
| D004958 | Estradiol | [bisphenol A co-treated with Estradiol] results in increased expression of CPD mRNA | 26496021 |
| D004958 | Estradiol | [Estradiol co-treated with Testosterone] results in increased expression of CPD mRNA | 11375906 |
| D001663 | Bilirubin | Bilirubin results in decreased expression of CPD mRNA | 20196124 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CPD mRNA | 29275510 |
| C006780 | bisphenol A | [bisphenol A co-treated with Estradiol] results in increased expression of CPD mRNA | 26496021 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CPD mRNA | 25181051|2909715 |
| C018475 | butyraldehyde | butyraldehyde results in decreased expression of CPD mRNA | 26079696 |
| D002101 | Cacodylic Acid | Cacodylic Acid results in decreased expression of CPD mRNA | 17720352 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of CPD mRNA | 17484886 |
| D002713 | Chlorine | [Ozone co-treated with Chlorine] results in decreased expression of CPD mRNA | 18636392 |
| C100187 | chloropicrin | chloropicrin results in increased expression of CPD mRNA | 26352163 |
| D002737 | Chloroprene | Chloroprene results in increased expression of CPD mRNA | 23125180 |
| D002794 | Choline | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | 20938992 |
| D003010 | Clorgyline | Clorgyline results in increased expression of CPD mRNA | 19691856 |
| D003300 | Copper | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CPD mRNA | 15467011 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CPD mRNA | 25562108 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in increased expression of CPD mRNA | 21266533 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of CPD mRNA | 18721800 |
| D002117 | Calcitriol | Calcitriol results in increased expression of CPD mRNA | 16002434 |
| D000431 | Ethanol | Ethanol results in increased expression of CPD mRNA | 15353170 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of CPD mRNA | 17942748 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPD mRNA | 17942748 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of CPD mRNA | 29097150 |
| C024565 | ethylene dichloride | ethylene dichloride results in decreased expression of CPD mRNA | 28189721 |
| D005472 | Fluorouracil | CPD protein affects the susceptibility to Fluorouracil | 16217747 |
| D005472 | Fluorouracil | TP53 protein affects the reaction [Fluorouracil results in decreased expression of CPD mRNA] | 15016801 |
| D005492 | Folic Acid | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | 20938992 |
| C546771 | gardiquimod | gardiquimod results in increased expression of CPD mRNA | 28003376 |
| C546771 | gardiquimod | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPD mRNA] | 28003376 |
| D005839 | Gentamicins | Gentamicins results in increased expression of CPD mRNA | 22061828 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPD mRNA | 25613284 |
| C544151 | jinfukang | jinfukang results in decreased expression of CPD mRNA | 27392435 |
| D001556 | Lindane | Lindane results in increased expression of CPD mRNA | 17785943 |
| D058185 | Magnetite Nanoparticles | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of CPD mRNA | 21641980 |
| D058185 | Magnetite Nanoparticles | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CPD mRNA | 26378955 |
| D008715 | Methionine | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | 20938992 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in increased expression of CPD mRNA | 23179753 |
| C583365 | N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide | "N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CPD mRNA" | 29244179 |
| D009569 | Nitric Oxide | CPD affects the chemical synthesis of Nitric Oxide | 21688280 |
| D009569 | Nitric Oxide | [PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide | 21688280 |
| D009569 | Nitric Oxide | [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide | 21688280 |
| D010126 | Ozone | [Ozone co-treated with Chlorine] results in decreased expression of CPD mRNA | 18636392 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in decreased expression of CPD mRNA | 19162173 |
| D010634 | Phenobarbital | Phenobarbital results in decreased expression of CPD mRNA | 23091169 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPD mRNA | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of CPD mRNA | 23811191 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of CPD mRNA | 23557933 |
| C035988 | procymidone | procymidone results in increased expression of CPD mRNA | 15686871 |
| D011441 | Propylthiouracil | Propylthiouracil results in decreased expression of CPD mRNA | 24780913 |
| D047428 | Protein Kinase Inhibitors | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPD mRNA] | 28003376 |
| D015474 | Isotretinoin | Isotretinoin results in decreased expression of CPD mRNA | 20436886 |
| C541923 | sandostatinLAR | sandostatinLAR results in decreased expression of CPD mRNA | 17210224 |
| D012643 | Selenium | Selenium results in decreased expression of CPD mRNA | 19244175 |
| D012822 | Silicon Dioxide | Silicon Dioxide analog results in decreased expression of CPD mRNA | 25895662 |
| C009277 | sodium arsenate | sodium arsenate results in increased expression of CPD mRNA | 21795629 |
| D004113 | Succimer | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of CPD mRNA | 21641980 |
| D004113 | Succimer | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CPD mRNA | 26378955 |
| C016766 | sulforafan | sulforafan results in increased expression of CPD mRNA | 26833863 |
| D013739 | Testosterone | SRD5A1 promotes the reaction [Testosterone results in increased expression of CPD mRNA] | 21688280 |
| D013739 | Testosterone | Testosterone results in increased expression of CPD mRNA | 21688280 |
| D013739 | Testosterone | [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide | 21688280 |
| D013739 | Testosterone | Testosterone results in increased expression of CPD protein | 21688280 |
| D013739 | Testosterone | [Estradiol co-treated with Testosterone] results in increased expression of CPD mRNA | 11375906 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPD mRNA | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of CPD mRNA | 16054898 |
| D013750 | Tetrachloroethylene | Tetrachloroethylene results in increased expression of CPD mRNA | 28973375 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPD mRNA | 25613284 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of CPD mRNA | 28065790 |
| D014241 | Trichloroethylene | Trichloroethylene results in increased methylation of CPD gene | 27618143 |
| C012589 | trichostatin A | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA" | 27188386 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of CPD mRNA | 26272509 |
| C057693 | troglitazone | troglitazone results in decreased expression of CPD mRNA | 28973697 |
| D014415 | Tunicamycin | Tunicamycin results in decreased expression of CPD mRNA | 17127020 |
| D014520 | Urethane | Urethane results in decreased expression of CPD mRNA | 16289808 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of CPD mRNA | 23179753|2915479 |
| D001335 | Vehicle Emissions | Vehicle Emissions affects the methylation of CPD gene | 25560391 |
| D000069470 | Venlafaxine Hydrochloride | Venlafaxine Hydrochloride results in increased expression of CPD mRNA | 25423262 |
| C025643 | vinclozolin | vinclozolin results in decreased expression of CPD mRNA | 23034163 |
| C029297 | vinylidene chloride | vinylidene chloride results in increased expression of CPD mRNA | 26682919 |
| C088658 | zoledronic acid | zoledronic acid results in increased expression of CPD mRNA | 20977926 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0004181 | metallocarboxypeptidase activity | - | IBA | 21873635 |
| GO:0004185 | serine-type carboxypeptidase activity | - | IEA | - |
| GO:0008270 | zinc ion binding | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006518 | peptide metabolic process | - | IBA | 21873635 |
| GO:0016485 | protein processing | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005615 | extracellular space | - | IBA | 21873635 |
| GO:0005886 | plasma membrane | - | IEA | - |
| GO:0016020 | membrane | - | HDA | 19946888 |
| GO:0016021 | integral component of membrane | - | IEA | - |
| GO:0070062 | extracellular exosome | - | HDA | 19199708 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-199991 | Membrane Trafficking | TAS |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | TAS |
| R-HSA-421837 | Clathrin derived vesicle budding | TAS |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | TAS |
| R-HSA-5653656 | Vesicle-mediated transport | TAS |
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