Gene: COL26A1

136227
EMI6|EMID2|EMU2|SH2B
collagen type XXVI alpha 1 chain
protein-coding
7q22.1
Ensembl:ENSG00000160963 MIM:608927 Vega:OTTHUMG00000150033 UniprotKB:Q96A83
NG_033785.2
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.687e-2 (AD)  1.580e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4727494chr7:101438517 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOBTB20.947
ABCG40.943
SLC8A20.943
CACNG30.942
SYNGR10.94
ADAM110.94
LRTM20.94
CACNB30.939
NGEF0.938
PGBD50.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.609
WWTR1-0.602
RAI14-0.591
YES1-0.584
TFPI2-0.571
SEPT10-0.569
FAM114A1-0.565
SGMS2-0.56
HEY2-0.555
SNHG18-0.555

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of COL26A1 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of COL26A1 mRNA"18648102
D001151ArsenicArsenic affects the methylation of COL26A1 gene25304211
D001241AspirinCOL26A1 polymorphism affects the susceptibility to Aspirin21086123
C487081belinostatbelinostat results in decreased expression of COL26A1 mRNA27188386
D004958EstradiolEstradiol results in increased expression of COL26A1 mRNA17962382
C006780bisphenol Abisphenol A results in decreased methylation of COL26A1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of COL26A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of COL26A1 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of COL26A1 mRNA25979313
D003471CuprizoneCuprizone results in increased expression of COL26A1 mRNA26577399
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of COL26A1 gene23968726
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of COL26A1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL26A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL26A1 mRNA17942748
D007854LeadLead affects the expression of COL26A1 mRNA28903495
D008628MercuryMercury results in decreased methylation of COL26A1 gene25748564
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of COL26A1 mRNA17475336
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of COL26A1 gene23968726
D010936Plant ExtractsPlant Extracts results in decreased expression of COL26A1 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of COL26A1 mRNA23012394
C005556propionaldehydepropionaldehyde results in decreased expression of COL26A1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of COL26A1 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of COL26A1 mRNA17962382
D012834SilverSilver results in increased expression of COL26A1 mRNA27131904
D013629TamoxifenTamoxifen affects the expression of COL26A1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL26A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COL26A1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL26A1 mRNA17942748
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of COL26A1 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of COL26A1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of COL26A1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of COL26A1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of COL26A1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0010811positive regulation of cell-substrate adhesion-IBA21873635  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0031012extracellular matrix-HDA23658023  
GO:0031012extracellular matrix-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal