Gene: KLF14

136259
BTEB5
Kruppel like factor 14
protein-coding
7q32.2
Ensembl:ENSG00000266265 MIM:609393 Vega:OTTHUMG00000188298 UniprotKB:Q8TD94
NG_016152.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.293e-1 (AD)  3.267e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM260.384
OPN1MW0.378
IFNA140.362
CLRN10.357
SERPINB40.352
PRAMEF60.344
EGFEM1P0.341
GOLGA6L20.339
OR4C110.335
TRIM480.334

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMILIN3-0.199
ALOX15B-0.198
CHRFAM7A-0.193
GLIPR1L2-0.183
DMRT3-0.181
HIST1H2AG-0.18
CARTPT-0.178
C10orf105-0.176
CLDN20-0.175
EPN3-0.173

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of KLF14 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLF14 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of KLF14 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KLF14 gene28505145
D003300CopperCopper deficiency results in increased expression of KLF14 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of KLF14 mRNA26033743
D010936Plant ExtractsPlant Extracts results in decreased expression of KLF14 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of KLF14 mRNA24780913
D014635Valproic AcidValproic Acid results in increased methylation of KLF14 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KLF14 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24759103  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP24759103  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26927145Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. (2016 Feb 26)Gao KInt J Environ Res Public Health