Gene: LRGUK

136332
CFAP246
leucine rich repeats and guanylate kinase domain containing
protein-coding
7q33
Ensembl:ENSG00000155530 MIM:616478 Vega:OTTHUMG00000155320 UniprotKB:Q96M69
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.272e-1 (AD)  8.190e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBPF150.545
HYDIN0.545
ARMC20.52
ZNF7370.518
ANKRD360.504
VPS13B0.5
RNPC30.496
ZNF5870.496
WDR190.494
CSPP10.487

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF13B-0.27
KRTAP1-1-0.262
GZMH-0.261
IL7R-0.242
KLRB1-0.236
TBX21-0.235
CCL5-0.232
OR56B4-0.232
CD79B-0.232
OR2A7-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C547126AZM551248AZM551248 results in decreased expression of LRGUK mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRGUK mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of LRGUK mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of LRGUK mRNA26079696
D002737ChloropreneChloroprene results in increased expression of LRGUK mRNA23125180
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LRGUK mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LRGUK mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LRGUK mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LRGUK mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of LRGUK mRNA"24972896
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LRGUK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LRGUK mRNA"25554681
D011192Potassium DichromatePotassium Dichromate results in decreased expression of LRGUK mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LRGUK mRNA25895662
C009495titanium dioxidetitanium dioxide results in decreased expression of LRGUK mRNA23557971

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004385guanylate kinase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-ISS-  
GO:0016310phosphorylation-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0035082axoneme assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-ISS-  
GO:0002177manchette-ISS-  
GO:0005829cytosol-IBA21873635  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18498660Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (2008 May 22)Laramie JMBMC Med Genet