Gene: CLDN4

1364
CPE-R|CPER|CPETR|CPETR1|WBSCR8|hCPE-R
claudin 4
protein-coding
7q11.23
Ensembl:ENSG00000189143 MIM:602909 Vega:OTTHUMG00000023425 UniprotKB:O14493
NG_012868.1
PubMed
ND
1   
9.184e-1 (AD)  6.055e-1 (ND)   (Frontal_Cortex)
3.615e-1 (AD)  4.400e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC36A10.691
SLC29A10.658
KCNK90.657
GRM20.657
TNFAIP8L10.655
OVOL20.652
SLC9A10.652
CACNA1F0.648
CABLES20.644
PPL0.644

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.462
YES1-0.435
HEY2-0.429
SEPT10-0.413
RAI14-0.408
ZFHX4-AS1-0.408
SNTB1-0.408
COPZ2-0.408
GNG12-0.406
REST-0.404

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLDN4 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CLDN4 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D020106AcrylamideAcrylamide affects the expression of CLDN4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLDN4 mRNA19770486
D000447AldehydesAldehydes results in increased expression of CLDN4 mRNA25014914
D000596Amino AcidsAmino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]26338884
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CLDN4 mRNA"22863853
D000872AnthocyaninsAnthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]25451569
D001151ArsenicArsenic results in increased expression of CLDN4 mRNA24349408
D001151ArsenicArsenic results in increased expression of CLDN4 protein24349408
D001151ArsenicArsenic affects the localization of CLDN4 protein24349408
C006632arsenic trioxideCLDN4 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in increased expression of CLDN4 mRNA18191166
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CLDN4 mRNA"25351596
D001280AtrazineAtrazine results in decreased expression of CLDN4 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDN4 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLDN4 mRNA19770486
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CLDN4 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CLDN4 mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of CLDN4 mRNA16474171
D004958EstradiolEstradiol results in decreased expression of CLDN4 protein21761342
D004958EstradiolEstradiol affects the expression of CLDN4 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of CLDN4 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of CLDN4 mRNA25181051
D001761BleomycinBleomycin results in increased expression of CLDN4 mRNA26345256
C018475butyraldehydebutyraldehyde results in increased expression of CLDN4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLDN4 mRNA25851441|2588268
D002737ChloropreneChloroprene results in increased expression of CLDN4 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CLDN4 mRNA25019507
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLDN4 mRNA20938992
C057270cisplatin-DNA adductCLDN4 protein results in increased abundance of cisplatin-DNA adduct23053666
D003300CopperCLDN4 protein results in increased abundance of Copper23053666
D003300Copper[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]23053666
D003300Copper[CLDN4 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper23053666
D003300CopperCopper results in increased expression of CLDN4 mRNA25646894
D019327Copper SulfateCopper Sulfate results in increased expression of CLDN4 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLDN4 mRNA"19167446
D003520CyclophosphamideAnthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]25451569
D003520CyclophosphamideCyclophosphamide results in decreased expression of CLDN4 protein25451569
D003520CyclophosphamidePlant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]25451569
D016572CyclosporineCyclosporine results in increased expression of CLDN4 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in decreased expression of CLDN4 mRNA21865292
D016572CyclosporineCyclosporine results in increased expression of CLDN4 mRNA21865292
C007262deoxynivalenoldeoxynivalenol results in decreased expression of and affects the localization of CLDN4 protein24568843
C007262deoxynivalenoldeoxynivalenol results in decreased expression of CLDN4 protein19289138|2036260
C007262deoxynivalenoldeoxynivalenol results in increased expression of CLDN4 mRNA20362602|2456884
C007262deoxynivalenoldeoxynivalenol results in increased expression of CLDN4 mRNA24568843
C007262deoxynivalenoldeoxynivalenol analog results in decreased expression of CLDN4 protein22859312
C007262deoxynivalenoldeoxynivalenol results in decreased expression of CLDN4 protein19289138|2285931
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN4 mRNA20600798
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN4 protein20600798
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN4 mRNA24084732
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN4 protein24084732
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLDN4 mRNA24893172
D002945Cisplatin[CLDN4 protein results in increased expression of SLC31A1 protein] which results in increased import of Cisplatin23053666
D002945CisplatinCLDN4 protein results in increased import of Cisplatin23053666
D002945CisplatinCLDN4 protein results in increased susceptibility to Cisplatin23053666
C121718dicyclanildicyclanil results in increased expression of CLDN4 mRNA15664270
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CLDN4 mRNA26924002
D002117CalcitriolCalcitriol results in increased expression of CLDN4 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of CLDN4 mRNA26924002
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D004178DiquatAmino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]26338884
D004178DiquatDiquat results in decreased expression of CLDN4 protein26338884
D007980Levodopa[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]23053666
D004317DoxorubicinDoxorubicin affects the expression of CLDN4 mRNA15033991
D000431EthanolEthanol results in decreased expression of and affects the localization of CLDN4 protein28412402
D000431EthanolFlavonoids inhibits the reaction [Ethanol affects the localization of CLDN4 protein]28412402
D000431EthanolFlavonoids inhibits the reaction [Ethanol results in decreased expression of and affects the localization of CLDN4 protein]28412402
D000431EthanolPlant Extracts inhibits the reaction [Ethanol results in decreased expression of and affects the localization of CLDN4 protein]28412402
D000431EthanolEthanol results in decreased expression of CLDN4 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CLDN4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLDN4 mRNA17942748
D005419FlavonoidsFlavonoids inhibits the reaction [Ethanol affects the localization of CLDN4 protein]28412402
D005419FlavonoidsFlavonoids inhibits the reaction [Ethanol results in decreased expression of and affects the localization of CLDN4 protein]28412402
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CLDN4 mRNA17187413
D005472FluorouracilCLDN4 protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in decreased expression of CLDN4 protein15352031
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLDN4 mRNA20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of CLDN4 mRNA27153755
C056933fumonisin B1illite inhibits the reaction [fumonisin B1 results in decreased expression of CLDN4 mRNA]27153755
C039281furanfuran results in increased expression of CLDN4 mRNA26194646|2738771
D019833GenisteinGenistein results in decreased expression of CLDN4 mRNA16474171
D005978GlutathioneGlutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
D005978GlutathioneGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D005978GlutathioneGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D005978GlutathioneGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D017313FenretinideFenretinide results in increased expression of CLDN4 mRNA16671099
D017313FenretinideFenretinide results in increased expression of CLDN4 mRNA28973697
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
D006861Hydrogen PeroxideGlutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CLDN4 protein23816505
D006861Hydrogen Peroxidepyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
C099089illiteillite affects the reaction [ochratoxin A results in decreased expression of CLDN4 mRNA]27153755
C099089illiteillite inhibits the reaction [fumonisin B1 results in decreased expression of CLDN4 mRNA]27153755
C099089illiteillite inhibits the reaction [T-2 Toxin results in decreased expression of CLDN4 mRNA]27153755
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex affects the localization of CLDN4 protein19540330
D016729LeuprolideLeuprolide results in decreased expression of CLDN4 protein21761342
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D008353MannitolMannitol results in increased expression of CLDN4 protein23816505
D019290Megestrol AcetateMegestrol Acetate results in decreased expression of and results in increased localization of CLDN4 protein23095775
D019290Megestrol AcetateMegestrol Acetate results in decreased expression of CLDN4 mRNA23095775
D008543Melanins[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]23053666
C042720mercuric bromidemercuric bromide results in increased expression of CLDN4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLDN4 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of CLDN4 mRNA21678067
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CLDN4 mRNA24810058
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN4 protein]17478549
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CLDN4 mRNA29162477
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CLDN4 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CLDN4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLDN4 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CLDN4 mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CLDN4 mRNA20551477
C025589ochratoxin Aillite affects the reaction [ochratoxin A results in decreased expression of CLDN4 mRNA]27153755
C025589ochratoxin Aochratoxin A results in decreased expression of CLDN4 mRNA27153755
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CLDN4 mRNA26272509
D010365PatulinPatulin affects the localization of CLDN4 protein19013514
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CLDN4 mRNA"25510870
C046012pentanalpentanal results in increased expression of CLDN4 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CLDN4 mRNA26272509
D010705PhosgenePhosgene affects the expression of CLDN4 mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of CLDN4 mRNA17426115
D010936Plant ExtractsPlant Extracts inhibits the reaction [Ethanol results in decreased expression of and affects the localization of CLDN4 protein]28412402
D010936Plant ExtractsPlant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]25451569
D028321Plant PreparationsPlant Preparations results in decreased expression of CLDN4 mRNA26945725
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of CLDN4 mRNA16474171
D011374ProgesteroneProgesterone results in decreased expression of CLDN4 mRNA18037150
D011374ProgesteroneProgesterone affects the expression of CLDN4 mRNA17251523
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN4 protein]17478549
D011374ProgesteroneProgesterone results in decreased expression of CLDN4 protein17478549
C005556propionaldehydepropionaldehyde results in decreased expression of CLDN4 mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of CLDN4 mRNA26079696
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D011794QuercetinQuercetin results in increased expression of and affects the localization of CLDN4 protein19297429
D011794QuercetinQuercetin results in increased expression of CLDN4 mRNA18492835
D011794QuercetinQuercetin results in increased expression of CLDN4 protein18492835
D011794QuercetinQuercetin results in decreased expression of CLDN4 mRNA28431985
D011794QuercetinQuercetin results in decreased expression of CLDN4 protein28431985
C012526quercitrinquercitrin affects the expression of CLDN4 mRNA25193878
C085746rottlerinrottlerin results in increased expression of and affects the localization of CLDN4 protein19297429
C005705sanguinarinesanguinarine results in decreased expression of CLDN4 protein19063874
D012643SeleniumSelenium results in increased expression of CLDN4 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of CLDN4 mRNA25351596
D012906SmokeSmoke results in decreased expression of CLDN4 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of CLDN4 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of CLDN4 mRNA24349408
C017947sodium arsenitesodium arsenite results in increased expression of CLDN4 protein24349408
C017947sodium arsenitesodium arsenite affects the localization of CLDN4 protein24349408
D012965Sodium ChlorideAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridediphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium ChlorideGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium ChlorideSodium Chloride results in increased expression of CLDN4 protein23816505
D012965Sodium ChlorideU 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium ChlorideAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium ChlorideAcetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridediphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium Chloridediphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium ChlorideGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium ChlorideGlutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium Chloridemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium Chloridepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium Chloridepyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D012965Sodium ChlorideSodium Chloride results in increased expression of CLDN4 mRNA23816505
D012965Sodium ChlorideSodium Chloride results in increased expression of CLDN4 protein23816505
D012965Sodium Chloride[[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505|2381650
D012965Sodium ChlorideU 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
D012965Sodium ChlorideU 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D053260SootSoot results in increased expression of CLDN4 mRNA26551751
D013605T-2 Toxinillite inhibits the reaction [T-2 Toxin results in decreased expression of CLDN4 mRNA]27153755
D013605T-2 ToxinT-2 Toxin results in decreased expression of CLDN4 mRNA27153755
D016559TacrolimusTacrolimus results in increased expression of CLDN4 mRNA21865292
D013629TamoxifenCLDN4 affects the susceptibility to Tamoxifen19142967
D013739TestosteroneTestosterone deficiency results in decreased expression of CLDN4 mRNA21761342
D013739TestosteroneTestosterone affects the expression of CLDN4 protein21761342
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN4 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN4 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLDN4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDN4 mRNA17942748
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CLDN4 mRNA19945525
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CLDN4 mRNA19945525
D013792ThalidomideThalidomide results in increased expression of CLDN4 mRNA26217789
C009495titanium dioxidetitanium dioxide results in decreased expression of CLDN4 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLDN4 mRNA27404394
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of CLDN4 mRNA"16650747|1795147
D014212TretinoinCYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]17035595
D014212TretinoinTretinoin results in increased expression of CLDN4 mRNA17035595
D014212TretinoinTretinoin results in increased expression of CLDN4 protein17035595
D014212TretinoinTretinoin results in increased expression of CLDN4 mRNA16236135
D014212TretinoinTretinoin results in increased expression of CLDN4 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CLDN4 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of CLDN4 mRNA19285010
C057693troglitazonetroglitazone results in increased expression of CLDN4 protein19285010
D014415TunicamycinTunicamycin results in increased expression of CLDN4 mRNA17127020
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]23816505
C113580U 0126U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
C113580U 0126U 0126 results in increased expression of CLDN4 mRNA19285010
C113580U 0126U 0126 results in increased expression of CLDN4 protein19285010
C113580U 0126U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]23816505
C113580U 0126U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]23816505
D014508UreaUrea results in increased expression of CLDN4 protein23816505
D014520UrethaneUrethane results in increased expression of CLDN4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CLDN4 mRNA23179753|2438349
C034028vanadyl sulfatevanadyl sulfate results in increased expression of CLDN4 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CLDN4 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLDN4 mRNA"27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CLDN4 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS9334247  
GO:0005198structural molecule activity-IEA-  
GO:0005254chloride channel activity-ISS-  
GO:0005515protein binding-IPI27647526  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-ISS-  
GO:0032570response to progesterone-IEA-  
GO:0061436establishment of skin barrier-IMP23407391  
GO:0070293renal absorption-ISS-  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA20375010  
GO:0005887integral component of plasma membrane-IMP23407391  
GO:0005923bicellular tight junction-IDA23407391  
GO:0005923bicellular tight junction-ISS-  
GO:0009925basal plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0016327apicolateral plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-420029Tight junction interactionsIEA
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-446728Cell junction organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27687058Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases. (2017 Jan)Moldvay JPathol Oncol Res