Gene info: ID 1365

Gene: CLDN3

GENE ID: 1365

Synonyms: C7orf1|CPE-R2|CPETR2|HRVP1|RVP1

Description: claudin 3

Gene type: protein-coding

Location: 7q11.23

dbXrefs: Ensembl:ENSG00000165215 MIM:602910 Vega:OTTHUMG00000023424 UniprotKB:O15551

RefSeq: NG_012023.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.124e-1 (AD) 7.526e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FOXE1	0.615
WDR72	0.612
TPO	0.597
TFF3	0.584
IYD	0.58
KRT7	0.579
DIO1	0.559
TG	0.554
SCGB2A1	0.54
PLA2G4F	0.524

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FBXL22	-0.285
TBC1D16	-0.267
LYPD6	-0.255
SORCS2	-0.254
FRMPD1	-0.25
TPCN1	-0.249
PCYT1B	-0.243
ANAPC1P1	-0.241
C21orf58	-0.24
MOXD1	-0.236

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CLDN3 mRNA"	23826121
C031903	1-UFT protocol	CLDN3 protein results in increased susceptibility to 1-UFT protocol	16734730
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CLDN3 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CLDN3 mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of CLDN3 mRNA"	23829299
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CLDN3 mRNA"	12097258
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of CLDN3 mRNA	25088246
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of CLDN3 mRNA	18544908
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CLDN3 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in decreased expression of CLDN3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of CLDN3 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of CLDN3 mRNA	18544908
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CLDN3 mRNA	27153755
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CLDN3 mRNA	19770486
D000447	Aldehydes	Aldehydes results in increased expression of CLDN3 mRNA	25014914
D000596	Amino Acids	Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]	26338884
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CLDN3 mRNA	16483693
D000941	Antigens	[deoxynivalenol results in increased susceptibility to Antigens] which results in decreased expression of CLDN3 mRNA	28935500
D000941	Antigens	[ochratoxin A results in increased susceptibility to Antigens] which results in decreased expression of CLDN3 mRNA	28935500
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CLDN3 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CLDN3 mRNA	19770486
D004958	Estradiol	Estradiol results in increased expression of CLDN3 mRNA	19484750
C095105	bexarotene	bexarotene results in increased expression of CLDN3 mRNA	16648578
C006780	bisphenol A	bisphenol A affects the expression of CLDN3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of CLDN3 mRNA	26079696
D019256	Cadmium Chloride	MT3 affects the reaction [Cadmium Chloride affects the expression of CLDN3 mRNA]	20371981
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of CLDN3 promoter	22457795
D000069287	Capecitabine	CLDN3 protein results in increased susceptibility to Capecitabine	16734730
D002220	Carbamazepine	Carbamazepine affects the expression of CLDN3 mRNA	25979313
D002922	Ciguatoxins	Ciguatoxins affects the expression of CLDN3 mRNA	18353800
C057270	cisplatin-DNA adduct	CLDN3 protein results in increased abundance of cisplatin-DNA adduct	23053666
D002994	Clofibrate	Clofibrate results in decreased expression of CLDN3 mRNA	17585979
D003300	Copper	Copper results in decreased expression of CLDN3 mRNA	25461751
D003300	Copper	CLDN3 protein results in increased abundance of Copper	23053666
D003300	Copper	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D003300	Copper	[CLDN3 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper	23053666
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of CLDN3 mRNA	20971185
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CLDN3 mRNA	15467011
D016572	Cyclosporine	Cyclosporine results in decreased expression of CLDN3 mRNA	20106945
C014347	decitabine	[decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	[decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	decitabine inhibits the reaction [MBD2 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	decitabine promotes the reaction [SP3 protein binds to CLDN3 promoter]	17986852
C014347	decitabine	decitabine results in increased expression of CLDN3 mRNA	16367923\|1798685
C014347	decitabine	decitabine results in increased expression of CLDN3 protein	17986852
C014347	decitabine	trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 mRNA]	17986852
C014347	decitabine	trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 protein]	17986852
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of and affects the localization of CLDN3 protein	24568843
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CLDN3 mRNA	24568843
C007262	deoxynivalenol	deoxynivalenol affects the expression of CLDN3 protein	24568843
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CLDN3 mRNA	24568843
C007262	deoxynivalenol	[deoxynivalenol results in increased susceptibility to Antigens] which results in decreased expression of CLDN3 mRNA	28935500
C007262	deoxynivalenol	deoxynivalenol analog results in decreased expression of CLDN3 protein	22859312
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of CLDN3 protein	19289138\|2285931
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CLDN3 mRNA	20600798
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CLDN3 protein	20600798
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of CLDN3 mRNA	24084732
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of CLDN3 protein	24084732
D002945	Cisplatin	[CLDN3 protein results in increased expression of SLC31A1 protein] which results in increased import of Cisplatin	23053666
D002945	Cisplatin	CLDN3 protein results in increased import of Cisplatin	23053666
D002945	Cisplatin	CLDN3 protein results in increased susceptibility to Cisplatin	23053666
C000944	dicrotophos	dicrotophos results in decreased expression of CLDN3 mRNA	28302478
C121718	dicyclanil	dicyclanil results in increased expression of CLDN3 mRNA	15664270
D004041	Dietary Fats	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CLDN3 mRNA"	12097258
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CLDN3 mRNA	25242112
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CLDN3 mRNA	15149470
D002117	Calcitriol	Calcitriol results in increased expression of CLDN3 mRNA	26485663
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CLDN3 mRNA"	12097258
D004178	Diquat	Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]	26338884
D004178	Diquat	Diquat results in decreased expression of CLDN3 protein	26338884
D007980	Levodopa	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
C025034	doxifluridine	CLDN3 protein results in increased susceptibility to doxifluridine	16734730
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CLDN3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CLDN3 mRNA	17942748
C056933	fumonisin B1	fumonisin B1 results in decreased expression of CLDN3 mRNA	27153755
C056933	fumonisin B1	illite inhibits the reaction [fumonisin B1 results in decreased expression of CLDN3 mRNA]	27153755
C039281	furan	furan results in increased methylation of CLDN3 gene	22079235
D019833	Genistein	Genistein results in decreased methylation of CLDN3 gene	28505145
D017313	Fenretinide	Fenretinide results in increased expression of CLDN3 mRNA	16671099
D017313	Fenretinide	Fenretinide results in increased expression of CLDN3 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CLDN3 mRNA	20044591
C099089	illite	illite affects the reaction [ochratoxin A results in decreased expression of CLDN3 mRNA]	27153755
C099089	illite	illite inhibits the reaction [fumonisin B1 results in decreased expression of CLDN3 mRNA]	27153755
C099089	illite	illite inhibits the reaction [T-2 Toxin results in decreased expression of CLDN3 mRNA]	27153755
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLDN3 mRNA	25613284
D007529	Isoflavones	Isoflavones results in decreased expression of CLDN3 mRNA	17374662
C011890	kojic acid	kojic acid results in decreased expression of CLDN3 mRNA	16595896
D008543	Melanins	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CLDN3 mRNA	24810058
D015741	Metribolone	Metribolone results in increased expression of CLDN3 mRNA	17010196
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN3 protein]	17478549
C031721	naphthalene	naphthalene results in increased expression of CLDN3 mRNA	18978301
D009532	Nickel	Nickel affects the expression of CLDN3 mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of CLDN3 mRNA]	14575637
C028007	nickel monoxide	nickel monoxide results in increased expression of CLDN3 mRNA	19167457
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of CLDN3 mRNA	20971185
C025589	ochratoxin A	illite affects the reaction [ochratoxin A results in decreased expression of CLDN3 mRNA]	27153755
C025589	ochratoxin A	ochratoxin A results in decreased expression of CLDN3 mRNA	27153755
C025589	ochratoxin A	[ochratoxin A results in increased susceptibility to Antigens] which results in decreased expression of CLDN3 mRNA	28935500
D010100	Oxygen	Oxygen deficiency results in increased expression of CLDN3 mRNA	26516004
D017239	Paclitaxel	CLDN3 protein results in decreased susceptibility to Paclitaxel	16734730
C016030	pantogab	pantogab results in decreased expression of CLDN3 mRNA	17379144
D010365	Patulin	Patulin affects the localization of CLDN3 protein	19013514
C410127	PCB 180	PCB 180 results in increased expression of CLDN3 mRNA	23829299
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of CLDN3 mRNA	23892564
C046012	pentanal	pentanal results in increased expression of CLDN3 mRNA	26079696
D010634	Phenobarbital	Phenobarbital results in decreased expression of CLDN3 mRNA	19162173
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CLDN3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of CLDN3 mRNA	18445702
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of CLDN3 mRNA	19162173
D011374	Progesterone	Progesterone affects the expression of CLDN3 mRNA	17251523
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN3 protein]	17478549
D011374	Progesterone	Progesterone results in decreased expression of CLDN3 protein	17478549
C005556	propionaldehyde	propionaldehyde results in increased expression of CLDN3 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CLDN3 mRNA	24780913
C428725	pyridaben	pyridaben results in decreased expression of CLDN3 mRNA	22563483
C079198	S 1 (combination)	CLDN3 protein results in increased susceptibility to S 1 (combination)	16734730
C005705	sanguinarine	sanguinarine results in decreased expression of CLDN3 protein	19063874
C017947	sodium arsenite	sodium arsenite results in decreased expression of CLDN3 mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in decreased expression of CLDN3 protein	25879800
D013605	T-2 Toxin	illite inhibits the reaction [T-2 Toxin results in decreased expression of CLDN3 mRNA]	27153755
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of CLDN3 mRNA	27153755
D013629	Tamoxifen	Tamoxifen affects the expression of CLDN3 mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CLDN3 mRNA	21296121
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CLDN3 mRNA	21570461\|2892240
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CLDN3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CLDN3 mRNA	16960034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CLDN3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CLDN3 mRNA	16054898
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CLDN3 mRNA	16960034
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of CLDN3 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLDN3 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CLDN3 mRNA	27404394
C012589	trichostatin A	[decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]	17986852
C012589	trichostatin A	[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]	17986852
C012589	trichostatin A	[decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]	17986852
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of CLDN3 mRNA]	14575637
C012589	trichostatin A	trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 mRNA]	17986852
C012589	trichostatin A	trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 protein]	17986852
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CLDN3 mRNA"	24407104
D014415	Tunicamycin	Tunicamycin results in increased expression of CLDN3 mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in increased methylation of CLDN3 gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of CLDN3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CLDN3 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of CLDN3 mRNA	20044591
C088658	zoledronic acid	zoledronic acid results in increased expression of CLDN3 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	TAS	9334247
GO:0005198	structural molecule activity	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEP	15174142
GO:0003382	epithelial cell morphogenesis	-	ISS	-
GO:0007165	signal transduction	-	IEA	-
GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0051260	protein homooligomerization	-	IMP	25849148
GO:0051291	protein heterooligomerization	-	IGI	25849148
GO:0070830	bicellular tight junction assembly	-	IMP	25849148

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0005887	integral component of plasma membrane	-	TAS	9334247
GO:0005923	bicellular tight junction	-	IDA	25849148
GO:0005923	bicellular tight junction	-	ISS	-
GO:0016021	integral component of membrane	-	TAS	9441748
GO:0016327	apicolateral plasma membrane	-	IEA	-
GO:0016328	lateral plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)
hsa04530	Tight junction
hsa04670	Leukocyte transendothelial migration
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-1500931	Cell-Cell communication	IEA
R-HSA-420029	Tight junction interactions	IEA
R-HSA-421270	Cell-cell junction organization	IEA
R-HSA-446728	Cell junction organization	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27687058	Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases. (2017 Jan)	Moldvay J	Pathol Oncol Res