Gene: CPM

1368
-
carboxypeptidase M
protein-coding
12q15
Ensembl:ENSG00000135678 MIM:114860 Vega:OTTHUMG00000169300 UniprotKB:P14384
NC_000012.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.026e-1 (AD)  4.071e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1195812chr12:68947245 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1144962chr12:68941205 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3BP40.796
CYP27A10.795
PREX10.787
RHOG0.782
CERS20.78
MAGT10.778
GLTP0.778
NDE10.773
SLC35D20.773
PLIN30.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOV-0.596
RTP1-0.588
KCNK3-0.583
FBLN7-0.583
CNTN5-0.581
MARCH4-0.576
MCHR1-0.565
CBLN4-0.56
KHDRBS2-0.557
CHRM4-0.557

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of CPM mRNA22193206
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPM mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CPM mRNA21420995|2906747
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CPM mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPM mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPM mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPM mRNA25908611
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CPM mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CPM mRNA20660070
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CPM mRNA26496021
C006780bisphenol Abisphenol A results in decreased methylation of CPM promoter27312807
C006780bisphenol Abisphenol A affects the expression of CPM mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CPM mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CPM mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CPM mRNA15336504
D002737ChloropreneChloroprene results in decreased expression of CPM mRNA23125180
C039671ciglitazoneciglitazone results in decreased expression of CPM mRNA22193206
D002922CiguatoxinsCiguatoxins affects the expression of CPM mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of CPM mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of CPM mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of CPM mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of CPM mRNA27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CPM mRNA27392435
D002945CisplatinCisplatin results in increased expression of CPM mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CPM mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CPM mRNA17394237
C024629dimethyl phthalatedimethyl phthalate affects the expression of CPM mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of CPM mRNA22193206
C118739entinostatentinostat results in increased expression of CPM mRNA27188386
C039281furanfuran results in decreased methylation of CPM gene27387713
C039281furanfuran results in increased expression of CPM mRNA27387713
C546771gardiquimodgardiquimod results in increased expression of CPM mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPM mRNA]28003376
D017313FenretinideFenretinide results in increased expression of CPM mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CPM protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CPM mRNA18951874
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of CPM mRNA16849584
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CPM mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CPM mRNA24796395|2675264
D008345ManganeseManganese results in decreased expression of CPM mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of CPM mRNA17175027
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CPM mRNA"20188158
C523799MRK 003MRK 003 results in decreased expression of CPM mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPM mRNA"25554681
D052638Particulate MatterParticulate Matter results in decreased expression of CPM mRNA17987463
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of CPM mRNA22790973
D010634PhenobarbitalPhenobarbital affects the expression of CPM mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CPM mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CPM mRNA23811191
D010938Plant OilsPlant Oils results in decreased expression of CPM mRNA23370395
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CPM mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of CPM mRNA17404688|1807036
D011374ProgesteroneProgesterone results in increased expression of CPM mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of CPM mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPM mRNA]28003376
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CPM mRNA19429434
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CPM mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog affects the expression of CPM mRNA23806026
D012906SmokeSmoke results in decreased expression of CPM mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of CPM mRNA25879800
D053260SootSoot results in decreased expression of CPM mRNA26551751
D013629TamoxifenTamoxifen results in increased expression of CPM mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPM mRNA19770486|2629044
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CPM protein18951874
C009495titanium dioxidetitanium dioxide results in decreased expression of CPM mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of CPM mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of CPM mRNA24935251|2854253
D014635Valproic AcidValproic Acid affects the expression of CPM mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CPM mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of CPM mRNA24896083
D014635Valproic AcidValproic Acid results in increased expression of CPM mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CPM mRNA17987463
D014810Vitamin EVitamin E results in decreased expression of CPM mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004180carboxypeptidase activity-TAS7797563  
GO:0004181metallocarboxypeptidase activity-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006518peptide metabolic process-IBA21873635  
GO:0009653anatomical structure morphogenesis-TAS7797563  
GO:0016485protein processing-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-HDA19581412  
GO:0031225anchored component of membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
6479376[A sensitive and specific radioimmunoassay for arginine vasopressin and its validation]. (1984 Mar 20)Oki YNihon Naibunpi Gakkai Zasshi
10760510Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. (2000 Apr 7)Wang XLFEBS Lett
16920799Nicotine: the link between cigarette smoking and the progression of renal injury? (2007 Jan)Jaimes EAAm J Physiol Heart Circ Physiol
24121172Endobronchial lipomatous tumors: clinicopathologic analysis of 12 cases with molecular cytogenetic evidence supporting classification as "lipoma". (2013 Nov)Boland JMAm J Surg Pathol
3808130[Central pontine myelinolysis]. (1986 Nov)Berlit PNervenarzt
23846780Increased postoperative complications in bilateral mastectomy patients compared to unilateral mastectomy: an analysis of the NSQIP database. (2013 Oct)Osman FAnn Surg Oncol
27413660Physical activity pattern, cardiorespiratory fitness, and socioeconomic status in the SCAPIS pilot trial - A cross-sectional study. (2016 Dec)Lindgren MPrev Med Rep
2090352[A preliminary study on the role of interleukin-1 in chronic lung disease]. (1990 Aug)Liu CTZhonghua Jie He He Hu Xi Za Zhi