Gene: CPOX

1371
CPO|CPX|HCP
coproporphyrinogen oxidase
protein-coding
3q11.2
Ensembl:ENSG00000080819 MIM:612732 Vega:OTTHUMG00000160016 UniprotKB:P36551
NG_015994.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.469e-1 (AD)  4.016e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02657160chr3:98311063CPOX2.400e-16Smoking27651444
cg02657160chr3:98311063CPOX1.140e-13Tobacco smoking28225026
cg02657160chr3:98311063CPOX1.200e-13Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABHD17B0.91
LRRC8D0.909
TTLL70.884
PXK0.882
UNC5C0.87
CCP1100.869
NXPE30.867
SPTLC20.867
CEP970.866
EDIL30.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.463
OR4F29-0.449
DIO2-0.3
WNT7B-0.292
HES5-0.29
RNF43-0.288
GLI1-0.279
SLC2A4-0.275
OR4F16-0.269
HKDC1-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CPOX mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CPOX mRNA19933214
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CPOX mRNA"20713471
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CPOX mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CPOX mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of CPOX protein26194647
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CPOX mRNA"23994337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA"27188386
C4199245-aminolevulinic acid hexyl ester5-aminolevulinic acid hexyl ester analog results in increased expression of CPOX mRNA20514459
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CPOX mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of CPOX mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CPOX mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CPOX gene27153756
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CPOX mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPOX mRNA21632981
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of CPOX mRNA]15034205
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CPOX mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPOX mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPOX mRNA15034205|1977048
D004958Estradiol[Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of CPOX mRNA18691609
C006780bisphenol Abisphenol A affects the expression of CPOX mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CPOX mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CPOX mRNA23741332
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of CPOX mRNA19549813
C028026coproporphyrinogen IIICPOX protein results in decreased carboxylation of coproporphyrinogen III19339664
C028026coproporphyrinogen IIIMercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]19339664
D003305CoproporphyrinogensCPOX protein results in decreased carbamoylation of Coproporphyrinogens11248690
D003306Coproporphyrins[Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins16214298
D016572CyclosporineCyclosporine results in decreased expression of CPOX mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CPOX mRNA27392435
D002945CisplatinCisplatin results in increased expression of CPOX mRNA27392435
C121718dicyclanildicyclanil results in increased expression of CPOX mRNA15664270
D004147DioxinsDioxins affects the expression of CPOX mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CPOX protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CPOX mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPOX mRNA17942748
D018120FinasterideFinasteride results in increased expression of CPOX mRNA24136188
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CPOX mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of CPOX mRNA28329830
C061365flusilazoleflusilazole results in decreased expression of CPOX mRNA22382673
D005485FlutamideFlutamide results in increased expression of CPOX mRNA24136188
D006418HemeCPOX protein results in increased chemical synthesis of Heme11248690
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CPOX protein]23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CPOX protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CPOX protein23178681
C492448ICG 001ICG 001 results in decreased expression of CPOX mRNA26191083
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of CPOX mRNA"23994337
C005524isocoproporphyrinCPOX polymorphism affects the abundance of isocoproporphyrin analog16214298
C005524isocoproporphyrinCPOX polymorphism results in increased chemical synthesis of isocoproporphyrin analog15967199
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CPOX mRNA27392435
C410337K 7174K 7174 results in decreased expression of CPOX mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of CPOX mRNA24967691
D008628MercuryCPOX polymorphism affects the susceptibility to Mercury16343843
D008628MercuryCPOX protein affects the susceptibility to Mercury19339664
D008628MercuryCPOX protein polymorphism affects the susceptibility to Mercury19339664
D008628MercuryMercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]19339664
D008628MercuryMercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]19339664
D008628MercuryMercury results in decreased activity of CPOX protein16214298|1933966
D008628Mercury[Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins16214298
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CPOX mRNA20713471
D008777MethyltestosteroneMethyltestosterone results in increased expression of CPOX mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CPOX mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CPOX mRNA"25620056
C051752nefazodonenefazodone results in increased expression of CPOX mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CPOX mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CPOX mRNA25729387
C034350pentacarboxylic porphyrinCPOX polymorphism results in increased metabolism of pentacarboxylic porphyrin15967199
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of CPOX mRNA28973697
D010634PhenobarbitalPhenobarbital results in decreased expression of CPOX mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPOX mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CPOX mRNA17426115|1830175
D011374ProgesteroneProgesterone results in increased expression of CPOX mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of CPOX mRNA21278054
C011539protoporphyrinogenCPOX protein results in increased chemical synthesis of protoporphyrinogen19339664
C011539protoporphyrinogenMercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]19339664
C011539protoporphyrinogenTGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]11248690
C011539protoporphyrinogenCPOX protein results in increased chemical synthesis of protoporphyrinogen11248690
D012906SmokeSmoke affects the methylation of CPOX gene24704585
C016104sodium bichromatesodium bichromate results in increased expression of CPOX mRNA12325037
D012969Sodium FluorideSodium Fluoride results in decreased expression of CPOX mRNA27862939
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CPOX mRNA"26680231
D013739TestosteroneTestosterone results in increased expression of CPOX mRNA21669218
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CPOX mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CPOX mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of CPOX mRNA18691609
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPOX mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CPOX gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPOX mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPOX mRNA15034205|1559103
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPOX protein27105554
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CPOX mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CPOX mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CPOX mRNA19042947
C080163trovafloxacintrovafloxacin results in decreased expression of CPOX mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CPOX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CPOX gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CPOX mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPOX gene25560391
C025643vinclozolinvinclozolin results in increased expression of CPOX mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004109coproporphyrinogen oxidase activity-IBA21873635  
GO:0004109coproporphyrinogen oxidase activity-TAS-  
GO:0005212structural constituent of eye lens-IEA-  
GO:0042803protein homodimerization activity-IDA16176984  
GO ID GO Term Qualifier Evidence PubMed
GO:0006782protoporphyrinogen IX biosynthetic process-IEA-  
GO:0006783heme biosynthetic process-TAS-  
GO:0010039response to iron ion-IEA-  
GO:0010288response to lead ion-IEA-  
GO:0017085response to insecticide-IEA-  
GO:0019353protoporphyrinogen IX biosynthetic process from glutamate-IBA21873635  
GO:0046685response to arsenic-containing substance-IEA-  
GO:0051597response to methylmercury-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005758mitochondrial intermembrane space-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25424692Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)Tsaprouni LGEpigenetics
24704585CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. (2014 Jul)Harlid SEnviron Health Perspect