Gene: NDUFAF6

137682
C8orf38
NADH:ubiquinone oxidoreductase complex assembly factor 6
protein-coding
8q22.1
Ensembl:ENSG00000156170 MIM:612392 Vega:OTTHUMG00000150173 UniprotKB:Q330K2
NG_016647.2
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.891e-1 (AD)  2.785e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ISCA10.89
GRSF10.887
SCOC0.887
SUB10.884
PIGX0.882
RTN40.882
RCN20.881
ACP10.881
MKKS0.879
FAM98B0.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.516
MAGEA12-0.444
CSAG1-0.434
RUNX3-0.425
GPR4-0.418
GJA4-0.412
KCNE4-0.404
TNFRSF10D-0.401
SH2D2A-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of NDUFAF6 mRNA21420995|2570463
D001280AtrazineAtrazine results in decreased expression of NDUFAF6 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of NDUFAF6 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of NDUFAF6 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NDUFAF6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NDUFAF6 gene28505145
C584509C646 compoundC646 compound results in decreased expression of NDUFAF6 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of NDUFAF6 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of NDUFAF6 mRNA28302478
D004026DieldrinDieldrin results in increased expression of NDUFAF6 mRNA20438755
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NDUFAF6 mRNA17557909
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFAF6 mRNA17183730
C492448ICG 001ICG 001 results in increased expression of NDUFAF6 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of NDUFAF6 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NDUFAF6 mRNA23430699
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NDUFAF6 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NDUFAF6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NDUFAF6 mRNA"25620056
D013853ThioacetamideThioacetamide results in increased expression of NDUFAF6 mRNA23411599
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFAF6 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of NDUFAF6 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of NDUFAF6 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016740transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009058biosynthetic process-IEA-  
GO:0032981mitochondrial respiratory chain complex I assembly-IBA21873635  
GO:0032981mitochondrial respiratory chain complex I assembly-IMP22019594  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005743mitochondrial inner membrane-IDA22019594  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal