Gene: CR1

1378
C3BR|C4BR|CD35|KN
complement C3b/C4b receptor 1 (Knops blood group)
protein-coding
1q32.2
Ensembl:ENSG00000203710 MIM:120620 Vega:OTTHUMG00000036311 UniprotKB:P17927
NG_007481.1
PubMed
0   ANCO-SNPs
CD|ND
10   
7.658e-1 (AD)  2.884e-1 (ND)   (Frontal_Cortex)
7.574e-2 (AD)  2.851e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB30.845
TLR80.84
CD300LF0.839
FPR20.815
CD1D0.809
LILRB20.804
PLBD10.789
ALPK10.784
CSF2RB0.781
IL21R0.774

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.508
LRRC73-0.506
SLC32A1-0.504
DLX1-0.503
HRH3-0.501
SCRT1-0.498
ASPDH-0.497
CORT-0.496
CDH22-0.493
KCNK4-0.493

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CR1 mRNA26690555
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CR1 mRNA24449571
C030583ceric oxideceric oxide results in decreased expression of CR1 protein23726862
D004397FonofosFonofos results in decreased methylation of CR1 promoter22847954
D006493HeparinHeparin results in decreased expression of CR1 protein8993250
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CR1 mRNA18951874
D015570JosamycinJosamycin results in decreased expression of CR1 protein8096833
D015570JosamycinRibomunyl inhibits the reaction [Josamycin results in decreased expression of CR1 protein]8096833
C030272maleic acidmaleic acid results in increased expression of CR1 mRNA28392987
D008345ManganeseManganese results in increased expression of CR1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of CR1 mRNA17175027
D008727MethotrexateMethotrexate results in decreased expression of CR1 mRNA24449571
D009532NickelNickel results in increased expression of CR1 mRNA24768652|2558310
D010278ParathionParathion results in decreased methylation of CR1 promoter22847954
D010476PerfumePerfume results in increased expression of CR1 mRNA24768652
D011692Puromycin AminonucleosideCR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
C034206RibomunylRibomunyl inhibits the reaction [Josamycin results in decreased expression of CR1 protein]8096833
C034206RibomunylRibomunyl results in increased expression of CR1 protein8096833
C012568terbufosterbufos results in decreased methylation of CR1 promoter22847954
C009495titanium dioxidetitanium dioxide results in decreased expression of CR1 protein23726862
C012589trichostatin Atrichostatin A results in increased expression of CR1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of CR1 mRNA24935251
D015032ZincZinc deficiency results in decreased expression of CR1 mRNA18356318
D015034Zinc OxideZinc Oxide results in decreased expression of CR1 protein23726862

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0001851complement component C3b binding-IDA2972794  
GO:0001855complement component C4b binding-IDA2972794  
GO:0001861complement component C4b receptor activity-IDA2972794  
GO:0004877complement component C3b receptor activity-IDA2972794  
GO ID GO Term Qualifier Evidence PubMed
GO:0002430complement receptor mediated signaling pathway-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-IEA-  
GO:0045589regulation of regulatory T cell differentiation-TAS-  
GO:0045957negative regulation of complement activation, alternative pathway-IDA10531307  
GO:0045959negative regulation of complement activation, classical pathway-IDA6910481  10531307  
GO:0046718viral entry into host cell-IEA-  
GO:1900004negative regulation of serine-type endopeptidase activity-IDA6910481  
GO:1900005positive regulation of serine-type endopeptidase activity-IDA2972794  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA6910481  
GO:0009986cell surface-IDA2972794  6978375  
GO:0030667secretory granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa04640Hematopoietic cell lineage
hsa05140Leishmaniasis
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9045748Changes in immunologic cell surface markers during cocaine withdrawal in pregnant women. (1996 Dec)Johnson TRBrain Behav Immun
3370311Identification of the major lectin-binding surface proteins of human neutrophils and alveolar macrophages. (1988 Jun)Christiansen NPBlood
24621201Tag SNPs in complement receptor-1 contribute to the susceptibility to non-small cell lung cancer. (2014 Mar 12)Yu XMol Cancer
25758854Risk factors for malaria and adverse birth outcomes in a prospective cohort of pregnant women resident in a high malaria transmission area of Papua New Guinea. (2015 May)Stanisic DITrans R Soc Trop Med Hyg
27841898Iloprost as an acute kidney injury-triggering agent in severely atherosclerotic patients. (2016 May/Jun)Uyar MECardiovasc J Afr
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
1833599Mechanisms of serum-enhanced adhesion of human alveolar macrophages to epithelial cells. (1991)McGowan SELung
23143793Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium. (2013 Feb)Rius CThorax
29279246Complement system biomarkers in first episode psychosis. (2017 Dec 23)Kopczynska MSchizophr Res
21912625An exploratory study on CLU, CR1 and PICALM and Parkinson disease. (2011)Gao JPLoS One