Gene: ADHFE1

137872
ADH8|HMFT2263|HOT
AD dehydrogenase, iron containing 1
protein-coding
8q13.1
Ensembl:ENSG00000147576 MIM:611083 Vega:OTTHUMG00000150215 UniprotKB:Q8IWW8
NC_000008.11
PubMed
0   ANCO-SNPs
AD
1   
2.878e-1 (AD)  9.371e-1 (ND)   (Frontal_Cortex)
1.765e-1 (AD)  7.856e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01988129chr8:67344936ADHFE12.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHX20.859
PRODH0.856
FGFR30.849
ETNPPL0.844
MMP280.841
PAMR10.84
SELENBP10.838
ACY10.835
DHTKD10.831
SLC1A20.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MIP-0.423
KLRG1-0.418
OR4F5-0.417
KLHL38-0.41
MUM1L1-0.395
OR4F29-0.393
RAX2-0.371
GAS2L3-0.367
PLS1-0.365
FGF10-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADHFE1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ADHFE1 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of ADHFE1 mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADHFE1 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of ADHFE1 mRNA26690555
D020106AcrylamideAcrylamide affects the expression of ADHFE1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADHFE1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADHFE1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADHFE1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ADHFE1 mRNA21757418
C547126AZM551248AZM551248 results in decreased expression of ADHFE1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADHFE1 mRNA20106945
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADHFE1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADHFE1 mRNA22228805
D004958EstradiolEstradiol affects the expression of ADHFE1 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of ADHFE1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ADHFE1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADHFE1 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ADHFE1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ADHFE1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ADHFE1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ADHFE1 mRNA27339419
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of ADHFE1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADHFE1 mRNA20938992
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of ADHFE1 mRNA21356183
D003300CopperCopper results in decreased expression of ADHFE1 mRNA21356183
D003407CreosoteCreosote results in increased expression of ADHFE1 mRNA19389177
D003471CuprizoneCuprizone results in decreased expression of ADHFE1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ADHFE1 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADHFE1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ADHFE1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ADHFE1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ADHFE1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ADHFE1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADHFE1 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ADHFE1 mRNA25380136
D005485FlutamideFlutamide results in decreased expression of ADHFE1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of ADHFE1 mRNA21525395|2648540
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADHFE1 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of ADHFE1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of ADHFE1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ADHFE1 mRNA24136188
D005947GlucoseGlucose results in decreased expression of ADHFE1 mRNA17178593
C412815GW 4064GW 4064 results in increased expression of ADHFE1 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of ADHFE1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADHFE1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ADHFE1 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADHFE1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ADHFE1 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADHFE1 mRNA"20371263
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADHFE1 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of ADHFE1 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADHFE1 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ADHFE1 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of ADHFE1 mRNA24136188
D009532NickelNickel results in decreased expression of ADHFE1 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of ADHFE1 mRNA24136188
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADHFE1 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of ADHFE1 mRNA26516004
D000073878Palm OilPalm Oil results in decreased expression of ADHFE1 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADHFE1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ADHFE1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ADHFE1 mRNA19429403
D010656PhenylephrinePhenylephrine results in decreased expression of ADHFE1 mRNA18158353
D010695PhlorhizinPhlorhizin results in decreased expression of ADHFE1 mRNA22538082
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADHFE1 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of ADHFE1 mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ADHFE1 mRNA27413110
C015586propiverinepropiverine binds to ADHFE1 protein29273565
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ADHFE1 mRNA21427059
C009277sodium arsenatesodium arsenate results in decreased expression of ADHFE1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of ADHFE1 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of ADHFE1 protein28918527
D012999SomanSoman results in decreased expression of ADHFE1 mRNA19281266
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADHFE1 mRNA"20371263
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of ADHFE1 mRNA22467014
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ADHFE1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADHFE1 mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of ADHFE1 mRNA22378314
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ADHFE1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of ADHFE1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADHFE1 mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of ADHFE1 mRNA15901671
C406224valdecoxibvaldecoxib results in decreased expression of ADHFE1 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of ADHFE1 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of ADHFE1 mRNA15901671
D014640VancomycinVancomycin results in increased expression of ADHFE1 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of ADHFE1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0047988hydroxyacid-oxoacid transhydrogenase activity-EXP16435184  
GO:0047988hydroxyacid-oxoacid transhydrogenase activity-IDA16435184  
GO ID GO Term Qualifier Evidence PubMed
GO:00061032-oxoglutarate metabolic process-TAS-  
GO:0006539glutamate catabolic process via 2-oxoglutarate-IDA16435184  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS
R-HSA-880009Interconversion of 2-oxoglutarate and 2-hydroxyglutarateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28196272Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. (2017 Apr)Clark SLAlcohol Clin Exp Res