Gene: PXDNL

137902
PMR1|PRM1|VPO2
peroxidasin like
protein-coding
8q11.22-q11.23
Ensembl:ENSG00000147485 MIM:615904 Vega:OTTHUMG00000164244 UniprotKB:A1KZ92
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.768e-2 (AD)  4.886e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4873568chr8:51644871 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC26A100.718
KCNAB30.71
SLX40.709
FANCA0.709
CES30.707
TRANK10.707
PHTF10.706
RDH130.704
SLIT20.699
CHRD0.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.397
HEY2-0.391
AKR1C3-0.391
MYL3-0.379
ROM1-0.362
RFTN2-0.36
RAB13-0.358
CPM-0.351
LRAT-0.348
TRDN-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D019327Copper SulfateCopper Sulfate results in increased expression of PXDNL mRNA23268349
D010269Paraquat[Quercetin co-treated with Paraquat] results in increased expression of PXDNL mRNA22996356
D010936Plant ExtractsPlant Extracts results in decreased expression of PXDNL mRNA23557933
D011794Quercetin[Quercetin co-treated with Paraquat] results in increased expression of PXDNL mRNA22996356
D011794QuercetinQuercetin results in increased expression of PXDNL mRNA22996356

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004519endonuclease activity-IEA-  
GO:0004601peroxidase activity-IBA21873635  
GO:0004601peroxidase activity-ISS-  
GO:0020037heme binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-IEA-  
GO:0042744hydrogen peroxide catabolic process-ISS-  
GO:0055114oxidation-reduction process-ISS-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-ISS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal