Gene info: ID 1380

Gene: CR2

GENE ID: 1380

Synonyms: C3DR|CD21|CR|CVID7|SLEB9

Description: complement C3d receptor 2

Gene type: protein-coding

Location: 1q32.2

dbXrefs: Ensembl:ENSG00000117322 MIM:120650 Vega:OTTHUMG00000036307 UniprotKB:P20023

RefSeq: NG_013006.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.307e-2 (AD) 3.276e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CLEC4F	0.647
FUT3	0.608
FAM76B	0.592
XRN1	0.592
LTB4R	0.592
GANC	0.574
OR52N4	0.571
FCHSD1	0.566
OR13A1	0.565
BRWD3	0.561

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARSF	-0.407
WNT7A	-0.386
ADRA2C	-0.368
ARSE	-0.367
HES5	-0.351
PLA2G5	-0.339
CPLX3	-0.32
SLC29A4	-0.317
DIO2	-0.316
MMD2	-0.315

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CR2 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C496492	abrine	abrine results in decreased expression of CR2 mRNA	22595364
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CR2 gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CR2 mRNA	24449571
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNA	16443354
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CR2 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CR2 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CR2 mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased expression of CR2 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of CR2 mRNA	26079696
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA	27858113
D019327	Copper Sulfate	Copper Sulfate affects the expression of CR2 mRNA	19549813
C014347	decitabine	decitabine results in decreased methylation of CR2 gene	27923600
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of CR2 mRNA	23894361
D004008	Diclofenac	Diclofenac affects the expression of CR2 mRNA	26934552
D004726	Endosulfan	Endosulfan results in decreased expression of CR2 mRNA	23208437
D004726	Endosulfan	Endosulfan results in decreased expression of CR2 protein	23208437
D004726	Endosulfan	Vitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 mRNA]	23208437
D004726	Endosulfan	Vitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 protein]	23208437
C118739	entinostat	entinostat results in increased expression of CR2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C546771	gardiquimod	gardiquimod results in increased expression of CR2 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CR2 mRNA]	28003376
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CR2 mRNA"	25620056
D010126	Ozone	TTPA protein affects the reaction [Ozone results in decreased expression of CR2 mRNA]	19555225
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of CR2 mRNA	26272509
D010575	Pesticides	Pesticides results in decreased methylation of CR2 gene	28396702
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of CR2 mRNA	21061450
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CR2 mRNA]	28003376
D053260	Soot	Soot results in decreased expression of CR2 mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CR2 mRNA	21570461
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNA	16443354
D014635	Valproic Acid	Valproic Acid results in increased expression of CR2 mRNA	19949822\|2493525
D014635	Valproic Acid	Valproic Acid affects the expression of CR2 mRNA	17963808
D014810	Vitamin E	Vitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 mRNA]	23208437
D014810	Vitamin E	Vitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 protein]	23208437

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0001848	complement binding	-	IDA	11034390
GO:0003677	DNA binding	-	IDA	22885687
GO:0004875	complement receptor activity	-	NAS	2827171
GO:0004888	transmembrane signaling receptor activity	-	NAS	2827171
GO:0005515	protein binding	-	IPI	7753047
GO:0042803	protein homodimerization activity	-	IDA	11728339

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002430	complement receptor mediated signaling pathway	-	IEA	-
GO:0006955	immune response	-	NAS	2827171
GO:0006958	complement activation, classical pathway	-	IEA	-
GO:0030183	B cell differentiation	-	IDA	2995485
GO:0030449	regulation of complement activation	-	TAS	-
GO:0042100	B cell proliferation	-	IDA	2995485
GO:0045087	innate immune response	-	IEA	-
GO:0046718	viral entry into host cell	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	NAS	2827171
GO:0043235	receptor complex	-	IDA	23382219
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades
hsa04640	Hematopoietic cell lineage
hsa04662	B cell receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-166658	Complement cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
9045748	Changes in immunologic cell surface markers during cocaine withdrawal in pregnant women. (1996 Dec)	Johnson TR	Brain Behav Immun
27841898	Iloprost as an acute kidney injury-triggering agent in severely atherosclerotic patients. (2016 May/Jun)	Uyar ME	Cardiovasc J Afr