Gene: CR2

1380
C3DR|CD21|CR|CVID7|SLEB9
complement C3d receptor 2
protein-coding
1q32.2
Ensembl:ENSG00000117322 MIM:120650 Vega:OTTHUMG00000036307 UniprotKB:P20023
NG_013006.1
PubMed
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.307e-2 (AD)  3.276e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC4F0.647
FUT30.608
FAM76B0.592
XRN10.592
LTB4R0.592
GANC0.574
OR52N40.571
FCHSD10.566
OR13A10.565
BRWD30.561

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.407
WNT7A-0.386
ADRA2C-0.368
ARSE-0.367
HES5-0.351
PLA2G5-0.339
CPLX3-0.32
SLC29A4-0.317
DIO2-0.316
MMD2-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CR2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C496492abrineabrine results in decreased expression of CR2 mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CR2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CR2 mRNA24449571
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNA16443354
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CR2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CR2 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CR2 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CR2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CR2 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CR2 mRNA27858113
D019327Copper SulfateCopper Sulfate affects the expression of CR2 mRNA19549813
C014347decitabinedecitabine results in decreased methylation of CR2 gene27923600
D016264Dextran SulfateDextran Sulfate results in increased expression of CR2 mRNA23894361
D004008DiclofenacDiclofenac affects the expression of CR2 mRNA26934552
D004726EndosulfanEndosulfan results in decreased expression of CR2 mRNA23208437
D004726EndosulfanEndosulfan results in decreased expression of CR2 protein23208437
D004726EndosulfanVitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 mRNA]23208437
D004726EndosulfanVitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 protein]23208437
C118739entinostatentinostat results in increased expression of CR2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C546771gardiquimodgardiquimod results in increased expression of CR2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CR2 mRNA]28003376
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CR2 mRNA"25620056
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of CR2 mRNA]19555225
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CR2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CR2 mRNA26272509
D010575PesticidesPesticides results in decreased methylation of CR2 gene28396702
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CR2 mRNA21061450
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CR2 mRNA]28003376
D053260SootSoot results in decreased expression of CR2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CR2 mRNA21570461
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNA16443354
D014635Valproic AcidValproic Acid results in increased expression of CR2 mRNA19949822|2493525
D014635Valproic AcidValproic Acid affects the expression of CR2 mRNA17963808
D014810Vitamin EVitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 mRNA]23208437
D014810Vitamin EVitamin E inhibits the reaction [Endosulfan results in decreased expression of CR2 protein]23208437

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0001848complement binding-IDA11034390  
GO:0003677DNA binding-IDA22885687  
GO:0004875complement receptor activity-NAS2827171  
GO:0004888transmembrane signaling receptor activity-NAS2827171  
GO:0005515protein binding-IPI7753047  
GO:0042803protein homodimerization activity-IDA11728339  
GO ID GO Term Qualifier Evidence PubMed
GO:0002430complement receptor mediated signaling pathway-IEA-  
GO:0006955immune response-NAS2827171  
GO:0006958complement activation, classical pathway-IEA-  
GO:0030183B cell differentiation-IDA2995485  
GO:0030449regulation of complement activation-TAS-  
GO:0042100B cell proliferation-IDA2995485  
GO:0045087innate immune response-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-NAS2827171  
GO:0043235receptor complex-IDA23382219  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa04640Hematopoietic cell lineage
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9045748Changes in immunologic cell surface markers during cocaine withdrawal in pregnant women. (1996 Dec)Johnson TRBrain Behav Immun
27841898Iloprost as an acute kidney injury-triggering agent in severely atherosclerotic patients. (2016 May/Jun)Uyar MECardiovasc J Afr