Gene info: ID 1385

Gene: CREB1

GENE ID: 1385

Synonyms: CREB|CREB-1

Description: cAMP responsive element binding protein 1

Gene type: protein-coding

Location: 2q33.3

dbXrefs: Ensembl:ENSG00000118260 MIM:123810 Vega:OTTHUMG00000132936 UniprotKB:P16220

RefSeq: NG_023299.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.593e-1 (AD) 9.983e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2254137	chr2:207579304 (GRCh38.p7)	C>A	opioid dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AGPS	0.905
CGGBP1	0.898
PBRM1	0.895
APPL1	0.891
C5orf24	0.888
USO1	0.882
YTHDF3	0.881
NAB1	0.879
EPC2	0.878
TRIP12	0.878

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.577
OR4F29	-0.564
S100A1	-0.272
NXNL1	-0.247
PLA2G5	-0.226
S100A14	-0.226
C6orf223	-0.213
TLCD1	-0.211
RLBP1	-0.205
BTBD17	-0.203

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00131	Adenosine monophosphate	Small Molecule	61-19-8	Approved\|Investigational\|Nutraceutical	Target
DB01183	Naloxone	Small Molecule	465-65-6	Approved	Target

ID	Drug Name	Action	PubMed
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of CREB1 protein"	21443188
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]"	15861431
C040756	1,2-naphthoquinone	"1,2-naphthoquinone binds to and results in decreased activity of CREB1 protein"	21530497
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CREB1 protein modified form"	21705713
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 results in decreased phosphorylation of CREB1 protein	15908479
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]"	17680988
C118559	1-bromopropane	1-bromopropane results in decreased phosphorylation of and results in decreased activity of CREB1 protein	19189864
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
C032904	2,2',3,5',6-pentachlorobiphenyl	"CREB1 protein results in increased susceptibility to 2,2',3,5',6-pentachlorobiphenyl"	22534176
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased phosphorylation of CREB1 protein]	28601556
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]	15608143
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of CREB1 protein]	15466214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	21813366
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of CREB1 protein]	16269011
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]	14622123
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]	16510265
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased phosphorylation of CREB1 protein"	19238344
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	"CREB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"	19238344
C539142	2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one	"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one results in increased phosphorylation of CREB1 protein"	26525565
C001073	2,4-dinitrobenzenesulfonic acid	"2,4-dinitrobenzenesulfonic acid affects the expression of CREB1 mRNA"	20385217
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CREB1 mRNA"	21346803
C000589286	2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein]	24726522
C000589286	2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein	24726522
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]	19962417
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein]	19962417
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of CREB1 protein	25605016
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [Potassium results in increased phosphorylation of CREB1 protein]	11707519
C003898	2-anisidine	2-anisidine affects the expression of CREB1 mRNA	28089782
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased phosphorylation of CREB1 protein"	23292070
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]"	23292070
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased phosphorylation of CREB1 protein"	27509375
C079215	3,5-dihydroxyphenylglycine	"3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein"	16600209
C079215	3,5-dihydroxyphenylglycine	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C079215	3,5-dihydroxyphenylglycine	"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]"	16600209
C079215	3,5-dihydroxyphenylglycine	"3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein"	16600209
C079215	3,5-dihydroxyphenylglycine	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C079215	3,5-dihydroxyphenylglycine	"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]"	16600209
C506282	3,5-dimethoxy-4'-hydroxystilbene	"3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein"	17135264
C506282	3,5-dimethoxy-4'-hydroxystilbene	"[3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein] which results in decreased expression of BCL2 mRNA"	17135264
C506282	3,5-dimethoxy-4'-hydroxystilbene	"S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]"	17135264
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CREB1 mRNA"	18648102
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Zinc Sulfate results in increased phosphorylation of CREB1 protein]	21333516
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased phosphorylation of CREB1 protein]	14687664
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in increased phosphorylation of CREB1 protein"	24824809
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA	12419474
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein	16337876
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein	16671086
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	tyrphostin AG 1478 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C041594	4-nonylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein	23626723
C041594	4-nonylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]	23626723
C105260	4-tert-octylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein	23626723
C105260	4-tert-octylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]	23626723
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of CREB1 protein"	23466342
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]"	16510265
C121465	6-methyl-2-(phenylethynyl)pyridine	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C121465	6-methyl-2-(phenylethynyl)pyridine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of CREB1 protein]	12377393
C121465	6-methyl-2-(phenylethynyl)pyridine	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C015929	8-((4-chlorophenyl)thio)cyclic-3',5'-AMP	"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of and results in increased activity of CREB1 protein"	14741741
C015929	8-((4-chlorophenyl)thio)cyclic-3',5'-AMP	"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of CREB1 protein"	20610540
D000082	Acetaminophen	Acetaminophen affects the expression of CREB1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of CREB1 mRNA	17585979
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
D000171	Acrolein	Acrolein results in increased phosphorylation of CREB1 protein	16337876
C016957	adenosine-3',5'-cyclic phosphorothioate	"adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]"	15522277
D000242	Cyclic AMP	Cyclic AMP promotes the reaction [CREB1 protein binds to CYP1B1 enhancer]	12859982
D000242	Cyclic AMP	[Dexamethasone co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein	22676303
D000242	Cyclic AMP	[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein	22676303
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CREB1 mRNA	19770486
C412373	AG 1879	AG 1879 inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	18004999
C412373	AG 1879	AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]	17272394
C412373	AG 1879	AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]	16510265
C412373	AG 1879	EGF protein inhibits the reaction [AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]	17272394
C103303	alitretinoin	alitretinoin results in increased phosphorylation of CREB1 protein	16280361
D018350	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein	14622123
D018350	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	FG 9041 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein]	14622123
D018350	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	GYKI 52466 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein]	14622123
D013196	Dihydrotestosterone	CREB1 protein promotes the reaction [Dihydrotestosterone results in increased expression of FOS mRNA]	15466214
C571662	alpha-iso-cubebenol	alpha-iso-cubebenol results in increased expression of CREB1 mRNA	24997245
C571662	alpha-iso-cubebenol	alpha-iso-cubebenol results in increased phosphorylation of CREB1 protein	24997245
C010845	aluminum chloride	aluminum chloride results in decreased phosphorylation of CREB1 protein	24973631
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]]	25309793
D010129	4-Aminobenzoic Acid	4-Aminobenzoic Acid affects the expression of CREB1 mRNA	20385217
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of CREB1 mRNA	18247414
C018453	ammonium hexachloroplatinate	ammonium hexachloroplatinate affects the expression of CREB1 mRNA	20385217
D003913	Dextroamphetamine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of CREB1 protein]	12377393
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of CREB1 mRNA	18475255
D003913	Dextroamphetamine	Dextroamphetamine results in increased phosphorylation of CREB1 protein	12377393
D003913	Dextroamphetamine	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of CREB1 protein]	12377393
D000661	Amphetamine	Amphetamine affects the phosphorylation of CREB1 protein	16983645
D000661	Amphetamine	Amphetamine results in decreased phosphorylation of CREB1 protein	19059431
D000661	Amphetamine	Baclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein]	16983645
D000661	Amphetamine	Amphetamine affects the activity of CREB1 protein	17878407
D000661	Amphetamine	Amphetamine affects the phosphorylation of CREB1 protein	17878407
D000661	Amphetamine	Amphetamine affects the reaction [Haloperidol results in increased activity of CREB1 protein modified form]	12125044
D000661	Amphetamine	Amphetamine results in increased expression of CREB1 mRNA	16896163
D000661	Amphetamine	Amphetamine results in increased expression of CREB1 protein	16896163
D000661	Amphetamine	CREB1 protein affects the susceptibility to Amphetamine	16896163
D000661	Amphetamine	KN 62 inhibits the reaction [Amphetamine results in increased phosphorylation of CREB1 protein]	14622123
C530884	anacetrapib	anacetrapib results in increased phosphorylation of CREB1 protein	25617244
D000841	Anisomycin	Anisomycin results in increased phosphorylation of CREB1 protein	12660819
D000841	Anisomycin	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]	12660819
D016718	Arachidonic Acid	Arachidonic Acid results in increased phosphorylation of CREB1 protein	17680988
D016718	Arachidonic Acid	Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]	17680988
D001151	Arsenic	Arsenic results in decreased expression of CREB1 mRNA	24019935
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CREB1 mRNA	24831965
C015001	arsenite	arsenite results in decreased phosphorylation of CREB1 protein	18309289
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein"	17322281
D017638	Asbestos, Crocidolite	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
D017638	Asbestos, Crocidolite	"tyrphostin AG 1478 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
D017638	Asbestos, Crocidolite	"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
C022870	asoxime chloride	[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]	21971501
D001262	Atenolol	Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C047046	atosiban	atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein]	27220266
D001280	Atrazine	Atrazine promotes the reaction [CGB3 protein results in increased phosphorylation of CREB1 protein]	26377646
D001280	Atrazine	Atrazine promotes the reaction [FSHB protein results in increased expression of CREB1 protein modified form]	25253736
D001285	Atropine	[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]	21971501
D001374	Azacitidine	Azacitidine promotes the reaction [CREB1 protein modified form binds to PPP2CA promoter]	19155497
D001418	Baclofen	Baclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein]	16983645
C028559	bathocuproine sulfonate	[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA	15477007
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the activity of CREB1 protein	20624995
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CREB1 mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CREB1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CREB1 mRNA"	26238291
C035982	beryllium fluoride	beryllium fluoride results in increased expression of CREB1 protein	11867686
C020711	beryllium sulfate	[beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein	10755711
D004958	Estradiol	CREB1 protein promotes the reaction [Estradiol results in increased expression of PPP1R9B protein]	15802184
D004958	Estradiol	Estradiol results in decreased phosphorylation of CREB1 protein	15901789
D004958	Estradiol	[Estradiol results in increased import of Calcium] which results in increased activity of CREB1 protein	15802184
D004958	Estradiol	Estradiol results in increased phosphorylation of and results in increased activity of CREB1 protein	15802184
D004958	Estradiol	Estradiol results in increased phosphorylation of CREB1 protein	15901789
D015784	Betaxolol	Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]	18596687
D001640	Bicuculline	Bicuculline results in increased phosphorylation of CREB1 protein	22534176
C073710	bilobalide	bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]	18001288
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
C006780	bisphenol A	bisphenol A promotes the reaction [CREB1 protein modified form binds to SOX2 enhancer]	28244015
C006780	bisphenol A	bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein	19654912
C006780	bisphenol A	bisphenol A results in increased phosphorylation of CREB1 protein	28244015
C006780	bisphenol A	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	19654912
C006780	bisphenol A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	21813366
C006780	bisphenol A	bisphenol A affects the methylation of CREB1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased phosphorylation of CREB1 protein	22484357
C006780	bisphenol A	bisphenol A results in increased expression of CREB1 protein	23545179
C006780	bisphenol A	bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein	21813366
C006780	bisphenol A	Pertussis Toxin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	21813366
C006780	bisphenol A	bisphenol A results in increased phosphorylation of CREB1 protein	15642633
C006780	bisphenol A	bisphenol A affects the localization of CREB1 protein	20096755
C006780	bisphenol A	bisphenol A results in decreased phosphorylation of CREB1 protein	26827910
C006780	bisphenol A	bisphenol A results in increased phosphorylation of CREB1 protein	20096755\|2606044
C006780	bisphenol A	bisphenol A results in decreased expression of CREB1 mRNA	26794494
C533207	BIX 02189	BIX 02189 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CREB1 protein]	22521884
D000068438	Brimonidine Tartrate	Brimonidine Tartrate results in increased phosphorylation of CREB1 protein	17680988
D000068438	Brimonidine Tartrate	Brimonidine Tartrate results in increased phosphorylation of CREB1 protein	17680988
D000068438	Brimonidine Tartrate	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]	17680988
D015124	8-Bromo Cyclic Adenosine Monophosphate	[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of CREB1 protein	18467523
D002047	Buprenorphine	Buprenorphine results in decreased phosphorylation of CREB1 protein	24321744
D020001	1-Butanol	1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	18004999
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CREB1 mRNA	12419474
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased phosphorylation of CREB1 protein	17003459
D020122	tert-Butylhydroperoxide	U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of CREB1 protein]	17003459
C584509	C646 compound	C646 compound results in increased expression of CREB1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of CREB1 mRNA	21694771
D002104	Cadmium	Cadmium results in increased phosphorylation of CREB1 protein	14499349
D019256	Cadmium Chloride	BIX 02189 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CREB1 protein]	22521884
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of CREB1 protein	22521884\|2788460
D019256	Cadmium Chloride	Cadmium Chloride promotes the reaction [CREB1 protein modified form binds to STAR promoter]	25786521
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of CREB1 protein	25786521
D019256	Cadmium Chloride	CREB1 protein promotes the reaction [Cadmium Chloride results in increased expression of STAR mRNA]	25786521
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of CREB1 mRNA	18654764
C037123	cadmium sulfate	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased phosphorylation of CREB1 protein]	14687664
C037123	cadmium sulfate	cadmium sulfate results in increased phosphorylation of CREB1 protein	14687664
D002110	Caffeine	Caffeine results in decreased expression of CREB1 mRNA	26367767
D002110	Caffeine	Caffeine results in decreased expression of CREB1 mRNA	26367767
D002118	Calcium	Calcium affects the expression of CREB1 mRNA	15913539
D002118	Calcium	"Calcium promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
D002118	Calcium	Calcium promotes the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
D002118	Calcium	[Estradiol results in increased import of Calcium] which results in increased activity of CREB1 protein	15802184
C058819	calphostin C	calphostin C inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]	15861431
D002185	Cannabidiol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased phosphorylation of CREB1 protein]	28601556
D002185	Cannabidiol	Cannabidiol results in increased phosphorylation of CREB1 protein	28601556
D002185	Cannabidiol	SB 203580 inhibits the reaction [Cannabidiol results in increased phosphorylation of CREB1 protein]	28601556
D002211	Capsaicin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614
D002211	Capsaicin	Capsaicin results in increased phosphorylation of CREB1 protein	15385614\|1563188
D002211	Capsaicin	KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614\|1563188
D002211	Capsaicin	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614\|1615939
D002211	Capsaicin	NPC 15437 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	16159392
D002211	Capsaicin	Ro 31-8425 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614
D002211	Capsaicin	U 0126 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	16159392
C005563	captax	captax results in decreased expression of CREB1 mRNA	20385217
D002245	Carbon Dioxide	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
D002245	Carbon Dioxide	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
D002245	Carbon Dioxide	[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein	24718106
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CREB1 protein modified form	27590029
D002251	Carbon Tetrachloride	Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CREB1 protein modified form]	27590029
C054133	casticin	casticin results in increased expression of CREB1 mRNA	27862857
D002392	Catechin	[Catechin co-treated with Quercetin] results in increased phosphorylation of CREB1 protein	26363153
D002392	Catechin	Catechin results in increased phosphorylation of CREB1 protein	26363153
C100187	chloropicrin	chloropicrin results in increased expression of CREB1 mRNA	26352163
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CREB1 mRNA	20350560
D002772	Cholera Toxin	Cholera Toxin results in increased phosphorylation of CREB1 protein	12837940
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB1 mRNA	20938992
C043867	cicaprost	cicaprost inhibits the reaction [CREB1 protein binds to CCNA2 promoter]	12869629
C433247	Cilomilast	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
C433247	Cilomilast	Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
C045645	cilostazol	cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]	12807996
C045645	cilostazol	iberiotoxin inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]	12807996
C045645	cilostazol	paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]	12807996
C045645	cilostazol	PTEN affects the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]	12807996
C045645	cilostazol	PTEN affects the reaction [iberiotoxin inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]	12807996
C045645	cilostazol	cilostazol results in increased phosphorylation of CREB1 protein	15978173
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of CREB1 mRNA	20385217
D015283	Citalopram	Citalopram results in decreased phosphorylation of and results in decreased activity of CREB1 protein	20122921
D003024	Clozapine	Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]	12871586
D003024	Clozapine	Clozapine results in decreased phosphorylation of CREB1 protein	12871586
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of CREB1 mRNA	18654764
C018021	cobaltous chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CREB1 protein	10559391
C018021	cobaltous chloride	cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein	18375950
C018021	cobaltous chloride	PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
D003042	Cocaine	CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	15665076
D003042	Cocaine	Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]	24358339
D003042	Cocaine	Cocaine results in increased expression of CREB1 protein	16710312
D003042	Cocaine	Cocaine results in increased phosphorylation of CREB1 protein	15665076\|1633903
D003042	Cocaine	"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of CREB1 protein]"	16710312
D003042	Cocaine	RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	16339038
D003042	Cocaine	SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	16339038
D003042	Cocaine	Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]	18596687
D003042	Cocaine	Cocaine affects the expression of CREB1 mRNA	20187946
D003042	Cocaine	Cocaine affects the phosphorylation of CREB1 protein	18596687
D003042	Cocaine	Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]	20810894
D003042	Cocaine	Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]	15470197
D003042	Cocaine	Cocaine results in increased phosphorylation of and results in increased activity of CREB1 protein	12595601
D003042	Cocaine	Cocaine results in increased phosphorylation of CREB1 protein	16219028
D003042	Cocaine	U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	16219028
D005576	Colforsin	Colforsin results in increased phosphorylation of CREB1 protein	15725338
D005576	Colforsin	Quinpirole inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	15725338
D005576	Colforsin	AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	24701590
D005576	Colforsin	Colforsin results in increased phosphorylation of CREB1 protein	17460731\|2470159
D005576	Colforsin	Colforsin results in increased activity of CREB1 protein	20512473
D005576	Colforsin	Colforsin results in increased phosphorylation of CREB1 protein	17141199\|2174519
D005576	Colforsin	oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]	20512473
D005576	Colforsin	oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17141199
D005576	Colforsin	tyrphostin AG 1478 inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17322281
D005576	Colforsin	"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]"	23292070
D005576	Colforsin	Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CREB1 protein modified form]	27590029
D005576	Colforsin	Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]	23292070
D005576	Colforsin	Colforsin results in increased expression of CREB1 protein modified form	27590029
D005576	Colforsin	Colforsin results in increased phosphorylation of CREB1 protein	10908723\|1552227
D005576	Colforsin	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	10908723\|1768098
D005576	Colforsin	Okadaic Acid inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]	23292070
D005576	Colforsin	resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]	23292070
D005576	Colforsin	resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	23292070
D005576	Colforsin	SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]	23292070
D005576	Colforsin	SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	23292070
D005576	Colforsin	SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	23292070
D005576	Colforsin	Colforsin results in increased phosphorylation of CREB1 protein	17680988
D005576	Colforsin	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17680988
D003300	Copper	Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein]	15367699
D003300	Copper	[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein	15367699
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CREB1 mRNA	19549813
D003345	Corticosterone	Corticosterone results in decreased phosphorylation of CREB1 protein	22850435
C029036	crocin	crocin results in increased expression of and results in increased phosphorylation of CREB1 protein	24401376
D065366	Cryptoxanthins	Cryptoxanthins inhibits the reaction [Lipopolysaccharides results in decreased expression of CREB1 mRNA]	26686910
D065366	Cryptoxanthins	Cryptoxanthins results in increased expression of CREB1 mRNA	26686910
D003474	Curcumin	[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA	22911773
D003474	Curcumin	Curcumin results in increased expression of CREB1 mRNA	18299980
D003474	Curcumin	Curcumin results in increased phosphorylation of CREB1 protein	17022948
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CREB1 protein modified form	18299998
C037304	cyhalothrin	cyhalothrin results in decreased expression of CREB1 protein modified form	28487251
C037304	cyhalothrin	cyhalothrin results in decreased phosphorylation of CREB1 protein	28495607
C004742	daidzein	daidzein results in increased phosphorylation of and results in increased activity of CREB1 protein	16972265
C411602	dalcetrapib	dalcetrapib results in decreased phosphorylation of CREB1 protein	25617244
D003634	DDT	DDT results in increased activity of CREB1 protein	18791200
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of CREB1 mRNA	23640034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CREB1 mRNA	23914054
C014347	decitabine	decitabine results in decreased expression of CREB1 mRNA	27915011
D003676	Deferoxamine	Deferoxamine results in increased activity of CREB1 protein	10559391
D013759	Dronabinol	CNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]	19912468
D013759	Dronabinol	Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein	19912468
D013759	Dronabinol	rimonabant inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]	19912468
D013759	Dronabinol	Dronabinol results in increased phosphorylation of CREB1 protein	15913574
D013759	Dronabinol	rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of CREB1 protein]	15913574
C007262	deoxynivalenol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
C007262	deoxynivalenol	AKT1 protein affects the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
C007262	deoxynivalenol	deoxynivalenol affects the localization of CREB1 protein	12604842
C007262	deoxynivalenol	deoxynivalenol promotes the reaction [CREB1 protein modified form binds to IL6 promoter]	16424113
C007262	deoxynivalenol	deoxynivalenol results in increased activity of CREB1 protein	16424113
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of CREB1 protein	16424113
C007262	deoxynivalenol	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol promotes the reaction [CREB1 protein modified form binds to IL6 promoter]]	16424113
C007262	deoxynivalenol	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased activity of CREB1 protein]	16424113
C007262	deoxynivalenol	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
C007262	deoxynivalenol	SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
D003891	Desipramine	Desipramine results in increased expression of CREB1 mRNA	8601816
D003891	Desipramine	Desipramine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	7603449
D003907	Dexamethasone	Dexamethasone results in increased phosphorylation of CREB1 protein	16239108
D003907	Dexamethasone	Dexamethasone results in decreased expression of CREB1 mRNA	21041162
D003907	Dexamethasone	Dexamethasone affects the expression of CREB1 mRNA	21804312
D003907	Dexamethasone	[Dexamethasone co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein	22676303
D003907	Dexamethasone	Dexamethasone results in decreased expression of CREB1 mRNA	29111458
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CREB1 protein modified form	23732363
D003975	Diazepam	Diazepam results in increased expression of CREB1 protein modified form	18585439
D003975	Diazepam	Plant Extracts inhibits the reaction [Diazepam results in increased expression of CREB1 protein modified form]	18585439
D003975	Diazepam	[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]	21971501
D003976	Diazinon	Diazinon results in decreased expression of CREB1 mRNA	23212306
D003976	Diazinon	Diazinon results in decreased expression of CREB1 mRNA	17452286
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CREB1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CREB1 mRNA	21266533
D003994	Bucladesine	Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]	12164941
D003994	Bucladesine	bisindolylmaleimide I inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D003994	Bucladesine	Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]	18787026\|1928238
D003994	Bucladesine	[Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter]	19282384
D003994	Bucladesine	Bucladesine results in increased phosphorylation of CREB1 protein	19282384
D003994	Bucladesine	CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]	19282384
D003994	Bucladesine	CREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]]	19282384
D003994	Bucladesine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D003994	Bucladesine	Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D003994	Bucladesine	Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased phosphorylation of CREB1 protein]	19282384
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CREB1 mRNA	27392435
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased activity of CREB1 protein	27589886
D004006	Dichlorvos	Dichlorvos results in decreased phosphorylation of CREB1 protein	19100812
D004026	Dieldrin	Dieldrin results in increased expression of CREB1 mRNA	20438755
D004041	Dietary Fats	CREB1 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]	27292126
D004041	Dietary Fats	HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]	27292126
D004041	Dietary Fats	MIR10A mRNA affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]	27292126
D004041	Dietary Fats	[RAPGEF3 protein affects the susceptibility to Dietary Fats] which affects the phosphorylation of CREB1 protein	27381457
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein	27292126
D004041	Dietary Fats	Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	22496244
D004041	Dietary Fats	Dietary Fats results in increased phosphorylation of CREB1 protein	22496244
D004041	Dietary Fats	Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]	22496244
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in decreased expression of CREB1 mRNA	20665664
D015116	5,7-Dihydroxytryptamine	"5,7-Dihydroxytryptamine inhibits the reaction [neurotropin affects the phosphorylation of CREB1 protein]"	25283187
D008559	Memantine	Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]	23562514
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of CREB1 mRNA	20385217
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene affects the expression of CREB1 mRNA	20385217
C493087	diphenylarsinic acid	diphenylarsinic acid results in increased phosphorylation of CREB1 protein	26645585\|2808783
C493087	diphenylarsinic acid	pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]	28087833
C493087	diphenylarsinic acid	SB 203580 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]	28087833
C493087	diphenylarsinic acid	SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of and results in increased expression of CREB1 protein]	28087833
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CREB1 protein]	25199686
D004221	Disulfiram	Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein]	15367699
D004221	Disulfiram	[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein	15367699
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA]	17434604
D016291	Dizocilpine Maleate	"Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]	17973980
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein	14622123
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in increased phosphorylation of CREB1 protein	15877933
D004281	Docosahexaenoic Acids	[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA	22911773
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol promotes the reaction [CREB1 protein modified form binds to IL6 promoter]]	16424113
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased activity of CREB1 protein]	16424113
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
D007980	Levodopa	Levodopa results in increased phosphorylation of CREB1 protein	25044243
D004298	Dopamine	Dopamine results in increased phosphorylation of CREB1 protein	15725338
D004298	Dopamine	Calcium promotes the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
D004298	Dopamine	Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
D004298	Dopamine	Dopamine binds to and results in increased activity of CREB1 protein	14622123
D004298	Dopamine	[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein	14622123
D004298	Dopamine	KN 62 inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
D004298	Dopamine	SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]	14622123
D004533	Egtazic Acid	Egtazic Acid results in decreased phosphorylation of CREB1 protein	21443188
D004726	Endosulfan	diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CREB1 protein]	25199686
D004726	Endosulfan	Endosulfan results in increased expression of CREB1 protein	25199686
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CREB1 protein	23301498
C062669	epicatechin gallate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]	29061316
C045651	epigallocatechin gallate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]	29061316
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CREB1 mRNA	22079256
D004837	Epinephrine	ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
D004837	Epinephrine	ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
D004837	Epinephrine	ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
D004837	Epinephrine	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]"	17680988
D004837	Epinephrine	Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	22496244
D004837	Epinephrine	Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]	22496244
D004837	Epinephrine	Epinephrine results in increased phosphorylation of CREB1 protein	17680988\|2249624
D004837	Epinephrine	Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
D004837	Epinephrine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
D000431	Ethanol	ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of CREB1 protein]	19332462
D000431	Ethanol	Ethanol results in increased phosphorylation of CREB1 protein	19332462
D000431	Ethanol	Ethanol results in decreased expression of and results in decreased activity of CREB1 protein	21655322
D000431	Ethanol	Ethanol results in decreased expression of CREB1 mRNA	20655511
D000431	Ethanol	Ethanol results in increased expression of CREB1 mRNA	23273579
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CREB1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CREB1 mRNA	29097150
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of CREB1 mRNA	28973639
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of CREB1 protein	28973639
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of CREB1 mRNA	23649840
C045989	eticlopride	eticlopride results in increased phosphorylation of CREB1 protein	12871586
D005047	Etoposide	Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein	20573984
D005047	Etoposide	Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein	20573984
D005047	Etoposide	HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein]	20573984
D005054	Eugenol	Eugenol affects the expression of CREB1 mRNA	20385217
D018691	Excitatory Amino Acid Antagonists	Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
C018541	falcarinol	falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]	18199429
C422415	farglitazar	farglitazar binds to and results in increased activity of CREB1 protein	22070604
C056723	FG 9041	FG 9041 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein]	14622123
D005411	Flame Retardants	Flame Retardants results in decreased phosphorylation of CREB1 protein	28903489
D005473	Fluoxetine	ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]	19477151
D005473	Fluoxetine	Fluoxetine affects the reaction [sodium arsenate affects the expression of CREB1 protein]	24952232
D005473	Fluoxetine	Fluoxetine results in decreased phosphorylation of and results in decreased activity of CREB1 protein	20122921
D005473	Fluoxetine	Fluoxetine results in increased expression of CREB1 protein	19477151
D005473	Fluoxetine	[Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein	14556240
D005473	Fluoxetine	Fluoxetine results in increased expression of CREB1 mRNA	8601816
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein	18573488
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of and results in increased localization of CREB1 protein	15138445
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of CREB1 protein	16887358\|2104897
D005473	Fluoxetine	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein]	18573488
D005473	Fluoxetine	staurosporine aglycone inhibits the reaction [Fluoxetine results in increased phosphorylation of CREB1 protein]	21048974
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB1 mRNA	20938992
D005492	Folic Acid	CREB1 protein promotes the reaction [Folic Acid results in increased expression of PTHLH mRNA]	15728788
D005492	Folic Acid	Folic Acid results in increased activity of CREB1 protein	15728788
D005492	Folic Acid	Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein]	15728788
D005557	Formaldehyde	bisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
D005557	Formaldehyde	CREB1 mutant form inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]	22138297
D005557	Formaldehyde	Formaldehyde results in decreased expression of CREB1 mRNA	20655997\|2364984
D005557	Formaldehyde	Formaldehyde results in increased phosphorylation of CREB1 protein	22138297
D005557	Formaldehyde	Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
D005557	Formaldehyde	SB 203580 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
D005557	Formaldehyde	Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA]	17434604
D005557	Formaldehyde	Formaldehyde results in increased expression of CREB1 mRNA	17434604
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of CREB1 mRNA	12400877
D005632	Fructose	Fructose results in increased expression of CREB1 mRNA	19196556
D005632	Fructose	Fructose results in increased expression of CREB1 protein	19196556
D005632	Fructose	rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]	19196556
D005632	Fructose	rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]	19196556
C039281	furan	furan results in increased methylation of CREB1 gene	22079235
D005707	Gallic Acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]	29061316
C057580	gallocatechol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]	29061316
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of CREB1 mRNA	21782745
C063170	Ginkgo biloba extract	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
C063170	Ginkgo biloba extract	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C063170	Ginkgo biloba extract	Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]	18001288
C063170	Ginkgo biloba extract	KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C063170	Ginkgo biloba extract	Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C058295	ginkgolide C	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
C058295	ginkgolide C	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C058295	ginkgolide C	ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]	18001288
C058295	ginkgolide C	KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
D005934	Glucagon	[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein	22676303
D005947	Glucose	Glucose results in increased activity of CREB1 protein	15767253
D005947	Glucose	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein]	24726522
D005947	Glucose	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein	24726522
C120099	GW 1929	GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	20032081
C120099	GW 1929	GW 1929 inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein]	20032081
C061950	GYKI 52466	GYKI 52466 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein]	14622123
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]]	25309793
D006220	Haloperidol	Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]	12871586
D006220	Haloperidol	Haloperidol results in increased phosphorylation of CREB1 protein	12871586
D006220	Haloperidol	Amphetamine affects the reaction [Haloperidol results in increased activity of CREB1 protein modified form]	12125044
D006220	Haloperidol	Haloperidol results in increased activity of CREB1 protein modified form	12125044
D003932	Heroin	Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]	25643298
C087869	histamine trifluoromethyl-toluidide	histamine trifluoromethyl-toluidide results in increased activity of CREB1 protein	18508907
C087869	histamine trifluoromethyl-toluidide	W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of CREB1 protein]	18508907
D012701	Serotonin	Serotonin results in increased expression of CREB1 mRNA	23056638
D012701	Serotonin	Serotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased phosphorylation of CREB1 protein]	26408985
D006861	Hydrogen Peroxide	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CREB1 mRNA	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of CREB1 protein	20302854
D006861	Hydrogen Peroxide	Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein]	20302854
C064719	iberiotoxin	iberiotoxin inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]	12807996
C064719	iberiotoxin	PTEN affects the reaction [iberiotoxin inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]	12807996
C010739	ifenprodil	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
D007099	Imipramine	Imipramine results in increased phosphorylation of CREB1 protein	22396798
D007099	Imipramine	Imipramine results in increased expression of CREB1 mRNA	8601816
D007099	Imipramine	Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]	8601816
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]	21177760
D015056	1-Methyl-3-isobutylxanthine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]	21177760
D007531	Isoflurophate	Isoflurophate affects the expression of CREB1 protein	19664648
D007531	Isoflurophate	Isoflurophate affects the phosphorylation of CREB1 protein	19664648
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of CREB1 protein	17141199\|2174519
D007545	Isoproterenol	oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]	17141199
D007545	Isoproterenol	CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]	12791704
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of CREB1 protein	12791704
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CREB1 mRNA	27392435
C471998	JTE 013	JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]	18612546
C468270	Kangen-karyu	Kangen-karyu affects the expression of CREB1 protein	20637274
D007654	Ketoconazole	Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]	12164941
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]	12164941
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]	12164941
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]	17680988
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
C439304	KMUP 1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein]	19962417
C439304	KMUP 1	KMUP 1 results in increased phosphorylation of CREB1 protein	19962417
C439304	KMUP 1	staurosporine aglycone inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein]	19962417
C063302	KN 62	"KN 62 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
C063302	KN 62	KN 62 inhibits the reaction [Amphetamine results in increased phosphorylation of CREB1 protein]	14622123
C063302	KN 62	KN 62 inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]	14622123
C063302	KN 62	KN 62 inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]	15861431
C072105	KN 93	KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614\|1563188
C072105	KN 93	KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
C011890	kojic acid	kojic acid results in decreased phosphorylation of CREB1 protein	27586645
C073601	KT 5823	KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C073601	KT 5823	KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C073601	KT 5823	KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
D007811	Lanthanum	Lanthanum results in decreased phosphorylation of CREB1 protein	21695898
D007840	Latex	Latex analog results in increased expression of CREB1 mRNA	24768652
C008261	lead acetate	lead acetate results in decreased expression of CREB1 mRNA	24260418
C008261	lead acetate	lead acetate results in decreased phosphorylation of CREB1 protein	23855546
C008261	lead acetate	Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CREB1 protein]	23855546
C008261	lead acetate	[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein	12480136
C008261	lead acetate	lead acetate results in decreased phosphorylation of CREB1 protein	12480136
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of CREB1 mRNA	18654764
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CREB1 mRNA"	11578593
D008070	Lipopolysaccharides	Cryptoxanthins inhibits the reaction [Lipopolysaccharides results in decreased expression of CREB1 mRNA]	26686910
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CREB1 mRNA	26686910
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of CREB1 protein	20512473
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased activity of CREB1 protein	10755711
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein	22363816
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of CREB1 protein	22952890
D008070	Lipopolysaccharides	oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein]	20512473
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]	22363816
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]	22952890
D008070	Lipopolysaccharides	[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]	22363816
D008070	Lipopolysaccharides	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]	22952890
C009900	lipoteichoic acid	[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA	19653804
C009900	lipoteichoic acid	[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA	19653804
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of CREB1 protein	18830594
D018021	Lithium Chloride	Lithium Chloride results in increased expression of CREB1 mRNA	19285016
D008095	Lithocholic Acid	[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]	18648741
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]	15728788
D019808	Losartan	Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein]	15728788
D008148	Lovastatin	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
C013099	mancozeb	mancozeb results in increased expression of CREB1 protein modified form	28330765
D008344	Maneb	[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA	27460631
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein	27460631
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form	27460631
D008345	Manganese	Manganese results in decreased expression of CREB1 mRNA	29205667
D008345	Manganese	Manganese results in decreased expression of CREB1 protein	29205667
D008345	Manganese	Manganese results in increased phosphorylation of CREB1 protein	16787641
D008345	Manganese	SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]	16787641
C025340	manganese chloride	manganese chloride results in increased phosphorylation of CREB1 protein	16787641
C025340	manganese chloride	SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein]	16787641
D008464	Mecamylamine	Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D008713	Methimazole	Methimazole results in increased expression of CREB1 mRNA	22504374
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB1 mRNA	20938992
D008727	Methotrexate	Methotrexate promotes the reaction [CREB1 protein binds to SOD2 promoter]	25575725
D008727	Methotrexate	Methotrexate results in decreased expression of CREB1 mRNA	25339124
D008727	Methotrexate	Methotrexate results in increased phosphorylation of CREB1 protein	25575725
D008727	Methotrexate	PRKAA1 mutant form inhibits the reaction [Methotrexate results in increased phosphorylation of CREB1 protein]	25575725
D008727	Methotrexate	PRKAA2 mutant form inhibits the reaction [Methotrexate results in increased phosphorylation of CREB1 protein]	25575725
D008731	Methoxychlor	Methoxychlor results in increased phosphorylation of CREB1 protein	16177237
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of CREB1 mRNA	21782745
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CREB1 mRNA	23273579
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CREB1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased phosphorylation of CREB1 protein	28267559
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CREB1 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased phosphorylation of CREB1 protein	24269647
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased phosphorylation of CREB1 protein	24269647
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of CREB1 protein"	27566062
C033069	methyl salicylate	methyl salicylate affects the expression of CREB1 mRNA	20385217
C008493	methylselenic acid	methylselenic acid results in increased expression of CREB1 mRNA	12517777
D015741	Metribolone	Metribolone results in increased phosphorylation of CREB1 protein	17272394
D015741	Metribolone	tyrphostin AG 1478 inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]	17272394
D008898	Mimosine	Mimosine results in increased activity of CREB1 protein	10559391
C002373	monobutyryl cyclic AMP	[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of CREB1 protein	18467523
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of CREB1 mRNA	20886546
D009020	Morphine	Morphine results in increased expression of CREB1 protein	23292329
D009020	Morphine	Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]	25643298
D009020	Morphine	Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]	25643298
D009020	Morphine	Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]	25643298
D009020	Morphine	Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]	25643298
D009020	Morphine	Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]	25643298
D009020	Morphine	Morphine results in decreased expression of CREB1 mRNA	15183518
D009020	Morphine	Morphine results in decreased phosphorylation of CREB1 protein	14750654\|1659870
D009151	Mustard Gas	Mustard Gas results in increased expression of CREB1 mRNA	18955075
D009173	Mycophenolic Acid	Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein]	20302854
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CREB1 mRNA"	29244179
C090413	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein]	18573488
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	19654912
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]	12164941
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FGF2 protein results in increased phosphorylation of CREB1 protein]	16269011
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]	21177760
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614\|1615939
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	10908723\|1768098
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]	17680988
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein]	24726522
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]	17680988
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17680988
C481448	N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C481448	N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide	"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]"	16600209
C481448	N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide	"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]"	16600209
C481448	N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide	"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]"	16600209
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CREB1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CREB1 mRNA"	25554681
C495860	naphthol AS-E phosphate	naphthol AS-E phosphate results in increased phosphorylation of CREB1 protein	25150140
C010491	neurotropin	"5,7-Dihydroxytryptamine inhibits the reaction [neurotropin affects the phosphorylation of CREB1 protein]"	25283187
C010491	neurotropin	neurotropin affects the phosphorylation of CREB1 protein	25283187
C029938	nickel sulfate	CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]	23526216
C029938	nickel sulfate	nickel sulfate affects the expression of CREB1 mRNA	20385217
C029938	nickel sulfate	[nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein	23526216
C029938	nickel sulfate	nickel sulfate results in increased phosphorylation of CREB1 protein	26607348
C029938	nickel sulfate	puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein]	26607348
D009538	Nicotine	CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]	25847246
D009538	Nicotine	Nicotine results in decreased expression of CREB1 mRNA	18247414
D009538	Nicotine	Nicotine results in increased phosphorylation of CREB1 protein	25847246
D009538	Nicotine	CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]	21113126
D009538	Nicotine	Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009538	Nicotine	KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009538	Nicotine	Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009538	Nicotine	Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]	21113126
D009538	Nicotine	Nicotine results in increased phosphorylation of CREB1 protein	21113126
D009538	Nicotine	Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009538	Nicotine	Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009543	Nifedipine	Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]	20128810
D009543	Nifedipine	Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	20128810
D009543	Nifedipine	Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
D009599	Nitroprusside	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
D009599	Nitroprusside	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
D009599	Nitroprusside	Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
D009599	Nitroprusside	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
D009599	Nitroprusside	Nitroprusside results in increased phosphorylation of CREB1 protein	18276108
D009599	Nitroprusside	Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
D009599	Nitroprusside	Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
D026423	S-Nitroso-N-Acetylpenicillamine	"S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]"	17135264
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein]	17135264
C478058	N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine	"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of CREB1 protein]"	16710312
C025256	nonylphenol	nonylphenol results in increased phosphorylation of and results in increased localization of and results in increased activity of CREB1 protein	20954072
C069701	NPC 15437	NPC 15437 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	16159392
C442478	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of CREB1 protein]	12377393
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]	23292070
C076029	olanzapine	[Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein	14556240
C000594117	ON123300	ON123300 results in decreased phosphorylation of CREB1 protein	24568969
C016340	o,p'-DDT	"o,p'-DDT affects the localization of CREB1 protein"	20678559
C016340	o,p'-DDT	"o,p'-DDT results in increased activity of CREB1 protein"	18791200
C016340	o,p'-DDT	"o,p'-DDT results in increased phosphorylation of CREB1 protein"	20678559
D008939	Mitotane	Mitotane results in increased activity of CREB1 protein	18791200
C029341	oxophenylarsine	oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]	20512473
C029341	oxophenylarsine	oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17141199
C029341	oxophenylarsine	oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]	17141199
C029341	oxophenylarsine	oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein]	20512473
D010100	Oxygen	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
D010100	Oxygen	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]	24718106
D010100	Oxygen	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein]	24726522
D010100	Oxygen	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein	24726522
D010100	Oxygen	[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein	24718106
D010208	Papaverine	Papaverine results in increased expression of CREB1 mRNA	8601816
D010269	Paraquat	[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D010269	Paraquat	Paraquat results in increased phosphorylation of CREB1 protein	16797015
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA	27460631
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein	27460631
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form	27460631
D052638	Particulate Matter	Particulate Matter results in increased expression of CREB1 mRNA	24769257
D052638	Particulate Matter	[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA	19653804
C048220	paxilline	paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]	12807996
C410127	PCB 180	PCB 180 affects the expression of CREB1 mRNA	21703328
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of CREB1 mRNA	18593933
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CREB1 mRNA	19756518\|2093730
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CREB1 protein	20127074
D030421	Peroxynitrous Acid	Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]	20128810
D030421	Peroxynitrous Acid	[Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein	20128810
D030421	Peroxynitrous Acid	Peroxynitrous Acid inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	20128810
D037342	Pertussis Toxin	Pertussis Toxin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]	21813366
D015232	Dinoprostone	Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]	12164941
D015232	Dinoprostone	CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]	23526216
D015232	Dinoprostone	Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]	12164941
D015232	Dinoprostone	Dinoprostone results in increased phosphorylation of CREB1 protein	12164941
D015232	Dinoprostone	Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]	12164941
D015232	Dinoprostone	Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]	12164941
D015232	Dinoprostone	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]	12164941
D015232	Dinoprostone	[nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein	23526216
D015232	Dinoprostone	Dinoprostone promotes the reaction [CREB1 protein binds to AREG promoter]	16088955
D010634	Phenobarbital	Phenobarbital results in decreased expression of CREB1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of CREB1 mRNA	23273579
D019800	Phenol	Phenol results in increased expression of CREB1 mRNA	20385217
D010656	Phenylephrine	"adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]"	15522277
D010656	Phenylephrine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D010656	Phenylephrine	Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]	15522277
D010656	Phenylephrine	Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein	14741741\|1552227
D010656	Phenylephrine	Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D010656	Phenylephrine	Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D010656	Phenylephrine	Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D010656	Phenylephrine	RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of and results in increased activity of CREB1 protein	17684035
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of CREB1 mRNA	17684035
C004479	pimagedine	pimagedine results in decreased phosphorylation of CREB1 protein	17135264
C008922	piperine	piperine results in decreased localization of CREB1 protein	15531295
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CREB1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of CREB1 mRNA	20813756
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Diazepam results in increased expression of CREB1 protein modified form]	18585439
D028321	Plant Preparations	Plant Preparations affects the localization of CREB1 protein modified form	25019244
D028321	Plant Preparations	Plant Preparations results in decreased expression of CREB1 mRNA	24973489
D011134	Polysaccharides	Polysaccharides affects the localization of CREB1 protein modified form	25019244
D011188	Potassium	2-aminoethoxydiphenyl borate inhibits the reaction [Potassium results in increased phosphorylation of CREB1 protein]	11707519
D011188	Potassium	Potassium results in increased phosphorylation of CREB1 protein	11707519
D011189	Potassium Chloride	Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]	20128810
D011189	Potassium Chloride	Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]	20128810
D011189	Potassium Chloride	[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein	20128810
D011189	Potassium Chloride	Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	20128810
D011189	Potassium Chloride	Peroxynitrous Acid inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	20128810
D011189	Potassium Chloride	Potassium Chloride promotes the reaction [CREB1 protein binds to BDNF promoter]	14593183
D011189	Potassium Chloride	Potassium Chloride results in increased phosphorylation of CREB1 protein	20128810
D011189	Potassium Chloride	1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	18004999
D011189	Potassium Chloride	AG 1879 inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	18004999
D011189	Potassium Chloride	PLD2 protein promotes the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	18004999
D011189	Potassium Chloride	Potassium Chloride results in increased phosphorylation of CREB1 protein	18004999\|2021198
D011189	Potassium Chloride	SRC protein affects the reaction [Potassium Chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18004999
D011189	Potassium Chloride	Desipramine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]	7603449
D011189	Potassium Chloride	Potassium Chloride results in increased phosphorylation of CREB1 protein	7603449
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CREB1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of CREB1 mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CREB1 protein	23718831
D011224	Prazosin	Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D044945	Proanthocyanidins	Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of CREB1 mRNA]	26802905
D011374	Progesterone	Progesterone results in decreased expression of CREB1 mRNA	21371490
D011433	Propranolol	Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CREB1 mRNA	22504374
C033607	puerarin	puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein]	26607348
C526689	punarnavine	punarnavine results in decreased localization of CREB1 protein	20192578
C432165	pyrazolanthrone	pyrazolanthrone results in decreased phosphorylation of CREB1 protein	25605016
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]	28087833
C030984	pyrene	pyrene results in decreased expression of CREB1 mRNA	22487263
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased phosphorylation of CREB1 protein"	11279263
C009131	pyrimidin-2-one beta-ribofuranoside	pyrimidin-2-one beta-ribofuranoside results in increased phosphorylation of CREB1 protein	18830594
C020972	pyrrolidine dithiocarbamic acid	[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA	15477007
D011794	Quercetin	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]"	18001288
D011794	Quercetin	KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
D011794	Quercetin	Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]	18001288
D011794	Quercetin	[Catechin co-treated with Quercetin] results in increased phosphorylation of CREB1 protein	26363153
D011794	Quercetin	Quercetin analog inhibits the reaction [POMC protein modified form results in increased phosphorylation of CREB1 protein]	26586997
D011794	Quercetin	Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CREB1 protein]	23855546
D011794	Quercetin	Quercetin results in decreased phosphorylation of CREB1 protein	17135264
D011794	Quercetin	[Quercetin results in decreased phosphorylation of CREB1 protein] which results in decreased expression of BCL2 mRNA	17135264
D011794	Quercetin	Quercetin results in increased phosphorylation of CREB1 protein	12826665\|2636315
D011794	Quercetin	S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein]	17135264
C502851	quinocetone	Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of CREB1 mRNA]	26802905
C502851	quinocetone	quinocetone metabolite affects the expression of CREB1 mRNA	26802905
D019257	Quinpirole	Quinpirole inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	15725338
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased activity of CREB1 protein]	19011540
C059514	resveratrol	resveratrol inhibits the reaction [CREB1 protein binds to MMP2 promoter]	25605016
C059514	resveratrol	resveratrol results in decreased phosphorylation of CREB1 protein	25605016
C059514	resveratrol	resveratrol results in increased activity of CREB1 protein	26446263
C059514	resveratrol	resveratrol results in increased phosphorylation of and results in increased activity of CREB1 protein	20080969
C059514	resveratrol	resveratrol results in increased phosphorylation of CREB1 protein	18222423
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]	22363816
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]	22952890
C059514	resveratrol	[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]	22363816
C059514	resveratrol	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]	22952890
C059514	resveratrol	"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]"	23292070
C059514	resveratrol	Okadaic Acid inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]	23292070
C059514	resveratrol	resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]	23292070
C059514	resveratrol	resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	23292070
C059514	resveratrol	SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]	23292070
D015474	Isotretinoin	Isotretinoin results in increased phosphorylation of CREB1 protein	16280361
C089032	rimonabant	rimonabant inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]	19912468
C089032	rimonabant	rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of CREB1 protein]	15913574
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	15522277
C071924	Ro 31-8425	Ro 31-8425 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	15385614
C424423	Roflumilast	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
C424423	Roflumilast	Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
C424423	Roflumilast	Roflumilast results in increased phosphorylation of CREB1 protein	18276108
D020889	Rolipram	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]	18276108
D020889	Rolipram	Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]	8601816
D020889	Rolipram	Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]	18276108
D020889	Rolipram	Rolipram results in increased expression of CREB1 mRNA	8601816
D020889	Rolipram	Rolipram results in increased phosphorylation of CREB1 protein	10908723
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	20032081
C089730	rosiglitazone	rosiglitazone inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein]	20032081
C089730	rosiglitazone	rosiglitazone results in decreased phosphorylation of CREB1 protein	15908479
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 mRNA]	19196556
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Fructose results in increased expression of CREB1 protein]	19196556
C089730	rosiglitazone	rosiglitazone binds to and results in increased activity of CREB1 protein	22070604
D012402	Rotenone	Rotenone promotes the reaction [CREB1 protein binds to PPARGC1A promoter]	21536665
D012402	Rotenone	Rotenone results in increased expression of CREB1 mRNA	21536665
C046245	rubimaillin	rubimaillin results in decreased expression of CREB1 mRNA	23466342
C046245	rubimaillin	rubimaillin results in decreased phosphorylation of CREB1 protein	23466342
D012433	Ryanodine	Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]	21113126
C036617	salsolinol	salsolinol results in decreased phosphorylation of CREB1 protein	23261589
C093642	SB 203580	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]	12660819
C093642	SB 203580	SB 203580 inhibits the reaction [Cannabidiol results in increased phosphorylation of CREB1 protein]	28601556
C093642	SB 203580	SB 203580 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]	22138297
C093642	SB 203580	SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of CREB1 protein]	12660819
C093642	SB 203580	SB 203580 results in decreased phosphorylation of CREB1 protein	25605016\|2804918
C093642	SB 203580	SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]	16424113
C093642	SB 203580	SB 203580 inhibits the reaction [AGT protein results in increased phosphorylation of CREB1 protein]	19145780
C093642	SB 203580	SB 203580 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]	28087833
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]	14741741
C093642	SB 203580	SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein]	16787641
C093642	SB 203580	SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]	16787641
C480767	SB219994	SB219994 binds to and results in increased activity of CREB1 protein	22070604
C534628	SCH 23390	"SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]"	14622123
C534628	SCH 23390	SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]	14622123
C534628	SCH 23390	SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]	14622123
C587178	SCH772984	SCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of and results in increased expression of CREB1 protein]	28087833
C587178	SCH772984	SCH772984 results in decreased phosphorylation of and results in decreased expression of CREB1 protein	28087833
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased phosphorylation of CREB1 protein	26408985
D012601	Scopolamine Hydrobromide	Serotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased phosphorylation of CREB1 protein]	26408985
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of CREB1 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of CREB1 mRNA	19244175
D020280	Sertraline	Sertraline results in increased expression of CREB1 mRNA	8601816
D000068677	Sildenafil Citrate	atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein]	27220266
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased phosphorylation of CREB1 protein	27220266
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]	23963992
D019821	Simvastatin	Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein]	20191585
D020123	Sirolimus	[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]	22363816
C071262	SK&F 82958	SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]	14622123
C071262	SK&F 82958	[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein	14622123
C424127	SL 327	SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	16339038
C009277	sodium arsenate	Fluoxetine affects the reaction [sodium arsenate affects the expression of CREB1 protein]	24952232
C009277	sodium arsenate	sodium arsenate affects the expression of CREB1 protein	24952232
C009277	sodium arsenate	sodium arsenate results in increased expression of CREB1 mRNA	21795629
C017947	sodium arsenite	CREB1 protein mutant form results in decreased susceptibility to sodium arsenite	27884605
C017947	sodium arsenite	SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of CREB1 protein]	12660819
C017947	sodium arsenite	sodium arsenite affects the methylation of CREB1 gene	28589171
C017947	sodium arsenite	[sodium arsenite co-treated with Vitamin K 3] results in increased phosphorylation of CREB1 protein	19082730
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of and results in increased activity of CREB1 protein	27884605
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of CREB1 protein	12660819\|1452399
C017947	sodium arsenite	[sodium arsenite results in increased stability of and affects the localization of HIPK1 protein] which results in increased phosphorylation of CREB1 protein	27884605
C017947	sodium arsenite	[sodium arsenite results in increased stability of and affects the localization of HIPK2 protein] which results in increased phosphorylation of CREB1 protein	27884605
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of CREB1 mRNA	20385217
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CREB1 mRNA	27862939
D012999	Soman	[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]	21971501
D012999	Soman	Soman affects the phosphorylation of CREB1 protein	21971501
C060506	sphingosine 1-phosphate	JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]	18612546
C060506	sphingosine 1-phosphate	sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein	18612546
C060506	sphingosine 1-phosphate	Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]	18612546
D019311	Staurosporine	Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]	18001288
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]	19962417
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein]	19962417
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [Fluoxetine results in increased phosphorylation of CREB1 protein]	21048974
D013311	Streptozocin	CREB1 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]	27292126
D013311	Streptozocin	HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]	27292126
D013311	Streptozocin	MIR10A mRNA affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]	27292126
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein	27292126
D013311	Streptozocin	Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]	23562514
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in decreased expression of CREB1 mRNA	20665664
D013311	Streptozocin	Streptozocin results in decreased phosphorylation of CREB1 protein	23562514
D013311	Streptozocin	xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]	23562514
D013395	Sucrose	Sucrose results in increased phosphorylation of CREB1 protein	12514263
D013498	Suramin	Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]	18612546
D013605	T-2 Toxin	T-2 Toxin affects the localization of CREB1 protein modified form	29079362
D013605	T-2 Toxin	T-2 Toxin promotes the reaction [CREB1 protein binds to AKNA promoter]	29079362
C061133	tamibarotene	tamibarotene affects the expression of CREB1 mRNA	15498508
C031655	tauroursodeoxycholic acid	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]"	15861431
C031655	tauroursodeoxycholic acid	calphostin C inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]	15861431
C031655	tauroursodeoxycholic acid	KN 62 inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]	15861431
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein	15861431
D013739	Testosterone	1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]	21177760
D013739	Testosterone	AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]	17272394
D013739	Testosterone	EGF protein inhibits the reaction [AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]	17272394
D013739	Testosterone	FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]	21177760
D013739	Testosterone	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]	21177760
D013739	Testosterone	Testosterone results in increased phosphorylation of CREB1 protein	17272394\|2117776
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of CREB1 mRNA	20189893
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased phosphorylation of CREB1 protein	20189893
C004648	testosterone enanthate	testosterone enanthate results in decreased expression of CREB1 mRNA	25603467
D013749	Tetrachlorodibenzodioxin	CREB1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPB mRNA]	14684744
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CREB1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CREB1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CEBPB promoter]	14684744
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CREB1 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]	17973980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]	17973980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of CREB1 protein	15897893
D013749	Tetrachlorodibenzodioxin	Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]	17973980
D013755	Tetradecanoylphorbol Acetate	GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	20032081
D013755	Tetradecanoylphorbol Acetate	rosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	20032081
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of CREB1 protein	18791200
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein	10601319\|2003208
D013755	Tetradecanoylphorbol Acetate	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D013755	Tetradecanoylphorbol Acetate	CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]	19282384
D013755	Tetradecanoylphorbol Acetate	CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]	19282384
D013755	Tetradecanoylphorbol Acetate	CREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]]	19282384
D013755	Tetradecanoylphorbol Acetate	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D013755	Tetradecanoylphorbol Acetate	PRKD1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	21047949
D013755	Tetradecanoylphorbol Acetate	PRKD1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	21047949
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]	19282384
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased phosphorylation of CREB1 protein]	19282384
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]	19282384\|2104794
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter]	19282384
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein	19282384\|2104794
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB1 mRNA	25613284
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein"	15725338
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein"	14622123
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein"	14622123
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"Calcium promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"KN 62 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]"	14622123
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]"	14622123
D013779	Tetrodotoxin	Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]	17973980
D013849	Thimerosal	Thimerosal results in decreased expression of CREB1 mRNA	24675092
D013893	Thiram	Thiram results in increased expression of CREB1 mRNA	20385217
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CREB1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CREB1 mRNA	22363418
D014050	Toluene	Toluene results in increased expression of CREB1 mRNA	16737738\|1787017
C494251	trans-phytol	trans-phytol results in decreased expression of and results in decreased phosphorylation of CREB1 protein	24853760
D014191	Tranylcypromine	Tranylcypromine results in increased expression of CREB1 mRNA	8601816
D014212	Tretinoin	bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
D014212	Tretinoin	Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
D014212	Tretinoin	RPS6KA1 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
D014212	Tretinoin	RPS6KA3 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
D014212	Tretinoin	Tretinoin affects the expression of CREB1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased activity of CREB1 protein	16280361
D014212	Tretinoin	Tretinoin results in increased phosphorylation of CREB1 protein	16280361
D014212	Tretinoin	U 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
C057693	troglitazone	troglitazone results in decreased phosphorylation of CREB1 protein	15908479
C057693	troglitazone	troglitazone results in decreased expression of CREB1 mRNA	28973697
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]	16671086
C101044	tyrphostin AG 1478	"tyrphostin AG 1478 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]	17322281
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]	17272394
C113580	U 0126	U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of CREB1 protein]	17003459
C113580	U 0126	U 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
C113580	U 0126	"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]"	17322281
C113580	U 0126	U 0126 inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]	14622123
C113580	U 0126	U 0126 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]	16159392
C113580	U 0126	U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]	16219028
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]	14741741
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of CREB1 mRNA	12400877
D014520	Urethane	Urethane results in decreased expression of CREB1 mRNA	12400877
D014635	Valproic Acid	Valproic Acid affects the expression of CREB1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid promotes the reaction [CREB1 protein binds to XPC promoter]	21507255
D014635	Valproic Acid	Valproic Acid results in decreased expression of CREB1 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of CREB1 mRNA	9098922
D014635	Valproic Acid	CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA]	18976638
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CREB1 gene	25560391
D001335	Vehicle Emissions	[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA	19653804
D014801	Vitamin A	Vitamin A results in increased phosphorylation of CREB1 protein	16280361
D014801	Vitamin A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]	16510265
D014801	Vitamin A	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]"	16510265
D014801	Vitamin A	AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]	16510265
D014801	Vitamin A	Vitamin A results in increased phosphorylation of CREB1 protein	16510265
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of CREB1 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of CREB1 mRNA	19244175
D024483	Vitamin K 3	[sodium arsenite co-treated with Vitamin K 3] results in increased phosphorylation of CREB1 protein	19082730
C017967	W 7	W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of CREB1 protein]	18508907
C009687	wortmannin	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]	23626723
C009687	wortmannin	wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]	15608143
C009687	wortmannin	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]	22952890
D017307	Xamoterol	Xamoterol results in increased phosphorylation of CREB1 protein	16671086
C548611	xanthoceraside	xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]	23562514
C104536	xanthohumol	xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein	27317025
D014978	Xenon	Xenon results in increased phosphorylation of CREB1 protein	16034370
C066632	yessotoxin	yessotoxin results in increased expression of CREB1 protein modified form	25576684
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of CREB1 mRNA	18593933
D015032	Zinc	Zinc deficiency results in increased activity of CREB1 protein	18356318
D019287	Zinc Sulfate	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Zinc Sulfate results in increased phosphorylation of CREB1 protein]	21333516
D019287	Zinc Sulfate	Zinc Sulfate affects the expression of CREB1 mRNA	20385217
D019287	Zinc Sulfate	Zinc Sulfate results in increased phosphorylation of CREB1 protein	21333516
C049109	zolpidem	zolpidem promotes the reaction [CREB1 protein binds to BDNF promoter]	24367698

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	9065434
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	IDA	19861239
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IC	-
GO:0001102	RNA polymerase II activating transcription factor binding	-	IPI	19861239
GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	-	IDA	19861239
GO:0001225	RNA polymerase II transcription coactivator binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	IDA	8798441
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IDA	19861239
GO:0003712	transcription coregulator activity	-	TAS	8552098
GO:0005515	protein binding	-	IPI	10722738 14506290 15733869 15964553 16325578 16799563 17476304 18160048 18316612 20102225 20159610 20541704 20936779 21172805 21418524 21988832 25609649
GO:0019899	enzyme binding	-	IPI	23382074
GO:0030544	Hsp70 protein binding	-	IEA	-
GO:0035035	histone acetyltransferase binding	-	IEA	-
GO:0035497	cAMP response element binding	-	IDA	19861239
GO:0042802	identical protein binding	-	IPI	20102225 25609649
GO:1990763	arrestin family protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0006468	protein phosphorylation	-	IDA	8798441
GO:0007165	signal transduction	-	TAS	2974179
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IEA	-
GO:0007409	axonogenesis	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007595	lactation	-	IEA	-
GO:0007613	memory	-	IEA	-
GO:0007623	circadian rhythm	-	ISS	-
GO:0008361	regulation of cell size	-	IEA	-
GO:0008542	visual learning	-	IEA	-
GO:0010033	response to organic substance	-	IDA	8798441
GO:0010944	negative regulation of transcription by competitive promoter binding	-	IDA	19861239
GO:0014823	response to activity	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0021983	pituitary gland development	-	IEA	-
GO:0032916	positive regulation of transforming growth factor beta3 production	-	IEA	-
GO:0033363	secretory granule organization	-	IEA	-
GO:0033762	response to glucagon	-	ISS	-
GO:0034670	chemotaxis to arachidonic acid	-	IEA	-
GO:0035094	response to nicotine	-	IEA	-
GO:0035729	cellular response to hepatocyte growth factor stimulus	-	IEA	-
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IEA	-
GO:0040018	positive regulation of multicellular organism growth	-	IEA	-
GO:0042752	regulation of circadian rhythm	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0045600	positive regulation of fat cell differentiation	-	ISS	-
GO:0045672	positive regulation of osteoclast differentiation	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	1655749 8798441 19861239
GO:0046887	positive regulation of hormone secretion	-	IEA	-
GO:0046889	positive regulation of lipid biosynthetic process	-	ISS	-
GO:0048145	regulation of fibroblast proliferation	-	IEA	-
GO:0050821	protein stabilization	-	ISS	-
GO:0055025	positive regulation of cardiac muscle tissue development	-	IEA	-
GO:0060251	regulation of glial cell proliferation	-	IEA	-
GO:0060430	lung saccule development	-	IEA	-
GO:0060509	type I pneumocyte differentiation	-	IEA	-
GO:0071294	cellular response to zinc ion	-	IEA	-
GO:0071398	cellular response to fatty acid	-	IEA	-
GO:1900273	positive regulation of long-term synaptic potentiation	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IEA	-
GO:1902065	response to L-glutamate	-	IEA	-
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	-
GO:1990314	cellular response to insulin-like growth factor stimulus	-	IEA	-
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	8798441
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0005719	nuclear euchromatin	-	IDA	19861239
GO:0005759	mitochondrial matrix	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:1990589	ATF4-CREB1 transcription factor complex	-	IDA	12871976

KEGG ID	KEGG Term
hsa04380	Osteoclast differentiation
hsa04612	Antigen processing and presentation
hsa04916	Melanogenesis
hsa04962	Vasopressin-regulated water reabsorption
hsa05016	Huntington's disease
hsa05215	Prostate cancer

Reactome ID	Reactome Term	Evidence
R-HSA-111885	Opioid Signalling	IEA
R-HSA-111931	PKA-mediated phosphorylation of CREB	IEA
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	IEA
R-HSA-111933	Calmodulin induced events	IEA
R-HSA-111996	Ca-dependent events	IEA
R-HSA-111997	CaM pathway	IEA
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	IEA
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1489509	DAG and IP3 signaling	IEA
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-1980145	Signaling by NOTCH2	IEA
R-HSA-198693	AKT phosphorylates targets in the nucleus	TAS
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	TAS
R-HSA-199920	CREB phosphorylation	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	IEA
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	IEA
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-400253	Circadian Clock	IEA
R-HSA-400253	Circadian Clock	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	TAS
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	TAS
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23183491	Genome-wide association study identifies a potent locus associated with human opioid sensitivity. (2014 Jan)	Nishizawa D	Mol Psychiatry
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics
15029152	Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. (2004 Jun)	Valverde O	Neuropsychopharmacology
24946391	[Genetic polymorphisms commonly influencing efficacy of diverse addictive substances]. (2014 Apr)	Nishizawa D	Nihon Arukoru Yakubutsu Igakkai Zasshi
23407025	The impact of adverse life events on clinical features and interaction with gene variants in mood disorder patients. (2013)	Serretti A	Psychopathology