Gene: ATF2

1386
CRE-BP1|CREB-2|CREB2|HB16|TREB7
activating transcription factor 2
protein-coding
2q31.1
Ensembl:ENSG00000115966 MIM:123811 Vega:OTTHUMG00000132424 UniprotKB:P15336
NG_047045.1
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.896e-1 (AD)  4.686e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13388308chr2:175141299 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1153676chr2:175116266 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2072538chr2:175097936 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs35522805chr2:175087402 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs212349chr2:175079670 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WASL0.972
CAMSAP20.968
SHOC20.965
RANBP90.964
RHOT10.964
FAM8A10.963
AASDHPPT0.962
SPIN10.961
KLHL70.96
FAM169A0.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.628
OR4F29-0.58
CSAG1-0.39
FZD10-0.347
KLRB1-0.321
ANPEP-0.311
TFPI2-0.302
MAGEA12-0.301
MTRNR2L10-0.3
COX4I2-0.291

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
ID Drug Name Action PubMed
C0149702-aminodiphenyl2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein23836369
C0149702-aminodiphenyl2-aminodiphenyl results in increased phosphorylation of ATF2 protein22288910
C0149702-aminodiphenylacetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
C0149702-aminodiphenylAcetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
C0149702-aminodiphenylpyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]23836369
C0149702-aminodiphenylU 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]23836369
C0149702-aminodiphenylU 0126 inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein19464336
C0312782-chloroethyl ethyl sulfide[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein]19464336
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein18675330
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of ATF2 mRNA19643169
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [MAPK14 protein modified form results in increased phosphorylation of and results in increased activity of ATF2 protein]9688607
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of ATF2 protein]19720122
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]12663670
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]12663670
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]12663670
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [nitroaspirin affects the phosphorylation of ATF2 protein]16169935
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein]14687664
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased phosphorylation of ATF2 protein11512036
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF2 mRNA"27188386
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF2 protein]"15772366
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]9918806
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF2 mRNA"27188386
C056165acetovanilloneacetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
D000111Acetylcysteine[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein]19464336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
D000111AcetylcysteineAcetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]19654923
D000111AcetylcysteineAcetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 protein]10661865
D000171Acrolein[Acrolein results in increased phosphorylation of MAPK14 protein] which results in increased phosphorylation of ATF2 protein12487375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ATF2 gene27153756
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein]19464336
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]14645110
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ATF2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ATF2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of ATF2 protein16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of ATF2 mRNA18305237
D000841AnisomycinAnisomycin results in increased phosphorylation of ATF2 protein12663670
D000841AnisomycinAnisomycin results in increased phosphorylation of ATF2 protein28975372
D000841Anisomycinpyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]28975372
D000841AnisomycinSB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]28975372
D016718Arachidonic Acid4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of ATF2 protein]19720122
D016718Arachidonic AcidArachidonic Acid results in increased phosphorylation of ATF2 protein19720122
D001151ArsenicArsenic affects the methylation of ATF2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased phosphorylation of ATF2 protein24934751
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased phosphorylation of ATF2 protein"17191120
D001280AtrazineAtrazine results in increased expression of ATF2 mRNA22378314
D001427Bacterial ToxinsBacterial Toxins results in increased phosphorylation of ATF2 protein17030583
D001427Bacterial ToxinsGlycosylphosphatidylinositols deficiency inhibits the reaction [Bacterial Toxins results in increased phosphorylation of ATF2 protein]17030583
D001427Bacterial Toxinsmethyl-beta-cyclodextrin inhibits the reaction [Bacterial Toxins results in increased phosphorylation of ATF2 protein]17030583
C038044baicalinbaicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]24312512
D001564Benzo(a)pyreneBenzo(a)pyrene analog results in increased phosphorylation of ATF2 protein24910982
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATF2 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATF2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATF2 mRNA22300585
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with TNF protein] results in increased phosphorylation of ATF2 protein21745554
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATF2 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of ATF2 mRNA19167446
C006780bisphenol Abisphenol A results in increased expression of ATF2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ATF2 gene28505145
D000069286BortezomibBortezomib results in increased expression of ATF2 mRNA20977926
D000069286BortezomibBortezomib results in increased phosphorylation of ATF2 protein12393500
D000069286Bortezomibpyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of ATF2 protein]12393500
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF2 mRNA20061341
C037123cadmium sulfate4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein]14687664
C037123cadmium sulfatecadmium sulfate results in increased phosphorylation of ATF2 protein14687664
C037123cadmium sulfatediphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein]14687664
D000074262Canola OilCanola Oil metabolite results in decreased expression of ATF2 mRNA27363782
D002220CarbamazepineCarbamazepine affects the expression of ATF2 mRNA24752500
D054715CardiotoxinsCardiotoxins results in increased phosphorylation of ATF2 protein17786558
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of ATF2 mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF2 gene20938992
C074702chromium hexavalent ionAcetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]19654923
C074702chromium hexavalent ionchromium hexavalent ion results in increased phosphorylation of ATF2 protein19654923
C074702chromium hexavalent ionMAP2K4 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]19654923
C028801chromium trioxidechromium trioxide results in increased phosphorylation of ATF2 protein9728050
C018021cobaltous chloridecobaltous chloride results in increased expression of ATF2 mRNA19376846
D003300CopperCopper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]15367699
D003300Copper[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein15367699
D019327Copper SulfateCopper Sulfate results in decreased expression of ATF2 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased phosphorylation of ATF2 protein9728050
D003375CoumestrolCoumestrol results in increased expression of ATF2 mRNA19167446
D003474CurcuminCurcumin analog results in decreased expression of ATF2 mRNA26409325
C057862cyanoginosin LRcyanoginosin LR results in increased expression of ATF2 protein modified form27393157
D003520CyclophosphamideCyclophosphamide results in increased expression of ATF2 mRNA11599041
D016572CyclosporineCyclosporine results in increased expression of ATF2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased phosphorylation of ATF2 protein10617104
C479072delta-tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein]19464336
C007262deoxynivalenoldeoxynivalenol results in increased expression of ATF2 mRNA22846391
C007262deoxynivalenol"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF2 protein]"15772366
C007262deoxynivalenoldeoxynivalenol affects the localization of ATF2 protein12604842
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of ATF2 protein15772366
C088674dibromoacetic aciddibromoacetic acid results in increased expression of ATF2 mRNA29155130
D003994BucladesineBucladesine promotes the reaction [ATF2 protein binds to ABCC2 promoter]26049102
D003994BucladesineBucladesine promotes the reaction [JUN protein binds to ATF2 protein]26049102
D003994BucladesineBucladesine results in increased expression of ATF2 protein modified form26049102
D003994BucladesineBucladesine results in increased phosphorylation of ATF2 protein26049102
D003994BucladesineKT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form]26049102
D002945Cisplatin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]12663670
D002945Cisplatin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]12663670
D002945Cisplatin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]12663670
D002945CisplatinATF2 protein results in decreased susceptibility to Cisplatin12663670
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of ATF2 mRNA27514524
D002945CisplatinCisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein12663670
D002945Cisplatinpyrazolanthrone inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]12663670
D002945Cisplatinpyrazolanthrone inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]12663670
D002945Cisplatinpyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]12663670
D002945CisplatinCisplatin results in increased phosphorylation of ATF2 protein15701814
D004008DiclofenacDiclofenac affects the expression of ATF2 mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of ATF2 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ATF2 mRNA23041725
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of ATF2 mRNA19690152
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein]14687664
D004221DisulfiramCopper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]15367699
D004221Disulfiram[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein15367699
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein]18089841
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of ATF2 protein]"23178662
D004365Drugs, Chinese Herbal"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]"23256447
D004656EnalaprilEnalapril results in increased expression of ATF2 protein15531746
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ATF2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATF2 mRNA29097150
D005047EtoposideEtoposide results in increased phosphorylation of and results in increased activity of ATF2 protein12663670
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum results in decreased expression of ATF2 mRNA"27351882
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF2 gene20938992
D024504gamma-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATF2 protein]19464336
D019833GenisteinGenistein results in decreased expression of ATF2 mRNA21782745
C007845gingerolgingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]18577375
D017261GlycosylphosphatidylinositolsGlycosylphosphatidylinositols deficiency inhibits the reaction [Bacterial Toxins results in increased phosphorylation of ATF2 protein]17030583
C081021Go 6976Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ATF2 mRNA18951874
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein]18089841
D007545IsoproterenolIsoproterenol results in increased phosphorylation of ATF2 protein18089841
C410337K 7174K 7174 results in increased expression of ATF2 mRNA24086573
C057416KT 5720KT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form]26049102
D007854LeadLead affects the splicing of ATF2 mRNA28903495
C018584linaloollinalool results in increased expression of ATF2 mRNA19922762
C440499lipopolysaccharide, Escherichia coli O111 B4"pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]"19549798
C440499lipopolysaccharide, Escherichia coli O111 B4"[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form"19549798
C440499lipopolysaccharide, Escherichia coli O111 B4"Drugs, Chinese Herbal affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of ATF2 protein]"23178662
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the phosphorylation of ATF2 protein"23178662
D008070Lipopolysaccharides"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]"23256447
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of ATF2 protein23106696
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of ATF2 protein23256447
D008070Lipopolysaccharidesbaicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]24312512
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of ATF2 protein24312512
D008094Lithium[Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein19430551
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ATF2 mRNA26378955
C025340manganese chloridemanganese chloride results in increased activity of ATF2 protein19084589|2015289
C025340manganese chloridemanganese chloride results in increased phosphorylation of ATF2 protein20152896
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF2 gene20938992
C081145methionylmethylsulfonium chloridemethionylmethylsulfonium chloride results in increased phosphorylation of and results in increased activity of ATF2 protein12663670
D008727MethotrexateMethotrexate results in increased expression of ATF2 mRNA24449571
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [Bacterial Toxins results in increased phosphorylation of ATF2 protein]17030583
C005219methyl cellosolvemethyl cellosolve results in increased expression of ATF2 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ATF2 mRNA20061341
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ATF2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ATF2 promoter"26251327
C008493methylselenic acidmethylselenic acid results in increased phosphorylation of and results in increased activity of ATF2 protein11830524
D008799MevinphosMevinphos results in increased phosphorylation of ATF2 protein23157661
C059539midostaurinmidostaurin results in increased expression of ATF2 mRNA20980353
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ATF2 mRNA20886546
D009151Mustard GasMustard Gas results in increased phosphorylation of ATF2 protein18200059
D009151Mustard GasMustard Gas affects the expression of ATF2 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ATF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ATF2 mRNA"25554681
C005274naringinnaringin affects the reaction [IL1B protein affects the phosphorylation of ATF2 protein]25632752
C022838nickel chloride[nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of ATF2 protein23536762
C102148nitroaspirin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [nitroaspirin affects the phosphorylation of ATF2 protein]16169935
C102148nitroaspirinnitroaspirin affects the phosphorylation of ATF2 protein16169935
C570000niuhuang"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]"23256447
C474958O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate"O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein"22003962
C474958O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate"pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein]"22003962
C030110oxaliplatinoxaliplatin results in increased phosphorylation of ATF2 protein19428505
C030110oxaliplatinSB 203580 inhibits the reaction [oxaliplatin results in increased phosphorylation of ATF2 protein]19428505
D010081OxazoloneOxazolone results in increased expression of ATF2 mRNA23999411
C029341oxophenylarsineoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of ATF2 mRNA18636392
D052638Particulate MatterMAP2K4 mutant form inhibits the reaction [Particulate Matter analog results in increased phosphorylation of ATF2 protein]24910982
D052638Particulate MatterParticulate Matter analog results in increased phosphorylation of ATF2 protein24910982
D052638Particulate MatterParticulate Matter results in decreased expression of ATF2 mRNA17987463
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of ATF2 mRNA28973697
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased phosphorylation of ATF2 protein27344344
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]27344344
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ATF2 mRNA27153767
C076994perfluorooctane sulfonic acidATF2 protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of MMP9 protein]27818224
C076994perfluorooctane sulfonic acidSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of ATF2 protein]27818224
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ATF2 mRNA17560707
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D010862Pilocarpine[Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein19430551
D010862PilocarpinePilocarpine results in increased expression of ATF2 mRNA17971868
C008911pimaric acid[pimaric acid co-treated with TNF protein] results in decreased expression of ATF2 protein modified form22705379
C008922piperinepiperine results in decreased localization of ATF2 protein15531295
D010882Piperonyl Butoxide[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of ATF2 mRNA19690152
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of ATF2 mRNA19690152
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased phosphorylation of ATF2 protein18228000
D011084Polycyclic Aromatic HydrocarbonsMAP2K4 mutant form inhibits the reaction [Polycyclic Aromatic Hydrocarbons analog results in increased phosphorylation of ATF2 protein]24910982
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased phosphorylation of ATF2 protein24910982
D011374ProgesteroneProgesterone results in increased phosphorylation of ATF2 protein21291521
C107773pterostilbene"pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]"19549798
C526689punarnavinepunarnavine results in decreased localization of ATF2 protein20192578
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]23836369
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]12663670
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of ATF2 protein]12393500
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]12663670
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]12663670
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein]"22003962
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]28975372
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]24525298
C020972pyrrolidine dithiocarbamic acidAcetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 protein]10661865
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 protein10661865
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of ATF2 mRNA27514524
C059514resveratrolresveratrol results in increased activity of ATF2 protein26446263
C059514resveratrolresveratrol results in increased phosphorylation of ATF2 protein18222423
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased expression of ATF2 protein]26499206
D015474IsotretinoinIsotretinoin affects the localization of and results in decreased activity of ATF2 protein18652567|1906612
C093642SB 203580SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of ATF2 protein]18215737
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
C093642SB 203580SB 203580 inhibits the reaction [TGFB1 protein results in increased phosphorylation of ATF2 protein]21303922
C093642SB 203580SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
C093642SB 203580SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]28975372
C093642SB 203580SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of ATF2 protein]27818224
C093642SB 203580SB 203580 inhibits the reaction [oxaliplatin results in increased phosphorylation of ATF2 protein]19428505
D012645SelenomethionineSelenomethionine affects the expression of ATF2 mRNA17222674
D020280SertralineSertraline results in increased expression of ATF2 mRNA24865413
C009250sevofluranesevoflurane results in increased phosphorylation of ATF2 protein18349187
D019821SimvastatinSimvastatin results in increased phosphorylation of ATF2 protein15488325
D012906SmokeSmoke results in increased phosphorylation of and results in increased activity of ATF2 protein21742783
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
C017947sodium arsenitepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
C017947sodium arsenitepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
C017947sodium arsenitepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]23591579
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]23591579
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]23591579
C017947sodium arsenitesodium arsenite results in decreased expression of ATF2 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased activity of ATF2 protein12220541|1529296
C017947sodium arsenitesodium arsenite results in increased expression of ATF2 mRNA12016162|1787925
C017947sodium arsenitesodium arsenite results in increased expression of ATF2 protein23591579
C017947sodium arsenitesodium arsenite results in increased expression of ATF2 protein modified form23591579
C017947sodium arsenitesodium arsenite results in increased phosphorylation of ATF2 protein9728050
C017947sodium arsenitesodium arsenite results in increased phosphorylation of ATF2 protein11807808
C017947sodium arsenitesodium arsenite promotes the reaction [[[ATF2 protein binds to ATF2 protein] which binds to PCK1 promoter] which results in increased expression of PCK1 mRNA]9712902
C017947sodium arsenitesodium arsenite results in increased expression of ATF2 protein modified form16797887
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased expression of ATF2 protein]26499206
D013311StreptozocinStreptozocin results in increased expression of ATF2 protein26499206
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ATF2 mRNA26378955
D013629Tamoxifenalpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]14645110
D013629TamoxifenTamoxifen results in increased phosphorylation of ATF2 protein14645110
D013629TamoxifenTamoxifen affects the expression of ATF2 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of ATF2 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATF2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATF2 mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATF2 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATF2 mRNA15897893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ATF2 protein15897893
D014028Tobacco Smoke PollutionATF2 protein affects the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]26763395
D014028Tobacco Smoke PollutionGo 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke Pollutionoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke PollutionPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke PollutionPLD1 protein affects the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke PollutionSB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein26763395
D014118Toxins, Biological"Toxins, Biological affects the expression of ATF2 mRNA"19682533
D014212TretinoinTretinoin affects the localization of ATF2 protein16511568
C011559tributyltintributyltin results in increased phosphorylation of ATF2 protein21626652
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ATF2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF2 mRNA"26179874
C080163trovafloxacinpyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]24525298
C080163trovafloxacintrovafloxacin results in increased phosphorylation of ATF2 protein24525298
C113580U 0126U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]23836369
C113580U 0126U 0126 inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]22288910
D014635Valproic AcidValproic Acid results in decreased expression of ATF2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of ATF2 gene29154799
C034028vanadyl sulfatevanadyl sulfate results in increased phosphorylation of ATF2 protein9728050
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ATF2 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ATF2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ATF2 mRNA23555832
D014810Vitamin EVitamin E results in increased phosphorylation of ATF2 protein11522656
D014873Water PollutantsWater Pollutants results in decreased expression of ATF2 mRNA23591932
D019287Zinc SulfateZinc Sulfate results in increased phosphorylation of ATF2 protein9728050

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IMP2516827  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA19861239  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001102RNA polymerase II activating transcription factor binding-IPI19861239  
GO:0001158enhancer sequence-specific DNA binding-IDA2196176  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC19861239  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IDA8798441  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IC19861239  
GO:0003713transcription coactivator activity-TAS2529117  
GO:0004402histone acetyltransferase activity-IDA10821277  
GO:0004402histone acetyltransferase activity-TAS-  
GO:0005515protein binding-IPI8440710  9748258  10327051  15105425  15916964  16511568  
18397884  20102225  20116378  20195357  20511396  22439931  
24705354  25416956  25609649  
GO:0008140cAMP response element binding protein binding-IDA19861239  
GO:0019901protein kinase binding-IPI21098032  
GO:0035497cAMP response element binding-IDA19861239  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0003151outflow tract morphogenesis-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP22304920  
GO:0006357regulation of transcription by RNA polymerase II-IC19861239  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006970response to osmotic stress-IDA21098032  
GO:0006974cellular response to DNA damage stimulus-IDA22304920  
GO:0006974cellular response to DNA damage stimulus-IMP15916964  
GO:0009414response to water deprivation-IEA-  
GO:0010628positive regulation of gene expression-IMP28977001  
GO:0016525negative regulation of angiogenesis-IMP28977001  
GO:0016573histone acetylation-IEA-  
GO:0031573intra-S DNA damage checkpoint-IMP15916964  
GO:0032915positive regulation of transforming growth factor beta2 production-IEA-  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0045444fat cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16300731  
GO:0050680negative regulation of epithelial cell proliferation-IEA-  
GO:0051090regulation of DNA-binding transcription factor activity-TAS-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP10821277  
GO:0060612adipose tissue development-IEA-  
GO:0097186amelogenesis-IEA-  
GO:0110024positive regulation of cardiac muscle myoblast proliferation-IDA22982025  
GO:1902110positive regulation of mitochondrial membrane permeability involved in apoptotic process-IMP22304920  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA8798441  18397884  19861239  21098032  22304920  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA22304920  
GO:0005741mitochondrial outer membrane-IDA22304920  
GO:0035861site of double-strand break-IDA15916964  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-400253Circadian ClockTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-450341Activation of the AP-1 family of transcription factorsTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26763395Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells. (2016 Feb)Koo JBJ Toxicol Sci