Gene: CREBBP

1387
CBP|KAT3A|RSTS|RSTS1
CREB binding protein
protein-coding
16p13.3
Ensembl:ENSG00000005339 MIM:600140 Vega:OTTHUMG00000129431 UniprotKB:Q92793
NG_009873.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.202e-1 (AD)  4.637e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDM2A0.936
NSD10.93
NCOA60.929
ZNF3840.915
TRRAP0.913
KANSL10.906
EP3000.906
FAM193A0.901
ZCCHC140.899
RNF2160.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.593
RPE65-0.297
KLRC2-0.288
NANOGNB-0.283
GSDMC-0.278
CD8B-0.277
ODAM-0.272
KLRF1-0.27
KLRC3-0.268

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB086559-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]"21443188
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]"18511507
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CREBBP protein"22609851
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of CREBBP mRNA11705990
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CREBBP mRNA"19114083
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]"22850435
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]]"22850435
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CREBBP mRNA"21346803
C0038982-anisidine2-anisidine results in increased expression of CREBBP mRNA28089782
C0188552-tert-butylhydroquinone"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]"21443188
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]21443188
C0188552-tert-butylhydroquinoneEgtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]21443188
C105509(3-(1-((3-(cyclohexylmethyl)hydroxyphosphinyl)-2-hydroxypropyl)amino)ethyl)benzoic acid(3-(1-((3-(cyclohexylmethyl)hydroxyphosphinyl)-2-hydroxypropyl)amino)ethyl)benzoic acid inhibits the reaction [Sodium Oxybate results in increased phosphorylation of CREBBP protein]16675135
C5758943,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide"3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide inhibits the reaction [[HIF1A protein binds to ARNT protein] binds to [EP300 protein binds to CREBBP protein]]"22032632
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]20199942
C4340033-(4-methylphenylsulfonyl)-2-propenenitrileHSPA9 protein promotes the reaction [3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]]20199942
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]"28751236
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREBBP mRNA"27188386
C0275764-hydroxy-2-nonenalCREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]16337876
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased expression of CREBBP mRNA"22745752
C5582435-(5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid5-(5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid inhibits the reaction [rosiglitazone promotes the reaction [PPARG protein binds to CREBBP protein]]21296151
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREBBP mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CREBBP mRNA17562736
D000171AcroleinCREBBP protein inhibits the reaction [Acrolein results in decreased expression of BDNF mRNA]16337876
D000242Cyclic AMPCREBBP protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]20360387
C430898AGN 194204AGN 194204 inhibits the reaction [CREBBP protein binds to EGFR promoter]21080969
C430898AGN 194204CREBBP affects the susceptibility to AGN 19420421080969
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of CDK1 protein]21080969
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of CDK4 protein]21080969
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of EGFR protein]21080969
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of MAPK3 protein]21080969
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of MYC protein]21080969
D000450AldosteroneAldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]19966502
D000450AldosteroneAldosterone results in increased expression of and results in increased localization of CREBBP protein19966502
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IL6 protein results in decreased expression of CREBBP protein]"15378487
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]22258452
D024502alpha-Tocopherolalpha-Tocopherol deficiency results in increased expression of CREBBP mRNA24657723
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CREBBP protein]]"22003094
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CREBBP mRNA16483693
D000728AndrogensCREBBP protein promotes the reaction [Androgens results in increased activity of AR protein]15378487
D000735AndrostenedioneAndrostenedione results in increased activity of CREBBP protein16467117
D000841AnisomycinAnisomycin results in increased expression of CREBBP mRNA24247028
D000068180AripiprazoleAripiprazole results in decreased expression of CREBBP mRNA17868501
D001151ArsenicArsenic affects the methylation of CREBBP gene25304211
D001151ArsenicArsenic results in increased expression of CREBBP mRNA28242323
C006632arsenic trioxidearsenic trioxide promotes the reaction [CREBBP protein binds to CDKN1A promoter]18822310
C006632arsenic trioxidearsenic trioxide promotes the reaction [[CREBBP protein binds to CDKN1A promoter] which results in increased expression of CDKN1A mRNA]18822310
C006632arsenic trioxidearsenic trioxide promotes the reaction [CREBBP protein results in increased expression of VCP mRNA]18822310
C006632arsenic trioxidearsenic trioxide results in decreased expression of CREBBP mRNA24831965
C015001arsenite3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]20199942
C015001arsenitearsenite promotes the reaction [RELA protein binds to CREBBP protein]20199942
C015001arsenitearsenite promotes the reaction [TP53 protein binds to CREBBP protein]20199942
C015001arseniteHSPA9 protein inhibits the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]20199942
C015001arseniteHSPA9 protein promotes the reaction [3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]]20199942
C015001arseniteHSPA9 protein promotes the reaction [arsenite promotes the reaction [RELA protein binds to CREBBP protein]]20199942
C015001arseniteRELA protein inhibits the reaction [arsenite promotes the reaction [TP53 protein binds to CREBBP protein]]20199942
D001241AspirinAspirin results in increased expression of CREBBP mRNA11906190
D001280AtrazineAtrazine results in decreased expression of CREBBP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CREBBP promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CREBBP mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Valproic Acid results in decreased expression of CREBBP protein]27381264
D001599BerberineBerberine results in increased expression of CREBBP mRNA27311644
D004958EstradiolEstradiol affects the expression of CREBBP mRNA23557687
D004958EstradiolCREBBP mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to ESR1 promoter]19620290
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to HOXB9 promoter]27182052
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to HOXC6 promoter]25725483
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to PTGS2 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to TTF1 promoter]19698761
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to CREBBP protein binds to BRCA1 protein]16417649
D004958EstradiolEstradiol promotes the reaction [TNF protein promotes the reaction [CREBBP protein binds to IL6 promoter]]24771768
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D004958EstradiolEstradiol results in decreased expression of CREBBP mRNA20068009
D001629BezafibrateBezafibrate affects the reaction [PPARA protein binds to CREBBP protein]19263263
C053541bicalutamidebicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein]15378487
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CREBBP protein modified form]28751236
C006780bisphenol Abisphenol A affects the expression of CREBBP mRNA23557687
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CREBBP protein modified form]28751236
C006780bisphenol Abisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [CREBBP protein binds to HOTAIR promoter]24533973
C006780bisphenol Abisphenol A promotes the reaction [CREBBP protein binds to HOXB9 promoter]27182052
C006780bisphenol Abisphenol A promotes the reaction [CREBBP protein binds to HOXC6 promoter]25725483
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
C006780bisphenol Abisphenol A affects the methylation of CREBBP promoter27334623
C006780bisphenol Abisphenol A affects the expression of CREBBP mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CREBBP mRNA24247028
D000069286BortezomibBortezomib results in decreased expression of CREBBP mRNA25913414
C018475butyraldehydebutyraldehyde results in decreased expression of CREBBP mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of CREBBP mRNA22687346
C059041calyculin Acalyculin A results in increased phosphorylation of CREBBP protein22142222
D002166CamptothecinCamptothecin inhibits the reaction [RELA protein binds to CREBBP protein]13679428
D002166CamptothecinCamptothecin promotes the reaction [TP53 protein binds to CREBBP protein]13679428
D002166Camptothecinpifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]13679428
D002166Camptothecinpifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]13679428
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CREBBP mRNA18395914
D002251Carbon Tetrachlorideoxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA]18395914
D002509CephaloridineCephaloridine results in decreased expression of CREBBP mRNA18500788
C084597chlorcyclizinechlorcyclizine results in decreased expression of CREBBP mRNA21058326
D002737ChloropreneChloroprene results in decreased expression of CREBBP mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CREBBP gene20938992
D002857ChromiumChromium affects the reaction [JUN protein binds to CREBBP protein]10593907
D002857ChromiumChromium inhibits the reaction [RELA protein binds to CREBBP protein]10593907
C039671ciglitazoneciglitazone inhibits the reaction [CREBBP protein binds to EGFR promoter]21080969
C039671ciglitazoneCREBBP affects the susceptibility to ciglitazone21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]]11278336
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of CDK1 protein]21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein]21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of EGFR protein]21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of MAPK3 protein]21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of MYC protein]21080969
D002994ClofibrateClofibrate inhibits the reaction [CREBBP protein binds to EGFR promoter]21080969
D002994ClofibrateCREBBP affects the susceptibility to Clofibrate21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of CDK1 protein]21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of CDK4 protein]21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of EGFR protein]21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of MAPK3 protein]21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of MYC protein]21080969
C018021cobaltous chloride[cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]]15735682
D003042CocaineCocaine results in increased expression of CREBBP mRNA17898221
D005576ColforsinColforsin promotes the reaction [GCM1 protein binds to CREBBP protein]16166624
D005576ColforsinCREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]16166624
D003300CopperCopper results in decreased expression of CREBBP mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of CREBBP mRNA19549813
D003345Corticosterone"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]"22850435
D003345CorticosteroneCorticosterone results in decreased expression of CREBBP protein22850435
D003345Corticosterone"KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]]"22850435
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]22258452
D003474CurcuminCurcumin results in decreased expression of CREBBP18462866
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]28751236
D017373Cyproterone Acetate[Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]15308689
D017373Cyproterone Acetate[Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter]15308689
D003634DDTDDT results in increased activity of CREBBP protein22609851
C014347decitabinedecitabine results in decreased expression of CREBBP mRNA27915011
C007262deoxynivalenoldeoxynivalenol results in increased expression of CREBBP mRNA24247028
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CREBBP mRNA21266533
D003994BucladesineBucladesine promotes the reaction [CREBBP protein binds to SOD2 promoter]20685861
D003994Bucladesine[Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter]19282384
D003994BucladesineCREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]]19282384
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CREBBP mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CREBBP mRNA27514524
D002945CisplatinCisplatin results in decreased expression of CREBBP mRNA27594783
D002945CisplatinCisplatin results in decreased expression of CREBBP protein17498666
D003632DichlorodiphenyldichloroethaneDichlorodiphenyldichloroethane results in increased activity of CREBBP protein22609851
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of CREBBP protein22609851|2758988
C000944dicrotophosdicrotophos results in increased expression of CREBBP mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CREBBP mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [CREBBP protein binds to HOTAIR promoter]24533973
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D002117CalcitriolCalcitriol affects the localization of CREBBP protein15647825
D002117CalcitriolCalcitriol promotes the reaction [CREBBP protein binds to CYP24A1 promoter]15647825
D002117CalcitriolCalcitriol promotes the reaction [CREBBP protein binds to SPP1 promoter]15647825
C024629dimethyl phthalatedimethyl phthalate affects the expression of CREBBP mRNA26924002
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of CREBBP mRNA28939011
D004237DiuronDiuron results in decreased expression of CREBBP mRNA21551480
D004317DoxorubicinDoxorubicin promotes the reaction [CREBBP protein binds to ESR1 promoter]19351845
D004317DoxorubicinDoxorubicin promotes the reaction [TP53 protein binds to CREBBP protein]19351845
D004317DoxorubicinDoxorubicin results in decreased expression of CREBBP protein17498666
D004317DoxorubicinDoxorubicin results in decreased expression of CREBBP mRNA28865727
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [CREBBP protein binds to KRT19 promoter]"17095596
D004533Egtazic AcidEgtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]21443188
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in decreased expression of CREBBP mRNA"15919760
D000431EthanolEthanol results in decreased expression of CREBBP mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of CREBBP mRNA]"20655511
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of CREBBP mRNA22213190
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CREBBP gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CREBBP mRNA20655997
C069837fullerene C60fullerene C60 results in decreased expression of CREBBP mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]24771768
C070081fulvestrantfulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]18511507
D005839GentamicinsGentamicins results in increased expression of CREBBP mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CREBBP mRNA22634610
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CREBBP mRNA24349266
D012978Sodium Oxybate(3-(1-((3-(cyclohexylmethyl)hydroxyphosphinyl)-2-hydroxypropyl)amino)ethyl)benzoic acid inhibits the reaction [Sodium Oxybate results in increased phosphorylation of CREBBP protein]16675135
D012978Sodium OxybateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Oxybate results in increased phosphorylation of CREBBP protein]16675135
D012978Sodium OxybateSodium Oxybate results in increased phosphorylation of CREBBP protein16675135
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREBBP mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of CREBBP mRNA18927307
C051890irinotecanirinotecan metabolite results in decreased expression of CREBBP mRNA15956246
C051890irinotecanirinotecan results in decreased expression of CREBBP mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CREBBP mRNA27392435
C073601KT 5823"KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]]"22850435
C045463leflunomideleflunomide results in increased expression of CREBBP mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CREBBP mRNA"24972896
D008070Lipopolysaccharides"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CREBBP protein]]"22003094
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [RELA protein binds to CREBBP protein]22003094
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CREBBP mRNA15919760|1684731
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CREBBP mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate promotes the reaction [CREBBP protein binds to SOD2 promoter]20685861
D008627Mercuric ChlorideMercuric Chloride affects the expression of CREBBP mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CREBBP gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CREBBP mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CREBBP mRNA20864626
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CREBBP mRNA"26251327
D015741Metribolonebicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein]15378487
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]28751236
D015741MetriboloneMetribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]11981028
D015741MetriboloneMetribolone results in decreased expression of CREBBP mRNA15378487
D015741MetriboloneMetribolone results in decreased expression of CREBBP protein15378487
C517398MF101 extractMF101 extract promotes the reaction [CREBBP protein binds to KRT19 promoter]17095596
D015735Mifepristone[Mifepristone binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]15308689
D015735Mifepristone[Mifepristone binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter]15308689
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CREBBP mRNA26924002
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Oxybate results in increased phosphorylation of CREBBP protein]16675135
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CREBBP mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of CREBBP mRNA19167457
D009534NiclosamideNiclosamide results in increased expression of CREBBP mRNA22576131
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of CREBBP mRNA]"20655511
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein]"16579968
D019787Linoleic AcidLinoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]19263263
D019301Oleic AcidOleic Acid results in decreased expression of CREBBP mRNA24349266
D019319Okadaic AcidOkadaic Acid results in increased expression of CREBBP mRNA28939011
D019319Okadaic AcidOkadaic Acid results in increased phosphorylation of CREBBP protein16059639
C016340o,p'-DDT"o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]"22609851
C016340o,p'-DDT"o,p'-DDT results in increased activity of CREBBP protein"22609851
C016340o,p'-DDT"SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of CREBBP protein]"22609851
D008939MitotaneMitotane results in increased activity of CREBBP protein22609851
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CREBBP mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of CREBBP mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of CREBBP mRNA]22629407
C037573oxymatrineoxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA]18395914
D010269ParaquatParaquat results in decreased expression of CREBBP mRNA28619522
D010269ParaquatParaquat results in increased expression of CREBBP protein20478973
C551803PCI 32765CREBBP protein mutant form results in decreased susceptibility to PCI 3276526254443
D010634PhenobarbitalPhenobarbital affects the expression of CREBBP mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of CREBBP mRNA23091169
D010656PhenylephrineCREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]11705990
D010656PhenylephrineCREBBP protein results in increased susceptibility to Phenylephrine12477714
D010656PhenylephrinePhenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]15522277
D010656PhenylephrinePhenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]19966502
D010656Phenylephrine[Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein12477714
D010656PhenylephrinePhenylephrine results in increased expression of and results in increased localization of CREBBP protein19966502
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein15006641
D010656Phenylephrine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
D010656PhenylephrineMAPK1 protein promotes the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
D010656PhenylephrinePhenylephrine results in increased expression of CREBBP mRNA11705990
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
D010695PhlorhizinPhlorhizin results in decreased expression of CREBBP mRNA22538082
C121565pifithrinpifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]13679428
C121565pifithrinpifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]13679428
C121565pifithrinpifithrin promotes the reaction [RELA protein binds to CREBBP protein]13679428
C006253pirinixic acidpirinixic acid affects the reaction [PPARA protein binds to CREBBP protein]19263263
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of CREBBP mRNA]11705990
C045950propiconazolepropiconazole results in decreased expression of CREBBP mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of CREBBP mRNA26079696
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CREBBP mRNA27514524
D011794QuercetinQuercetin results in decreased expression of CREBBP protein15580028
D011794QuercetinQuercetin results in increased expression of CREBBP mRNA14715546
D011794QuercetinQuercetin inhibits the reaction [CREBBP protein binds to CXCL10 promoter]21857970
D011794QuercetinQuercetin inhibits the reaction [CREBBP protein binds to CXCL2 promoter]21857970
D011794QuercetinQuercetin inhibits the reaction [TNF protein promotes the reaction [CREBBP protein binds to CXCL10 promoter]]17449583
D011794QuercetinQuercetin inhibits the reaction [TNF protein promotes the reaction [CREBBP protein binds to CXCL2 promoter]]17449583
D011794QuercetinQuercetin affects the activity of CREBBP modified form19423323
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [CREBBP protein binds to PTGS2 promoter]17872375
C059514resveratrolBCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to CREBBP protein]]19631782
C059514resveratrolCREBBP mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
C059514resveratrolfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]24771768
C059514resveratrolresveratrol promotes the reaction [PML protein binds to CREBBP protein]19631782
C059514resveratrolresveratrol promotes the reaction [TNF protein promotes the reaction [CREBBP protein binds to IL6 promoter]]24771768
C059514resveratrolresveratrol promotes the reaction [TP53 protein binds to PML protein binds to CREBBP protein]19631782
C059514resveratrolresveratrol results in increased expression of CREBBP mRNA15149879
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to RELA protein]]16474181
C059514resveratrolresveratrol inhibits the reaction [CREBBP protein results in increased acetylation of FOXO1 protein]19740748
C089730rosiglitazone5-(5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid inhibits the reaction [rosiglitazone promotes the reaction [PPARG protein binds to CREBBP protein]]21296151
C089730rosiglitazonerosiglitazone promotes the reaction [PPARG protein binds to CREBBP protein]21296151
D012402RotenoneRotenone results in increased expression of CREBBP mRNA21536665
C093642SB 203580"SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of CREBBP protein]"22609851
D012643SeleniumSelenium results in decreased expression of CREBBP mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of CREBBP mRNA12377979
C017947sodium arsenitesodium arsenite results in increased expression of CREBBP mRNA19822182
D012999SomanSoman results in decreased expression of CREBBP mRNA19281266
D013311StreptozocinStreptozocin results in decreased expression of CREBBP mRNA25905778
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CREBBP mRNA26378955
D013739TestosteroneTestosterone results in increased expression of CREBBP mRNA21880219
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CREBBP protein binds to CYP1A1 promoter]15964790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CREBBP mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CREBBP promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CREBBP mRNA19465110
D013755Tetradecanoylphorbol AcetateCREBBP protein inhibits the reaction [ciglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]]11278336
D013755Tetradecanoylphorbol AcetateCREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]]19282384
D013755Tetradecanoylphorbol AcetatePRKD1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to STAR promoter]]21047949
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to RELA protein]]16474181
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter]19282384
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to RELA protein]16474181
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to STAR promoter]21047949
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREBBP mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of CREBBP mRNA24247028
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CREBBP mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CREBBP mRNA25729387
D014212TretinoinTretinoin inhibits the reaction [[CREBBP protein binds to MAPK3 promoter] which affects the expression of MAPK3 mRNA]16050810
D014212TretinoinTretinoin promotes the reaction [CREBBP protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin promotes the reaction [CREBBP protein binds to PDK4 promoter]16757381
D014212TretinoinTretinoin promotes the reaction [CREBBP protein binds to RARA protein]16417649
D014212TretinoinTretinoin results in increased expression of CREBBP mRNA28053092
D014212TretinoinTretinoin inhibits the reaction [CREBBP protein binds to RETN promoter]15047602
C012589trichostatin Atrichostatin A promotes the reaction [CREBBP protein binds to PDK4 promoter]16757381
C057693troglitazoneRXRA protein inhibits the reaction [CREBBP protein results in increased susceptibility to troglitazone]15581905
C057693troglitazonetroglitazone results in decreased expression of CREBBP mRNA28973697
C057693troglitazoneCREBBP protein results in increased susceptibility to troglitazone15581905
D014520UrethaneUrethane results in increased expression of CREBBP mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CREBBP mRNA19493473
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREBBP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CREBBP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CREBBP mRNA19101580|2208335
D014635Valproic AcidValproic Acid results in decreased methylation of CREBBP gene28853863
D014635Valproic AcidValproic Acid results in increased methylation of CREBBP gene29154799
D014635Valproic Acidbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Valproic Acid results in decreased expression of CREBBP protein]27381264
D014635Valproic AcidValproic Acid results in decreased expression of CREBBP mRNA19136453|2738126
D014635Valproic AcidValproic Acid results in decreased expression of CREBBP protein27381264
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CREBBP gene25560391
D014750VincristineVincristine results in increased expression of CREBBP mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of CREBBP mRNA19244175
C111237vorinostatvorinostat promotes the reaction [PML protein binds to CREBBP protein]19631782
C111237vorinostatvorinostat promotes the reaction [TP53 protein binds to PML protein binds to CREBBP protein]19631782
D015032ZincZinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]18458062

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000987proximal promoter sequence-specific DNA binding-IDA21539536  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21539536  
GO:0001085RNA polymerase II transcription factor binding-IPI21539536  
GO:0001102RNA polymerase II activating transcription factor binding-TAS11001584  
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-IDA21539536  
GO:0002039p53 binding-IPI9194565  
GO:0003682chromatin binding-IDA24939902  
GO:0003684damaged DNA binding-IDA24939902  
GO:0003700DNA-binding transcription factor activity-TAS7913207  
GO:0003713transcription coactivator activity-IDA12169688  12435739  12586840  12929931  14645221  
GO:0003713transcription coactivator activity-IPI8684459  
GO:0003713transcription coactivator activity-TAS10362258  11001584  
GO:0004402histone acetyltransferase activity-IDA11742995  
GO:0004402histone acetyltransferase activity-TAS10362258  
GO:0005515protein binding-IPI8684459  9018065  9194564  9323138  9687513  9811832  
9887100  10049825  10196247  10347196  10428834  10487758  
10722728  10722738  10823891  10866662  11113179  11438528  
11568182  11799127  11897665  11940655  11971985  12435739  
12482968  14645221  14716005  15075319  15126506  15220471  
15273251  15674325  16043483  16154084  16291753  16611888  
16799563  17075044  17362989  17382325  17476304  17500595  
17923090  18309294  18316612  18836453  19234109  19805293  
20541699  20541704  20581830  21602890  21670263  21751375  
21903422  23273993  23434580  23441852  23746807  24361270  
24939902  25241761  25314079  25609649  
GO:0008134transcription factor binding-IPI15509593  
GO:0008270zinc ion binding-IEA-  
GO:0016407acetyltransferase activity-EXP12456660  16135789  
GO:0016407acetyltransferase activity-IDA11742995  15273251  24939902  
GO:0034212peptide N-acetyltransferase activity-TAS-  
GO:0043426MRF binding-IDA8621548  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA21539536  
GO:0001666response to hypoxia-TAS15261140  
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0006355regulation of transcription, DNA-templated-IDA12169688  
GO:0006355regulation of transcription, DNA-templated-TAS15261140  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006473protein acetylation-IDA15273251  24939902  
GO:0006473protein acetylation-TAS28386764  
GO:0007165signal transduction-NAS15261140  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0008589regulation of smoothened signaling pathway-TAS11001584  
GO:0016032viral process-IEA-  
GO:0016573histone acetylation-IDA11742995  
GO:0018076N-terminal peptidyl-lysine acetylation-IDA12435739  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0031648protein destabilization-IMP24939902  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0034644cellular response to UV-IDA24939902  
GO:0042592homeostatic process-NAS15261140  
GO:0042733embryonic digit morphogenesis-TAS11001584  
GO:0042981regulation of apoptotic process-TAS-  
GO:0045637regulation of myeloid cell differentiation-TAS-  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA11742995  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048511rhythmic process-IEA-  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0065003protein-containing complex assembly-TAS7913207  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IEA-  
GO:0000790nuclear chromatin-IDA21539536  
GO:0005634nucleus-IC12169688  
GO:0005634nucleus-IDA12929931  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12929931  
GO:0016604nuclear body-IDA15488321  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04350TGF-beta signaling pathway
hsa04520Adherens junction
hsa04630Jak-STAT signaling pathway
hsa04720Long-term potentiation
hsa04916Melanogenesis
hsa05016Huntington's disease
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1234158Regulation of gene expression by Hypoxia-inducible FactorTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-3134973LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionTAS
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371568Attenuation phaseTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-4839726Chromatin organizationIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5621575CD209 (DC-SIGN) signalingTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsTAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25839328Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)Zhang LAm J Hum Genet
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology