Gene: ATF6B

1388
CREB-RP|CREBL1|G13
activating transcription factor 6 beta
protein-coding
6p21.32
Ensembl:ENSG00000213676 MIM:600984 Vega:OTTHUMG00000031296 UniprotKB:Q99941
NG_033940.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04821129chr6:32084658ATF6BGene body2.305e-5Alcohol use disorders26763658
cg21834063chr6:32085541ATF6BGene body7.863e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMUB20.928
PBX20.922
HECTD30.922
GANAB0.922
SIDT20.92
SH2B10.919
NLGN20.919
INTS30.918
VPS390.918
CALCOCO10.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.734
OR4F29-0.688
MTRNR2L6-0.323
MTRNR2L9-0.315
MTRNR2L10-0.272
OR6C74-0.27
TFPI2-0.251
C9orf153-0.25
KLRC2-0.245
PPBP-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein]"28181380
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of ATF6B protein"28181380
D000082AcetaminophenAcetaminophen results in decreased expression of ATF6B mRNA29067470
D000393Air PollutantsAir Pollutants analog results in decreased expression of ATF6B mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ATF6B mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of ATF6B mRNA19774075
D001104ArbutinArbutin results in decreased expression of ATF6B mRNA17103032
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF6B protein25258189
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATF6B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATF6B mRNA22300585
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of ATF6B mRNA"20162321
C006780bisphenol Abisphenol A affects the methylation of ATF6B promoter27334623
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ATF6B promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATF6B mRNA27339419
D000068579CelecoxibCelecoxib results in increased expression of ATF6B mRNA28201806
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF6B gene20938992
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATF6B mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ATF6B mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ATF6B mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of ATF6B mRNA25016146
C017875fisetin"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein]"28181380
C017875fisetinfisetin results in increased expression of ATF6B protein28181380
D005492Folic AcidFolic Acid affects the expression of ATF6B mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF6B gene20938992
D017313FenretinideFenretinide results in decreased expression of ATF6B mRNA16467112
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ATF6B mRNA27392435
C544151jinfukangjinfukang results in increased expression of ATF6B mRNA27392435
C011890kojic acidkojic acid results in decreased expression of ATF6B mRNA16595896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ATF6B gene20938992
D008727MethotrexateMethotrexate results in increased expression of ATF6B mRNA24449571
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of ATF6B mRNA16467112
C028007nickel monoxidenickel monoxide results in increased expression of ATF6B mRNA19167457
C010615Nonidet P-40Nonidet P-40 results in increased expression of ATF6B mRNA26552463
D010126OzoneOzone results in increased expression of ATF6B mRNA27206323
D010126OzoneOzone results in decreased expression of ATF6B mRNA12763052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ATF6B mRNA19710929
C031280pyrazolepyrazole results in increased expression of ATF6B mRNA17945193
D013739TestosteroneTestosterone results in decreased expression of ATF6B mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATF6B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATF6B mRNA24058054
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ATF6B gene27618143
C001899triptolidetriptolide results in decreased expression of ATF6B protein26990902
D014635Valproic AcidValproic Acid results in decreased methylation of ATF6B gene29154799
D014635Valproic AcidValproic Acid affects the expression of ATF6B mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ATF6B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ATF6B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toIDA11256944  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toIC-  
GO:0003700DNA-binding transcription factor activity-IDA11256944  
GO:0005515protein binding-IPI12445808  
GO:0035497cAMP response element binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IDA11256944  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-TAS8586413  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007165signal transduction-TAS8586413  
GO:0036500ATF6-mediated unfolded protein response-TAS22013210  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14973138  
GO:1903892negative regulation of ATF6-mediated unfolded protein response-IDA9837962  
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-IDA11256944  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA8870652  
GO:0005634nucleus-IDA11256944  
GO:0005730nucleolus-IDA-  
GO:0005789endoplasmic reticulum membrane-IDA11256944  
GO:0005794Golgi apparatus-TAS22013210  
GO:0030176integral component of endoplasmic reticulum membrane-NAS11256944  
GO:0030176integral component of endoplasmic reticulum membrane-TAS22013210  
GO:0032993protein-DNA complex-IDA11256944  
GO:0090575RNA polymerase II transcription factor complex-IDA11256944  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29459183Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018 Apr)Nikodemova MEnviron Int