Gene info: ID 1390

Gene: CREM

GENE ID: 1390

Synonyms: CREM-2|ICER|hCREM-2

Description: cAMP responsive element modulator

Gene type: protein-coding

Location: 10p11.21

dbXrefs: Ensembl:ENSG00000095794 MIM:123812 Vega:OTTHUMG00000017953 UniprotKB:Q03060

RefSeq: NG_029065.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.507e-1 (AD) 5.670e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14656043	chr10:35419996	CREM		9.100e-16	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NXT1	0.808
CD63	0.794
SAT1	0.794
UBE2L6	0.793
SEC61B	0.785
TSEN34	0.785
ARFGAP3	0.782
EIF4A1	0.781
PSME1	0.78
PFN1	0.779

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.552
OR4F29	-0.522
ATP12A	-0.233
PCDHAC1	-0.22
CALHM1	-0.217
NEUROD6	-0.214
PKD2L1	-0.212
ADTRP	-0.21
LRRC38	-0.209
EDN3	-0.207

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of CREM mRNA	23792671
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CREM mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CREM mRNA"	23829299
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CREM mRNA"	28433925
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CREM mRNA"	21346803
C518576	2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate	"2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of CREM mRNA"	17327690
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CREM protein alternative form"	16081525
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREM mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREM mRNA"	27188386
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of CREM mRNA	19371601
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREM mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREM mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of CREM mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of CREM mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CREM mRNA]	25381014
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CREM gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CREM mRNA	19770486
D000638	Amiodarone	Amiodarone affects the expression of CREM mRNA	18355885\|1948338
D000639	Amitriptyline	Amitriptyline affects the expression of CREM mRNA	18355885
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CREM mRNA	16483693
C018453	ammonium hexachloroplatinate	ammonium hexachloroplatinate results in increased expression of CREM mRNA	19371601
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of CREM mRNA	12558987\|1919437
D000661	Amphetamine	CREM protein results in increased susceptibility to Amphetamine	16899718
D000661	Amphetamine	Amphetamine results in increased expression of CREM mRNA	16899718
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CREM mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of CREM mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CREM mRNA	20458559
D001374	Azacitidine	Azacitidine results in decreased expression of CREM mRNA	20823114
C028559	bathocuproine sulfonate	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D001553	Benzbromarone	Benzbromarone affects the expression of CREM mRNA	19483382
D001554	Benzene	Benzene results in increased expression of CREM mRNA	15929907
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CREM mRNA	26377693
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of CREM mRNA	19737606
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CREM mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of CREM mRNA	22641617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CREM mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CREM mRNA	20823114
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in increased expression of CREM mRNA	24758408
D004958	Estradiol	Estradiol results in decreased expression of CREM mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of CREM mRNA	20106945
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of CREM mRNA	18192240
D001629	Bezafibrate	Bezafibrate results in decreased expression of CREM mRNA	18787029
C006780	bisphenol A	bisphenol A results in decreased expression of CREM mRNA	29275510
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CREM mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of CREM mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of CREM mRNA	17553608
D000069286	Bortezomib	Bortezomib results in increased expression of CREM mRNA	20977926
D002065	Buspirone	Buspirone results in decreased expression of CREM mRNA	24136188
D002104	Cadmium	Cadmium results in increased expression of CREM mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CREM mRNA	25993096
D002235	Carbofuran	Carbofuran results in increased expression of CREM mRNA	20211217
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of CREM mRNA	27188386
C418118	CI 1044	CI 1044 results in increased expression of CREM mRNA	17569694
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of CREM mRNA	19524605
D002994	Clofibrate	Clofibrate affects the expression of CREM mRNA	19483382
D002997	Clomipramine	Clomipramine affects the expression of CREM mRNA	18355885
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CREM mRNA	19376846
D003042	Cocaine	Cocaine affects the expression of CREM mRNA	18355967
D003042	Cocaine	Cocaine results in increased expression of CREM mRNA	27899881
D005576	Colforsin	Colforsin results in increased expression of CREM mRNA	12791704
D005576	Colforsin	Colforsin results in increased expression of CREM mRNA alternative form	8810303
D005576	Colforsin	Colforsin results in increased expression of CREM protein	8810303
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of CREM mRNA	20971185
C030973	cupric oxide	cupric oxide results in increased expression of CREM mRNA	22077320
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of CREM mRNA	17624719
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of CREM protein	17624719
D003520	Cyclophosphamide	"Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]"	17624719
D003520	Cyclophosphamide	"Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]"	17624719
D016572	Cyclosporine	Cyclosporine results in increased expression of CREM mRNA	20106945\|2798913
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CREM mRNA	23640034
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CREM mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CREM mRNA	21266533
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CREM mRNA	20823114
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased activity of CREM protein	27589886
D004041	Dietary Fats	Dietary Fats affects the expression of CREM mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of CREM mRNA	18042831
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CREM mRNA"	28433925
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CREM mRNA	18164116
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CREM mRNA	17374397\|1937160
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of CREM mRNA	21362464
D004280	Dobutamine	CREM protein affects the susceptibility to Dobutamine	12475904
D004317	Doxorubicin	Doxorubicin results in increased expression of CREM mRNA	20211217
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]"	17624719
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]"	17624719
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CREM mRNA	20064776
D000431	Ethanol	Ethanol results in increased expression of CREM mRNA	15353170\|1609850
D005001	Ethionine	Ethionine affects the expression of CREM mRNA	19483382
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of CREM mRNA	28973639
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of CREM protein	28973639
D005047	Etoposide	CREM protein affects the susceptibility to Etoposide	16217747
D005054	Eugenol	Eugenol results in increased expression of CREM mRNA	17374397
C039281	furan	furan results in decreased expression of CREM mRNA	26194646
C039281	furan	furan results in increased methylation of CREM gene	22079235
D005897	Glafenine	Glafenine results in decreased expression of CREM mRNA	24136188
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CREM mRNA]	25381014
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CREM mRNA	25381014
D007099	Imipramine	Imipramine affects the expression of CREM mRNA	18355885
D015759	Ionomycin	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D015759	Ionomycin	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA	15477007
D007545	Isoproterenol	CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]	12791704
D007545	Isoproterenol	CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]	12791704
D007545	Isoproterenol	CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]	12791704
D007545	Isoproterenol	Isoproterenol affects the localization of CREM protein	12791704
D007545	Isoproterenol	Isoproterenol results in increased expression of CREM mRNA	12791704\|2021121
D007545	Isoproterenol	Isoproterenol results in increased expression of CREM protein	12791704
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of CREM mRNA	17085751
D007654	Ketoconazole	Ketoconazole affects the expression of CREM mRNA	18355885
C045463	leflunomide	leflunomide results in decreased expression of CREM mRNA	24136188
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CREM mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA]	16415329
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CREM mRNA	20823114
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CREM mRNA	16507785
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of CREM mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of CREM mRNA	19564919
D008727	Methotrexate	Methotrexate results in decreased expression of CREM mRNA	24449571
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of CREM mRNA	28392392
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CREM mRNA"	26251327
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of CREM mRNA	17412507
C002373	monobutyryl cyclic AMP	CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased activity of HIF1A protein]	25381014
C002373	monobutyryl cyclic AMP	CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of IRS2 mRNA]	25381014
C002373	monobutyryl cyclic AMP	CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of NR4A2 mRNA]	25381014
C002373	monobutyryl cyclic AMP	CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of PPARGC1A mRNA]	25381014
C002373	monobutyryl cyclic AMP	CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of VEGFA protein]	25381014
C002373	monobutyryl cyclic AMP	CREM protein results in decreased susceptibility to monobutyryl cyclic AMP	25381014
C002373	monobutyryl cyclic AMP	monobutyryl cyclic AMP results in increased expression of CREM mRNA	25381014
D009020	Morphine	Morphine results in increased expression of CREM mRNA	22454534
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CREM mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CREM mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of CREM mRNA	24136188
D009532	Nickel	Nickel affects the expression of CREM mRNA	14575637
D009532	Nickel	Nickel results in increased expression of CREM mRNA	24768652
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of CREM mRNA]	14575637
C029938	nickel sulfate	nickel sulfate results in increased expression of CREM mRNA	16780908\|1737439
C012655	nimesulide	nimesulide results in decreased expression of CREM mRNA	24136188
D009638	Norepinephrine	Norepinephrine results in increased expression of CREM mRNA	11171092
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of CREM mRNA	20971185
D009853	Omeprazole	Omeprazole affects the expression of CREM mRNA	19483382
C507134	ON 01910	ON 01910 results in increased expression of CREM mRNA	22351695
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CREM mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of CREM mRNA	17374397
D000073878	Palm Oil	Palm Oil affects the expression of CREM mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of CREM mRNA	18042831
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of CREM mRNA	18593933
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of CREM mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CREM mRNA	25868421
D010634	Phenobarbital	Phenobarbital affects the expression of CREM mRNA	23091169
D010634	Phenobarbital	Phenobarbital affects the expression of CREM mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of CREM mRNA	12791704\|1815835
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREM mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of CREM mRNA	26272509
C018637	phorone	phorone affects the expression of CREM mRNA	18198479
C006253	pirinixic acid	pirinixic acid results in increased expression of CREM mRNA	20813756
C006253	pirinixic acid	pirinixic acid affects the expression of CREM mRNA	19483382
D010938	Plant Oils	Plant Oils results in increased expression of CREM mRNA	23370395
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of CREM mRNA	23608068
D011374	Progesterone	Progesterone results in decreased expression of CREM mRNA	19690047
C045950	propiconazole	propiconazole results in decreased expression of CREM mRNA	19423681
D011441	Propylthiouracil	Propylthiouracil affects the expression of CREM mRNA	19483382
C020972	pyrrolidine dithiocarbamic acid	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA]	16415329
D012110	Reserpine	Reserpine promotes the reaction [CREM protein binds to TH promoter]	11438978
D012110	Reserpine	Reserpine results in increased expression of CREM mRNA alternative form	8810303
D012110	Reserpine	Reserpine results in increased expression of CREM protein	8810303
D012110	Reserpine	Reserpine results in increased expression of CREM protein alternative form	11438978
C059514	resveratrol	resveratrol results in decreased expression of CREM mRNA	25905778
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of CREM mRNA	19564919
C009250	sevoflurane	sevoflurane affects the expression of CREM mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CREM mRNA	19073995
C017947	sodium arsenite	sodium arsenite affects the methylation of CREM gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of and results in increased activity of CREM protein alternative form	14523996
C016104	sodium bichromate	sodium bichromate results in decreased expression of CREM mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CREM protein	28918527
D012999	Soman	Soman results in increased expression of CREM mRNA	19281266
C446685	systhane	systhane results in decreased expression of CREM mRNA	19423681
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of CREM mRNA	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CREM mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CREM mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CREM mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D013755	Tetradecanoylphorbol Acetate	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]	15477007
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA	15477007
D013853	Thioacetamide	Thioacetamide affects the expression of CREM mRNA	19483382
D013893	Thiram	Thiram results in increased expression of CREM mRNA	19371601
C009495	titanium dioxide	titanium dioxide results in decreased expression of CREM mRNA	23557971
C066340	tolcapone	tolcapone results in decreased expression of CREM mRNA	24136188
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CREM mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of CREM mRNA	19164467\|2322803
C032910	triadimefon	triadimefon results in decreased expression of CREM mRNA	19423681
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of CREM mRNA	17905399
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREM mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of CREM mRNA	28542535
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of CREM mRNA]	14575637
C012589	trichostatin A	trichostatin A results in decreased expression of CREM mRNA	26272509
C012589	trichostatin A	trichostatin A results in increased expression of CREM mRNA	27188386
C001899	triptolide	triptolide results in decreased expression of CREM mRNA	23639586
C406224	valdecoxib	valdecoxib results in decreased expression of CREM mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of CREM mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CREM gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CREM mRNA	23179753\|2915479
D000068756	Valsartan	Valsartan results in decreased expression of CREM mRNA	19027736
D014640	Vancomycin	Vancomycin results in decreased expression of CREM mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CREM gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of CREM mRNA	19015723
C111237	vorinostat	vorinostat results in increased expression of CREM mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of CREM mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	16899810
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IC	-
GO:0003677	DNA binding	-	NAS	7916662
GO:0005515	protein binding	-	IPI	21976679
GO:0008140	cAMP response element binding protein binding	-	NAS	8206879

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	12626549
GO:0006006	glucose metabolic process	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IDA	8206879
GO:0006355	regulation of transcription, DNA-templated	-	NAS	7916662
GO:0006631	fatty acid metabolic process	-	IEA	-
GO:0006687	glycosphingolipid metabolic process	-	IEA	-
GO:0007165	signal transduction	-	TAS	7916662
GO:0007275	multicellular organism development	-	IEA	-
GO:0007283	spermatogenesis	-	IEA	-
GO:0030154	cell differentiation	-	IEA	-
GO:0042752	regulation of circadian rhythm	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048384	retinoic acid receptor signaling pathway	-	IEA	-
GO:0048511	rhythmic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	NAS	8206879
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0005667	transcription factor complex	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-400253	Circadian Clock	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12670709	Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. (2003 Apr 10)	Ammon S	Brain Res Mol Brain Res