Gene info: ID 1392

Gene: CRH

GENE ID: 1392

Synonyms: CRF|CRH1

Description: corticotropin releasing hormone

Gene type: protein-coding

Location: 8q13.1

dbXrefs: Ensembl:ENSG00000147571 MIM:122560 Vega:OTTHUMG00000164474 UniprotKB:P06850

RefSeq: NG_016127.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 66

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.535e-1 (AD) 9.658e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SST	0.818
DLX1	0.795
PNOC	0.77
VIP	0.758
VWC2	0.758
VGF	0.748
SMIM18	0.745
GAD2	0.738
ELFN1	0.729
ST8SIA2	0.726

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CP	-0.616
CDA	-0.575
SLC52A3	-0.573
RGL3	-0.564
IL4R	-0.561
NID1	-0.559
CFH	-0.552
PLA1A	-0.55
OSMR	-0.549
PARP4	-0.545

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01285	Corticotropin	BiotechDrug	12427-33-7	Approved\|Investigational	Target
DB02556	D-Phenylalanine	Small Molecule	673-06-3	Experimental	Target
DB02952	Alpha-Aminoisobutyric Acid	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA"	28189027
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH protein"	28189027
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C511295	2,2',4,4'-tetrabromodiphenyl ether	"bisindolylmaleimide inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C511295	2,2',4,4'-tetrabromodiphenyl ether	"pyrazolanthrone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C511295	2,2',4,4'-tetrabromodiphenyl ether	"SB 203580 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aflatoxin B1 results in increased expression of CRH mRNA]	26026912
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zeranol results in increased expression of CRH mRNA]	23538034
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]	21959975
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH protein]	21959975
C471210	2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine	"2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine inhibits the reaction [CRH protein results in increased secretion of Testosterone]"	23133512
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CRH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CRH mRNA"	27188386
C001969	acephate	acephate promotes the reaction [FOS protein binds to CRH promoter]	12039681
C001969	acephate	acephate results in increased expression of CRH mRNA	12039681
C001969	acephate	acephate results in increased secretion of CRH protein	12039681
C001969	acephate	Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
C001969	acephate	Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
C001969	acephate	gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
C001969	acephate	gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
C001969	acephate	Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
C001969	acephate	Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
D000109	Acetylcholine	Acetylcholine results in increased expression of CRH mRNA	7588217
D000242	Cyclic AMP	[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP	20702571
D000242	Cyclic AMP	Progesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]	20702571
D000242	Cyclic AMP	CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [[Cholera Toxin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [Cholera Toxin results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [[LHB protein co-treated with Guanylyl Imidodiphosphate] results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [LHB protein results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP]	2153673
D000242	Cyclic AMP	Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]	2153673
D000242	Cyclic AMP	Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]	2153673
D000324	Adrenocorticotropic Hormone	Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
D000324	Adrenocorticotropic Hormone	Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]	18835572
D000324	Adrenocorticotropic Hormone	CRH protein results in increased secretion of Adrenocorticotropic Hormone	18835572
D000324	Adrenocorticotropic Hormone	E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
D000324	Adrenocorticotropic Hormone	Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]	18835572
D016604	Aflatoxin B1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aflatoxin B1 results in increased expression of CRH mRNA]	26026912
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CRH gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CRH mRNA	26026912
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CRH protein	26026912
D016604	Aflatoxin B1	bisindolylmaleimide I inhibits the reaction [Aflatoxin B1 results in increased expression of CRH mRNA]	26026912
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CRH mRNA	26968497
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CRH protein	26968497
D000525	Alprazolam	Alprazolam results in decreased activity of CRH protein	7883836
C010845	aluminum chloride	aluminum chloride results in increased expression of CRH protein	27476752
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CRH mRNA	16483693
D000661	Amphetamine	Amphetamine affects the expression of CRH protein	15238432
C103016	antalarmin	antalarmin affects the reaction [CRH protein results in increased abundance of Hydrocortisone]	14997174
C103016	antalarmin	antalarmin affects the reaction [CRH protein results in increased expression of POMC protein alternative form]	14997174
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CRH mRNA	15761015
D016589	Astemizole	Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
C120841	astressin B	astressin B inhibits the reaction [CRH protein results in increased abundance of Hydrocortisone]	14997174
C120841	astressin B	astressin B inhibits the reaction [CRH protein results in increased expression of POMC protein alternative form]	14997174
C120841	astressin B	astressin B inhibits the reaction [CRH protein results in increased secretion of POMC protein alternative form]	10447963
D001280	Atrazine	Atrazine results in decreased expression of CRH mRNA	25929836
D001285	Atropine	[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein	12906840
D001285	Atropine	Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
D001285	Atropine	Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
D001285	Atropine	Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
D001285	Atropine	Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CRH mRNA	22316170
D001615	beta-Endorphin	beta-Endorphin inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]	3031743
D001615	beta-Endorphin	beta-Endorphin results in decreased secretion of CRH protein	3031743
D001615	beta-Endorphin	Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]	3031743
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of CRH protein	20833230
D004958	Estradiol	Estradiol inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	22384198
D015784	Betaxolol	Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]	18596687
C088060	bisindolylmaleimide	"bisindolylmaleimide inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Aflatoxin B1 results in increased expression of CRH mRNA]	26026912
C006780	bisphenol A	bisphenol A results in increased expression of CRH mRNA	22564983\|2578427
C006780	bisphenol A	bisphenol A results in increased expression of CRH mRNA	23545179
C006780	bisphenol A	bisphenol A results in increased expression of CRH protein	23545179
C006780	bisphenol A	[bisphenol A co-treated with Thyroxine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	[bisphenol A co-treated with Triiodothyronine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	bisphenol A inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	bisphenol A results in decreased expression of CRH mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CRH mRNA	24857958\|2606044
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Testosterone]]	2153673
D002104	Cadmium	Cadmium results in increased expression of CRH mRNA	24521933
C040048	caffeic acid	caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]	25404496
D002245	Carbon Dioxide	CRH protein results in increased susceptibility to Carbon Dioxide	8957205
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of CRH mRNA	16205782
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CRH mRNA	20682304
D002772	Cholera Toxin	CRH protein inhibits the reaction [[Cholera Toxin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]	2153673
D002772	Cholera Toxin	CRH protein inhibits the reaction [[Cholera Toxin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]	2153673
D002772	Cholera Toxin	CRH protein inhibits the reaction [Cholera Toxin results in increased chemical synthesis of Cyclic AMP]	2153673
D002772	Cholera Toxin	CRH protein inhibits the reaction [Cholera Toxin results in increased chemical synthesis of Testosterone]	2153673
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Ethanol] results in decreased expression of CRH mRNA"	22384198
D003024	Clozapine	Clozapine results in decreased expression of CRH mRNA	16205782
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of CRH protein	11232018
D003042	Cocaine	Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]	18596687
D003042	Cocaine	Cocaine affects the expression of CRH mRNA	11597771\|1278239
D003042	Cocaine	Cocaine affects the expression of CRH protein	7796157
D003042	Cocaine	Cocaine affects the reaction [CRH protein affects the secretion of Excitatory Amino Acid Agents]	15930388
D003042	Cocaine	SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]	11597771
D003078	Colchicine	Colchicine results in decreased expression of CRH protein	2453250
D003078	Colchicine	Colchicine results in increased expression of CRH mRNA	1850078
D005576	Colforsin	CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]	2153673
D005576	Colforsin	CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]	2153673
D005576	Colforsin	CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]	2153673
D005576	Colforsin	CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone]	2153673
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CRH mRNA	19549813
D003345	Corticosterone	CRH protein results in increased abundance of Corticosterone	21359208
D003345	Corticosterone	Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
D003345	Corticosterone	Corticosterone affects the expression of CRH mRNA	7816204
D003345	Corticosterone	Corticosterone affects the reaction [Nitroprusside results in increased secretion of CRH protein]	3015567
D003345	Corticosterone	Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]	18835572
D003345	Corticosterone	Corticosterone results in increased expression of CRH mRNA	26821211
D003345	Corticosterone	E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
C045089	corticotropin releasing hormone (9-41)	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]	1320258
C045089	corticotropin releasing hormone (9-41)	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Norepinephrine]	1320258
C045089	corticotropin releasing hormone (9-41)	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin]	14575894
D003471	Cuprizone	Cuprizone results in decreased expression of CRH mRNA	26577399\|2752363
D003484	Cyanamide	[Cyanamide co-treated with Ethanol] results in increased expression of CRH mRNA	16375214
D003484	Cyanamide	Cyanamide results in increased expression of CRH mRNA	10718921\|1097865
D003484	Cyanamide	[Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNA	11139417
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CRH mRNA	17335920
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CRH mRNA	15276878
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CRH protein	16614059
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
C017180	decamethrin	decamethrin results in increased expression of CRH mRNA	19017407
D013759	Dronabinol	Dronabinol results in decreased expression of CRH mRNA	21955143
D013759	Dronabinol	Dronabinol affects the reaction [rimonabant results in decreased expression of CRH mRNA]	15099659
D013759	Dronabinol	Dronabinol results in increased expression of CRH	10219981
D013759	Dronabinol	Dronabinol results in increased expression of CRH mRNA	11528220
D003907	Dexamethasone	Dexamethasone results in increased expression of CRH mRNA	18819432
D003976	Diazinon	Diazinon results in increased expression of CRH mRNA	20682304
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of CRH mRNA	26924002
D004026	Dieldrin	Dieldrin results in increased expression of CRH mRNA	20682304
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of CRH mRNA	26924002
D004177	Dipyrone	Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]	11852909
D004177	Dipyrone	Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]	11852909
D004177	Dipyrone	Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]	11852909
D004177	Dipyrone	Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein]	11852909
D004315	Doxapram	Doxapram results in increased expression of CRH mRNA	16269353
D004315	Doxapram	Doxapram results in increased expression of CRH protein	16269353
D004399	Dynorphins	Dynorphins inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]	3031743
D004399	Dynorphins	Dynorphins results in decreased secretion of CRH protein	3031743
D004399	Dynorphins	Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]	3031743
C063968	E 4031	E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]	18835572
D004837	Epinephrine	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]	1320258
D004837	Epinephrine	CRH results in increased abundance of Epinephrine	1320258
D000431	Ethanol	Ethanol results in increased expression of CRH mRNA	21955143
D000431	Ethanol	"[Cholesterol, Dietary co-treated with Ethanol] results in decreased expression of CRH mRNA"	22384198
D000431	Ethanol	[Cyanamide co-treated with Ethanol] results in increased expression of CRH mRNA	16375214
D000431	Ethanol	Estradiol inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	22384198
D000431	Ethanol	Ethanol affects the expression of CRH mRNA	18819432
D000431	Ethanol	[Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNA	11139417
D000431	Ethanol	Ethanol results in decreased expression of CRH mRNA	22039522
D000431	Ethanol	Ethanol results in increased expression of CRH mRNA	16925589\|2153323
D000431	Ethanol	Mifepristone inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	22039522
D018683	Excitatory Amino Acid Agents	Cocaine affects the reaction [CRH protein affects the secretion of Excitatory Amino Acid Agents]	15930388
D005283	Fentanyl	Fentanyl affects the expression of CRH mRNA	18819432
D018120	Finasteride	[Finasteride results in increased susceptibility to IL1B protein] which results in increased expression of CRH mRNA	19458216
D005411	Flame Retardants	Flame Retardants results in increased expression of CRH mRNA	19945756
D005419	Flavonoids	Flavonoids results in decreased expression of CRH mRNA	18035473
D005473	Fluoxetine	Fluoxetine results in decreased expression of CRH mRNA	20692053
D005473	Fluoxetine	Fluoxetine results in decreased expression of CRH mRNA	20374287
D005473	Fluoxetine	Fluoxetine results in decreased expression of CRH mRNA	1351783
D005473	Fluoxetine	Fluoxetine results in increased expression of CRH mRNA	9740405
D005557	Formaldehyde	Formaldehyde results in increased expression of CRH protein	15196973\|1580573
D019833	Genistein	"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in increased expression of CRH mRNA"	21816468
D019833	Genistein	"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in increased expression of CRH protein"	21816468
D005938	Glucocorticoids	CRH protein results in increased abundance of Glucocorticoids	7821275
C094503	glyceryl 2-arachidonate	CRH protein results in increased abundance of glyceryl 2-arachidonate	26821211
C004312	glycidol	glycidol results in decreased expression of CRH mRNA	24915197
C081021	Go 6976	CRH protein inhibits the reaction [Go 6976 results in increased abundance of Progesterone]	17170093
C081021	Go 6976	CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA]	17170093
C081021	Go 6976	CRH protein inhibits the reaction [Go 6976 results in increased expression of HSD3B1 mRNA]	17170093
D006160	Guanosine Triphosphate	Guanosine Triphosphate results in decreased activity of CRH protein	2153673
D006165	Guanylyl Imidodiphosphate	CRH protein inhibits the reaction [[LHB protein co-treated with Guanylyl Imidodiphosphate] results in increased chemical synthesis of Cyclic AMP]	2153673
D006165	Guanylyl Imidodiphosphate	Guanylyl Imidodiphosphate results in decreased activity of CRH protein	2153673
D006220	Haloperidol	Haloperidol results in decreased expression of CRH mRNA	16205782
D006427	Hemin	Hemin results in increased secretion of CRH protein	11232018
D006427	Hemin	mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]	11232018
D012701	Serotonin	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]	14575894
D012701	Serotonin	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin]	14575894
D012701	Serotonin	CRH protein results in increased secretion of Serotonin	14575894
C062018	HU 211	HU 211 results in decreased expression of CRH mRNA	12968131
C062018	HU 211	rimonabant inhibits the reaction [HU 211 results in decreased expression of CRH mRNA]	12968131
D006854	Hydrocortisone	CRH protein results in increased abundance of Hydrocortisone	2831029
D006854	Hydrocortisone	CRH protein results in increased abundance of Hydrocortisone	20570051\|8888355
D006854	Hydrocortisone	antalarmin affects the reaction [CRH protein results in increased abundance of Hydrocortisone]	14997174
D006854	Hydrocortisone	astressin B inhibits the reaction [CRH protein results in increased abundance of Hydrocortisone]	14997174
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CRH mRNA	26339600
D019329	Idazoxan	Idazoxan results in decreased expression of CRH mRNA	1351783
D007099	Imipramine	Imipramine affects the activity of CRH protein	2553044
D007213	Indomethacin	Indomethacin inhibits the reaction [IL1B protein results in increased secretion of CRH protein]	11852909
D007213	Indomethacin	Indomethacin inhibits the reaction [IL6 protein results in increased secretion of CRH protein]	11852909
D007213	Indomethacin	Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]	11852909
D007213	Indomethacin	Indomethacin inhibits the reaction [TNF protein results in increased secretion of CRH protein]	11852909
D007649	Ketamine	Ketamine results in decreased expression of CRH mRNA	20080153
C002385	linsidomine	CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]	10460269
C002385	linsidomine	linsidomine results in increased expression of CRH mRNA	10460269
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in increased expression of CRH mRNA"	21816468
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in increased expression of CRH protein"	21816468
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of CRH mRNA	15667454
D008070	Lipopolysaccharides	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]	21959975
D008070	Lipopolysaccharides	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH protein]	21959975
D008070	Lipopolysaccharides	Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]	11852909
D008070	Lipopolysaccharides	Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]	11852909
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CRH mRNA	21959975
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CRH protein	21959975
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of CRH protein	11852909
D008070	Lipopolysaccharides	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]	21959975
D008294	Malathion	caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]	25404496
D008294	Malathion	Malathion results in decreased expression of CRH mRNA	20233601\|2540449
D008345	Manganese	CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP]	2153673
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CRH mRNA	25064382
C031468	mesoporphyrin IX	mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]	11232018
C014655	methamidophos	Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
C014655	methamidophos	Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
C014655	methamidophos	gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
C014655	methamidophos	gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
C014655	methamidophos	methamidophos promotes the reaction [FOS protein binds to CRH promoter]	12039681
C014655	methamidophos	methamidophos results in increased expression of CRH mRNA	12039681
C014655	methamidophos	methamidophos results in increased secretion of CRH protein	12039681
C014655	methamidophos	Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
C014655	methamidophos	Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of CRH mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of CRH mRNA	19564919
D008729	Methoxamine	Methoxamine results in increased secretion of CRH protein	7816204
D008729	Methoxamine	Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein]	7816204
D015735	Mifepristone	Mifepristone inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	22039522
C517284	monomethyl phthalate	monomethyl phthalate results in decreased expression of CRH mRNA	26924002
D009020	Morphine	Morphine results in increased expression of CRH mRNA	21955143
D009270	Naloxone	Naloxone results in decreased expression of CRH mRNA	12431775
D009271	Naltrexone	Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]	3031743
D009271	Naltrexone	Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]	3031743
D009271	Naltrexone	Naltrexone results in increased secretion of CRH protein	3031743
C557222	N-arachidonoylethanolamine	CRH protein results in decreased abundance of N-arachidonoylethanolamine	26821211
D009532	Nickel	Nickel results in decreased expression of CRH mRNA	20682304
D009538	Nicotine	Nicotine results in decreased expression of CRH mRNA	21955143
D009538	Nicotine	Nicotine results in decreased expression of CRH mRNA	22265867
D009538	Nicotine	Nicotine results in decreased expression of CRH protein	22265867
D009538	Nicotine	Nicotine results in increased expression of CRH protein	23623838
D009569	Nitric Oxide	CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]	10460269
D009569	Nitric Oxide	Nitric Oxide results in increased expression of CRH mRNA	10460269
D020030	Nitric Oxide Donors	CRH protein affects the reaction [Nitric Oxide Donors results in increased secretion of POMC protein alternative form]	10460269
D020030	Nitric Oxide Donors	Nitric Oxide Donors results in increased expression of CRH mRNA	10460269
D009599	Nitroprusside	beta-Endorphin inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]	3031743
D009599	Nitroprusside	Corticosterone affects the reaction [Nitroprusside results in increased secretion of CRH protein]	3015567
D009599	Nitroprusside	Dynorphins inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]	3031743
D009599	Nitroprusside	Nitroprusside results in increased expression of and results in increased secretion of CRH protein	3497798
D009599	Nitroprusside	Nitroprusside results in increased secretion of CRH protein	3015567\|3031743
D009599	Nitroprusside	Yohimbine inhibits the reaction [Nitroprusside results in increased expression of and results in increased secretion of CRH protein]	3497798
D009599	Nitroprusside	Nitroprusside affects the expression of and affects the localization of CRH protein	19210399
D009638	Norepinephrine	corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Norepinephrine]	1320258
D009638	Norepinephrine	CRH results in increased abundance of Norepinephrine	1320258
D009638	Norepinephrine	Norepinephrine affects the expression of and affects the secretion of CRH protein	3497798
D009638	Norepinephrine	Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]	3497798
D009638	Norepinephrine	Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]	3497798
D009638	Norepinephrine	Norepinephrine affects the secretion of CRH protein	19210399
D017371	8-Hydroxy-2-(di-n-propylamino)tetralin	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]	14575894
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of CRH mRNA	22039834
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CRH mRNA	19945756
D010424	Pentobarbital	Pentobarbital affects the expression of CRH mRNA	18819432
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CRH mRNA	19703701
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of and results in decreased secretion of CRH protein	24440345
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CRH mRNA	24440345
D026023	Permethrin	Permethrin results in increased expression of CRH mRNA	19017407
D010575	Pesticides	Pesticides results in decreased expression of CRH mRNA	20233601
D010624	Phenelzine	Phenelzine results in decreased expression of CRH mRNA	1351783
D010672	Phenytoin	Phenytoin affects the expression of CRH mRNA	20345932
D011239	Prednisolone	Prednisolone results in decreased expression of CRH protein	9625448
D011239	Prednisolone	sairei-to inhibits the reaction [Prednisolone results in decreased expression of CRH protein]	9625448
D011280	Pregnanolone	Pregnanolone affects the expression of CRH mRNA	7816204
D011280	Pregnanolone	Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein]	7816204
D011374	Progesterone	CRH protein inhibits the reaction [Go 6976 results in increased abundance of Progesterone]	17170093
D011374	Progesterone	CRH protein results in decreased abundance of Progesterone	17170093
D011374	Progesterone	Progesterone promotes the reaction [CRHR1 protein binds to and results in increased activity of CRH protein]	20702571
D011374	Progesterone	Progesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]	20702571
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of CRH protein	20833230
D011374	Progesterone	CRH protein results in increased secretion of Progesterone	23133512
D011395	Promazine	Promazine results in decreased expression of CRH mRNA	16205782
D011433	Propranolol	Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]	3497798
D011433	Propranolol	Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]	12039681
D011433	Propranolol	Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]	12039681
D011433	Propranolol	Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]	12039681
D011433	Propranolol	Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]	12039681
C432165	pyrazolanthrone	"pyrazolanthrone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
D011794	Quercetin	Quercetin affects the expression of CRH mRNA	19423323
D020891	Raclopride	Raclopride results in decreased expression of CRH mRNA	16205782
D012110	Reserpine	Reserpine results in increased expression of CRH mRNA	1850078
D012110	Reserpine	Reserpine results in increased expression of CRH protein	1850078
C089032	rimonabant	Dronabinol affects the reaction [rimonabant results in decreased expression of CRH mRNA]	15099659
C089032	rimonabant	rimonabant inhibits the reaction [HU 211 results in decreased expression of CRH mRNA]	12968131
C089032	rimonabant	rimonabant results in decreased expression of CRH mRNA	15099659
D018967	Risperidone	Risperidone results in decreased expression of CRH mRNA	16205782
C025759	saikosaponin	saikosaponin results in increased expression of CRH mRNA	8552307
C080903	sairei-to	CRH protein affects the reaction [sairei-to results in increased expression of POMC protein]	8247339
C080903	sairei-to	sairei-to inhibits the reaction [Prednisolone results in decreased expression of CRH protein]	9625448
C080903	sairei-to	sairei-to results in increased expression of CRH protein	8233027
C080903	sairei-to	[sairei-to results in increased expression of CRH protein] which results in increased expression of POMC mRNA	8233027
C080903	sairei-to	[sairei-to results in increased expression of CRH protein] which results in increased expression of POMC protein	8233027
C093642	SB 203580	"SB 203580 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]"	28189027
C093642	SB 203580	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]	21959975
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of CRH mRNA	19564919
C534628	SCH 23390	SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]	11597771
C534628	SCH 23390	SCH 23390 results in increased expression of CRH mRNA	19564919
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CRH mRNA	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of CRH protein	22960421
D012999	Soman	Soman results in increased expression of CRH mRNA	19281266
D013110	Sphingosine	Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]	2153673
C085215	SR 140333	[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein	12906840
C073839	SR 48968	[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein	12906840
D019311	Staurosporine	Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]	2153673
D014284	Triiodothyronine	[bisphenol A co-treated with Triiodothyronine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D014284	Triiodothyronine	Cycloheximide inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D014284	Triiodothyronine	Dactinomycin inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D013726	Terbutaline	Terbutaline results in decreased expression of CRH mRNA	17127497
D013739	Testosterone	"2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine inhibits the reaction [CRH protein results in increased secretion of Testosterone]"	23133512
D013739	Testosterone	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Testosterone]]	2153673
D013739	Testosterone	CGA protein promotes the reaction [CRH protein results in increased secretion of Testosterone]	23133512
D013739	Testosterone	CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Testosterone]	2153673
D013739	Testosterone	CRH protein inhibits the reaction [CGB3 results in increased abundance of Testosterone]	18719027
D013739	Testosterone	CRH protein inhibits the reaction [[Cholera Toxin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]	2153673
D013739	Testosterone	CRH protein inhibits the reaction [Cholera Toxin results in increased chemical synthesis of Testosterone]	2153673
D013739	Testosterone	CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]	2153673
D013739	Testosterone	CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone]	2153673
D013739	Testosterone	CRH protein results in increased secretion of Testosterone	23133512
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CRH mRNA	11568361
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CRH mRNA	18824019
D019789	Tetraethylammonium	Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]	18835572
D013779	Tetrodotoxin	Tetrodotoxin results in decreased activity of CRH protein	12906840
D013881	Thioridazine	Thioridazine results in decreased expression of CRH mRNA	16205782
D013974	Thyroxine	[bisphenol A co-treated with Thyroxine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D013974	Thyroxine	Thyroxine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D014050	Toluene	Toluene results in increased expression of CRH protein	15707876
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of CRH mRNA	11959675
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of CRH mRNA	11668029
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CRH mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CRH mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CRH mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of CRH mRNA	24383497
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of CRH mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CRH gene	25560391
D020888	Vigabatrin	Vigabatrin results in increased expression of CRH mRNA	15869561
C025643	vinclozolin	vinclozolin results in decreased expression of CRH mRNA	21570938
D015016	Yohimbine	Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]	3497798
D015016	Yohimbine	Yohimbine inhibits the reaction [Nitroprusside results in increased expression of and results in increased secretion of CRH protein]	3497798
D015029	Zeranol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zeranol results in increased expression of CRH mRNA]	23538034
D015029	Zeranol	Zeranol results in increased expression of CRH mRNA	23538034
D015029	Zeranol	Zeranol results in increased expression of CRH protein	23538034

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	7477348
GO:0005179	hormone activity	-	TAS	7585095
GO:0005184	neuropeptide hormone activity	-	TAS	7867564
GO:0005515	protein binding	-	IPI	18234674 18801728 25416956
GO:0017045	corticotropin-releasing hormone activity	-	IBA	21873635
GO:0051430	corticotropin-releasing hormone receptor 1 binding	-	IEA	-
GO:0051431	corticotropin-releasing hormone receptor 2 binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IEA	-
GO:0001963	synaptic transmission, dopaminergic	-	IDA	12895416
GO:0003085	negative regulation of systemic arterial blood pressure	-	IEA	-
GO:0006704	glucocorticoid biosynthetic process	-	IEA	-
GO:0006954	inflammatory response	-	IDA	18559919
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	TAS	7867564
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007268	chemical synaptic transmission	-	TAS	7477348
GO:0007565	female pregnancy	-	IDA	18559919
GO:0007567	parturition	-	TAS	7585095
GO:0007611	learning or memory	-	TAS	7477348
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008306	associative learning	-	IEA	-
GO:0008628	hormone-mediated apoptotic signaling pathway	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IEA	-
GO:0010629	negative regulation of gene expression	-	IEA	-
GO:0010700	negative regulation of norepinephrine secretion	-	IEA	-
GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	-	NAS	18329818
GO:0010942	positive regulation of cell death	-	IEA	-
GO:0014062	regulation of serotonin secretion	-	IEA	-
GO:0016101	diterpenoid metabolic process	-	IEA	-
GO:0021854	hypothalamus development	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0030325	adrenal gland development	-	IEA	-
GO:0032811	negative regulation of epinephrine secretion	-	IBA	21873635
GO:0033685	negative regulation of luteinizing hormone secretion	-	IEA	-
GO:0035641	locomotory exploration behavior	-	IEA	-
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0035902	response to immobilization stress	-	IEA	-
GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	-	NAS	18329818
GO:0043627	response to estrogen	-	IEA	-
GO:0043950	positive regulation of cAMP-mediated signaling	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0045472	response to ether	-	IEA	-
GO:0048265	response to pain	-	IEA	-
GO:0050801	ion homeostasis	-	IEA	-
GO:0051412	response to corticosterone	-	IEA	-
GO:0051461	positive regulation of corticotropin secretion	-	IDA	11329063
GO:0051464	positive regulation of cortisol secretion	-	IBA	21873635
GO:0051464	positive regulation of cortisol secretion	-	IDA	18329818
GO:0060291	long-term synaptic potentiation	-	IEA	-
GO:0060456	positive regulation of digestive system process	-	IEA	-
GO:0060548	negative regulation of cell death	-	IEA	-
GO:0070093	negative regulation of glucagon secretion	-	IBA	21873635
GO:0071314	cellular response to cocaine	-	IEA	-
GO:0071549	cellular response to dexamethasone stimulus	-	IEA	-
GO:0090280	positive regulation of calcium ion import	-	IEA	-
GO:2000310	regulation of NMDA receptor activity	-	IDA	12895416
GO:2000854	positive regulation of corticosterone secretion	-	IEA	-
GO:2000987	positive regulation of behavioral fear response	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	18559919
GO:0005737	cytoplasm	-	IEA	-
GO:0043196	varicosity	-	IEA	-
GO:0043204	perikaryon	-	IEA	-

KEGG ID	KEGG Term
hsa04730	Long-term depression

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
2854897	Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls. (1988)	von Bardeleben U	Prog Neuropsychopharmacol Biol Psychiatry
29080551	The dexamethasone corticotropin releasing hormone test in healthy and depressed women with and without childhood adversity. (2018 Jan)	Spitzer C	Psychoneuroendocrinology
19349312	Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. (2009 Apr)	Brady KT	Arch Gen Psychiatry
24456850	Corticotropin releasing factor: a key role in the neurobiology of addiction. (2014 Apr)	Zorrilla EP	Front Neuroendocrinol
20585760	Central serotonin transporter levels are associated with stress hormone response and anxiety. (2011 Feb)	Reimold M	Psychopharmacology (Berl)
17086345	Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. (2006 Oct 31)	Sher L	ScientificWorldJournal
17015825	Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. (2006 Oct 10)	Hansson AC	Proc Natl Acad Sci U S A
15511714	Neuroendocrine pathways of addictive behaviour. (2004 Sep-Dec)	Kiefer F	Addict Biol
20570051	Influence of cocaine dependence and early life stress on pituitary-adrenal axis responses to CRH and the Trier social stressor. (2010 Nov)	Moran-Santa Maria MM	Psychoneuroendocrinology
15203442	No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism. (2004 Mar)	Soyka M	Addict Biol
19726138	Reactivity to laboratory stress provocation predicts relapse to cocaine. (2010 Jan 1)	Back SE	Drug Alcohol Depend
18449521	Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders. (2008 Jun)	Sommer WH	J Mol Med (Berl)
17293045	Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration. (2007 Mar 30)	Mantsch JR	Neurosci Lett
9696732	Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. (1998 Aug 1)	Chrousos GP	Ann Intern Med
21075083	Effects of perinatal cocaine exposure on open field behavior and the response to corticotropin releasing hormone (CRH) in rat offspring. (2011 Jan 25)	Sithisarn T	Brain Res
18209858	Pitfalls in the diagnosis of Cushing's syndrome. (2007 Nov)	Vilar L	Arq Bras Endocrinol Metabol
20618729	Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration. (2010 Jul 1)	Kramer MS	Paediatr Perinat Epidemiol
16325948	The hypothalamic-pituitary-adrenal (HPA) axis in habitual smokers. (2006 Mar)	Rohleder N	Int J Psychophysiol
28265716	Don't stress about CRF: assessing the translational failures of CRF1antagonists. (2017 May)	Spierling SR	Psychopharmacology (Berl)
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