Gene: CRHBP

1393
CRF-BP|CRFBP
corticotropin releasing hormone binding protein
protein-coding
5q13.3
Ensembl:ENSG00000145708 MIM:122559 Vega:OTTHUMG00000102133 UniprotKB:P24387
NC_000005.10
PubMed
0   ANCO-SNPs
CD|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.697e-1 (AD)  7.694e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SST0.883
TAC10.869
NXPH10.828
CORT0.828
GAD10.828
GAD20.825
KCNS30.819
RAB3B0.815
LHX60.812
VWC20.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC14A-0.567
NBPF10-0.55
STK17B-0.54
PARD3-0.538
HIF3A-0.536
CDA-0.528
NHSL1-0.522
HVCN1-0.519
TGFBR3-0.516
STON2-0.512

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRHBP mRNA"25614096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CRHBP mRNA"28973690
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRHBP mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of CRHBP mRNA16715494
C015001arsenitearsenite results in increased methylation of CRHBP promoter23974009
D001280AtrazineAtrazine results in increased expression of CRHBP mRNA26891955
D004958EstradiolEstradiol results in increased expression of CRHBP mRNA20833230
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of CRHBP mRNA]20833230
C006780bisphenol Abisphenol A affects the expression of CRHBP mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CRHBP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CRHBP gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CRHBP mRNA22079614
C054133casticincasticin results in decreased expression of CRHBP mRNA28444820
D004390ChlorpyrifosChlorpyrifos results in increased expression of CRHBP mRNA26775027
D004390ChlorpyrifosChlorpyrifos results in increased expression of CRHBP protein26775027
D003024ClozapineClozapine results in decreased expression of CRHBP mRNA16715494
D003042CocaineCocaine results in increased expression of CRHBP mRNA27899881
D003300CopperCopper deficiency results in increased expression of CRHBP mRNA26033743
C016366dibenzothiophenedibenzothiophene results in increased expression of CRHBP mRNA23656968
D004026DieldrinDieldrin results in decreased expression of CRHBP mRNA23041725
D019422Dietary SucroseDietary Sucrose results in increased expression of CRHBP mRNA26033743
D004317DoxorubicinDoxorubicin affects the expression of CRHBP mRNA15205334
D005472FluorouracilFluorouracil affects the expression of CRHBP mRNA15205334
D019833Genistein"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in decreased expression of CRHBP mRNA"21816468
D006220HaloperidolHaloperidol results in decreased expression of CRHBP mRNA16715494
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Genistein] results in decreased expression of CRHBP mRNA"21816468
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRHBP mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRHBP mRNA23483921
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CRHBP mRNA23483921
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CRHBP mRNA23458150
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of CRHBP mRNA22401849
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CRHBP mRNA26705709
C045362prochlorazprochloraz results in decreased expression of CRHBP mRNA21158436
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of CRHBP mRNA]20833230
D011441PropylthiouracilPropylthiouracil results in increased expression of CRHBP mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of CRHBP mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CRHBP mRNA23806026
D012999SomanSoman results in increased expression of CRHBP mRNA19281266
D014212TretinoinTretinoin results in decreased expression of CRHBP mRNA20488242
D014635Valproic AcidValproic Acid affects the expression of CRHBP mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CRHBP mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRHBP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18234674  
GO:0042277peptide binding-ISS-  
GO:0051424corticotropin-releasing hormone binding-IBA21873635  
GO:0051424corticotropin-releasing hormone binding-IDA1846945  
GO:0051424corticotropin-releasing hormone binding-IPI18234674  
GO ID GO Term Qualifier Evidence PubMed
GO:0001963synaptic transmission, dopaminergic-ISS-  
GO:0002125maternal aggressive behavior-IEA-  
GO:0006954inflammatory response-IDA18559919  
GO:0007165signal transduction-TAS7477348  
GO:0007565female pregnancy-IBA21873635  
GO:0007565female pregnancy-IDA18559919  
GO:0007565female pregnancy-IEP1846945  
GO:0007611learning or memory-TAS7477348  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0009755hormone-mediated signaling pathway-IDA18234674  
GO:0035690cellular response to drug-ISS-  
GO:0035865cellular response to potassium ion-IDA21624661  
GO:0042445hormone metabolic process-IBA21873635  
GO:0042445hormone metabolic process-IEA-  
GO:0045055regulated exocytosis-IDA21624661  
GO:0048149behavioral response to ethanol-IMP21039637  
GO:0051459regulation of corticotropin secretion-IDA13150566  
GO:0051460negative regulation of corticotropin secretion-IBA21873635  
GO:0051460negative regulation of corticotropin secretion-IDA1846945  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071314cellular response to cocaine-ISS-  
GO:0071320cellular response to cAMP-ISS-  
GO:0071356cellular response to tumor necrosis factor-IDA15345745  
GO:0071391cellular response to estrogen stimulus-IDA15345745  
GO:0071392cellular response to estradiol stimulus-IDA15345745  
GO:0080135regulation of cellular response to stress-IMP21039637  
GO:0097211cellular response to gonadotropin-releasing hormone-ISS-  
GO:1900011negative regulation of corticotropin-releasing hormone receptor activity-IBA21873635  
GO:1900011negative regulation of corticotropin-releasing hormone receptor activity-IDA18234674  
GO:2000310regulation of NMDA receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA1846945  18559919  
GO:0005622intracellular-ISS-  
GO:0005634nucleus-ISS-  
GO:0005767secondary lysosome-ISS-  
GO:0005771multivesicular body-ISS-  
GO:0005783endoplasmic reticulumNOTIDA21624661  
GO:0005794Golgi apparatusNOTIDA21624661  
GO:0005874microtubule-ISS-  
GO:0030141secretory granule-IBA21873635  
GO:0030141secretory granule-IDA21624661  
GO:0030425dendrite-ISS-  
GO:0031045dense core granule-ISS-  
GO:0043196varicosity-ISS-  
GO:0043204perikaryon-ISS-  
GO:0043679axon terminus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21810631Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system. (2011 Dec)Ribbe KArch Gen Psychiatry
27845775Defining the role of corticotropin releasing factor binding protein in alcohol consumption. (2016 Nov 15)Haass-Koffler CLTransl Psychiatry
23294766Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. (2013 Mar 1)Zorrilla EPDrug Alcohol Depend
29510883The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system? (2017 Oct 13)Haass-Koffler CLAlcohol
21143246Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. (2011 Mar)Kertes DAAlcohol Clin Exp Res
24766650Drug addiction and stress-response genetic variability: association study in African Americans. (2014 Jul)Levran OAnn Hum Genet