Gene: HDX

139324
CXorf43|D030011N01Rik
highly divergent homeobox
protein-coding
Xq21.1
Ensembl:ENSG00000165259 MIM:300994 Vega:OTTHUMG00000021926 UniprotKB:Q7Z353
NG_017158.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBR10.871
EPC20.866
FBXO280.862
KRR10.861
RNGTT0.856
CEP1700.852
RAB3GAP20.852
CDC400.851
ZNF5100.851
PPP2R5E0.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.413
OLAH-0.395
OR4F5-0.37
ACOX2-0.365
MYOM1-0.36
ASB4-0.357
FXYD3-0.35
PHYHD1-0.347
C22orf31-0.346
ACSF2-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of HDX mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of HDX mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HDX gene27153756
D000638AmiodaroneAmiodarone results in increased expression of HDX mRNA19774075
D001280AtrazineAtrazine results in increased expression of HDX mRNA25929836
C006780bisphenol Abisphenol A affects the methylation of HDX promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HDX mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of HDX mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of HDX mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HDX mRNA27392435
C118739entinostatentinostat results in decreased expression of HDX mRNA27188386
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HDX mRNA27392435
C544151jinfukangjinfukang results in decreased expression of HDX mRNA27392435
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HDX mRNA24058054
D013849ThimerosalThimerosal results in increased expression of HDX mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HDX mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of HDX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HDX mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of HDX gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26230583Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)Slattery MLPLoS One