Gene: CRHR1

1394
CRF-R|CRF-R-1|CRF-R1|CRF1|CRFR-1|CRFR1|CRH-R-1|CRH-R1|CRHR|CRHR1L
corticotropin releasing hormone receptor 1
protein-coding
17q21.31
Ensembl:ENSG00000120088 MIM:122561 Vega:OTTHUMG00000178271 UniprotKB:P34998
NG_009902.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
25   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.716e-1 (AD)  6.258e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNMA30.924
COL26A10.917
RHOBTB20.913
ABCG40.909
NPM20.903
LRTM20.902
ADAM110.901
PKNOX20.898
SLC6A70.896
LRFN20.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNN2-0.601
WWTR1-0.597
REST-0.596
RAI14-0.582
SGMS2-0.575
CLEC2B-0.573
YES1-0.566
BAZ1A-0.566
RBPMS-0.551
KIAA0040-0.548

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09067Corticorelin ovine triflutateSmall Molecule121249-14-7ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CRHR1 mRNA"19114083
C4712102-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine"2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine binds to and results in decreased activity of CRHR1 protein"15593376
C4712102-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine"2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine binds to and results in decreased activity of CRHR1 protein"15831766|1642014
C5292954-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridine"4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridine binds to and results in decreased activity of CRHR1 protein"23294766
C4517254-(2-chloro-4-methoxy-5-methylphenyl)-N(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine"4-(2-chloro-4-methoxy-5-methylphenyl)-N(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine binds to and results in decreased activity of CRHR1 protein"21618986|2329476
C4171904-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine binds to and results in decreased activity of CRHR1 protein"11641109|1567384
C5479264-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)-1,3,5-triazine"4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)-1,3,5-triazine binds to and results in decreased activity of CRHR1 protein"21618986
D000082AcetaminophenAcetaminophen results in decreased expression of CRHR1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CRHR1 mRNA26690555
D019342Acetic AcidCRHR1 gene mutant form results in increased susceptibility to Acetic Acid28434951
D000242Cyclic AMP[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP20702571
D000242Cyclic AMPProgesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]20702571
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRHR1 mRNA16483693
C103016antalarminantalarmin binds to and results in decreased activity of CRHR1 protein16014403
C103016antalarminantalarmin binds to and results in decreased activity of CRHR1 protein9645712
C103016antalarminantalarmin binds to and results in decreased activity of CRHR1 protein14997174|1933961
D001151ArsenicArsenic results in decreased expression of CRHR1 protein18573533
C104416astressinastressin binds to and results in decreased activity of CRHR1 protein15593376
C104416astressinastressin binds to and results in decreased activity of CRHR1 protein16014403
C120841astressin Bastressin B binds to and results in decreased activity of CRHR1 protein11641109|1274630
D004958EstradiolEstradiol results in increased expression of CRHR1 mRNA alternative form20702571
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CRHR1 mRNA20833230
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CRHR1 protein20833230
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CRHR1 gene28505145
C584056BMS-764459BMS-764459 binds to and results in decreased activity of CRHR1 protein23831372
C018475butyraldehydebutyraldehyde results in increased expression of CRHR1 mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CRHR1 mRNA24763279
D003042CocaineCocaine results in increased expression of CRHR1 protein17079348
D003345CorticosteroneCorticosterone results in decreased expression of CRHR1 mRNA18363858
C045089corticotropin releasing hormone (9-41)corticotropin releasing hormone (9-41) results in decreased activity of CRHR1 protein15486230
C101628CP 154526CP 154526 binds to and results in decreased activity of CRHR1 protein17119930
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Methamphetamine17119930
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone24398105
C101628CP 154526CP 154526 binds to and results in decreased activity of CRHR1 protein11027923|1127500
C117406CRA1000CRA1000 binds to and results in decreased activity of CRHR1 protein12631246
D003346Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone results in decreased activity of CRHR1 protein12093084
D003346Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA12093084
D003346Corticotropin-Releasing HormonePentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]12093084
D003346Corticotropin-Releasing HormonePentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]12093084
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CRHR1 mRNA23640034
D003976DiazinonDiazinon results in increased methylation of CRHR1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CRHR1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of CRHR1 mRNA18721800
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CRHR1 mRNA28871463
D005473FluoxetineFluoxetine results in increased expression of CRHR1 mRNA9740405
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CRHR1 gene28505145
C030691gluconic acidgluconic acid results in increased expression of CRHR1 mRNA16556975
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CRHR1 mRNA24763279
C552097GW 876008GW 876008 binds to and results in decreased activity of CRHR1 protein23294766
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CRHR1 mRNA12419474
D007608Kainic AcidKainic Acid results in increased expression of CRHR1 mRNA12093084
D007854LeadLead results in increased expression of CRHR1 mRNA19921347
C002385linsidominelinsidomine results in increased expression of CRHR1 mRNA10460269
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CRHR1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CRHR1 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRHR1 mRNA23483921
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CRHR1 protein23483921
D008694Methamphetamine[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Methamphetamine17119930
D008713MethimazoleMethimazole results in decreased expression of CRHR1 mRNA17403546
D008731MethoxychlorMethoxychlor results in increased methylation of CRHR1 gene23303685
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CRHR1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of CRHR1 mRNA12710931
D009020MorphineCRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]25582704
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]24398105
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]24398105
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]24398105
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]24398105
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]24398105
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency24398105
C561056N-(1-ethylpropyl)-(3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl)amineN-(1-ethylpropyl)-(3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl)amine binds to and results in decreased activity of CRHR1 protein21618986
D009270NaloxoneCRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]25582704
D009270NaloxoneCRHR1 gene mutant form results in increased susceptibility to Naloxone28434951
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]24398105
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]24398105
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]24398105
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone24398105
C556497NBI 77860NBI 77860 binds to and results in decreased activity of CRHR1 protein23294766
D009569Nitric OxideNitric Oxide results in increased expression of CRHR1 mRNA10460269
D020030Nitric Oxide DonorsNitric Oxide Donors results in increased expression of CRHR1 mRNA10460269
D009638Norepinephrine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]24398105
D009638Norepinephrine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]24398105
C025589ochratoxin Aochratoxin A results in increased acetylation of CRHR1 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of CRHR1 promoter] which results in increased expression of CRHR1 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of CRHR1 mRNA29098329
D010416PentachlorophenolPentachlorophenol results in increased expression of CRHR1 mRNA23892564
C046012pentanalpentanal results in increased expression of CRHR1 mRNA26079696
D010424PentobarbitalPentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]12093084
D010424PentobarbitalPentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]12093084
C494474perchlorateperchlorate results in decreased expression of CRHR1 mRNA17403546
C542342pexacerfontpexacerfont binds to and results in decreased activity of CRHR1 protein19342506|2045524
C113202phenylalanyl corticotropin-releasing factor (12-41)phenylalanyl corticotropin-releasing factor (12-41) binds to and results in decreased activity of CRHR1 protein10516337
C113202phenylalanyl corticotropin-releasing factor (12-41)phenylalanyl corticotropin-releasing factor (12-41) binds to and results in decreased activity of CRHR1 protein11797056|1914522
D010936Plant ExtractsPlant Extracts results in decreased expression of CRHR1 mRNA23557933
D011374ProgesteroneProgesterone promotes the reaction [CRHR1 protein binds to and results in increased activity of CRH protein]20702571
D011374ProgesteroneProgesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]20702571
D011374ProgesteroneProgesterone results in increased expression of CRHR1 mRNA20702571
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CRHR1 mRNA20833230
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CRHR1 protein20833230
C005556propionaldehydepropionaldehyde results in decreased expression of CRHR1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CRHR1 mRNA17403546
C412383R 121919R 121919 binds to and results in decreased activity of CRHR1 protein21220416
C412383R 121919R 121919 binds to and results in decreased activity of CRHR1 protein12746300|1593675
D012293RifampinRifampin results in decreased expression of CRHR1 mRNA24552687
D018038Sodium SeleniteSodium Selenite results in increased expression of CRHR1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRHR1 mRNA21296121
D014230TriazolesTriazoles analog binds to and results in decreased activity of CRHR1 protein11720866
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CRHR1 mRNA15178552
D014635Valproic AcidValproic Acid results in increased methylation of CRHR1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRHR1 gene25560391
D015029ZeranolZeranol results in increased expression of CRHR1 mRNA24120472

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18801728  
GO:0015056corticotrophin-releasing factor receptor activity-IBA21873635  
GO:0015056corticotrophin-releasing factor receptor activity-IDA18292205  
GO:0017046peptide hormone binding-IBA21873635  
GO:0043404corticotropin-releasing hormone receptor activity-IBA21873635  
GO:0051424corticotropin-releasing hormone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS7692441  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA18292205  
GO:0007190activation of adenylate cyclase activity-TAS10598591  
GO:0007565female pregnancy-NAS7585095  
GO:0007567parturition-TAS10598591  
GO:0010578regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway-IMP23863939  
GO:0051458corticotropin secretion-ISS-  
GO:0071376cellular response to corticotropin-releasing hormone stimulus-IDA18292205  
GO:1901386negative regulation of voltage-gated calcium channel activity-IDA18292205  
GO:2000852regulation of corticosterone secretion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10598591  
GO:0016021integral component of membrane-IDA23863939  
GO:0031226intrinsic component of plasma membrane-IDA18292205  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21810631Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system. (2011 Dec)Ribbe KArch Gen Psychiatry
29497387Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism. (2018)Logrip MLFront Psychiatry
24845178Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)Levran OPsychoneuroendocrinology
23294766Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. (2013 Mar 1)Zorrilla EPDrug Alcohol Depend
28237884Effects of crack cocaine addiction and stress-related genes on peripheral BDNF levels. (2017 Jul)Rovaris DLJ Psychiatr Res
27544317Effects of corticotropin-releasing hormone receptor 1 SNPs on major depressive disorder are influenced by sex and smoking status. (2016 Nov 15)da Silva BSJ Affect Disord
29391279Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. (2018 May 1)Xiao HWToxicol Lett
16550213Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. (2006 Jun)Treutlein JMol Psychiatry
21193270Genetic moderators and psychiatric mediators of the link between sexual abuse and alcohol dependence. (2011 Jun 1)Copeland WEDrug Alcohol Depend
22113086Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. (2012 Mar)Molander ANeuropsychopharmacology
20374216Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. (2010 Jun)Chen ACAlcohol Clin Exp Res
29325449Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. (2018 Jan 12)Marzi SJAm J Psychiatry
20813242Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. (2010)Bjork KInt Rev Neurobiol
19878140H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. (2010 Jan)Nelson ECAddict Biol
23473364The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G x E effects. (2013 Jun)Ray LAGenes Brain Behav
17015825Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. (2006 Oct 10)Hansson ACProc Natl Acad Sci U S A
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
15992556Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence. (2005 Sep)Dahl JPJ Psychiatr Res
17585886Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. (2008 Jan 15)Sommer WHBiol Psychiatry
19210659Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. (2009 Mar)Kim WJRespirology
21998007A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. (2011 Dec)Kranzler HRAm J Med Genet B Neuropsychiatr Genet
24623788Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex. (2014 Mar 12)Glaser YGJ Neurosci
25802844Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. (2015)Tang XBiomed Res Int
24091936Genetic influences on the development of alcoholism. (2013 Nov)Enoch MACurr Psychiatry Rep
27397864Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction. (2016 Sep)Rovaris DLEur Neuropsychopharmacol