Gene: CRHR2

1395
CRF-RB|CRF2|CRFR2|HM-CRF
corticotropin releasing hormone receptor 2
protein-coding
7p14.3
Ensembl:ENSG00000106113 MIM:602034 Vega:OTTHUMG00000023218 UniprotKB:Q13324
NG_029169.1
PubMed
0   ANCO-SNPs
OD|AD
4   
7.522e-1 (AD)  6.362e-1 (ND)   (Frontal_Cortex)
8.039e-1 (AD)  3.016e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNC30.822
VWA70.818
TIAM20.803
RTN4RL10.802
CACNA1C0.801
CACNA1B0.798
FAM135B0.795
DLGAP20.792
EML60.791
FSTL40.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.483
HEY2-0.473
YES1-0.458
AAMDC-0.457
MYL3-0.448
MBNL3-0.436
SNHG18-0.436
PINLYP-0.435
NXT2-0.426
BCL7C-0.423

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRHR2 mRNA16483693
D000661AmphetamineAmphetamine results in increased expression of CRHR2 protein18585412
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CRHR2 mRNA24449571
D001151ArsenicArsenic affects the methylation of CRHR2 gene25304211
C104416astressinastressin binds to and results in decreased activity of CRHR2 protein15593376
C104416astressinastressin binds to and results in decreased activity of CRHR2 protein16014403
C528574astressin-2Bastressin-2B binds to and results in decreased activity of CRHR2 protein11751155|1565265
C120841astressin Bastressin B binds to and results in decreased activity of CRHR2 protein16014403
C120841astressin Bastressin B binds to and results in decreased activity of CRHR2 protein11641109
D001280AtrazineAtrazine results in increased expression of CRHR2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CRHR2 mRNA27195522
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CRHR2 mRNA20833230
D004958EstradiolEstradiol results in increased expression of CRHR2 protein20833230
C006780bisphenol Abisphenol A results in decreased expression of CRHR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CRHR2 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CRHR2 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CRHR2 mRNA12734012
D002713ChlorineChlorine results in increased expression of CRHR2 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CRHR2 mRNA18636392
D003520CyclophosphamideCyclophosphamide results in increased expression of CRHR2 protein16614059
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CRHR2 mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of CRHR2 mRNA15620428
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CRHR2 mRNA17555576
D019833GenisteinGenistein results in increased expression of CRHR2 mRNA22553218
C008261lead acetatelead acetate results in increased expression of CRHR2 mRNA22613225
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CRHR2 mRNA"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CRHR2 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CRHR2 mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CRHR2 mRNA27935865
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CRHR2 mRNA18636392
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CRHR2 mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of CRHR2 mRNA23602845
C113202phenylalanyl corticotropin-releasing factor (12-41)phenylalanyl corticotropin-releasing factor (12-41) binds to and results in decreased activity of CRHR2 protein19145226
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CRHR2 mRNA27935865
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CRHR2 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of CRHR2 mRNA17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of CRHR2 mRNA23557933
C035988procymidoneprocymidone results in decreased expression of CRHR2 mRNA15686871
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CRHR2 mRNA20833230
D011441PropylthiouracilPropylthiouracil results in decreased expression of CRHR2 mRNA24780913
C025727sauvaginesauvagine binds to and results in decreased activity of CRHR2 protein11641109|1565265
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CRHR2 mRNA25895662
D053260SootSoot results in increased expression of CRHR2 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of CRHR2 mRNA17555576
C041348tcdA protein, Clostridium difficile"CRHR2 protein affects the reaction [tcdA protein, Clostridium difficile results in increased expression of CCL2 mRNA]"16920976
C041348tcdA protein, Clostridium difficile"CRHR2 protein affects the reaction [tcdA protein, Clostridium difficile results in increased expression of CXCL1 mRNA]"16920976
C041348tcdA protein, Clostridium difficile"CRHR2 protein affects the susceptibility to tcdA protein, Clostridium difficile"16920976
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRHR2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRHR2 mRNA20558275
D013974ThyroxineThyroxine results in decreased expression of CRHR2 mRNA17403546
C009495titanium dioxidetitanium dioxide results in decreased expression of CRHR2 mRNA23557971
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRHR2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CRHR2 mRNA15686871

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11329063  
GO:0015056corticotrophin-releasing factor receptor activity-IBA21873635  
GO:0015056corticotrophin-releasing factor receptor activity-TAS9717834  
GO:0017046peptide hormone binding-IBA21873635  
GO:0043404corticotropin-releasing hormone receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-TAS8536644  
GO:0060291long-term synaptic potentiation-IBA21873635  
GO:0071376cellular response to corticotropin-releasing hormone stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8536644  
GO:0030424axon-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0043679axon terminus-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24845178Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)Levran OPsychoneuroendocrinology
17585886Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. (2008 Jan 15)Sommer WHBiol Psychiatry
19630743From QTL to candidate gene: a genetic approach to alcoholism research. (2009 May)Spence JPCurr Drug Abuse Rev
24611993Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. (2014 May)Yong WAlcohol Clin Exp Res