Gene info: ID 1398

Gene: CRK

GENE ID: 1398

Synonyms: CRKII|p38

Description: CRK proto-oncogene, adaptor protein

Gene type: protein-coding

Location: 17p13.3

dbXrefs: Ensembl:ENSG00000167193 MIM:164762 Vega:OTTHUMG00000090317 UniprotKB:P46108

RefSeq: NG_029008.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.946e-1 (AD) 2.906e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UBE2D3	0.938
NCOA4	0.921
SERBP1	0.917
CAP1	0.917
GOLPH3	0.917
TMED2	0.916
RAB10	0.915
COPB2	0.914
CANX	0.914
EIF3J	0.914

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.787
OR4F29	-0.769
TCL1A	-0.152
HES5	-0.132
NXNL1	-0.127
PATE3	-0.125
TPPP2	-0.124
C16orf97	-0.123
RNASE8	-0.122
SMCP	-0.119

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]"	16187300
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of CRK mRNA	20829426
D000082	Acetaminophen	Acetaminophen results in increased expression of CRK mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of CRK mRNA	15800402
D000082	Acetaminophen	Acetaminophen results in increased expression of CRK protein	15800402
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CRK mRNA	19770486
D006710	Homocysteine	[Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein	17116298
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CRK mRNA	16483693
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of CRK mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CRK mRNA	27858113
D001554	Benzene	Benzene results in increased expression of CRK mRNA	15929907
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CRK mRNA	27858113
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in increased expression of CRK protein modified form	24464499
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CRK mRNA	27858113
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CRK mRNA"	19150397\|2001819
D004958	Estradiol	[Estradiol co-treated with Testosterone] results in increased expression of CRK mRNA	11375906
C006780	bisphenol A	bisphenol A results in decreased expression of CRK mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CRK mRNA	29097150
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CRK mRNA	28628672
D002087	Butyrates	Butyrates results in decreased expression of CRK mRNA	14674679
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CRK mRNA	18804290
D012844	Sincalide	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]"	16187300
D012844	Sincalide	Egtazic Acid inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]	16187300
D012844	Sincalide	Sincalide results in increased phosphorylation of CRK protein	16187300
D012844	Sincalide	Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]	16187300
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of CRK mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CRK mRNA	23650126
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CRK mRNA	27858113
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CRK mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of CRK mRNA	26577399
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CRK mRNA	23914054
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CRK mRNA	28628672
D003976	Diazinon	Diazinon affects the expression of CRK mRNA	22546817
D002945	Cisplatin	[Piroxicam co-treated with Cisplatin] results in decreased expression of CRK mRNA	21858171
D002945	Cisplatin	Cisplatin results in increased expression of CRK mRNA	21151649
D004026	Dieldrin	Dieldrin affects the expression of CRK mRNA	22546817
D004237	Diuron	Diuron results in increased expression of CRK mRNA	21551480
D004533	Egtazic Acid	Egtazic Acid inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]	16187300
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CRK mRNA	12655031
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRK mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CRK mRNA	29097150
D005419	Flavonoids	Flavonoids results in decreased expression of CRK mRNA	18035473
D005472	Fluorouracil	CRK protein affects the susceptibility to Fluorouracil	16217747
D019833	Genistein	Genistein results in increased expression of CRK mRNA	17341692
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [CRK protein binds to PTK2B protein]	16187300
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of CRK protein	16187300
D006861	Hydrogen Peroxide	tyrphostin B44 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CRK protein]	16187300
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CRK mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CRK mRNA	28628672
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CRK mRNA"	18930950
D008148	Lovastatin	Lovastatin results in increased expression of CRK mRNA	20493250
D008694	Methamphetamine	Methamphetamine results in decreased expression of CRK protein	19826936
D008715	Methionine	[Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein	17116298
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CRK mRNA	18804290
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of CRK protein	26558463
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CRK mRNA"	26251327
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CRK mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CRK mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CRK mRNA"	25620056
C022838	nickel chloride	nickel chloride affects the expression of CRK mRNA	22546817
D009569	Nitric Oxide	Nitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein]	12714323
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CRK mRNA	22037397
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of CRK mRNA	18636392
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CRK protein	19954255
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased expression of CRK mRNA	28973697
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CRK mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of CRK mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of CRK mRNA	19363144
D010634	Phenobarbital	Phenobarbital results in increased expression of CRK mRNA	22037397
D010656	Phenylephrine	ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]	17615370
D010656	Phenylephrine	ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]	17615370
D010656	Phenylephrine	Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]	17615370
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CRK mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of CRK mRNA	18445702
D010894	Piroxicam	[Piroxicam co-treated with Cisplatin] results in decreased expression of CRK mRNA	21858171
C045950	propiconazole	propiconazole results in decreased expression of CRK mRNA	19363144
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of CRK mRNA"	21152443
C009166	retinol acetate	retinol acetate results in increased expression of CRK mRNA	16772331
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CRK protein	28918527
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in increased expression of CRK protein modified form	24464499
D053260	Soot	Soot results in decreased expression of CRK protein modified form	24464499
D013012	Sorbitol	Sorbitol results in increased phosphorylation of CRK protein	16187300
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of CRK mRNA	16214533
D013739	Testosterone	[Estradiol co-treated with Testosterone] results in increased expression of CRK mRNA	11375906
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CRK mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRK mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CRK mRNA	19465110\|2135428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CRK mRNA	15358164
D019284	Thapsigargin	Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]	16187300
C001899	triptolide	triptolide results in decreased expression of CRK mRNA	23639586
C001899	triptolide	triptolide results in increased expression of CRK mRNA	23639586
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CRK mRNA"	18930950
C100661	tyrphostin B44	tyrphostin B44 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CRK protein]	16187300
C100661	tyrphostin B44	tyrphostin B44 results in decreased phosphorylation of CRK protein	16187300
D014635	Valproic Acid	Valproic Acid results in increased expression of CRK mRNA	23179753
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CRK gene	25560391
D014859	Warfarin	Warfarin results in increased expression of CRK mRNA	20493250
D014873	Water Pollutants	Water Pollutants results in decreased expression of CRK mRNA	23591932

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IPI	20624904
GO:0005070	SH3/SH2 adaptor activity	-	IDA	12384576 17515907
GO:0005159	insulin-like growth factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	7561682 8524328 8621483 8626543 9472046 9546424 9788432 10464310 10733900 11316748 12384576 12799422 12878163 14657239 15581361 15834156 15886098 16189514 16273093 16713569 16982329 17038317 17474147 17515907 19004829 19380743 19447967 20534451 21044950 21988832 23275563 23397142 24658140 24728074 25241761 25416956 25544563 25814554 26871637 27107012
GO:0008092	cytoskeletal protein binding	-	IEA	-
GO:0017124	SH3 domain binding	-	IPI	12384576
GO:0042169	SH2 domain binding	-	IPI	9472046 12384576
GO:0043621	protein self-association	-	IDA	17515907
GO:0045309	protein phosphorylated amino acid binding	-	IDA	12384576
GO:0046875	ephrin receptor binding	-	IPI	11870224
GO:0097110	scaffold protein binding	-	IEA	-
GO:1990782	protein tyrosine kinase binding	-	IPI	12384576

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000186	activation of MAPKK activity	-	TAS	-
GO:0001878	response to yeast	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	10748058
GO:0008360	regulation of cell shape	-	IMP	17515907
GO:0009966	regulation of signal transduction	-	IDA	17515907
GO:0014911	positive regulation of smooth muscle cell migration	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0032956	regulation of actin cytoskeleton organization	-	IDA	11870224
GO:0035020	regulation of Rac protein signal transduction	-	IEA	-
GO:0035728	response to hepatocyte growth factor	-	IEA	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043087	regulation of GTPase activity	-	IDA	11870224
GO:0043393	regulation of protein binding	-	IMP	17515907
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	-	IEA	-
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048013	ephrin receptor signaling pathway	-	IDA	11870224
GO:0061045	negative regulation of wound healing	-	IDA	17515907
GO:0061045	negative regulation of wound healing	-	IMP	17515907
GO:0061847	response to cholecystokinin	-	IEA	-
GO:0071538	SH2 domain-mediated complex assembly	-	IDA	12384576
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	-
GO:0071732	cellular response to nitric oxide	-	IEA	-
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	-	IMP	19004829
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	-
GO:1990314	cellular response to insulin-like growth factor stimulus	-	IEA	-
GO:1990859	cellular response to endothelin	-	IEA	-
GO:2000146	negative regulation of cell motility	-	IDA	17515907
GO:2000146	negative regulation of cell motility	-	IMP	17515907

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	TAS	10748058
GO:0005737	cytoplasm	-	IC	11870224
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0015629	actin cytoskeleton	-	IEA	-
GO:0032991	protein-containing complex	-	IPI	12384576
GO:0045121	membrane raft	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04062	Chemokine signaling pathway
hsa04510	Focal adhesion
hsa04666	Fc gamma R-mediated phagocytosis
hsa04722	Neurotrophin signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa05100	Bacterial invasion of epithelial cells
hsa05131	Shigellosis
hsa05200	Pathways in cancer
hsa05211	Renal cell carcinoma
hsa05220	Chronic myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-169893	Prolonged ERK activation events	TAS
R-HSA-169893	Prolonged ERK activation events	IEA
R-HSA-170984	ARMS-mediated activation	TAS
R-HSA-170984	ARMS-mediated activation	IEA
R-HSA-186763	Downstream signal transduction	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	IEA
R-HSA-187687	Signalling to ERKs	TAS
R-HSA-187687	Signalling to ERKs	IEA
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-354192	Integrin alphaIIb beta3 signaling	TAS
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-8848021	Signaling by PTK6	TAS
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	TAS
R-HSA-8875555	MET activates RAP1 and RAC1	TAS
R-HSA-8875656	MET receptor recycling	TAS
R-HSA-8875878	MET promotes cell motility	TAS
R-HSA-9006921	Integrin signaling	TAS
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-912631	Regulation of signaling by CBL	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27111700	Crack-cocaine dependence and aging: effects on working memory. (2016 Mar)	Sanvicente-Vieira B	Rev Bras Psiquiatr