Gene: ADORA3

140
A3AR
adenosine A3 receptor
protein-coding
1p13.2
Ensembl:ENSG00000282608 MIM:600445 Vega:OTTHUMG00000011957 UniprotKB:P0DMS8
NG_032119.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.499e-1 (AD)  2.133e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAPTM50.933
HAVCR20.924
HCLS10.911
ALOX5AP0.907
ITGB20.906
C3AR10.902
SASH30.902
FGD20.898
SIGLEC100.897
PTPN60.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.432
ATP2C2-0.426
HES5-0.42
KCNIP3-0.397
MARCH4-0.396
YBX2-0.383
ABCC12-0.381
CPLX3-0.364
NEUROD6-0.363
ADRA1D-0.358

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00640AdenosineSmall Molecule58-61-7Approved|InvestigationalTarget
DB00824EnprofyllineSmall Molecule41078-02-8Approved|InvestigationalTarget
DB01223AminophyllineSmall Molecule317-34-0ApprovedTarget
DB05511PiclidenosonSmall Molecule152918-18-8InvestigationalTarget
ID Drug Name Action PubMed
C4191462,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate binds to and results in decreased activity of ADORA3 protein"19966059|2086066
C4191462,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]"19966059
C4191462,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]"19966059
C4191462,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate binds to and results in decreased activity of ADORA3 protein"10854059|1191183
C0010732,4-dinitrobenzenesulfonic acid"2,4-dinitrobenzenesulfonic acid results in increased expression of ADORA3 mRNA"20860664
C0010732,4-dinitrobenzenesulfonic acid"2,4-dinitrobenzenesulfonic acid results in increased expression of ADORA3 protein"20860664
C0900342-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide binds to and results in increased activity of ADORA3 protein18727925
C0900342-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide[2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to cobaltous chloride18727925
C0900342-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamideADORA3 protein affects the susceptibility to 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide20132822
C0900342-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide binds to and results in increased activity of ADORA3 protein20860664
C0900342-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide binds to and results in increased activity of ADORA3 protein10854059|1601186
C5616364-allyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo(2,1-i)purin-5(4H)-one"4-allyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo(2,1-i)purin-5(4H)-one analog inhibits the reaction [MRE 3008-F20 binds to ADORA3 protein]"21675777
C4386138-ethyl-4-methyl-2-phenyl-4,5,7,8-tetrahydro-1H-imidazo(2,1-i)purin-5-one"8-ethyl-4-methyl-2-phenyl-4,5,7,8-tetrahydro-1H-imidazo(2,1-i)purin-5-one binds to and results in decreased activity of ADORA3 protein"21675777
C1100419-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline"9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline binds to and results in decreased activity of ADORA3 protein"18079280
C1100419-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline"9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline binds to and results in decreased activity of ADORA3 protein"11911839|1598727
D020106AcrylamideAcrylamide results in decreased expression of ADORA3 mRNA28959563
D000241AdenosineAdenosine analog binds to and affects the activity of ADORA3 protein20571079
D000241AdenosineAdenosine analog binds to and results in decreased activity of ADORA3 protein18404447
D000241AdenosineAdenosine analog binds to and results in increased activity of ADORA3 protein11520205
D000241AdenosineAdenosine binds to ADORA3 protein18404447
D000241AdenosineAdenosine results in increased expression of ADORA3 mRNA20067761
D000241AdenosinePD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]20571079
D000241AdenosineVUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]20571079
D000241AdenosineAdenosine results in increased activity of ADORA3 protein19488739
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ADORA3 gene27153756
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]"19966059
C523965alpha,beta-methyleneadenosine 5'-diphosphate"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]"19966059
D000638AmiodaroneAmiodarone results in increased expression of ADORA3 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADORA3 mRNA16483693
D001241AspirinADORA3 protein affects the susceptibility to Aspirin20716228
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADORA3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ADORA3 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of ADORA3 mRNA25181051
D002104CadmiumCadmium results in decreased expression of ADORA3 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADORA3 mRNA12160620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADORA3 mRNA18263696
C478920CF101CF101 results in decreased expression of ADORA3 mRNA17101059
C478920CF101CF101 results in decreased expression of ADORA3 protein17101059
C478920CF101CF101 binds to and results in increased activity of ADORA3 protein17101059
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of ADORA3 mRNA18636392
D0157622-ChloroadenosineADORA3 protein results in increased susceptibility to 2-Chloroadenosine18838560
C018021cobaltous chloride[2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to cobaltous chloride18727925
C018021cobaltous chlorideADORA3 protein results in decreased susceptibility to cobaltous chloride18727925
D019327Copper SulfateCopper Sulfate results in decreased expression of ADORA3 mRNA19549813
D004205Cromolyn SodiumCromolyn Sodium results in decreased activity of ADORA3 protein15641640
D016572CyclosporineCyclosporine results in decreased methylation of ADORA3 promoter27989131
D003907DexamethasoneDexamethasone results in increased expression of ADORA3 mRNA7730645
D003907DexamethasoneDexamethasone results in increased expression of ADORA3 protein7730645
D002945CisplatinCisplatin results in increased expression of ADORA3 mRNA27594783
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ADORA3 mRNA15620428
C014476diethyl maleatediethyl maleate results in decreased expression of ADORA3 mRNA21161181
D002117CalcitriolCalcitriol results in decreased expression of ADORA3 mRNA26485663
D004176DipyridamoleDipyridamole results in increased expression of ADORA3 protein17101059
D016291Dizocilpine Maleate[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate12672554
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) binds to ADORA3 protein21186795
D007213IndomethacinIndomethacin results in increased expression of ADORA3 mRNA17568578
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADORA3 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADORA3 mRNA20067761
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADORA3 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADORA3 mRNA10975854
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of ADORA3 mRNA20843944
D008694MethamphetamineADORA3 affects the susceptibility to Methamphetamine21867746
D008694MethamphetamineMethamphetamine results in decreased expression of ADORA3 mRNA19564919
D008727MethotrexateMethotrexate results in increased expression of ADORA3 protein17101059
D008727MethotrexateMethotrexate results in increased expression of ADORA3 mRNA17101059
D008727MethotrexateMethotrexate results in increased expression of ADORA3 protein17101059
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA3 mRNA23519560
C405605MRE 3008-F20"4-allyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo(2,1-i)purin-5(4H)-one analog inhibits the reaction [MRE 3008-F20 binds to ADORA3 protein]"21675777
C405605MRE 3008-F20MRE 3008-F20 binds to ADORA3 protein21675777
C523799MRK 003ADORA3 results in increased susceptibility to MRK 00319903844
C107728MRS 1191MRS 1191 binds to and results in decreased activity of ADORA3 protein18079280
C107728MRS 1191[MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]15345477
C107728MRS 1191[MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BCL2 protein]15345477
C107728MRS 1191[MRS 1191 results in decreased activity of ADORA3 protein] which results in decreased susceptibility to resveratrol15345477
C107728MRS 1191MRS 1191 binds to and results in decreased activity of ADORA3 protein11992407|1601186
C107728MRS 1191MRS 1191 results in decreased activity of ADORA3 protein15345477
C086112N(6)-2-(4-aminophenyl)ethyladenosineN(6)-2-(4-aminophenyl)ethyladenosine binds to and results in increased activity of ADORA3 protein11992407
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein12672554
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate12672554
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine Hydrobromide12672554
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]"19966059
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]"19966059
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein15452191|1996605
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]19966059
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]19966059
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein16025880|1608812
C409723N(6)-benzyl-5'-N-ethylcarboxamidoadenosineN(6)-benzyl-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein11992407
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ADORA3 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADORA3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADORA3 mRNA"25554681
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of ADORA3 mRNA18636392
C075004PD 81723PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]20571079
D010634PhenobarbitalPhenobarbital results in decreased expression of ADORA3 mRNA19162173
D010656Phenylephrine"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]"19966059
D010656Phenylephrine"2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]"19966059
D010656PhenylephrineADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]"19966059
D010656Phenylephrine"alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]"19966059
D010656PhenylephrineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]19966059
D010656PhenylephrineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA3 mRNA19966059
D010656PhenylephrinePhenylephrine results in increased expression of ADORA3 protein19966059
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]19966059
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]19966059
C043680ptaquilosideptaquiloside results in decreased expression of ADORA3 mRNA23274088
D011720PyrazolesPyrazoles analog binds to and results in decreased activity of ADORA3 protein16033279
D011804QuinolinesQuinolines analog binds to and results in decreased activity of ADORA3 protein16033279
C059514resveratrol[MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BAD protein]15345477
C059514resveratrol[MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [resveratrol results in increased phosphorylation of BCL2 protein]15345477
C059514resveratrol[MRS 1191 results in decreased activity of ADORA3 protein] which results in decreased susceptibility to resveratrol15345477
D012601Scopolamine Hydrobromide[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine Hydrobromide12672554
D012834SilverSilver results in decreased expression of ADORA3 mRNA26551752
C016104sodium bichromatesodium bichromate results in decreased expression of ADORA3 mRNA17685462
D053260SootSoot results in increased expression of ADORA3 mRNA26551751
C016766sulforafansulforafan results in increased expression of ADORA3 mRNA26833863
C061133tamibarotenetamibarotene affects the expression of ADORA3 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ADORA3 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA3 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADORA3 mRNA25613284
D014212TretinoinTretinoin affects the expression of ADORA3 mRNA15498508
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADORA3 gene25560391
C438612VUF 5455VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]20571079

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001609G-protein coupled adenosine receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001973adenosine receptor signaling pathway-IEA-  
GO:0006954inflammatory response-TAS9164961  
GO:0007165signal transduction-TAS8399349  9380026  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007190activation of adenylate cyclase activity-TAS9380026  
GO:0008016regulation of heart contraction-TAS9837869  
GO:0008285negative regulation of cell proliferation-IMP27886186  
GO:0009611response to wounding-TAS9837869  
GO:0030336negative regulation of cell migration-IMP27886186  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP27886186  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8399349  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-417973Adenosine P1 receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19635926Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. (2009 Aug 15)Shaykhiev RJ Immunol