Gene: CRMP1

1400
CRMP-1|DPYSL1|DRP-1|DRP1|ULIP-3
collapsin response mediator protein 1
protein-coding
4p16.2
Ensembl:ENSG00000072832 MIM:602462 Vega:OTTHUMG00000125489 UniprotKB:Q14194
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.304e-1 (AD)  8.833e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7654446chr4:5837110 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FARSA0.973
ATP6V0D10.967
RNF1870.965
OTUB10.965
PPP5C0.964
DNAJC50.964
LSM14B0.963
VPS26B0.963
CADM30.961
COPS7A0.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.677
OR4F29-0.613
RAI14-0.444
TFPI2-0.427
CXCR2-0.424
KCNJ15-0.416
CST7-0.415
REST-0.411
CLEC2B-0.411
IL18RAP-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of CRMP1 protein"27026707
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CRMP1 mRNA"20406850
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in decreased expression of CRMP1 mRNA14610520
D000082AcetaminophenAcetaminophen results in increased expression of CRMP1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CRMP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CRMP1 mRNA22100608
D000068180AripiprazoleAripiprazole results in increased expression of CRMP1 mRNA17868501
D004958EstradiolEstradiol results in decreased phosphorylation of CRMP1 protein27026707
C006780bisphenol Abisphenol A affects the expression of CRMP1 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of CRMP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CRMP1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CRMP1 mRNA24982889
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CRMP1 mRNA20360939
D013759DronabinolDronabinol results in increased expression of CRMP1 protein18584336
D002945CisplatinCisplatin results in increased phosphorylation of CRMP1 protein22006019
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CRMP1 mRNA20360939
D004397FonofosFonofos results in increased methylation of CRMP1 promoter22847954
D005947GlucoseCRMP1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
D007657Ketone BodiesKetone Bodies results in increased expression of CRMP1 mRNA16807920
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CRMP1 protein"21135415
D010100OxygenOxygen deficiency results in increased expression of CRMP1 protein25937538
D010100OxygenCRMP1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
D010278ParathionParathion results in increased methylation of CRMP1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CRMP1 protein19954255
C046012pentanalpentanal results in increased expression of CRMP1 mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CRMP1 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in increased expression of CRMP1 mRNA24780913
C488333Ro 65-7199Ro 65-7199 results in decreased expression of CRMP1 mRNA14610520
D012402RotenoneRotenone affects the expression of CRMP1 mRNA23186747
D012645SelenomethionineSelenomethionine affects the expression of CRMP1 mRNA17222674
C017947sodium arsenitesodium arsenite affects the methylation of CRMP1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of CRMP1 mRNA25879800
D018038Sodium SeleniteSodium Selenite results in decreased expression of CRMP1 mRNA18175754
C012568terbufosterbufos results in increased methylation of CRMP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRMP1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CRMP1 mRNA25680692
D014212TretinoinTretinoin results in decreased expression of CRMP1 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CRMP1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of CRMP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CRMP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CRMP1 mRNA23179753|2519280
D014635Valproic AcidValproic Acid affects the expression of CRMP1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRMP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15383276  16169070  21900206  25416956  
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds-IEA-  
GO:0031005filamin binding-IPI25358863  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IEA-  
GO:0006139nucleobase-containing compound metabolic process-TAS8973361  
GO:0007399nervous system development-TAS8973361  
GO:0007411axon guidance-IEA-  
GO:0010977negative regulation of neuron projection development-IGI25358863  
GO:1904530negative regulation of actin filament binding-IDA25358863  
GO:1904530negative regulation of actin filament binding-IMP25358863  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA-  
GO:0005819spindle-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0030496midbody-IDA19799413  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal