Gene: CRX

1406
CORD2|CRD|LCA7|OTX3
cone-rod homeobox
protein-coding
19q13.33
Ensembl:ENSG00000105392 MIM:602225 Vega:OTTHUMG00000170610 UniprotKB:O43186
NG_008605.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.209e-1 (AD)  8.122e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEC10.777
KRT33A0.767
TPRX10.751
RBM460.747
ARL14EPL0.692
SBK30.683
FOXA30.664
NCR30.651
TMEM950.64
HTR3D0.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK4-0.269
CKMT1B-0.255
OMG-0.249
C2orf27A-0.245
ASIC2-0.239
PDGFRA-0.228
CAMK1G-0.22
MYT1-0.214
NXPH1-0.214
RAB26-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CRX mRNA"25614096
D000082AcetaminophenAcetaminophen affects the expression of CRX mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRX mRNA16483693
C006780bisphenol Abisphenol A affects the methylation of CRX promoter27334623
D002166CamptothecinCRX mRNA results in decreased susceptibility to Camptothecin25269479
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CRX mRNA26033743
D003300CopperCopper deficiency results in increased expression of CRX mRNA26033743
C016366dibenzothiophenedibenzothiophene results in decreased expression of CRX mRNA23656968
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CRX mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CRX mRNA26033743
C008261lead acetatelead acetate results in decreased expression of CRX mRNA22641619
D010936Plant ExtractsPlant Extracts results in decreased expression of CRX mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CRX mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of CRX mRNA26079696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRX mRNA16962184|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRX mRNA24058054
D014118Toxins, Biological"Toxins, Biological affects the expression of CRX mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of CRX mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CRX mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10625658  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10625658  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI16189514  22458338  25416956  25910212  26871637  27107014  
GO:0035257nuclear hormone receptor binding-ISS-  
GO:0043522leucine zipper domain binding-IPI10887186  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007601visual perception-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0009887animal organ morphogenesis-TAS9390563  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10625658  
GO:0046534positive regulation of photoreceptor cell differentiation-IEA-  
GO:0050896response to stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
15895516Seasonal changes in the relationship between serum concentration of beta-cryptoxanthin and serum lipid levels. (2004 Dec)Sugiura MJ Nutr Sci Vitaminol (Tokyo)
18932026Characteristics of lung cancer patients with asbestos-related radiological findings. (2008)Ak GTuberk Toraks
15386932Multiple linear regression analysis of the seasonal changes in the serum concentration of beta-cryptoxanthin. (2004 Jun)Sugiura MJ Nutr Sci Vitaminol (Tokyo)