Gene: NEK7

140609
-
NIMA related kinase 7
protein-coding
1q31.3
Ensembl:ENSG00000151414 MIM:606848 Vega:OTTHUMG00000035658 UniprotKB:Q8TDX7
NC_000001.11
SNP Mapped
7   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.869e-1 (AD)  4.273e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16842754chr1:198308005 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs12407433chr1:198305778 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10494769chr1:198305231 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs16842733chr1:198304970 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs16842730chr1:198304759 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs1475423chr1:198254360 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10494765chr1:198245912 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF5B0.917
KLHL50.912
FGF10.91
SNX60.893
ZEB20.893
SOS20.887
ANKRD400.881
RASSF20.879
HIPK20.879
ZCCHC240.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH22-0.557
PCDH8-0.533
KCNK3-0.53
PNPLA5-0.529
ASB2-0.529
TCERG1L-0.525
ABCG4-0.52
LRRC73-0.515
KCNQ4-0.512
SCRT2-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of NEK7 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NEK7 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of NEK7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NEK7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NEK7 mRNA23630614
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NEK7 mRNA"23195993
C006632arsenic trioxidearsenic trioxide results in increased expression of NEK7 mRNA22521957
D001280AtrazineAtrazine results in increased expression of NEK7 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of NEK7 gene25435355
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NEK7 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEK7 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEK7 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NEK7 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of NEK7 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NEK7 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of NEK7 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NEK7 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of NEK7 mRNA26496021
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NEK7 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of NEK7 mRNA19376846
D003471CuprizoneCuprizone results in decreased expression of NEK7 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of NEK7 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NEK7 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NEK7 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NEK7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NEK7 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of NEK7 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of NEK7 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of NEK7 mRNA]19030233
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NEK7 mRNA28196854
D018120FinasterideFinasteride results in increased expression of NEK7 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NEK7 mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of NEK7 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of NEK7 mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NEK7 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NEK7 mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NEK7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NEK7 mRNA"25620056
D009532NickelNickel results in decreased expression of NEK7 mRNA23195993
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NEK7 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of NEK7 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of NEK7 mRNA18301758|1844570
C045950propiconazolepropiconazole results in decreased expression of NEK7 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of NEK7 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NEK7 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of NEK7 mRNA14699072
C089032rimonabantrimonabant affects the expression of NEK7 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of NEK7 mRNA]19030233
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NEK7 mRNA25895662
D013467SulindacSulindac results in decreased expression of NEK7 mRNA24136188
D013629TamoxifenESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of NEK7 mRNA14699072
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of NEK7 mRNA26496021
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NEK7 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEK7 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEK7 mRNA19770486|2527062
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NEK7 mRNA15034205
D014520UrethaneUrethane results in increased expression of NEK7 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of NEK7 gene29154799
C025643vinclozolinvinclozolin affects the expression of NEK7 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of NEK7 mRNA20566332
C025643vinclozolinvinclozolin results in increased expression of NEK7 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0005515protein binding-IPI20562859  27173435  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA12840024  
GO:0007346regulation of mitotic cell cycle-TAS17727698  
GO:0032212positive regulation of telomere maintenance via telomerase-IMP21531765  
GO:0051225spindle assembly-TAS17727698  
GO:0051973positive regulation of telomerase activity-IMP21531765  
GO:1904355positive regulation of telomere capping-IMP21531765  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005874microtubule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7TAS
R-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal